| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.55017051 |
| Association of Raf 1 with either 14 3 3 protein or insulin receptor was not influenced by insulin and was similar in all control and insulin treated cell lines . 0.55017051^^^ |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| We conclude that insulin can rapidly activate the Raf 1 kinase in some insulin sensitive cell types but that this activation probably occurs through a mechanism distinct from direct phosphorylation of the Raf 1 protein by the insulin receptor protein tyrosine kinase . . ^^^ |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| While insulin administration ( 15 micrograms / 100 g body weight ) led to insulin receptor beta subunit tyrosine phosphorylation and internalization , there was little detectable tyrosine phosphorylation of SHC , recruitment of GRB 2 , association of a complex with mSOS or any detectable change in the mobility of Raf 1 . ^^^ |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| Here we show that the maximal hyperphosphorylation of Raf 1 and MAPKK ( 10 min ) was substantially achieved after the maximal activation of MAPKKK of Raf 1 , MAPKK ( 2 5 min ) , and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor ( CHO HIR cells ) treated with insulin or 12 O tetradecanoylphorbol 13 acetate ( TPA ) . ^^^ |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| In contrast , in Chinese hamster ovary cells overexpressing the human insulin receptor ( CHO HIR cells ) , neither wortmannin nor LY 294002 inhibited the insulin induced activation of Raf 1 kinase , and wortmannin had little effect on the activation of MAP kinase by insulin . ^^^ |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| The present work shows that in human hepatoma Hep3B cells , insulin receptor ( IR ) can be coimmunoprecipitated with other components of the ERKs cascade : insulin receptor substrate ( IRS ) , Raf 1 , and ERKs . ^^^ |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor , insulin receptor substrate 1 , Raf 1 , and Mek 1 during hormonal hepatocarcinogenesis by intrahepatic pancreatic islet transplantation in diabetic rats . ^^^ Thus , we investigated FAHs , HCAs , and HCCs for altered expression of insulin receptor , insulin receptor substrate 1 ( IRS 1 ) , Raf 1 and Mek 1 . ^^^ |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| DHT treatment also reduced the insulin mediated insulin receptor substrate 1 and Raf 1 phosphorylation , the upstream molecules of ERK in insulin signaling pathway . ^^^ |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| Overexpression of 14 3 3epsilon in 3T3 hIR cells significantly reduced IRS 1 bound PKCalpha activity , without altering IRS 1 / PKCalpha co precipitation . 14 3 3epsilon overexpression also increased insulin stimulated insulin receptor and IRS 1 tyrosine phosphorylation , followed by increased activation of Raf 1 , ERK1 / 2 , and Akt / protein kinase B . ^^^ |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| After low number islet transplantation ( n = 450 ) , the liver acini downstream of the islets show insulin induced alterations : massive glycogen and / or fat accumulation , translocation of the insulin receptor , decrease in glucose 6 phosphatase activity , increase in expression of insulin like growth factor ( IGF ) 1 , IGF II / mannose 6 phosphate receptor , insulin receptor substrate 1 , Raf 1 , and Mek 1 , corresponding to clear cell preneoplastic foci of altered hepatocytes known from chemical hepatocarcinogenesis and identical to that in streptozotocin diabetic Lewis rats . ^^^ |
|
| Interacting proteins: P06213 and P04049 |
Pubmed |
SVM Score :0.0 |
| During the next 12 24 months , many peri insular ductules progressed via tumor like cystic lesions to large cystic cholangiomas , accompanied by a translocation of the insulin receptor into the cytoplasm and an increase in expression of insulin related signaling proteins ( Insulin receptor substrate 1 , Raf 1 , Mek 1 ) . ^^^ |
|