| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Activated insulin and insulin like growth factor 1 receptors transmit downstream signals via the insulin receptor substrate ( IRS 1 and IRS 2 ) and a series of proteins containing Src homology 2 ( SH 2 ) domains , including SH 2 containing protein tyrosine phosphatase 2 ( SHP 2 ) . ^^^ |
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| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| The role of IRS 2 as a signaling molecule for GH is further demonstrated by the finding that GH stimulates association of IRS 2 with the 85 kDa regulatory subunit of phosphatidylinositol 3 ' kinase and with the protein tyrosine phosphatase SHP 2 . ^^^ |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| We did not observe the association of IRS 2 with JAK 2 , Grb 2 , or PTP1D . ^^^ |
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| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Despite this , a variety of PTB or SH 2 domain containing signaling proteins , including IRS 2 , mSos 1 , Shc , p 85 subunit of phosphatidylinositol 3 kinase , SHP 2 , Raf 1 , and JAK 2 , were not associated with the INR beta Myc . ^^^ |
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| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Although a direct association between PI3K and Mpl could not be demonstrated , we found that several proteins , including SHP 2 , Gab 2 , and IRS 2 , undergo phosphorylation and association in BaF3 / Mpl cells in response to TPO stimulation , complexes that recruit and enhance the enzymatic activity of PI3K . ^^^ In primary murine MKs , TPO also induced phosphorylation of SHP 2 , its association with p 85 and enhanced PI3K activity , but in contrast to the results in cell lines , neither Gab 2 nor IRS 2 are phosphorylated in MKs . ^^^ |
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| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| These tyrosine phosphorylations lead to IRS 1 and IRS 2 induced recruitment of p85PI3K , SHP 2 , and Grb 2 and increase in PI 3 kinase activity associated with IRS 1 . ^^^ |
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| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| SHP 1 seems to be predominately activated by IL 4 and to influence the PI 3 kinase , in contrast , SHP 2 seems to be predominately activated by IL 13 and to influence Jak 1 , Tyk 2 and IRS 2 . ^^^ |
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| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| In the present study , we examined the protein levels and phosphorylation state of insulin receptor ( IR ) , IRS 1 and IRS 2 , the association between IRSs and PI3K and SHP 2 , the insulin induced IRSs associated PI 3 kinase activities , and the phosphorylation status of AKT and atypical PKCzeta / lambda in the liver and the muscle of 6 month old Wistar rats treated with DHEA . ^^^ |
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| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|