| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.72567935 |
| It is possible that Shc and insulin receptor substrate ( IRS ) 1 can interact competitively , via their phosphotyrosine binding ( PTB ) domains , with the activated IGF 1 receptor . 0.72567935^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.84220487 |
| Cloning , chromosome localization , expression , and characterization of an Src homology 2 and pleckstrin homology domain containing insulin receptor binding protein hGrb10gamma . hGrb10alpha ( previously named Grb IR ) is a Src homology 2 domain containing protein that binds with high affinity to the tyrosine phosphorylated insulin receptor and insulin like growth factor 1 receptor . 0.84220487^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.63371979 |
| The carboxyl terminal domain of insulin like growth factor 1 receptor interacts with the insulin receptor and activates its protein tyrosine kinase . 0.63371979^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Three IgG mAbs were specific for the human IGF 1 receptor and displayed negligible crossreactivity with the human insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| IGF 1 receptor and insulin receptor mRNA could be detected on Northern blot without any degradation . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| This increase in binding was associated with increased steady state levels of insulin receptor and IGF 1 receptor mRNA levels . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The subunit sizes of the B 2 reactive IGF 1 receptor were similar to those of the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| These effects were blocked by the insulin receptor monoclonal antibody MA 10 , but not by the IGF 1 receptor antibody alpha IR 3 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In undifferentiated cells the IGF 1 receptor concentration is twice that of the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In these characteristics , the retinal IGF 1 receptor is similar to the retinal insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The rat IGF 1 receptor has no equivalent to the alternatively spliced exon 11 of the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The ligands and the IGF 1 receptor are structurally related to insulin and to the insulin receptor , respectively . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The yyFH mutation results in an IGF 1 receptor with the amino acids found in the homologous position of the human insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Both undamaged and damaged utricles showed mRNA for Insulin receptor , IGF 1 receptor , FGF receptor 1 , EGF receptor , and PDGF alpha receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Sos complexes from the IGF 1 receptor , as it is from the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| These findings confirmed the absence of the insulin receptor and indicated that insulin acts here through activation of the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The adapter protein Grb 10 associates preferentially with the insulin receptor as compared with the IGF 1 receptor in mouse fibroblasts . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We identified insulin receptor substrate 1 ( IRS 1 ) as a common substrate for insulin and IGF 1 receptor tyrosine kinases . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Early bovine embryos also express IGF 1 , IGF 2 , IGF 1 receptor , IGF 2 receptor , and insulin receptor mRNAs . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor ( IR ) shares structural and functional homology with the IGF 1 receptor ( IGF IR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| A significant increase in the expression of IGF 1 , IGF 2 , the IGF 1 receptor , and the insulin receptor also was noted . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Further , during early bone growth GLUT 4 may be regulated through the IGF 1 receptor rather than via the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| VSMC antiproliferative strategies employing receptor blockade should be directed against the IGF 1 receptor , not the insulin receptor . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Properties of an insulin receptor with an IGF 1 receptor loop exchange in the cysteine rich region . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In parallel , IGF 1 activates IGF 1 receptor , insulin receptor substrate 1 ( IRS 1 ) , phosphatidylinositol 3 ( PI 3 ) kinase , and FAK . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Mitogenic potencies in general correlated better with IGF 1 receptor affinities than with insulin receptor off rates . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| This may be mediated via the IGF 1 receptor , by cross reactivity with the insulin receptor , or by activation of hybrid receptors . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor ( IR ) and IGF 1 receptor ( IGF IR ) are structurally and functionally related and belong to the tyrosine kinase receptor family . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| On the contrary , insulin induced cell migration was inhibited by blocking the insulin receptor but not the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Furthermore , beta cell expression of IGF 1 receptor ( Igf1r ) and insulin receptor ( Insr ) is mandatory for several steps of insulin secretion . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Our aim was to characterise the expression and function of IGF 1 receptor ( IGF IR ) and insulin receptor ( IR ) in HCASMCs . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| By contrast , both IGF 1 receptor and insulin receptor mRNA levels increase in day 7 AH 130 hosts . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Involvement of Src homology / collagen ( SHC ) proteins in signaling through the insulin receptor and the insulin like growth factor 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| How does the mitogenic insulin like growth factor 1 receptor differ from the metabolic insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 1 receptor and insulin receptor association with a Src homology 2 domain containing putative adapter . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We have identified a member of the insulin receptor ( InsR ) / insulin like growth factor 1 receptor ( IGF 1R ) family . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| IRR , insulin receptor ( IR ) , and insulin like growth factor 1 receptor ( IGF 1 R ) are all tyrosine kinases . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor ( IR ) and insulin like growth factor 1 receptor ( IGF IR ) are closely related receptor tyrosine kinases . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 1 receptor signaling and nuclear translocation of insulin receptor substrates 1 and 2 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin , insulin receptor and insulin like growth factor 1 receptor on the human ocular surface . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 is an interacting partner of the insulin like growth factor 1 receptor ( IGF IR ) and the insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Its receptor ( IGF1R ) displays considerable structural similarity to the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Moreover , the IGF IR and its two substrates , insulin receptor substrate 1 and SHC , were contained within the E cadherin complexes . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Interaction of MAD 2 with the carboxyl terminus of the insulin receptor but not with the IGFIR . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Transcripts for all three receptors ( insulin receptor , IGF1R , IGF2R ) were present in human oocytes and preimplantation embryos . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| These actions are mediated through the type 1 IGF receptor ( IGF 1R ) , a tyrosine kinase that resembles the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Primary bovine mammary cells express the two IGF receptors ( IGF IR , IGF IIR ) , insulin receptor , and four IGFBPs ( IGFBP 2 , 3 , 4 , and 5 ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Downstream of IGF IR , insulin receptor substrate 1 was phosphorylated , leading to the activation of phosphatidylinositol 3 ' kinase ( PI 3K ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| H 19 7 / IGF IR cells have low levels of expression of insulin receptor substrate l ( IRS 1 ) , a major substrate of the IGF IR . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Immunohistology was also performed for insulin receptor IGF 1R and IGF binding proteins 3 and 4 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| This effect involves an interaction between Rad 51 and the major IGF IR signaling molecule , insulin receptor substrate 1 ( IRS 1 ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| A 12 did not block insulin binding to the insulin receptor but could block binding to atypical IGF IR in MCF 7 cells . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Design of specific kinase inhibitors is problematic because of homology between the IGF1R and insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| CLA decreased IGF IR and insulin receptor substrate ( IRS ) 1 protein levels . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In addition , IGF 1 induced IGF IR and insulin receptor substrate 1 phosphorylation were greatly impaired in ATM deficient cells . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Tumors from AS [ S ] ODN treated mice showed a decrease in IGF IR expression and in insulin receptor substrate 1 tyrosine phosphorylation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Expression of insulin receptor , IGF 1R , TrkA and C was decreased in BB / Wor rats , whereas BBZDR / Wor rats showed milder or no deficits . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In vitro , IGF IR deficient Arg59Ter cells expressed less IGF IR and unchanged insulin receptor ( IR ) protein . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The IGF 1 receptor that is a tyrosine kinase and closely related with the insulin receptor and the IGF II / mannose 6 phosphate ( IGF II / Man 6 P ) receptor that is identical with the cation independent mannose 6 phosphate receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The actions of the IGFs are mediated through their activation of specific cell surface receptors , primarily the IGF 1 receptor , although some effects may be mediated through the IGF 2 receptor and the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To approach the question of why insulin like growth factor 1 ( IGF 1 ) and insulin have different physiological actions , we developed antibodies directed against cytoplasmic regions of the IGF 1 receptor exhibiting a low degree of homology with the corresponding sequences of the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Subtypes of insulin growth factor 1 ( IGF 1 ) receptors , including hybrid receptors containing insulin receptor alpha beta dimers associated with IGF 1 receptor alpha beta dimers , have been described in a number of systems . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Cells expressing both receptors also express hybrid receptors that contain one insulin receptor alpha and beta subunit , and one IGF 1 receptor alpha and beta subunit . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The biological activity of insulin like growth factor 1 ( IGF 1 ) is mediated by a transmembrane glycoprotein ( type 1 IGF receptor or IGF 1 receptor ) that shows considerable sequence homology with the insulin receptor . ^^^ The cDNA fragment corresponded to nucleotides 326 599 of the human IGF 1 receptor cDNA and showed 86 . 1 and 69 . 3 % homology at the nucleotide level and 96 . 7 and 80 . 2 % homology at the amino acid level with the human IGF 1 receptor and insulin receptor respectively . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Although the regulation of the insulin receptor tyrosine kinase has been extensively investigated , the mechanisms involved in phosphorylation / dephosphorylation of the IGF 1 receptor have received only little attention . ^^^ The sensitivity of the activated human IGF 1 receptor to dephosphorylation on tyrosine leads to the speculation that IGF 1 receptor activity might be regulated by mechanisms such as those described for the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| These results suggest that insulin via the IGF 1 receptor or insulin receptor can function as an autocrine or paracrine growth factor in these T ALLs . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The abundance of insulin receptor mRNA exceeded that for IGF 1 receptor mRNA in liver and yolk sac at all times studied . ^^^ This difference was greater in liver , where insulin receptor mRNAs were three to more than 50 times more abundant than IGF 1 receptor mRNA on gestation days E 13 E16 , times which antedate the development of significant hepatic metabolic actions of insulin . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Colloidal gold immunocytochemistry with antibodies directed against the insulin receptor , IGF 1 receptor and IGF 1 ligand has confirmed the presence of these molecules in bovine blastocysts . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin stimulated PDH activity 3 4 fold in cells that overexpressed normal human insulin receptors , but not in cells expressing TMI receptors , composed of the ligand binding domain of the insulin receptor coupled to the transmembrane and intracellular components of the IGF 1 receptor , or CEX receptors , in which the carboxy terminal 110 amino acid portion of the insulin receptor was exchanged for the corresponding portion of the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| These results indicate that ( 1 ) the high affinity of binding of insulin to its receptor can occur in the absence of insulin receptor specific residues encoded by exon 3 , the cysteine rich region ; ( 2 ) the cysteine rich region of the IGF 1 receptor can confer high affinity binding to both IGF 1 and IGF 2 ; and 3 ) the IRR is unlikely to be a receptor for either IGF 1 , IGF 2 , or relaxin . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin and insulin like growth factor 1 ( IGF 1 ) initiate their metabolic , growth , and differentiation effects through binding to the insulin receptor and the IGF 1 receptor , two members of the tyrosine kinase family of receptors . ^^^ To study the role of these peptides and receptors in early development , we used the polymerase chain reaction and embryo derived RNA to generate partial cDNA sequences of the insulin receptor and IGF 1 receptor from the amphibian Xenopus laevis . ^^^ On the basis of these similarities , the pattern of conserved amino acids , and the tetraploid nature of the Xenopus genome , we suggest that XTK 1a and XTK 1b most likely represent the product of two different nonallelic insulin receptor genes , while XTK 2 may be one of the probable two Xenopus IGF 1 receptor genes . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We found that replacement of the amino terminal 137 amino acids of the insulin receptor ( IR ) with the corresponding 131 amino acids of the IGF 1 receptor ( IGF 1R ) resulted in loss of affinity for both ligands . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Binding of both hormones to their own receptors was highly specific as compared with binding to the respective other receptor ( insulin receptor : KD = 3 . 6 nM , KI of IGF 1 greater than 500 nM ; IGF 1 receptor , KD = 1 . 1 nM , KI of insulin = 191 nM ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Chem . 264 , 9994 10001 ] that polylysine had no effect on the IGF 1 receptor TPK despite its 84 % identity to the insulin receptor TPK . ^^^ We report that the IGF 1 receptor TPK is stimulated by polycations and basic proteins in a manner similar to their effects on the insulin receptor TPK . ^^^ When effects of polylysine and polyarginine on both receptor TPKs were closely compared , subtle qualitative differences were found : Polylysine stimulated autophosphorylation and exogenous substrate phosphorylation activities of both insulin receptor TPK and IGF 1 receptor TPK similarly . ^^^ In contrast , another polycation , polyarginine , affected both TPKs in a manner quite different from polylysine : Polyarginine stimulated insulin receptor autophosphorylation to a greater extent than polylysine did while it had a very small effect on the IGF 1 receptor autophosphorylation as well as the exogenous substrate phosphorylation activities of the two receptor TPKs . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The increase in phosphorylation of insulin receptor in response to IGF 1 correlated with the dose response of IGF 1 stimulated phosphorylation of the IGF 1 receptor . 4 . ^^^ The IGF 1 stimulated phosphorylation of the insulin receptor could be blocked by preincubation with a monoclonal antibody that blocks IGF 1 binding to the IGF 1 receptor . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We report two chicken sequences that , by comparison with known tyrosine kinases , appear to correspond to the tyrosine kinase domain of the insulin receptor homologue ( CTK 1 ) and the IGF 1 receptor homologue ( CTK 2 ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| It thus appears that IGF 1 and IGF 2 are mitogens for normal and transformed human keratinocytes and that their actions are primarily mediated through the type 1 IGF receptor , whereas insulin is a mitogen through both the IGF 1 receptor and the insulin receptor . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Two color flow cytometric analysis of mononuclear cells stained with mouse monoclonal antibodies specific for the human IGF 1 receptor , the human insulin receptor , and monoclonal antibodies directed against specific monocyte and lymphocyte subset cell surface antigens revealed that both IGF 1 receptors and insulin receptors were present on nearly all monocytes and B lymphocytes , but were present on only 2 % of T lymphocytes . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In contrast , insulin receptor transcripts were restricted to certain areas in which they were coexpressed with the IGF 1 receptor transcripts . ^^^ However , astrocytes expressed preferentially IGF 1 receptor transcripts , while young progenitors for oligodendrocytes expressed high levels of insulin receptor transcripts . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Binding studies revealed that a construct comprising an IGF 1 receptor in which the 68 N terminal amino acids of the insulin receptor alpha subunit had replaced the equivalent IGF 1 receptor segment displayed a markedly increased affinity for insulin . ^^^ We have previously shown that exchanging exons 1 , 2 , and 3 of the insulin receptor with the corresponding IGF 1 receptor sequence results in loss of high affinity for insulin and gain of high affinity for IGF 1 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To examine the role of the N terminal part of the insulin like growth factor 1 ( IGF 1 ) receptor and insulin receptor in determining ligand specificity , we prepared an expression vector encoding a hybrid receptor where exon 1 ( encoding the signal peptide and seven amino acids of the alpha subunit ) , exon 2 , and exon 3 of the insulin receptor were replaced with the corresponding IGF 1 receptor cDNA ( 938 nucleotides ) . ^^^ To allow direct quantitative comparison of the binding capabilities of this hybrid receptor with those of the human IGF 1 receptor and the insulin receptor , all three receptors were expressed in baby hamster kidney ( BHK ) cells as soluble molecules and partially purified before characterization . ^^^ The hybrid IGF I / insulin receptor bound IGF 1 with an affinity comparable to that of the wild type IGF 1 receptor . ^^^ These results directly demonstrate that it is possible to change the specificity of the insulin receptor to that of the IGF 1 receptor and , furthermore , that the binding specificity for IGF 1 is encoded within the nucleotide sequence from 135 to 938 of the IGF 1 receptor cDNA . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In contrast , antibodies to other cytoplasmic regions did not recognize the IGF 1 receptor as well as the insulin receptor . ^^^ In addition , these results suggest that a portion of the insulin receptor is highly homologous to that of the IGF 1 receptor . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| It is concluded that the anti ( insulin receptor ) antibodies do not react directly with IGF 1 receptor polypeptide , and that the apparent immunoreactivity of a subfraction of IGF 1 receptors reflects their physical association with insulin receptors , both in cell extracts and in intact cells . ^^^ The most likely basis for this association appears to be a ' hybrid ' receptor containing one half ( alpha beta ) of insulin receptor polypeptide and the other ( alpha ' beta ' ) of IGF 1 receptor polypeptide within the native ( alpha beta beta ' alpha ' ) heterotetrameric structure . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In addition , the alpha subunit of IGF 1 receptor is approximately 10 , 000 Mr larger than the alpha subunit of insulin receptor , and IGF 1 stimulates phosphorylation of the beta subunit of the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Because IGF 1 binding to the fibroblasts from the patient was normal and alpha subunit of IGF 1 receptor was 135 KDa , the defect was specific to the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In contrast , insulin stimulated phosphorylation of the beta subunit of the IGF 1 receptor at hormone concentrations that were associated with significant occupancy of the insulin receptor but negligible IGF 1 receptor occupancy . ^^^ These findings indicate that the IGF 1 receptor can be a substrate for the hormone activated insulin receptor tyrosine kinase activity in intact L 6 skeletal muscle cells . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| An MAb that specifically binds to the IGF 1 receptor ( but not to the insulin receptor ) mediates a dose dependent inhibition of cell growth in basal media as well as IGF 1 , IGF 2 , or insulin supplemented media . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In analogy with the 152 , 784 Mr insulin receptor precursor , cleavage of the Arg Lys Arg Arg sequence at position 707 of the IGF 1 receptor precursor will generate alpha ( 80 , 423 Mr ) and beta ( 70 , 866 Mr ) subunits , which compare with approximately 135 , 000 Mr ( alpha ) and 90 , 000 Mr ( beta ) fully glycosylated subunits . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Monoclonal antibodies that preferentially recognize either the insulin receptor or the IGF 1 receptor were utilized to examine which receptors mediated the biological effects of these hormones . ^^^ The effects of insulin on both myoblasts and myotubes appeared to be mediated in part by the insulin receptor and in part by the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| A monoclonal antibody that inhibits the insulin receptor kinase was found to inhibit the IGF 1 receptor kinase with the same potency with which it inhibits the insulin receptor . ^^^ In contrast , monoclonal antibodies to other parts of the insulin receptor only poorly recognized the IGF 1 receptor . ^^^ Thus , the IGF 1 receptor is structurally , antigenically , and functionally similar to but not identical with the insulin receptor . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The IGF 1 receptor was similar to the insulin receptor with respect to subunit structure ( beta alpha alpha beta ) , apparent sizes of deglycosylated alpha ( Mr = approximately 88 , 000 ) and beta ( Mr = approximately 67 , 000 ) subunits , and amino acid composition of the subunits . ^^^ Monoclonal antibody specific to each receptor recognized its own receptor whereas polyclonal anti human insulin receptor antibody cross reacted with the IGF 1 receptor , indicating that the receptors share one or more antigenic sites . ^^^ Further characterization of the purified IGF 1 receptor tyrosine protein kinase activity indicated that by analogy with the insulin receptor the monomeric alpha beta form of the IGF 1 receptor appears to have higher kinase activity than the intact receptor in the alpha 2 beta 2 form . ^^^ The IGF 1 receptor alpha subunit lacks residues corresponding to the N terminal 4 amino acids of the insulin receptor alpha subunit . ^^^ These results provide the first direct proof that the IGF 1 receptor is a molecule distinct from the insulin receptor despite numerous similarities . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| These results indicate that 1 ) the defect is specific to the insulin receptor binding in these patients , 2 ) insulin and IGF 1 activate glucose incorporation and alpha aminoisobutyric acid uptake mainly through their own specific receptors , but 3 ) the IGF 1 receptor appears to have a more important role in stimulating thymidine incorporation than the insulin receptor in physiological condition or , alternatively , an unknown postreceptor process with cascade signal transmission may overcome the decreased insulin receptor binding to produce a normal dose response curve . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Time , temperature , and pH dependence of peptide binding were characterized for the T cell IGF 1 receptor and the B cell insulin receptor and were consistent with previously described models for these receptors . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| By using this antibody , it is shown directly that insulin can act through the IGF 1 receptor to stimulate DNA synthesis but can also activate this effect through the insulin receptor itself . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Thus , functional IGF 1 receptors are present in rat brain , and the doses of insulin typically used to evaluate insulin receptor tyrosine kinase activity will stimulate IGF 1 receptor tyrosine kinase activity as well . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| These data demonstrate that human erythrocytes have specific receptors for IGF 1 , and that this IGF 1 receptor , like the insulin receptor , undergoes ligand stimulated autophosphorylation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Adsorption specificity to this affinity matrix demonstrates that low coupling ratios of IGF 1 analog to agarose yield preparations that are highly selective in purifying IGF 1 receptor with minimal cross contamination by the insulin receptor present in the same placental extracts . ^^^ The characteristics of the IGF 1 receptor associated tyrosine kinase are remarkably similar to those of the insulin receptor kinase . ^^^ The concentration of ATP required for half maximal ( 30 microM ) activation of the IGF 1 receptor kinase is similar to that of the insulin receptor kinase . ^^^ Like the insulin receptor kinase , the elevated kinase activity of the phosphorylated IGF 1 receptor is reversed following dephosphorylation of the receptor beta subunit with alkaline phosphatase . ^^^ Furthermore , the phosphorylation of the IGF 1 receptor beta subunit doublet is enhanced by 7 8 fold when reductant is included in the reaction medium , as is observed for the insulin receptor kinase . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| A human polyclonal IgG ( pIgG ) , previously characterized as anti insulin receptor antibody , able to inhibit insulin receptor kinase activity , was used to further investigate subunit homologies and differences in antigenicity and functional regulation between IGF 1 and insulin receptors , IGF 1 receptor tyrosine kinase was stimulated by a IGF 1 analog ( aIGF 1 ) , produced by DNA recombinant technology , pIgG was able to inhibit IGF 1 receptor kinase activity , thus revealing antigenic homologies between the kinase domains of insulin and IGF 1 receptors . ^^^ However the more pronounced inhibition of IGF 1 receptor compared with insulin receptor kinase activity by pIgG suggests the existence of different regulatory mechanisms . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Cross linking of 125I insulin and 125I IGF 1 to their receptors , using disuccinimidyl suberate ( DSS ) , and identification of the receptor with sodium dodecyl sulfate polyacrylamide gel electrophoresis and autoradiography showed a band with a molecular mass of 135 kDa , probably corresponding to the alpha subunit of the insulin receptor and a major band with a molecular mass of 145 kDa for the alpha subunit of the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Serum from a patient with circulating autoantibodies to the insulin receptor competes for insulin but not IGF 1 binding , whereas alpha IR 3 , a monoclonal antibody directed toward the human IGF 1 receptor inhibits IGF 1 but not insulin binding . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Antibodies to deduced sequences of the insulin receptor distinguish conserved and nonconserved regions in the IGF 1 receptor . ^^^ An antibody directed to a cytoplasmic domain near the membrane spanning region of the proreceptor inhibited the protein tyrosine kinase activity of both receptors whereas an antibody directed to the C terminus of the insulin receptor showed no cross reactivity with the IGF 1 receptor . ^^^ The results establish that the cloned cDNA from the human placenta encodes the insulin receptor and not the closely related IGF 1 receptor , that the IGF 1 and insulin receptors share a specific amino acid sequence necessary for the expression of enzymatic activity , and that the C terminus of the insulin receptor is not conserved in the IGF 1 receptor . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Affinity cross linking of 125I IGF 2 to the Mr = 250 , 000 type 2 IGF receptor structure in rat liver membranes was blocked by the anti receptor Ig , while no effect on affinity labeling of insulin receptor with 125I insulin or IGF 1 receptor with 125I IGF 1 or 125I IGF 2 was observed . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| These studies indicate , therefore , that this monoclonal antibody binds preferentially to the insulin receptor but also crossreacts to a lesser extent with the IGF 1 receptor . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The close correspondence between an approximate 50 % effective dose ( ED 50 ) of phosphorylation and an approximate Kd for IGF 1 binding leads us to conclude that a high affinity IGF 1 receptor , not the structurally similar insulin receptor , is the mediator of IGF 1 stimulated kinase activity . ^^^ Immunoprecipitation indicates that both the beta subunit of the IGF 1 receptor and the beta subunit of the insulin receptor are targets for the IGF 1 stimulated protein kinase . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Thiol redox reactions are known to play a role in regulating conformational changes in the insulin receptor and possibly also in the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Signal transduction pathways stimulated by insulin or insulin like growth factor 1 ( IGF 1 ) were compared in transfected NIH3T3 fibroblast cell lines expressing the human insulin receptor , IGF 1 receptor , or a chimeric IGF 1 receptor with its carboxy terminal tail replaced with that of the insulin receptor ( approximately 1 10 10 ( 6 ) receptors / cell ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The effect of ethanol on IGF 1 receptor and insulin receptor substrate 1 ( IRS 1 ) tyrosine phosphorylation was determined by immunoprecipitation and Western blotting , as was the phosphatidylinositol 3 kinase content within IRS 1 immunoprecipitates . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor mRNA and IGF 1 receptor mRNA were both present and showed a similar , widespread pattern throughout retina development . ^^^ These findings suggest a near constitutive expression of insulin receptor and IGF 1 receptor genes , while IGF 1 and IGFBP 5 showed a highly focal spatiotemporal regulation of gene expression . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Interaction of the p 85 subunit of PI 3 kinase with the insulin receptor ( IR ) and the IGF 1 receptor ( IGF 1R ) was investigated using the two hybrid system by assessing for his 3 and lacZ activation in S . cerevisiae . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Their anabolic and growth promoting actions are mediated via the IGF 1 receptor , present in all cells apart from liver and adipose cells , which contains the homologous insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The relationship of the two proteins to the IGF 1 receptor was further probed by an antibody ( a HF ) raised against a specific sequence in the beta subunit of the human IGF 1 receptor , and a polyclonal antibody raised against the liver insulin receptor ( L 1 ) which cross reacts with the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The function of the insulin receptor tyrosine kinase in signal transduction has been studied extensively in contrast to the IGF 1 receptor tyrosine kinase . ^^^ A mutant IGF 1 receptor , in which 3 tyrosines ( Tyr 1131 , Tyr 1135 , and Tyr 1136 ) analogous to the three major autophosphorylation sites in the insulin receptor kinase were replaced by phenylalanines , was devoid of kinase activity in vivo and in vitro and inactive with respect to IGF 1 internalization and stimulation of thymidine incorporation . ^^^ Our data suggest that the structure function relationship of the IGF 1 receptor tyrosine kinase activation and signal transduction is similar to that of the insulin receptor . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| These data demonstrate that the replacement of the C terminal tail of the IGF 1 receptor by that of the insulin receptor has changed the receptor characteristics studied in a cell free system . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The effect of insulin was biphasic , suggesting some stimulation mediated directly by the insulin receptor and some by cross reaction with the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The exact nature of how the insulin molecule interacts with the insulin receptor is obscure although chimeric receptors have shown that the ligand specificity of the insulin receptor and the IGF 1 receptor ( i . e . the sequences that discriminate between insulin and insulin like growth factor 1 ) reside in different regions of a common binding site and that the N terminal 68 amino acids of the insulin receptor are involved in conferring specificity for insulin on this receptor ( Kjeldsen , T . , Andersen , A . ^^^ Furthermore , replacement of the insulin receptor amino acid phenylalanine 39 with the corresponding IGF 1 receptor amino acid , serine 35 , decreased insulin affinity 8 fold . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| These studies suggest , therefore , that the IGF 1 receptor , like the insulin receptor , induces the formation of multiple signaling complexes that most likely mediate the proliferative effects of these receptors . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin / insulin like growth factor 1 ( IGF 1 ) hybrid receptors are composed of an alpha beta heterodimer from an insulin receptor and an alpha beta heterodimer from an IGF 1 receptor . ^^^ The kinase defective insulin receptor heterodimer functions as a dominant negative , inhibiting phosphorylation by the kinase competent IGF 1 receptor heterodimer . ^^^ Despite an increasing percentage of insulin / IGF 1 hybrid receptors in the three cell lines studied , the rates of IGF 1 internalization and degradation remain similar to those mediated by the IGF 1 receptor and distinct from those of insulin receptor heterotetramers . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| However , in PCO ovaries from patients without hyperinsulinemia , insulin receptor expression was apparent in both granulosa and thecal stromal cells , with a similar intensity to that observed in normal ovaries , while IGF 1 receptor expression was negligible in granulosa cells but sustained in thecal stromal cells . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 1 ( IGF 1 ) is a useful therapeutic agent in insulin resistant diabetes mellitus due to insulin receptor disease because of its hypoglycaemic effects through the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor substrate 1 ( IRS 1 ) is the major substrate of insulin receptor and IGF 1 receptor tyrosine kinases ; it has an apparent relative molecular mass of 160 190 , 000 ( M ( r ) , 160 190K ) on SDS polyacrylamide gel . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In the present work , we report that while the IGF 1 receptor exhibits negative cooperativity like the insulin receptor , the concentration dependence of the dissociation kinetics is distinct from that of native human insulin by not being bell shaped , but monophasic like that of insulin analogues mutated at the hexamer forming surface ; it is changed to an insulin type curve by substitution of IGF 1 receptor ' s sequence including residues 382 565 with the homologous insulin receptor domain . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To clarify the specific signalling pathway of IGF 1 , we studied the functional role of heterodimers composed of IGF 1 receptor and insulin receptor for the IGF 1 signalling . ^^^ Heterodimers between rat IGF 1 receptor and exogenous insulin receptors were identified by a human specific anti insulin receptor monoclonal antibody after ligand affinity labeling . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To stimulate growth , therapy with rhGH was initiated , the rationale being to stimulate hepatic IGF 1 production and IGF 1 receptor signaling , and bypass the inherited block in insulin receptor signaling . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The IGF 1 receptor , which binds IGF 1 with the highest affinity and which is very similar to the insulin receptor , is thought to mediate most , if not all , of the IGF induced biological functions . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| IRS 1 has a central role as an adaptor molecule that links the insulin receptor and IGF 1 receptor kinases with enzymes that regulate cellular metabolism and growth . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In situ hybridization was used to investigate the cellular distribution of IDE mRNA and to compare it with insulin receptor ( IR ) and IGF 1 receptor ( IGFR ) gene expression in serial thin sections from a variety of tissues in embryonic and adult rats . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence microscopy was carried out on twelve meningotheliomatous meningiomas using antibodies directed against insulin , IGF 1 , IGF 2 , insulin receptor and IGF 1 receptor . ^^^ In addition , the IGF 1 receptor was expressed in four of the tumors while the insulin receptor was expressed in 10 out of 12 meningiomas . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The intraassay variation was 9 % ( n = 22 ) for the IGF 1 receptor concentration and 12 % ( n = 22 ) for the insulin receptor . ^^^ The interassay variation was 5 % ( n = 4 ) for the IGF 1 receptor and 10 % ( n = 4 ) for the insulin receptor . ^^^ The coefficient of variation of the dissociation constants ( Kd ) was 26 % ( n = 7 ) for the IGF 1 receptor and 24 % ( n = 7 ) for the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The purified CT domain stimulated the kinase activities of purified insulin receptor transmembrane / cytoplasmic domain ( IRTMTPK ) and its CT domain deletion mutant ( IRTMTPK delta CT ) , 3 . 3 fold and 2 . 3 fold , respectively , while it was less effective in stimulating the kinase activity of purified IGF 1 receptor transmembrane / cytoplasmic domain ( IGFIRTMTPK ) ( 1 . 4 fold ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor ( IR ) and IGF 1 receptor ( IGF R ) content in the primary tumors varied between 23 . 8 321 . 4 and 16 . 4 554 . 2 ng / 0 . 1 mg DNA , respectively . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The function of insulin receptor and IGF 1 receptor was investigated in placentas from 10 healthy control mothers , 8 diabetic mothers with appropriate for gestational age babies ( AGA group ) and 9 diabetic mothers with large for gestational age babies ( LGA group ) . ^^^ Autophosphorylation studies were performed with partially purified receptors equalized for similar binding capacity , then immunoprecipitated with anti insulin receptor antibody or anti IGF 1 receptor antibody . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The presence of a 95 , 000 M ( r ) IGF 1 receptor beta subunit distinct from the insulin receptor beta subunit in human muscle was confirmed by the demonstration of an IGF 1 sensitive receptor with a beta subunit of this size after insulin receptor immunodepletion . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Purified insulin receptor and IGF 1 receptor phosphorylated recombinant baculovirus produced IRS 1 on similar sites in vitro , and phosphorylated baculovirus produced IRS 1 bound PtdIns 3 ' kinase activity from lysates of quiescent cells . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In general , the dephosphorylation of IGF 1 receptor follows a pattern similar to that of insulin receptor except in red skeletal muscle in which it is not modified . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| MAIN OUTCOME MEASURE : The expression of IGF 1 receptor and insulin receptor transcripts were analyzed by Northern blot . ^^^ RESULTS : In the separated thecal tissue both IGF 1 receptor and insulin receptor transcripts were detected . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Messenger RNA expression consistent with both known forms of the insulin receptor , the IGF 1 receptor , and the IGF 2 receptor was observed in human fetal ovaries and uteri at 10 , 15 , 19 , and 22 weeks ' gestation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The purified proteins have kinase activity , demonstrating that the catalytic domain of IGF 1 receptor , like that of insulin receptor , is active independent of its ligand binding and transmembrane domains . ^^^ Insulin and IGF 1 receptors show distinct preferences for these peptides ; whereas insulin receptor prefers peptides based on Tyr 987 or Tyr 727 of insulin receptor substrate 1 , the IGF 1 receptor preferentially recognizes the Tyr 895 site . ^^^ The catalytic activity of IGF 1 receptor is stimulated approximately 3 . 4 fold by treatment with purified 5 Src , while insulin receptor shows very little effect of Src phosphorylation under these conditions . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In both cell lines , 25 mM glucose impaired receptor and insulin receptor substrate 1 phosphorylation by 34 % , but IGF 1 receptor phosphorylation was unaffected . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction ( RT PCR ) analyses showed that mRNAs encoding insulin , IGF 2 , insulin receptor , and IGF 1 receptor were present in both precardiac mesoderm and endoderm , as well as in the forming heart at stage 8 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| IGF 1 rapidly stimulated beta chain IGF 1 receptor autophosphorylation , which peaked at a physiological / mitogenic concentration ( 1 . 4 nM ) and also stimulated tyrosine phosphorylation of insulin receptor substrate 1 ( IRS 1 ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| IGF 1 receptor beta subunit , insulin receptor substrate 1 ( IRS 1 ) , and mitogen activated protein ( MAP ) kinase were all phosphorylated in response to 6 . 5 nM IGF 1 after 10 min incubation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In cells incubated with IL 1 beta ( 100 U / ml ) , insulin receptor ( IR ) protein and messenger RNA were increased by 100 % , while IGF 1 receptor protein and transcript were not significantly changed . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In non disease states the insulin receptor is primarily involved in metabolic functions whereas the IGF 1 receptor mediates growth and differentiation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| A lipophilic analogue of peptide HC , stearyl peptide HC , added to intact CHO / HIRc cells enhanced significantly insulin stimulated insulin receptor autophosphorylation while having no effect on ligand stimulated receptor phosphorylation in CHO cells overexpressing either the IGF 1 receptor or epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The affinity of 4 Gly IGF 1 for the IGF 1 receptor was approximately 100 fold lower than that of wild type IGF 1 and the affinity for the insulin receptor was approximately 10 fold lower . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We investigated signal transduction through IGF 1 receptor in comparison with epidermal growth factor ( EGF ) receptor in early passages of cultured skin fibroblasts from a normal subject and a patient with leprechaunism whose insulin receptor tyrosine kinase was almost nonexistent . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Although TAM can increase IGFBP 3 expression in MCF 7 cells , and this binding protein has been shown to be able to inhibit IGF action , TAM had no effect on IGF 1 stimulated tyrosine phosphorylation of IGF 1 receptor or the downstream signaling molecule , insulin receptor substrate 1 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In addition , ASPB 10 was twofold more potent than insulin in stimulating insulin receptor autophosphorylation but significantly more potent in stimulating IGF 1 receptor autophosphorylation in both cell lines . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Most of the actions of both IGF 1 and IGF 2 are mediated by their activation of the IGF 1 receptor , a transmembrane tyrosine kinase that is structurally and functionally related to the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Taken together with the fact that pancreatic beta cells express little or no insulin receptor but large amounts of IGF 1 receptor , these data strongly suggest a new regulatory feedback loop model for the control of insulin secretion . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| However , replacement of the C terminal domain of the beta subunit of the IGF 1 receptor with the corresponding fragment in the insulin receptor restored ligand stimulated pp 120 phosphorylation , suggesting that this domain plays a regulatory role in pp 120 phosphorylation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Although 5 src is a more potent inducer of tyrosine phosphorylation than c src 527 , the extent of phosphorylation of either insulin receptor substrate 1 or Shc , two of the major substrates of the IGF 1 receptor , does not seem sufficiently different to explain the qualitative difference in soft agar growth . 5 src , however , is considerably more efficient than c src 527 in its ability to tyrosyl phosphorylate , in R cells , the focal adhesion kinase , Stat 1 , and p130cas . ^^^ |
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| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Two different beta subunits of IGF 1 receptor were detected , and their autophosphorylation was followed by increases in the phosphotyrosine content of extracellular signal regulated kinases ( ERKs ) , insulin receptor substrate 1 , phospholipase C gamma 1 , and phosphatidylinositol 3 kinase . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Modifications in the B 10 and B 26 30 regions of the B chain of human insulin alter affinity for the human IGF 1 receptor more than for the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To examine whether these differences relate to intrinsic signaling properties of the intracellular domains of their respective receptors , chimeric receptors were constructed using the extracellular domain of the neurotrophin 3 ( NT 3 ) receptor , TrkC , and the intracellular domain of either the insulin receptor or the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor / IGF 1 receptor hybrids are widely distributed in mammalian tissues : quantification of individual receptor species by selective immunoprecipitation and immunoblotting . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| These data indicate significant insulin / IGF 1 receptor interplay in normal bovine fibroblasts and suggest that insulin receptor initiated signaling can profoundly alter proto oncogene expression induced by growth factors sharing components of a common intracellular signaling network . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin and insulin like growth factor 1 ( IGF 1 ) treatment of cells overexpressing the insulin receptor or the IGF 1 receptor promotes phosphorylation and activation of Janus kinases JAK 1 and JAK 2 but not of TYK 2 . ^^^ |
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| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Genetic crosses of insulin receptor and insulin like growth factor 1 ( IGF 1 ) receptor deficient mice indicate , however , that insulin receptors play an important role in late gestational growth , and that absence of growth retardation in insulin receptor deficient ( IR / ) mice may be due to a compensatory increase in IGF 1 receptor levels . ^^^ |
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| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Peri implantation mouse embryos synthesize insulinlike growth factor ( IGF ) 2 ligand , insulin receptor , IGF 1 receptor , and IGF 2 receptor and respond to IGF 2 , IGF 1 , and insulin metabolically and mitogenically . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| However , replacement of the C terminal domain of the IGF 1 receptor beta subunit with the corresponding segment of the insulin receptor restored pp 120 phosphorylation by the chimeric receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Cell systems derived from knockout mice for the insulin receptor ( IR ) or the IGF 1 receptor ( IGF 1R ) represent unique tools for dissecting complex interplay in the actions of insulin and insulin like growth factors through their cognate versus non cognate receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In mammalian cells , the insulin receptor substrate 1 protein ( IRS 1 ) is a specific substrate for insulin and IGF 1 receptor tyrosine kinases which is involved in mediating metabolic and mitogenic actions of insulin and IGFs . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To detect changes in the functional activity of the brain insulin neuromodulatory system of SDAT patients , we determined the concentrations of insulin and c peptide as well as insulin receptor binding and IGF 1 receptor binding in several regions of postmortem brain cortex during aging and Alzheimer ' s disease . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To determine whether blocking alphaVbeta 3 occupancy could alter IGF 1 receptor mediated signal transduction , the ability of IGF 1 to stimulate phosphorylation of insulin receptor substrate 1 ( IRS 1 ) was analyzed . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor related receptor ( IRR ) , a member of the insulin receptor tyrosine kinase family , has structural homology to the insulin receptor ( IR ) and the IGF 1 receptor ( IGF IR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Presumed common evolutionary origin of insulin and IGF 1 receptors and poor ability of lamprey insulin receptor to discriminate between two ligands , implies that lamprey insulin receptor is closer to putative ancestral protein that IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that in the case of DNA synthesis the effects of IGF 2 are mediated via the IGF 1 receptor and those of insulin via the insulin receptor , whereas in the case of glycogenesis both are mediated via the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the affinity of IGF 1 swap for the insulin receptor was approximately 200 fold lower than that of native IGF 1 indicating that the binding surface complementary to the insulin receptor ( or the ability to attain it ) is disturbed to a greater extent than that to the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| This decrease in bioavailable IGF 2 ultimately resulted in diminished IGF 1 receptor signaling in vivo as evidenced by diminished receptor kinase activity and decreased tyrosine phosphorylation of the IGF 1 receptor downstream effectors , insulin receptor substrate 1 ( IRS 1 ) , extracellular signal regulatory kinase ( Erk ) 1 , and Erk 2 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Compared with TPN control , IGF 1 or IGF 1 + GH stimulated jejunal mucosal hyperplasia ; IGF 1 treatment increased serum IGF 1 by 2 to 3 fold and decreased serum insulin concentrations by 60 % , decreased IGF 1 receptor number by 50 % ( P < 0 . 001 ) , and increased insulin receptor affinity and insulin receptor protein content . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The wild type insulin receptor chimera mediated approximately 2 fold greater phosphorylation of insulin receptor substrate 1 ( IRS 1 ) , association of IRS 1 with phosphoinositide 3 kinase , stimulation of glucose uptake , and GLUT 4 translocation , compared with the IGF 1 receptor chimera . ^^^ In contrast , the IGF 1 receptor chimera mediated more effective Shc phosphorylation , association of Shc with Grb 2 , and activation of mitogen activated protein kinase compared with the insulin receptor chimera . ^^^ We conclude that the insulin receptor mediates some aspects of metabolic signaling in adipocytes more effectively than the IGF 1 receptor , as a consequence of more efficient phosphorylation of IRS 1 and greater recruitment / activation of phosphoinositide 3 kinase . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The mRNA transcript of the IGF 1 receptor was not detected in oviduct epithelial cells , but a prominent band corresponding to the insulin receptor was observed . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| When plasma levels of insulin and IGF 1 were decreased by fasting , insulin receptor numbers fell 3 . 6 fold and IGF 1 receptor numbers fell 2 . 2 fold . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We will focus on the mechanisms that determine signalling specificity by the receptor tyrosine kinases , especially the insulin receptor and the type 1 insulin like growth factor receptors ( IGF 1 receptor ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Treatment with insulin or IGF 1 for 4 h increased the abundance of VEGF mRNA in NIH3T3 fibroblasts expressing either the human insulin receptor ( NIH IR ) or the human IGF 1 receptor ( NIH IGFR ) by 6 and 8 fold , respectively . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The addition of the anti receptor antibody to IGF 1 receptor or insulin receptor partially suppressed erythroid colony formation supported with insulin or IGF 1 in both CD34+ / Kit+ cells and LDBMCs . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In this study , we report on the isolation of a PDZ domain protein , here designated as IIP 1 , insulin like growth factor 1 ( IGF 1 ) receptor interacting protein 1 , which binds to the IGF 1 receptor , but not to the related insulin receptor , and which is involved in the regulation of cell motility . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We speculate that the IGF 1 activated IGF 1 receptor , in response to E 2 , directly or indirectly modifies insulin receptor substrate 2 , probably through phosphorylation , leading to ubiquitination and subsequent degradation of this docking protein by the proteasome . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Extremely high insulin concentrations ( 860 nM ) and 10 nM trIGF 1 , a truncated form of IGF 1 with the same affinity for the IGF 1 receptor as the full length IGF 1 , but with lower activity on the insulin receptor , also upregulated UCP 3 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The IGF 1 receptor and the related insulin receptor are similar in structure and activate many of the same postreceptor signaling pathways , yet they mediate distinct biological functions . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| While SH SY5Y and SHEP cells use different insulin receptor substrate ( IRS ) isoforms to transduce signals from the IGF 1 receptor , IGF 1 has the same relative effect on the motility of both cell lines . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| They had phosphorylation of the IGF 1 receptor beta subunit , phosphorylation of insulin receptor substrate ( IRS ) 1 , and association of the p 85 subunit ( phosphatidylinositol 3 kinase [ PI3K ] ) with the IGF 1 receptor and IRS 1 in D NOD cells in the basal state . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Activation of the IGF 1 receptor also leads to phosphorylation of an 185 kDa molecule that is homologous to the substrate of the insulin receptor present in human cells , the insulin receptor substrate 1 ( IRS 1 ) . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| However , the levels of expression of IGF 1 receptor , or the activation of Insulin Receptor Substrate 1 in response to IGF 1 , were not affected by the levels of dlk expression . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We designed and developed nine different calibration curves , based on recombinant DNA plasmid standards and established them on a constant real time PCR platform for the following factors : growth hormone receptor ( GHR ) , insulin like growth factor ( IGF ) 1 , IGF 1 receptor ( IGF 1R ) , IGF 2 , IGF 2 receptor ( IGF 2R ) , insulin receptor ( INSR ) , and IGF binding proteins ( IGF BP ) 1 , 2 and 3 . ^^^ Real time RT PCR quantification of insulin like growth factor ( IGF ) 1 , IGF 1 receptor , IGF 2 , IGF 2 receptor , insulin receptor , growth hormone receptor , IGF binding proteins 1 , 2 and 3 in the bovine species . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Identification of insulin in the tear film and insulin receptor and IGF 1 receptor on the human ocular surface . ^^^ Frozen sections of human cornea ( n = 4 ) and conjunctiva ( n = 3 ) were incubated with anti insulin receptor and anti IGF 1 receptor antibodies and developed with a secondary antibody peroxidase conjugate . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Tissue specific knockout of the insulin receptor ( betaIRKO ) or IGF 1 receptor ( betaIGFRKO ) in pancreatic beta cells leads to altered glucose sensing and glucose intolerance in adult mice , and betaIRKO mice show an age dependent decrease in islet size and beta cell mass . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The fact that insulin can influence the primordial to primary follicle transition at low concentrations ( i . e . 5 ng / ml ) and that IGF 1 has no effect suggests that insulin is acting at the insulin receptor , not the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Combined inactivation of insulin receptor ( Insr ) and Igf 1 receptor ( Igf1r ) , but not of either receptor alone , resulted in a 90 % decrease in the size of the exocrine pancreas , because of decreased cellular proliferation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Previous studies have suggested that antiestrogens inhibit MCF 7 cell proliferation by alteringthe expression or activity of components of the insulin like growth factor 1 ( IGF 1 ) signaling pathway , including IGF 1 receptor , insulin receptor substrate 1 , and phosphatidylinositol 3 kinase . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| TNF alpha and IL 1beta act by inhibiting the IGF 1 receptor from tyrosine phosphorylating insulin receptor substrate 1 without affecting tyrosine kinase activity of the IGF IR itself . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In an attempt to uncover the molecular mechanisms underlying their divergent functions , we compared insulin receptor ( IR ) and IGF 1 receptor ( IGF 1R ) regulation of gene expression by microarray analysis , using 3T3 L 1 cells expressing either TrkC / IR or TrkC / IGF 1R chimeric receptors to ensure the highly selective activation of each receptor tyrosine kinase . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| EtOH did not alter the total amount or tyrosine phosphorylation of the insulin receptor , IGF 1 receptor , insulin receptor substrate ( IRS ) 1 , or protein kinase B ( PKB ) / Akt under basal or hormone stimulated conditions . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| IGF 1 ( 10 nM ) inhibited K ( + ) as well as veratridine evoked ACh release from rat hippocampal slices and the effect is possibly mediated via the activation of a typical IGF 1 receptor and the subsequent phosphorylation of the insulin receptor substrate 1 ( IRS 1 ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To investigate the mechanism of severe impairment of insulin action in type B insulin resistance , we extracted IgG from the serum of a patient with type B insulin resistance ( B IgG ) and analyzed the inhibiting effect of B IgG not only on insulin signaling but also on IGF 1 signaling in Chinese hamster ovary ( CHO ) cells expressing human insulin receptor or human IGF 1 receptor . ^^^ Preincubation with 1 mg / ml B IgG prevented insulin induced phosphorylation of insulin receptor and insulin receptor substrate 1 ( IRS 1 ) but did not alter the IGF 1 induced phosphorylation of the IGF 1 receptor and IRS 1 . ( 125 ) 1 insulin binding was inhibited by 93 % after preincubation with B IgG at 37 degrees C and was recovered up to 50 % of the control value by acid washing . ^^^ This effect of B IgG was specific for the insulin receptor with no effect on either IGF 1 receptor or IRS 1 , as reflected by the IGF 1 effectiveness on glycemic control in this patient . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Both medulloblastoma cell lines and medulloblastoma biopsies are characterized by the abundant presence of the IGF 1 receptor ( IGF IR ) and its major signaling molecule , insulin receptor substrate 1 ( IRS 1 ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| However , only 5 . 3 % of hybrid embryos developed into blastocyst stage compared to 21 . 7 % in buffalo . mRNA phenotyping of insulin like growth factor family ( Insulin , insulin receptor , IGF 1 , IGF 1 receptor , IGF 2 , and IGF 2 receptor ) and glucose transporter isoforms ( GLUT 1 , 2 , 3 , 4 ) in hybrid embryos clearly showed that these molecules were not expressed after 8 cell stage onward . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| SUBJECTS AND METHODS : Five MSG tissue sections from SS and seven from mucocele patients were stained immunohistochemically using antibody to IGF 1 receptor and insulin receptor in a horse radish peroxidase and DAB system . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To precisely define the role of insulin and IGF 1 signaling in endothelium in these processes , we have used the oxygen induced retinopathy model to study mice with a vascular endothelial cell specific knockout of the insulin receptor ( VENIRKO ) or IGF 1 receptor ( VENIFARKO ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Genistein , biochanin A , quercetin and kaempferol reduced the insulin receptor substrate 1 ( IRS 1 ) content of AT6 . 3 cells and prevented the down regulation of IGF 1 receptor beta in response to IGF 1 binding . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In this paper we tested the hypothesis that polymorphic variants of IGF 1 response pathway genes , namely IGF IR ( IGF 1 receptor ; G / A , codon 1013 ) , PI3KCB ( phosphoinositol 3 kinase ; T / C , 359 bp ; A / G , 303 bp ) , IRS 1 ( insulin receptor substrate 1 ; G / A , codon 972 ) , and FOXO1A ( T / C , +97347 bp ) , play a role in systemic IGF 1 regulation and human longevity . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In a further series of experiments we demonstrate that IGF 1 is able to replace insulin in the DIP lactogenic hormone mix and by the use of a specific IGF 1 receptor blocking antibody indicate that the action of IGF 1 is mediated through the cell surface IGF 1 receptor and not by cross reaction of IGF 1 ligand at the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We found that insulin receptor substrate 2 ( IRS 2 ) levels were markedly induced by progesterone and the synthetic progestin R 5020 in MCF 7 and other progesterone receptor ( PR ) positive breast cancer cell lines , whereas IRS 1 and the IGF 1 receptor were not induced . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The angiogenic response of IGF 2 could be reversed by the addition of beta galactosidase or rabbit antihuman IGF II / M6P receptor antiserum , whereas blocking antibodies against IGF 1 receptor or insulin receptor influenced IGF 2 induced sprout formation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Since 1996 , seven genetic mouse models have been reported to show increased lifespan : Ames and Snell dwarf mice , the ' little mouse ' ( Ghrhr ( lit / lit ) ) , mice null for either growth hormone receptor / binding protein ( GHR / BP ( / ) ) or p 66 ( shc ) ( p 66 ( shc / ) ) , mice heterozygous for the IGF 1 receptor ( Igf1r ( + / ) ) , and fat specific insulin receptor knockout mice . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| DCA induced activation of the insulin receptor correlated with enhanced phosphorylation of insulin receptor substrate 1 , effects that were both blocked by the insulin receptor inhibitor AG 1024 and by expression of the dominant negative IGF 1 receptor ( K1003R ) , which inhibited in trans . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In these protein kinase B / Akt 1 RNA interference cells , the signal molecules upstream of protein kinase B / Akt 1 , such as IGF 1 receptor and insulin receptor substrate 1 , were normally activated by insulin stimulation , whereas insulin stimulated phosphorylation of forkhead transcription factor ( FKHR ) , which is a downstream molecule of PKB / Akt 1 , was blocked . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The induced tumors showed upregulated expression of insulin receptor substrate 1 and phosphorylated forms of IGF 1 receptor and Akt , mimicking activated IGF signaling found in human MBs . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To define precisely the signaling specific to the insulin receptor ( IR ) or the IGF 1 receptor , we have generated brown preadipocyte cell lines that lack either receptor ( insulin receptor knockout ( IRKO ) or insulin like growth factor receptor knockout ( IGFRKO ) ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Deletion of the pleckstrin and phosphotyrosine binding domains of insulin receptor substrate 2 does not impair its ability to regulate cell proliferation in myeloid cells . 32D IGF 1 receptor ( IR ) cells are IL 3 dependent myeloid cells that can be induced to differentiate into granulocytes by IGF 1 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| EP 2 stimulation failed to inhibit tyrosine phosphorylation either of IGF 1 receptor or IRS 1 ( insulin receptor substrate 1 ) , or activation of phosphoinositide 3 kinase or Akt in response to IGF 1 , but potently and dose dependently inhibited IGF 1 induced activation of cellular Rac activity and membrane ruffling . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| A newly developed bridging yeast tri hybrid assay showed that APS dimerizes JAK 2 , insulin receptor and IGF 1 receptor kinases using its SH 2 and dimerization domains . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis of the interaction between insulin receptor and IGF 1 receptor with c Crk and Crk L in a yeast two hybrid system . ^^^ We have employed a yeast two hybrid approach and mutational analysis to dissect the capabilities of the insulin receptor and the IGF 1 receptor to directly associate with Crk isoforms . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Both cell lines exhibit androgen responsive patterns of IGF 1 receptor ( IGF IR ) expression , activation , and signaling to insulin receptor substrate 2 and AKT . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| By reverse transcriptase polymerase chain reaction ( RT PCR ) analysis , mRNA of IGF 1 and 2 , IGF 1 receptor ( IGF IR ) , insulin receptor ( insulin R ) , and IGF binding protein ( IGFBP ) 2 , 3 , 4 , 5 , and 6 was detected in the taste bud containing epithelium of the circumvallate papillae of mice . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In the present work , we investigated the potential of the third member of the family , insulin receptor related receptor ( IRR ) , to associate with known interaction partners of the InsR and the IGF 1 receptor in a yeast two hybrid assay . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis revealed an approximate 200 % increase in insulin receptor protein levels and an approximate 50 % increase in IGF 1 receptor protein levels in the hippocampus of Pcmt 1 / mice . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| This study initially confirmed in mouse osteoblast cultures that PTH treatment increased IGF 1 mRNA and protein levels and alkaline phosphatase activity , which were accompanied by phosphorylations of IGF 1 receptor , insulin receptor substrate ( IRS ) 1 and IRS 2 , essential adaptor molecules for the IGF 1 signaling . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The biological effects of the IGFs are mediated by the IGF 1 receptor ( IGFR ) , a covalent homodimer composed of two alpha and two beta chains , similar in structure to the insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| IRS 1 ( Insulin Receptor Substrate 1 ) is an adaptor protein important for insulin and IGF 1 receptor ( Insulin like Growth Factor IR ) transduction to downstream targets . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Thus , insulin aspart is equivalent to human insulin on key in vitro parameters such as insulin receptor affinity , insulin receptor dissociation rate , insulin receptor tyrosine kinase activation , IGF 1 receptor binding affinity , metabolic and mitogenic potency . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The TbetaR 5 signaling cascade appears to cross talk with the TbetaR I / TbetaR 2 , insulin receptor ( IR ) , IGF 1 receptor ( IGF IR ) , integrin and c Met signaling cascades . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Identical data were obtained expressing a dominant negative IGF 1 receptor in hepatocytes ; a receptor which acts to inhibit both the IGF 1 receptor and the insulin receptor in trans . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| IGF 1 receptor and insulin receptor substrate 2 levels were increased in LTED versus the Wt MCF 7 cells , and ICI but not TAM reduced their expression in a dose dependent fashion . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The IGF 1 receptor is a member of the family of tyrosine kinase growth factor receptors , and is highly homologous ( 70 % ) to the insulin receptor , especially in the tyrosine kinase domain ( 84 % ) ADDIN . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Inhibition of CCN 6 expression promoted anchorage independent growth of HME cells and rendered them more responsive to the growth effects of IGF 1 , which was coupled with the increased phosphorylation of IGF 1 receptor and insulin receptor substrate 1 ( IRS 1 ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In these cells , the type 1 insulin like growth factor ( IGF 1 ) and granulocytic colony stimulating factor ( G CSF ) induce differentiation to granulocytes . 32D cells do not express insulin receptor substrate 1 ( IRS 1 ) or IRS 2 , docking proteins of the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| METHODS : Expression of insulin receptor , IGF 1 receptor , and SCF was studied in gastric muscles and purified ICC by immunohistochemistry and reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| These abnormalities were associated reduced expression of genes encoding insulin , IGF 2 , insulin receptor , IGF 1 receptor , and insulin receptor substrate 1 , and reduced ligand binding to the insulin and IGF 2 receptors . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| IRS 2 phosphorylation induced by both insulin and AspB 10 insulin was nearly insensitive to blocking the insulin receptor , being predominantly mediated by the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We have previously shown , using truncated soluble recombinant receptors , that substituting the 62 N terminal amino acids of the alpha subunit from the insulin like growth factor 1 receptor ( IGFIR ) with the corresponding 68 amino acids from the insulin receptor ( IR ) results in a chimeric receptor with an approximately 200 fold increase in affinity for insulin and only a 5 fold decrease in insulin like growth factor 1 ( IGFI ) affinity ( Kjeldsen , T . , Andersen , A . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| This was observed whether or not the insulin signal was transduced through a coexpressed human insulin receptor or the endogenous oocyte insulin like growth factor 1 receptor . ^^^ We conclude that the expressed human insulin receptor is able to couple efficiently with preexisting postreceptor regulatory pathways in oocytes and that the regulation of hexose transport in these cells can be mediated through the combined actions of the expressed human insulin receptor and the endogenous oocyte insulin like growth factor 1 receptor . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The effects of cationic polyamino acids on phosphorylation of the insulin and insulin like growth factor 1 receptor kinases were studied and the following observations were made . ( a ) Polylysine stimulated both tyrosine and serine phosphorylation of the insulin receptor and of additional proteins present in lectin purified membrane preparations from rat liver . ( b ) Polylysine synergized with insulin to enhance phosphorylation of the insulin receptor and of additional proteins ( pp 40 and pp 110 ) . ( c ) Polylysine effects were more pronounced upon increasing the polylysine chain length . ( d ) The effect of polylysine was biphasic with an optimum at 100 micrograms / ml . ( e ) Polylysine was found ineffective in stimulating the phosphorylation of immobilized insulin receptors . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Chimeric receptors containing different portions of the homologous human insulin receptor , insulin like growth factor 1 receptor , and insulin receptor related receptor were utilized to identify the epitopes recognized by various anti insulin receptor antibodies . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| This study was undertaken to find out whether hyperglycaemia in these patients may be influenced by the administration of recombinant human insulin like growth factor 1 which exerts insulin like effects through the insulin receptor as well as the type 1 insulin like growth factor 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To delineate the structural determinants of the insulin receptor ( IR ) and insulin like growth factor 1 receptor ( IGFIR ) which affect hormone binding specificity we have constructed seven chimeric receptor cDNAs and stably expressed them in Chinese hamster ovary cells . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| This inhibitor has been used to examine the importance of terminal sugar groups in the biosynthesis and function of both the insulin receptor and the insulin like growth factor 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Thrombin stimulates phosphorylation of insulin like growth factor 1 receptor , insulin receptor substrate 1 , and phospholipase C gamma 1 in rat aortic smooth muscle cells . ^^^ These proteins are insulin like growth factor 1 receptor beta subunit ( IGF IR beta ) , insulin receptor substrate 1 ( IRS 1 ) , and phospholipase C gamma 1 ( PLC gamma 1 ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Non SH 2 domains within insulin receptor substrate 1 and SHC mediate their phosphotyrosine dependent interaction with the NPEY motif of the insulin like growth factor 1 receptor . ^^^ Insulin receptor substrate 1 ( IRS 1 ) and SHC become rapidly phosphorylated upon tyrosines after insulin like growth factor 1 receptor ( IGFIR ) activation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Using the yeast two hybrid system , a genetic assay for studying protein protein interactions , we have examined and compared the interaction of the insulin like growth factor 1 receptor ( IGF IR ) and the insulin receptor ( IR ) with their two known substrates p52Shc and the insulin receptor substrate 1 ( IRS 1 ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The role of the insulin receptor substrate 1 ( IRS 1 ) in cellular transformation was studied in R cells , which are 3T3 like fibroblasts derived from mouse embryos with a targeted disruption of the insulin like growth factor 1 receptor gene . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We have shown previously that the extracellular sequences of the human insulin receptor ( IR ) and the insulin like growth factor 1 receptor ( IGFR ) have an inhibitory effect on protein tyrosine kinase ( PTK ) activity and on the biological functions of their respective Gag receptor fusion proteins . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In contrast to the widespread expression of insulin receptor and insulin like growth factor 1 receptor mRNAs in the brain , the expression of IRR mRNA was highly restricted to the forebrain cholinergic neurons . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Signalling through the insulin receptor and the insulin like growth factor 1 receptor . ^^^ The insulin receptor and the insulin like growth factor 1 receptor belong to the family of tyrosine kinase receptors . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In contrast to the widespread expression of insulin receptor and insulin like growth factor 1 receptor messenger RNA ( mRNA ) , the expression of IRR mRNA is highly restricted to the kidney and stomach . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Kinetic data for tyrosine phosphorylation of hIRS p 30 by partially purified insulin receptor and insulin like growth factor 1 receptor and by baculovirus expressed insulin receptor kinase domain were determined . ^^^ Native insulin receptor demonstrated the highest affinity to hIRS p 30 ( Km = 6 . 8 + / 0 . 6 microM ) , followed by the insulin like growth factor 1 receptor ( Km = 9 . 9 + / 1 . 0 microM ) . ^^^ Our results indicate that the recombinant hIRS p 30 protein is a high affinity substrate for insulin receptor and insulin like growth factor 1 receptor in vitro . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor related receptor ( IRR ) demonstrates striking structural homology to the insulin receptor ( IR ) and insulin like growth factor 1 receptor ( IGFR ) , suggesting that IRR is a member of the IR family . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Vanadyl ( 4+ ) but not vanadate ( 5+ ) inhibits receptor tyrosine kinases such as the insulin receptor ( IC 50 value = 23 + / 4 microM ) and the insulin like growth factor 1 receptor ( IC 50 = 19 + / 3 microM ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To determine whether these residues contribute to receptor binding specificity for the insulin like growth factor 1 receptor ( IGF 1R ) relative to the insulin receptor ( IR ) we examined the binding of hIGF 1 analogs in which these residues have been replaced with either alanine or the corresponding residue of insulin . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The affinities of a number of insulin analogues for the human insulin receptor , a truncated soluble form of the insulin receptor , and the human insulin like growth factor 1 receptor were determined . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Ala > Gly mutation in the putative catalytic loop confers temperature sensitivity on Ros , insulin receptor , and insulin like growth factor 1 receptor protein tyrosine kinases . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Frozen section specimens were incubated with antibodies against insulin , insulin like growth factor 1 , insulin receptor , and insulin like growth factor 1 receptor . ^^^ RESULTS : The fetal endometrium at 19 and 22 weeks of gestation contained insulin , insulin like growth factor 1 , insulin receptor , and insulin like growth factor 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 1 receptor number appeared to be unaltered in both phases , whereas insulin receptor numbers and tyrosine kinase activity in the secretory phase were significantly increased . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor related insulin like growth factor 1 receptor also showed no functional changes . ^^^ These findings demonstrate that the primary genetic lesion in Seip Berardinelli ' s lipodystrophy is outside the insulin receptor gene and that an involvement of the insulin like growth factor 1 receptor is also unlikely . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 1 receptor as well as the insulin receptor displays the capacity to phosphorylate the beta 2 adrenergic receptor in vitro , establishing a new paradigm , i . e . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| G protein and tyrosine kinase receptor cross talk in rat aortic smooth muscle cells : thrombin and angiotensin 2 induced tyrosine phosphorylation of insulin receptor substrate 1 and insulin like growth factor 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Activation of the phosphatidyl inositol 3 kinase ( PI 3 kinase ) is one of the immediate events in signaling by the insulin receptor ( IR ) and the insulin like growth factor 1 receptor ( IGF IR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The interaction was specific for the insulin receptor and the insulin like growth factor 1 receptor , and it required a catalytically active receptor kinase domain and an intact Grb 10 SH2 domain . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Increased tyrosine phosphorylation of these proteins is also observed in cells expressing a transforming chicken c Src ( mutant Phe 527 ) and in cells with the activated tyrosine kinase domains of the Drosophila insulin receptor , human insulin like growth factor 1 receptor , and human insulin receptor related receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Estradiol stimulates tyrosine phosphorylation of the insulin like growth factor 1 receptor and insulin receptor substrate 1 in the uterus . ^^^ Analysis of immunoprecipitates from uterine extracts revealed that E 2 enhanced tyrosine phosphorylation of the insulin like growth factor 1 receptor ( IGF 1R ) and insulin receptor substrate 1 ( IRS 1 ) by 6 hr . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Interaction of SH 2 containing protein tyrosine phosphatase 2 with the insulin receptor and the insulin like growth factor 1 receptor : studies of the domains involved using the yeast two hybrid system . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Here , using two hybrid assays and in vitro assays of protein interaction , we show that the epsilon isoform of 14 3 3 interacts with the insulin like growth factor 1 receptor ( IGFIR ) and with insulin receptor substrate 1 ( IRS 1 ) , but not with the insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Receptors affected by MHC 1 peptides do , indeed , have such sequence similarity , as illustrated here by insulin receptor ( IR ) and insulin like growth factor 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To identify molecular defects responsible for this disease , we tested the implication of 14 candidate genes coding for proteins involved either in insulin action , i . e . insulin receptor , insulin receptor substrate 1 , insulin like growth factor 1 receptor , diabetes associated ras like protein ( Rad ) , and glycogen synthase , or in lipid metabolism , i . e . lipoprotein lipase ; apolipoproteins CII , AII , and CIII ; hepatic lipase ; hormone sensitive lipase ; the beta 3 adrenergic receptor ; leptin ; and fatty acid binding protein 2 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The twin tyrosine residues at 1250 and 1251 of the insulin like growth factor 1 receptor ( IGF IR ) are missing in the corresponding homologous region of the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To characterize the structural basis for the interaction between hGrb 10 and the insulin receptor and the insulin like growth factor 1 receptor , different mutant receptors containing a segment of deletion in either the juxtamembrane domain or in the C terminus of the receptors , or containing tyrosine to phenylalanine point mutations in these regions of the insulin receptor , were generated . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 1 receptor internalization regulates signaling via the Shc / mitogen activated protein kinase pathway , but not the insulin receptor substrate 1 pathway . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 interacts differentially with the insulin receptor , insulin like growth factor 1 receptor , and epidermal growth factor receptor via the Grb 10 Src homology 2 ( SH 2 ) domain and a second novel domain located between the pleckstrin homology and SH 2 domains . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylated ( Tyr ( P ) ) insulin like growth factor 1 receptor ( IGF 1R ) and the insulin receptor substrate ( IRS ) 1 are found in the uterus of mice treated with estradiol . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 1 induced DNA synthesis in insulin secreting cell line RINm5F is associated with phosphorylation of the insulin like growth factor 1 receptor and the insulin receptor substrate 2 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Antibody blockade of the insulin receptor abolished insulin ' s stimulatory action , whereas effective antibody blockade of the insulin like growth factor 1 receptor did not alter insulin ' s stimulation of thecal testosterone biosynthesis . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In contrast , ligand induced autophosphorylation of the epidermal growth factor ( EGF ) receptor , insulin receptor , and the insulin like growth factor 1 receptor , as well as c fos mRNA expression induced by EGF , fibroblast growth factor , and phorbol ester , was insensitive to inhibition by CGP 53716 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In cells , DAPH 2 inhibits signal output from the EGF receptor , but not from other classes of receptor protein tyrosine kinases , such as the platelet derived growth factor receptor , fibroblast growth factor receptor , insulin like growth factor 1 receptor , and insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To determine whether potentiation of cell survival is an intrinsic function among the insulin receptor tyrosine kinase ( RTK ) family , we compared the ability of insulin receptor ( IR ) and insulin like growth factor 1 receptor ( IGF IR ) cytoplasmic tails to attenuate apoptosis . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor family consists of the homologous tyrosine kinase receptors , insulin receptor ( IR ) , insulin like growth factor 1 receptor ( IGF1R ) and insulin receptor related receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The extensive colocalization of insulin receptor ( IR ) and insulin like growth factor 1 receptor ( IGFR ) messenger RNAs during central nervous system development , together with the effects of insulin and IGF 1 in neurogenesis , raises the question of how stage and factor specific signaling occurs . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation experiments showed that insulin like growth factor 1 receptor and insulin receptor substrate 1 were tyrosine phosphorylated to the same extent in both cells treated with colchicine and in those not exposed to the drug . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Interaction of insulin receptor substrate 3 with insulin receptor , insulin receptor related receptor , insulin like growth factor 1 receptor , and downstream signaling proteins . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Myocardial glut 1 , glut 4 , insulin receptor ( Ins R ) and insulin like growth factor 1 receptor ( IGF 1 R ) protein levels were unaffected by 36 weeks of chronic exercise . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We have investigated the role of the C terminal of the alpha subunit in the insulin receptor family by characterizing chimeric mini receptor constructs comprising the first three domains ( 468 amino acids ) of insulin receptor ( IR ) or insulin like growth factor 1 receptor ( IGFIR ) combined with C terminal domain from either insulin receptor ( IR ) ( residues 704 719 ) , IGFIR , or insulin receptor related receptor ( IRRR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The differential effects of pp 120 ( Ceacam 1 ) on the mitogenic action of insulin and insulin like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor . pp 120 ( Ceacam 1 ) undergoes ligand stimulated phosphorylation by the insulin receptor , but not by the insulin like growth factor 1 receptor ( IGF 1R ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Differential roles of insulin receptor and insulin like growth factor 1 receptor in differentiation of murine skin keratinocytes . ^^^ The insulin receptor and the insulin like growth factor 1 receptor are widely expressed tyrosine kinases that mediate insulin and insulin like growth factor 1 signaling . ^^^ We have studied the regulation of insulin receptor and insulin like growth factor 1 receptor in the differentiation of cultured murine keratinocytes . ^^^ Terminal differentiation resulted in a decrease in insulin receptor autophosphorylation , whereas insulin like growth factor 1 receptor autophosphorylation was abolished . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Mice with access to the ethanol solution drank an average of 5 . 35+ / 0 . 77 g of ethanol / kg body weight per day . [ 125I ] Insulin like growth factor 1 receptor binding sites were found to be significantly increased in all subfields of the hippocampal formation , but not in the cerebellum , of ethanol treated mice compared to controls . [ 125I ] Insulin like growth factor 2 and [ 125I ] insulin receptor binding sites , on the other hand , did not exhibit any alterations either in the hippocampus or cerebellum following chronic exposure to ethanol . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Transient expression of Vav in 293T and NIH 3T3 cells demonstrated that ligand stimulation of several RPTKs ( epidermal growth factor receptor [ EGFR ] , Ros , insulin receptor [ IR ] , and insulin like growth factor 1 receptor [ IGFR ] ) led to tyrosine phosphorylation of Vav 3 and its association with the receptors as well as their downstream signaling molecules , including Shc , Grb 2 , phospholipase C ( PLC gamma ) , and phosphatidylinositol 3 kinase . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Hybrid receptors ( HRs ) , insulin receptor ( IR ) / insulin like growth factor 1 receptor ( IGF 1 R ) heterodimers have been reported increased in skeletal muscle of obese and type 2 diabetic patients and to contribute to the patient insulin resistance . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Down regulation of insulin like growth factor 1 receptor and insulin receptor substrate 1 expression in advanced human breast cancer . ^^^ We investigated the expression pattern of insulin like growth factor 1 receptor ( IGF IR ) , insulin receptor ( IR ) and insulin receptor substrate 1 ( IRS 1 ) , a core downstream signaling protein , in 69 primary breast cancer specimens of different grades and in 21 control tissues by immunohistochemistry . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Here we investigate the requirement of MAP ( MAPK ) and phosphatidylinositol 3 ( PI3K ) kinases in the transformation of rat intestinal epithelial ( RIE ) cells by oncogenic forms of insulin receptor ( gag IR ) , insulin like growth factor 1 receptor ( gag IGFR ) , and 5 Src . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Activation of the insulin receptor by its ligand , or cross activation of the insulin like growth factor 1 receptor , has been shown to be mitogenic and promote tumorigenesis in various model systems . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Estrogen can increase insulin like growth factor 1 receptor ( IGF IR ) and insulin receptor substrate 1 ( IRS 1 ) expression , two key components of IGF 1 mediated signaling . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| A receptor binding assay based on the surface plasmon resonance ( SPR ) biosensor technique was developed to study the interaction between insulin like growth factor 1 receptor ( IGF 1R ) and its intracellular substrate protein insulin receptor substrate 1 ( IRS 1 ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor ( IR ) and the insulin like growth factor 1 receptor ( IGF IR ) belong to the same subfamily of receptor tyrosine kinases with two extracellular alpha subunits and two transmembrane beta subunits . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor and insulin like growth factor 1 receptor ( IGF 1R ) , activated by their ligands , control metabolism , cell survival , and proliferation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Both the insulin receptor and the insulin like growth factor 1 receptor are capable of stimulating glucose uptake into skeletal muscle . ^^^ One model involves the gene deletion of muscle glucose transport protein 4 , which leads to severe insulin resistance and hyperglycemia , and a second model using a transgenic approach abrogates the function of the insulin like growth factor 1 receptor and the insulin receptor resulting in severe insulin resistance and progression to diabetes . ^^^ Both models demonstrate that abrogation of the insulin like growth factor 1 receptor and the insulin receptor or a common signalling pathway must be inhibited to cause sufficient insulin resistance to lead to type 2 diabetes ; with either glucotoxicity or lipotoxicity being involved in the progression from severe to resistance to full blown type 2 diabetes . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor ( IR ) and the insulin like growth factor 1 receptor ( IGF IR ) have a highly homologous structure , but different biological effects . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The most efficient agent , AG 1024 , known as an inhibitor of insulin like growth factor 1 receptor and insulin receptor , arrested melanoma cell growth in vitro at nanomolar concentrations within 24 h of application . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor ( IR ) and the insulin like growth factor 1 receptor ( IGF 1R ) are members of the same subfamily of receptor tyrosine kinases . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Because the elevated expression of insulin receptor ( IR ) / insulin like growth factor 1 receptor ( IGF IR ) hybrids has been associated with insulin resistance in some studies , we hypothesized that IR / IGF IR hybrid abundance and binding affinity increase with development . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In the presence of 4 nM insulin , 3 nM C peptide significantly increased autophosphorylation of the insulin receptor ( IR ) but not that of the insulin like growth factor 1 receptor ( IGF 1R ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The spatial and temporal distribution of the three insulin like growth factor receptors ( insulin like growth factor 1 receptor , insulin like growth factor II / mannose 6 phosphate receptor and insulin receptor ) in rat metanephros during both normal and streptozotocin induced diabetic renal development was investigated using in situ hybridization and immunohistochemistry . ^^^ Insulin receptor and insulin like growth factor 1 receptor expressions were unchanged in diabetic metanephroi . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Structural changes in a long acting insulin analog , insulin glargine , may change its binding properties to insulin receptor and structurally homologous receptors , such as the insulin like growth factor 1 receptor , and thereby alter its vascular effects . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The importance of the insulin receptor ( IR ) and the insulin like growth factor 1 receptor ( IGF 1R ) for glucose regulated insulin secretion and gene expression in pancreatic islet beta cells is at present unresolved . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| This effect is associated with inhibition of insulin receptor ( IR ) and insulin like growth factor 1 receptor ( IGF IR ) autophosphorylation , which implicates these receptors as direct targets for ethanol . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In addition , the IRS 1 ( 925 1008 ) G972R peptide acted as a competitive inhibitor of insulin receptor and insulin like growth factor 1 receptor autophosphorylation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The Meg1 / Grb10 protein has been implicated as an adapter protein in the signaling pathways from insulin receptor ( IR ) and insulin like growth factor 1 receptor ( IGF1R ) in vitro . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Insulin receptor substrate 1 ( IRS 1 ) transmits signals from the insulin like growth factor 1 receptor ( IGF IR ) and insulin receptor ( IR ) and has been associated with the pathogenesis of cancer . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , T antigen does not operate directly , but utilizes insulin receptor substrate 1 ( IRS 1 ) , which is the major signaling molecule for insulin like growth factor 1 receptor ( IGF IR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| De novo and acquired resistance , however , have been reported to gefitinib and here we describe evidence which indicates that the type 2 receptor tyrosine kinases ( RTKs ) insulin like growth factor 1 receptor ( IGF IR ) and / or insulin receptor ( InsR ) play important roles in the mediation of responses to gefitinib in the de novo and acquired resistance phenotypes in several cancer types . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The aims of this study were to determine : ( 1 ) whether HCB is co carcinogenic in a medium term assay of N nitroso N methylurea ( NMU ) induced mammary tumors in rats ; ( 2 ) the effect of HCB on insulin receptor ( IR ) , insulin like growth factor 1 receptor ( IGF IR ) and insulin receptor substrate 1 ( IRS 1 ) levels and on IRS 1 phosphorylation ; ( 3 ) microsomal and cytosolic Protein Tyrosine Kinase ( PTK ) activities in mammary glands and NMU induced tumors . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The cyclolignan PPP was recently demonstrated to inhibit the activity of insulin like growth factor 1 receptor ( IGF 1R ) , without affecting the highly homologous insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To locate a second site , we examined the binding properties of chimeric receptors in which the L 1 and L 2 domains and the first Fibronectin Type 3 repeat of the insulin like growth factor 1 receptor were replaced by corresponding regions of the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin and IGF 2 promoted cell growth and pEGFR Tyr 845 , Tyr 1068 and Tyr 1173 activity and conversely , the insulin like growth factor 1 receptor ( IGF 1R ) / InsR inhibitor ABDP ( 1 muM ) inhibited growth and reduced pEGFR activity at all three tyrosine residues . pInsR and pAkt levels were increased after gefitinib treatment . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The first three domains of the insulin receptor differ structurally from the insulin like growth factor 1 receptor in the regions governing ligand specificity . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To determine whether the insulin receptor ( IR ) , insulin like growth factor 1 receptor ( IGF IR ) , and IGF 1 are expressed differentially in fibroblasts isolated from normal peritoneal and adhesion tissue before and after 24 hour treatment with increasing glucose concentrations . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Comparison of the IGFIR promoter with that of the human insulin receptor ( IR ) revealed structural similarities , although the arrangement of promoter elements differed . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Mouse embryo cells expressing a wild type number of insulin like growth factor 1 receptors ( IGF IR ) ( W cells ) can be transformed either by simian virus 40 large T antigen ( SV 40 T ) or by overexpressed insulin receptor substrate 1 ( IRS 1 ) , singly transfected . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Chimeric receptors were generated in which structurally defined subdomains of the insulin receptor ( IR ) and insulin growth factor 1 receptor ( IGF 1R ) alpha subunits were exchanged between their respective receptor backbone structures . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| MDA MB 468 is a human breast cancer cell line which expresses insulin receptor and high levels of epidermal growth factor / transforming growth factor alpha receptor but low levels of IGF IR . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| However , both autophosphorylation of the IGF 1R beta subunit ( i . e . , IGF 1R tyrosine kinase ) and the IGF 1R tyrosine kinase activity towards exogenous insulin receptor substrate 1 , a natural substrate for IGF 1R tyrosine kinase , were reduced in CRF fats . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| A D amino acid analog of IGF 1 , JB 3 , inhibited SMC replication and dose dependently inhibited insulin receptor substrate 1 ( IRS 1 ) and IGF 1R phosphorylation in vitro . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Primary sequence comparisons show that the ILP receptor is a member of the insulin receptor family , which in mammals includes the insulin receptor ( IR ) , type 1 IGF receptor ( IGF IR ) , and IR related receptor ( IRR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To study the interaction between insulin receptor ( IR ) and insulin like growth factor 1 ( IGF 1 ) receptor ( IGF IR ) tyrosine kinases , we examined IGF 1 action in Rat 1 cells expressing a naturally occurring tyrosine kinase deficient mutant IR ( Asp 1048 IR ) . ^^^ These results suggest that the Asp 1048 IR causes a dominant negative effect on IGF IR in transmitting signals to Shc and MAP kinase activation , which leads to decreased IGF 1 stimulated DNA synthesis , and that the kinase defective insulin receptor does not affect IGF 1 stimulated IRS 1 phosphorylation , which leads to the normal IGF 1 stimulated glycogen synthesis . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Direct interaction of effector proteins such as the p 85 regulatory subunit of phosphatidylinositol 3 kinase ( PI 3 kinase ) , SYP ( SH 2 domain containing tyrosine phosphatase ) and GAP ( Ras GTPase activating protein ) with the insulin receptor ( IR ) and insulin like growth factor 1 ( IGF 1 ) type 1 receptor ( IGF 1R ) has been reported in some studies . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| From these results , we conclude that IGF 2 can stimulate cell proliferation not only through its cognate IGF1R but also through the insulin receptor . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To determine whether XR is the insulin receptor ( IR ) , we examined embryos nullizygous for both Igf1r and Insr . ^^^ The Igf1r / Insr double nullizygotes are phenotypically indistinguishable from double mutants lacking IGF1R and IGF 2 and from other double and triple mutants in which all of the IGF ligand / receptor interactions have been eliminated . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To evaluate the function of 2 post receptor signaling molecules , insulin receptor substrate 1 ( IRS 1 ) ( a major substrate of the IGF IR ) and SHC ( a common substrate of tyrosine kinase receptors ) , we developed several MCF 7 derived cell clones in which the synthesis of either IRS 1 or SHC was blocked by antisense RNA . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| WF cells demonstrated a greater degree of ligand stimulated insulin receptor substrate 1 phosphorylation when compared with W cells , suggesting that expression of the EWS / FLI 1 fusion protein alters the IGF IR signaling pathway . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In 293 cells association of p55PIK with insulin receptor substrate 1 and with IGF IR was dependent on PI 3 kinase , since it was increased by wortmannin , an inhibitor of PI 3 kinase . ^^^ Importantly , this dominant negative mutant was more efficient than wild type p55PIK in associating to IGF IR and insulin receptor substrate 1 in 293 cells . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin / IGF 1 hybrid receptors composed of an insulin receptor ( IR ) alphabeta hemireceptor and a type 1 IGF receptor ( IGF IR ) alphabeta hemireceptor are formed in tissues expressing both molecules . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The hp 55 gamma protein interacts strongly with the activated IGFIR but not with the kinase negative mutant receptor . hp 55 gamma also interacts with the insulin receptor ( IR ) in the yeast two hybrid system . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We have used a yeast two hybrid system to identify proteins which bind to the cytosolic portion of the type 1 insulin like growth factor ( IGF ) receptor ( IGFIR ) but not the insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Although the mitogenic function of the IGF IR may require the activation of insulin receptor substrate 1 ( IRS 1 ) or IRS 2 , an overexpressed IGF IR is able to protect 32D cells , which lack IRS 1 and IRS 2 , from apoptosis caused by Interleukin 3 ( IL 3 ) withdrawal . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The type 1 insulin like growth factor receptor ( IGF 1R ) and insulin receptor ( IR ) are closely related members of the tyrosine kinase receptor superfamily . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To this end we developed several MCF 7 clones that overexpressed insulin receptor substrate 1 ( IRS 1 ) , one of the principal substrates of the IGF IR . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We report here that IGF 1 stimulated the tyrosine phosphorylation of the type 1 IGF receptor ( IGF IR ) and insulin receptor substrate 2 ( IRS 2 ) in a time and concentration dependent manner . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Here , we studied the effects of ICI 182 , 780 on IGF IR signal transduction in MCF 7 breast cancer cells and in MCF 7 derived clones overexpressing either the IGF IR or its 2 major substrates , insulin receptor substrate 1 ( IRS 1 ) or src / collagen homology proteins ( SHC ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The overexpression of IGF IR caused the transfectants to proliferate in response to IGF 1 in the absence of insulin receptor substrate ( IRS ) expression . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We find that one of the major substrates of the IGF IR , the insulin receptor substrate 1 inhibits IGF 1 mediated differentiation of 32D cells . ^^^ In the absence of insulin receptor substrate 1 , functional impairment of another major substrate of the IGF IR , the Shc proteins , is associated with a decrease in the extent of differentiation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Because R cells do not express the IGF IR , they are ideal for studying the biological effects of the insulin receptor ( IR ) , independently from any contribution by the IGF IR . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Most of its effects are mediated by the Type 1 IGF receptor ( IGF IR ) , a heterotetramer that has tyrosine kinase activity and phosphorylates insulin receptor substrates ( IRS 1 and 2 ) which leads to the activation of two downstream signaling cascades : the MAP kinase and the phosphatidylinositol 3 kinase ( P3K ) cascades . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Genetic ablation experiments of insulin receptor substrate 1 ( IRS 1 ) and 2 ( IRS 2 ) , two important molecules in the IR and IGF IR signaling pathways , are also beginning to shed light onto the mechanisms accounting for the specificity of IR and IGF IR signaling . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor ( IR ) and the insulin like growth factor receptor 1 ( IGF IR ) have different functions in cell growth , apoptosis , differentation , and transformation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 has been described as a cellular partner of several receptor tyrosine kinases , including the insulin receptor ( IR ) and the insulin like growth factor 1 ( IGF 1 ) receptor ( IGF IR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In 32D cells ( a murine hemopoietic cell line devoid of insulin receptor substrate 1 [ IRS 1 ] ) , the IGF 1R activates alternative pathways for protection from apoptosis induced by withdrawal of interleukin 3 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor ( IR ) and the structurally related insulin like growth factor type 1 receptor ( IGF 1R ) belong to the tyrosine kinase ( TK ) receptor family . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| PSM / SH2 B has been described as a cellular partner of the FcepsilonRI receptor , insulin receptor ( IR ) , insulin like growth factor 1 ( IGF 1 ) receptor ( IGF IR ) , and nerve growth factor receptor ( TrkA ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Ethanol inhibits IGF IR tyrosine autophosphorylation , which subsequently interferes with the activation of key downstream signaling mediators including insulin receptor substrate 1 , phosphatidylinositol 3 kinase , and mitogen activated protein ( MAP ) kinase . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The two major substrates of the IGF IR , insulin receptor substrate 1 ( IRS 1 ) and the Shc proteins , are known to contribute to this activation . ^^^ The importance of the C terminus of the IGF IR in ERK activation ( in the absence of IRS 1 ) is confirmed by the failure of the insulin receptor to give a sustained activation of ERK . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In COS 7 cells , IGF 1 stimulation causes tyrosine phosphorylation of the IGF 1R beta subunit , the EGFR , insulin receptor substrate 1 ( IRS 1 ) , and the Shc adapter protein . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| After an initial burst of cell proliferation , the type 1 insulin like growth factor receptor ( IGF IR ) induces granulocytic differentiation of 32D IGF IR cells , an interleukin 3 dependent murine hemopoietic cell line devoid of insulin receptor substrate 1 ( IRS 1 ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Taken together , these results demonstrate that up regulation and activation of IGF IR and the downstream signaling pathway involving insulin receptor substrate 2 , phosphatidylinositol 3 ' kinase , and p70S6K may play an important role in the development of a broad spectrum of plasma cell tumors . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Our recent work demonstrated that activation of the insulin like growth factor receptor ( IGF IR ) / insulin receptor substrate ( IRS ) / phosphatidylinositol 3 ' kinase ( PI 3 ' K ) pathway was evident in the tumor lines derived from both species . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We found that human SOCS 3 protein interacts directly with the cytoplasmic domains of the activated IGFIR and the insulin receptor ( IR ) in the yeast two hybrid assay . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The search for these compounds utilized two novel in vitro assays and was aided by the knowledge of the three dimensional structure of the insulin receptor kinase domain , which is 84 % homologous to the IGF 1R kinase domain . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Importantly , signaling molecules such as IGF IR , insulin receptor , and insulin receptor substrate 1 , leading to the MAP kinase pathway , were found to be concomitantly overexpressed within certain tumor lines , i . e . , MCF 7 and T 47D . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Functional studies demonstrated that insulin induced a dose dependent phosphorylation of the insulin receptor , IGF 1R , insulin receptor substrates 1 and 2 , Shc , and STAT 1 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In estrogen receptor ( ER ) positive breast tumors , the levels of the IGF IR and its substrate , insulin receptor substrate 1 ( IRS 1 ) , are often elevated , and these characteristics have been linked with increased radioresistance and cancer recurrence . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| To study the role of kinase dimerization in the activation of the insulin receptor ( IR ) and the insulin like growth factor receptor 1 ( IGF 1R ) , we have cloned , expressed , and purified monomeric and dimeric forms of the corresponding soluble kinase domains via the baculovirus expression system . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation of both receptor forms by antibodies against the alpha subunit and against the carboxy terminus of the beta subunit of the IGF IR suggests that the 75 kDa form could be the beta chain truncated at the amino terminus above the alpha beta disulphide bridges . 3 ) The ATA activated IGF IR forms underwent slow dephosphorylation , compared with a rapid dephosphorylation of the IGF 1 activated receptor . 4 ) The insulin receptor substrate 1 / 2 associated PI3K , Shc proteins , and the kinases Akt and Erk1 / 2 , downstream mediators of the antiapoptotic signaling by IGF IR , were activated to a higher extent and for a longer time period by ATA , compared with IGF 1 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| IGF IR ( / ) brown adipocytes lacked IGF IR protein expression ; insulin receptor ( IR ) expression remained unchanged as compared with wild type cells . ^^^ Upon insulin stimulation , tyrosine phosphorylation of ( insulin receptor substrate 1 ) IRS 1 was much higher in IGF IR ( / ) brown adipocytes , although IRS 1 protein content was reduced . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We identified RACK 1 , a WD repeat family member and a Gbeta homologue , and demonstrated that RACK 1 interacts with the IGF IR but not with the closely related insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Recent studies in a human cell line and a mouse model suggest that metastatic prostate cancer cell detachment may be favored by impairing cadherin function via loss of expression of insulin receptor substrate 1 ( IRS 1 ) , the principal IGF1R docking molecule . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Results of this study show that the majority of cases examined were characterized by the abundant presence of the receptor for IGF 1 ( IGF IR ) protein ( 16 of 20 cases ) , and its major signaling molecule , insulin receptor substrate 1 ( IRS 1 ; 15 of 20 ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| IGF IR ( / ) cells showed an increased insulin sensitivity regarding insulin receptor substrate 1 ( IRS 1 ) tyrosine phosphorylation despite a substantial reduction in IRS 1 protein content . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| However these agents induce relatively modest IGF1R down regulation and affect insulin receptor levels . ^^^ This strategy enabled selection of antisense oligonucleotides that generated high heteroduplex yield with IGF1R but not insulin receptor transcripts . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation / Western blot studies revealed that CLA inhibited IGF 1 induced phosphorylation of IGF IR and insulin receptor substrate ( IRS ) 1 , recruitment of the p 85 regulatory subunit of phosphatidylinositol 3 kinase ( PI3K ) to IGF IR , IGF IR associated PI3K activity , and phosphorylated Akt and extracellular signal regulated kinase ( ERK ) 1 / 2 levels . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| EM 164 was initially selected by a rapid cell based screen of hybridoma supernatants to identify antibodies that bind to IGF IR but not to the homologous insulin receptor and that show maximal inhibition of IGF 1 stimulated autophosphorylation of IGF IR . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that 1 ) IGF 1 causes the colocalization of signaling proteins in caveolae through a phosphorylation regulated mechanism ; and 2 ) the time course of phosphorylation and recruitment of substrates in caveolae by insulin receptor and IGF IR could determine the specific actions of these receptors . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Problems for the clinical introduction of this approach may include toxicity due to normal tissue IGF1R expression and cross reactivity with the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 proteins are binding partners for several trans membrane tyrosine kinase receptors , including the insulin like growth factor receptor ( IGF IR ) and the insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor substrate 1 and 2 ( IRS 1 and IRS 2 ) , two major downstream molecules of IGF 1R , are known to be important in the genesis of diabetes . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Here we show that the insulin receptor tyrosine kinase family , comprising Ir , Igf1r and Irr , is required for the appearance of male gonads and thus for male sexual differentiation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Interestingly , autophosphorylation of the IGF IR and phosphorylation of the downstream substrate , insulin receptor substrate 1 ( IRS 1 ) , was not inhibited in doxycycline / IGF 1 treated cells , suggesting the possibility that activation of downstream substrates other than the IRS 1 may be critical for optimal cell proliferation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The type 1 insulin like growth factor receptor ( IGF IR ) and its docking protein , insulin receptor substrate 1 ( IRS 1 ) , play important roles in cell transformation , cell differentiation and aging . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| This is explained by the fact that IGF 1R is highly homologous to the insulin receptor , coinhibition of which may cause diabetic response . ^^^ PPP did not affect the insulin receptor or compete with ATP in an in vitro kinase assay , suggesting that it may inhibit IGF 1R autophosphorylation at the substrate level . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In colostrum fed calves , DEXA decreased ( P < 0 . 05 ) mRNA levels of IGF 1 ( esophagus , fundus , duodenum , and ileum ) , IGF 2 ( fundus ) , IGFBP 2 ( fundus ) , IGFBP 3 ( fundus ) , IGF1R ( esophagus , ileum , and colon ) , IGF2R ( fundus ) , GHR ( fundus ) , and InsR ( esophagus , fundus ) , but in formula fed calves DEXA increased mRNA levels of IGF 1 ( esophagus , rumen , jejunum , and colon ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Most of the compounds also inhibited the closely related insulin receptor to varying degrees , although some compounds showed selectivity for IGF1R or insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The beta1A integrin forms a complex with the IGF IR and insulin receptor substrate 1 ( IRS 1 ) ; this complex does not promote IGF 1 mediated cell adhesion to laminin ( LN ) , although it does support IGF mediated cell proliferation . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Recently , we demonstrated that the cyclolignan PPP efficiently inhibited phosphorylation of IGF 1R without interfering with insulin receptor activity . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We found that IGF 1 activated the IGF 1R , insulin receptor substrate ( IRS ) 1 , phosphatidylinositol 3 kinase , and Akt in a time dependent manner in alphaT 3 cells . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We found no statistical evidence that GHRHR , IGF1R , INSR , PROP 1 , or TRX delay or that ATM + TERC , BubR 1 , klotho , LMNA , PRDX 1 , p 53 , WRN + TERC , or TOP3B accelerate mouse aging . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factors 1 and 2 , IGFBP 2 and 3 , and receptors for IGF type 1 and type 2 ( IGF 1R , IGF 2R ) , growth hormone ( GHR ) , and insulin ( InsR ) in neonatal calves are variably expressed among gastrointestinal sites and thought to exert site specific physiological functions . ^^^ We studied by real time reverse transcription PCR , whether there are differences in the abundance of mRNA coding for IGF 1 , IGF 2 , IGFBP 2 , IGFBP 3 , IGF 1R , IGF 2R , GHR , and InsR in compartmentalized layers ( fractions ) of jejunum and ileum of 5 d old calves fed colostrum . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| However , antisense agents cause only modest IGF1R down regulation , and can affect the insulin receptor . ^^^ Using an array based screen to identify accessible regions of IGF1R mRNA , we designed small interfering RNAs ( siRNAs ) that induce potent IGF1R gene silencing without affecting the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| In this review , several points relevant to targeting IGF 1R will be discussed , including the signalling pathways downstream of the receptor , the potential role for the insulin receptor in regulating IGF action and multiple cancer phenotypes regulated by this receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The growth and survival signals of IGF IR are mediated through multiple intracellular pathways , many of which emanate from insulin receptor substrate 1 ( IRS 1 ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| One of these receptors , the insulin like growth factor II / mannose 6 phosphate receptor ( IGF2R , also called the Type 2 IGF receptor ) , has a structure distinct from IGF1R or the insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor substrate ( IRS ) proteins are major docking molecules for the type 1 insulin like growth factor ( IGF ) receptor ( IGF IR ) and mediate their effects on downstream signaling molecules . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The widespread IGF 1R expression in normal tissues and its close homology to the insulin receptor had led to the assumption that IGF 1R inhibition would cause unacceptable toxicities in vivo . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Here , we describe the characterization of a fully human anti IGF IR monoclonal antibody 19D12 that inhibits IGF binding and autophosphorylation of both IGF IR / IGF IR homodimers and IGF IR / insulin receptor heterodimers . 19D12 does not recognize insulin receptor homodimers . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Coimmunoprecipitation studies demonstrated that IGF IR and insulin receptor substrate 1 associated with caveolin , a caveolar marker , in 3T3L1 and NWTb 3 cells . ^^^ Immunoblotting revealed that methyl cyclodextrin had no effect on IGF 1 induced activation of the IGF IR or insulin receptor substrate 1 but increased and decreased the phosphorylation of MAPK and protein kinase B , respectively . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Although relatively high concentrations of IGF 1 also resulted in the activation of the insulin receptor ( IR ) , its effect was more significant on the IGF 1R . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We studied expression of the ligands IGF 1 and IGF 2 , the inhibitory IGF binding protein 3 , the type 1 IGF receptor ( IGF IR ) , and the downstream mediator insulin receptor substrate 1 by immunohistochemistry in 56 tissue specimens ( 28 low grade and 28 high grade prostate adenocarcinomas ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The gene expression profile of TC / ET cells indicated , among up regulated genes , an increase in expression of insulin like growth factor receptor 1 ( IGF IR ) and one of its major intracellular mediators , insulin receptor substrate 1 . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Intracellular association of RACK 1 via its N terminal WD domains 1 to 4 ( WD 1 4 ) with insulin receptor ( IR ) / IGF 1R is augmented upon respective ligand stimulation , whereas association with STAT 3 is constitutive . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin like growth factor receptor ( IGF IR ) and insulin receptor are either overactivated and / or overexpressed in a wide range of tumor types and contribute to tumorigenicity , proliferation , metastasis , and drug resistance . ^^^ Here , we show that BMS 554417 , a novel small molecule developed as an inhibitor of IGF IR , inhibits IGF IR and insulin receptor kinase activity and proliferation in vitro , and reduces tumor xenograft size in vivo . ^^^ BMS 554417 treatment inhibited IGF IR and insulin receptor signaling through extracellular signal related kinase as well as the phosphoinositide 3 kinase / Akt pathway , as evidenced by decreased Akt phosphorylation at Ser 473 . ^^^ BMS 554417 is a member of a novel class of IGF IR / insulin receptor inhibitors that have potential clinical applications because of their antiproliferative and proapoptotic activity in vitro and in vivo . . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| IGF 1 stimulated invasion and proliferation were abolished by functional blocking monoclonal antibody against IGF 1R , whereas these cellular functions were unaffected by either IgG or monoclonal antibody to insulin receptor . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| We have been hypothesizing that targeting IGF 2 in addition to blocking its interaction with the IGF receptor type 1 ( IGF IR ) would also allow to block that portion of the signal transduction through the insulin receptor that is due to its interaction with IGF 2 . ^^^ The most potent neutralizer , IgG 1 m610 , inhibited phosphorylation of the IGF IR and the insulin receptor , as well as phosphorylation of the downstream kinases Akt and mitogen activated protein kinase with an IC ( 50 ) of the order of 1 nmol / L at IGF 2 concentration of 10 nmol / L . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and insulin have all been implicated in regulating several aspects of the malignant phenotype via the type 1 IGF receptor ( IGF1R ) and insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Investigating the signaling pathway downstream of IGF 1R reveals that insulin receptor substrate 2 ( IRS 2 ) overexpression compensates for the lack of IGF 1R , whereas IRS 1 overexpression does not . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| Receptor protein , phosphorylation of IGF IR and IR beta subunit as well as the presence of hybrid insulin receptor / Insulin like growth factor 1 receptor ( Hybrid IR / IGF IR ) was analyzed by immunoprecipitation and Western blot . ^^^ RESULTS : The gene expression of IGF IR was several folds higher than that of IR . and insulin receptor isoform A ( IR A ) was 20 fold more expressed than insulin receptor isoform B ( IR B ) in HCAEC . ^^^ |
|
| Interacting proteins: P08069 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor is expressed in two isoforms , IR A and IR B ; the former also functions as a high affinity receptor for IGF 2 and is implicated , along with IGF 1R , in malignant transformation . ^^^ |
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