| Interacting proteins: Q9Y4H2 and P29350 |
Pubmed |
SVM Score :0.0 |
| AT 2 receptor stimulation increased the association of a protein tyrosine phosphatase , SHP 1 , with IRS 2 . ^^^ Overexpression of a catalytically inactive dominant negative SHP 1 markedly attenuated the AT 2 receptor mediated inhibition of IRS 2 associated PI3K activity , Akt phosphorylation , and antiapoptotic effect induced by insulin . ^^^ Taken together , these results indicate that AT 2 receptor mediated activation of SHP 1 and the consequent inhibition IRS 2 associated PI3K activity contributed at least partly to the inhibition of Akt phosphorylation , thereby inducing apoptosis . . ^^^ |
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| Interacting proteins: Q9Y4H2 and P29350 |
Pubmed |
SVM Score :0.0 |
| SHP 1 seems to be predominately activated by IL 4 and to influence the PI 3 kinase , in contrast , SHP 2 seems to be predominately activated by IL 13 and to influence Jak 1 , Tyk 2 and IRS 2 . ^^^ |
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| Interacting proteins: Q9Y4H2 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
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