pathDIP is an annotated database of signaling cascades, comprising core pathways from major curated pathways databases, and extended pathways predicted by using physical protein interactions. Data integration and predictions increase coverage of pathway annotations for protein-coding genes to 86%, and provide novel annotations for 5,732 pathway orphans. PathDIP annotates 17,070 protein-coding genes with 4,678 pathways, and provides multiple query, analysis and output options.

Please cite the following paper for this database:
Sara Rahmati, Mark Abovsky, Chiara Pastrello, Igor Jurisica. pathDIP: an annotated resource for known and predicted human gene-pathway associations and pathway enrichment analysis. Nucleic Acids Research 2016; doi: 10.1093/nar/gkw1082 ( URL , PDF )


Jurisica Lab Krembil Research Institute


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