| Interacting proteins: P01344 and P14735 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P14735 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P14735 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P14735 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P14735 |
Pubmed |
SVM Score :0.0 |
| We propose that this patient inactivated insulin at the injection site because of an insulin protease in his tissues that would normally be inhibited by serum IGF 2 . . ^^^ |
|
| Interacting proteins: P01344 and P14735 |
Pubmed |
SVM Score :0.0 |
| The effect of insulin like growth factors ( IGF 1 and IGF 2 ) on insulin degradation was studied with the use of a preparation of insulin protease from rat skeletal muscle . ^^^ Insulin protease also degraded 125I iodo IGF 1 and 125I iodo IGF 2 . 125I iodo IGF 2 was degraded more rapidly than was 125I iodo IGF 1 . 125I iodoinsulin was degraded more rapidly than 125I iodo IGF 2 . ^^^ |
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| Interacting proteins: P01344 and P14735 |
Pubmed |
SVM Score :0.0 |
| A human insulin degrading enzyme purified from IM 9 lymphocytes was tested for its ability to degrade insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor 2 ( IGF 2 ) . ^^^ The IGF 2 degrading activity chromatofocused with the insulin degrading activity and was absorbed by specific antibodies to the insulin degrading enzyme . ^^^ These studies indicate , therefore , that a human insulin degrading enzyme can degrade IGF 2 and , to a lesser extent , IGF I . . ^^^ |
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| Interacting proteins: P01344 and P14735 |
Pubmed |
SVM Score :0.0 |
| IDE and IGFR mRNAs are colocalized in oocytes , while IDE is colocalized with the IGF 2 receptor in spermatocytes , suggesting that IDE may be involved with degradation of IGF 2 in the testis . ^^^ |
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| Interacting proteins: P01344 and P14735 |
Pubmed |
SVM Score :0.0 |
| Since IGF 2 is the major autocrine / paracrine growth factor for neuroblastoma cells , we studied the expression and the role of IDE in this system . ^^^ |
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| Interacting proteins: P01344 and P14735 |
Pubmed |
SVM Score :0.0 |
| Atrial natriuretic peptide ( ANP ) , relaxin , glucagon , proinsulin , and insulin like growth factor 2 ( IGF 2 ) bind to and are degraded by IDE . ^^^ To explore the potential mechanism for the IDE control of MCP activity , dose response curves for insulin like growth factor 1 ( IGF 1 ) and IGF 2 effects on MCP chymotrypsin like activity were determined . ^^^ IGF 2 , which ( similar to insulin ) is a good substrate for IDE , had a substantial inhibitory effect , whereas IGF 1 , which is bound but poorly degraded , had little inhibitory activity on MCP . ^^^ |
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| Interacting proteins: P01344 and P14735 |
Pubmed |
SVM Score :0.0 |
| Insulin degrading enzyme ( IDE ) , a cytosolic metalloendoprotease , can degrade insulin , insulin like growth factor 2 , insulin like growth factor 1 , and transforming growth factor alpha . ^^^ Insulin degrading enzyme ( IDE ) , a cytosolic metalloendoprotease , can degrade insulin , insulin like growth factor 2 , insulin like growth factor 1 , and transforming growth factor alpha . ^^^ |
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