| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.55624428 |
| Treatment with PI 3 K inhibitors induced an increased association of IRS 2 with Grb 2 , probably as a result of the increased IRS 2 tyrosine phosphorylation . 0.55624428^^^ However , even though the PI 3 K inhibitors enhanced the association of Grb 2 with IRS 2 , these compounds suppressed IGF 1 induced mitogen activated protein kinase activation and neurite outgrowth . 0.50031798^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.72029332 |
| By contrast , association of phosphorylated IRS 2 with GRB 2 was not detected in resting B cells after IL 4 treatment although both proteins were expressed . 0.72029332^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| IRS 2 from FD 5 cells stimulated with either IL 4 or insulin bound to glutathione S transferase fusion proteins of the p 85 subunit of phosphoinositol 3 ' kinase , Grb 2 , and Syp , paralleling reported associations of IRS 1 with these molecules and indicating phosphorylation of the corresponding residues on IRS 2 . . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| We did not observe the association of IRS 2 with JAK 2 , Grb 2 , or PTP1D . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Concurrently , amino acids inhibit early steps in insulin action critical for glucose transport and inhibition of gluconeogenesis , including decreased insulin stimulated tyrosine phosphorylation of IRS 1 and IRS 2 , decreased binding of grb 2 and the p 85 subunit of phosphatidylinositol 3 kinase to IRS 1 and IRS 2 , and a marked inhibition of insulin stimulated phosphatidylinositol 3 kinase . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| However , IRS 2 associated Grb 2 phosphorylation was barely detected . ^^^ While a strong association between IRS 1 / Grb 2 was found , IRS 2 / Grb 2 association was virtually absent in response to insulin / IGF 1 , as also demonstrated in competition studies with a phosphopeptide containing the phosphotyrosine 895 residue within the putative Grb 2 binding domain . ^^^ Our results suggest that both IRS 1 and IRS 2 are required for phosphatidylinositol 3 kinase activation that leads to adipogenic and thermogenic differentiation of fetal brown adipose tissue ; meanwhile , IRS 1 and SHC , but not IRS 2 , associate with Grb 2 leading to the ras mitogen activated protein kinase signaling pathway required for fetal brown adipocyte proliferation . . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| In contrast , IGF 1 induces a transient tyrosine phosphorylation of IRS 2 and an association of IRS 2 with Grb 2 . ^^^ The time course of IRS 2 tyrosine phosphorylation and IRS 2 Grb 2 and IRS 2 p 85 association closely resembles the time course of IGF 1 mediated membrane ruffling . ^^^ Immunolocalization studies show IRS 2 and Grb 2 , but not Shc , concentrated at the tip of the extending growth cone where membrane ruffling is most active . ^^^ Collectively , these results suggest that the association of Shc with Grb 2 is essential for IGF 1 mediated neurite outgrowth , whereas the IRS 2 Grb 2 phosphatidylinositol 3 ' kinase complex may regulate growth cone extension and membrane ruffling . . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Grb 2 and phosphatidylinositol 3 kinase association to IRS 1 and IRS 2 reflected the phosphorylation levels of the two IRSs . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Glucose ( > 3 mM ) independently increased tyrosine phosphorylation mediated recruitment of growth factor bound protein 2 ( Grb 2 ) / murine sons of sevenless 1 protein ( mSOS ) and PI3 ' K to insulin receptor substrate ( IRS ) 1 and IRS 2 , as well as SH 2 containing protein ( Shc ) association with Grb2 / mSOS and downstream activation of mitogen activated protein kinase and 70 kDa S 6 kinase . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Insulin promoted the association of Grb 2 with IRS 1 and IRS 4 , whereas IRS 2 weakly bound Grb 2 ; consequently , IRS 1 and IRS 4 enhanced insulin stimulated mitogen activated protein kinase activity . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Ret oncogene signal transduction via a IRS 2 / PI 3 kinase / PKB and a SHC / Grb 2 dependent pathway : possible implication for transforming activity in NIH3T3 cells . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| These tyrosine phosphorylations lead to IRS 1 and IRS 2 induced recruitment of p85PI3K , SHP 2 , and Grb 2 and increase in PI 3 kinase activity associated with IRS 1 . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Insulin and IGF 1 stimulated PI 3 K activity was mainly associated with insulin receptor substrate ( IRS ) isoforms IRS 1 and IRS 2 and less so with the IRS isoform Grb 2 associated binder 1 ( Gab 1 ) . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| The tyrosine phosphorylation of IGF IR , IRS 2 , Shc , and p42 / p44 MAP kinase ( MAPK ) , and the association of Grb 2 with Shc , were examined by immunoprecipitations and Western blotting . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Furthermore , progestin treatment prior to IGF 1 stimulation resulted in higher tyrosine phosphorylated IRS 2 levels , increased binding of IRS 2 to Grb 2 and the PI3K regulatory subunit p 85 , and correspondingly enhanced ERK and Akt activation , as compared with IGF 1 only conditions . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| Notably , T cells expressing CCR 5 in which tyrosine 339 in the intracellular region is replaced by phenylalanine no longer support virus replication or virus inducible activation of specific host cell signaling effectors IRS 2 , Grb 2 , and Erk1 / 2 . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|