| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.86185031 |
| First , using a yeast two hybrid system , we show that SOCS 3 binds to the insulin receptor at phosphotyrosine 960 , which is precisely where Stat5B binds . 0.86185031^^^ |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.64057775 |
| Once induced , SOCS 3 interacts with the insulin receptor , JAK 2 , IRS 1 , and IRS 2 . 0.64057775^^^ |
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| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| We found that human SOCS 3 protein interacts directly with the cytoplasmic domains of the activated IGFIR and the insulin receptor ( IR ) in the yeast two hybrid assay . ^^^ |
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| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| When expressed , SOCS 3 binds to phosphorylated Tyr ( 960 ) of the insulin receptor and prevents Stat 5B activation by insulin . ^^^ Here we show that in COS 7 cells SOCS 3 decreases insulin induced insulin receptor substrate 1 ( IRS 1 ) tyrosine phosphorylation and its association with p 85 , a regulatory subunit of phosphatidylinositol 3 kinase . ^^^ |
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| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| TNF alpha results in insulin insensitivity , indirectly by stimulating stress hormone production and directly by sustained induction of SOCS 3 which decreases insulin induced insulin receptor substrate 1 ( IRS 1 ) tyrosine phosphorylation and its association with the p 85 , regulatory subunit of phosphatidylinositol 3 kinase ; and by negative regulation of PPAR gamma . ^^^ |
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| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| Ectopically expressed SOCS 3 associated with the IR and suppressed insulin dependent receptor autophosphorylation , insulin receptor substrate 1 ( IRS 1 ) tyrosine phosphorylation , association of IRS 1 with the p 85 subunit of phosphatidylinositol 3 kinase , and activation of Akt . ^^^ SOCS 3 was also a direct inhibitor of insulin receptor autophosphorylation in vitro . ^^^ |
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| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| Hepatitis C virus down regulates insulin receptor substrates 1 and 2 through up regulation of suppressor of cytokine signaling 3 . ^^^ |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14543 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|