| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.52156879 |
| We did not observe the association of IRS 2 with JAK 2 , Grb 2 , or PTP1D . 0.52156879^^^ |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| Leptin activates PI 3 kinase in C2C12 myotubes via janus kinase 2 ( JAK 2 ) and insulin receptor substrate 2 ( IRS 2 ) dependent pathways . ^^^ |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| In normal cells , we detected the activation of the classic IRS 2 or JAK1 / STAT6 pathways , the phosphorylation of JAK 2 , while Tyk 2 was constitutively phosphorylated and not modified by both cytokines . ^^^ |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| After receptor binding , growth hormone ( GH ) induces GH receptors ( GHR ) dimerization and JAK 2 is activated after its association with a dimerized GHR , stimulating the tyrosyl phosphorylation of insulin receptor substrate 1 ( IRS 1 ) , IRS 2 and Shc proteins . ^^^ |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| Upon stimulation of JAK 2 tyrosine phosphorylation , leptin induced JAK 2 co immunoprecipitation with STAT 3 , STAT5b , IRS 1 and IRS 2 . ^^^ Simultaneous treatment with both hormones yielded no change in maximal phosphorylation of STAT 3 , IRS 1 , IRS 2 and Akt , but led to a marked increase in tyrosine phosphorylation of JAK 2 and STAT5b when compared with isolated administration of insulin or leptin . ^^^ |
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| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| We then identified an increase in JAK 2 , IRS 1 and IRS 2 tyrosine phosphorylation and in their association with p 85 , a subunit of PI3K . ^^^ |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| Recent data suggest involvement of the Janus tyrosine kinase 2 ( JAK 2 ) in human GH induced tyrosine phosphorylation of the GH receptor and the insulin receptor substrates 1 and 2 ( IRS 1 and IRS 2 ) , leading to activation of the phosphatidylinositol 3 kinase and the acute insulin like effects in primary rat adipocytes . ^^^ The inhibition of lipogenesis and antilipolysis exhibited the same staurosporine dose dependency ( IC 50 , approximately 40 nM ) as inhibition of JAK 2 and IRS 1 tyrosine phosphorylation as well as binding of the p 85 subunit of phosphatidylinositol 3 kinase to IRS 1 and IRS 2 . ^^^ |
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| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| This phenomenon appears to involve JAK 2 tyrosine kinase , which associates with the AT 1 receptor and IRS 1 / IRS 2 after AII stimulation . ^^^ |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| Characterization of the mechanism of signaling utilized by GH indicated that tyrosine residues in GH receptor are not necessary for tyrosyl phosphorylation of IRS 2 ; however , the regions of GH receptor necessary for IRS 2 tyrosyl phosphorylation are the same as those required for JAK 2 association and tyrosyl phosphorylation . ^^^ |
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| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| Binding of interleukin ( IL ) 4 to its transmembrane receptor results in the Jak mediated tyrosine phosphorylation of a number of protein components of the IL 4 signaling cascade , including Jak 1 , Jak 2 , Jak 3 , Tyk 2 , IL 4Ralpha , IRS 1 , IRS 2 , and Stat 6 in appropriate cell types . ^^^ |
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| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| GH increased the tyrosine phosphorylation of IRS 1 , IRS 2 , JAK 2 , and Shc proteins in the liver , heart , kidney , muscle , and adipose tissue of rats . ^^^ |
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| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| Despite this , a variety of PTB or SH 2 domain containing signaling proteins , including IRS 2 , mSos 1 , Shc , p 85 subunit of phosphatidylinositol 3 kinase , SHP 2 , Raf 1 , and JAK 2 , were not associated with the INR beta Myc . ^^^ |
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| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| The ability of GH to stimulate lipogenesis and tyrosine phosphorylation of the GH receptor ( GHR ) , Janus kinase 2 ( Jak 2 ) , insulin receptor substrate 1 ( IRS 1 ) and 2 ( IRS 2 ) was greatly reduced in refractory as compared to responsive primary rat adipocytes . ^^^ Our data suggest that GH induces refractoriness to the insulin like effects in a negative feedback manner by inhibiting GH induced GHR / Jak2 / IRS 1 / IRS 2 phosphorylation through upregulation of SOCS 3 , which almost completely blocks Jak 2 activation . . ^^^ |
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| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| AngII induced Janus kinase 2 tyrosine phosphorylation and coimmunoprecipitation with insulin receptor substrate 1 ( IRS 1 ) and IRS 2 as well as an increase in tyrosine phosphorylation of IRS and its association with growth factor receptor binding protein 2 . ^^^ |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| Here we report that SH 2 B , a JAK 2 interacting protein , promotes activation of the PI 3 kinase pathway by recruiting insulin receptor substrate 1 ( IRS 1 ) and IRS 2 in response to leptin . ^^^ SH 2 B mutants with lower affinity for IRS 1 and IRS 2 exhibited reduced ability to promote association of JAK 2 with IRS 1 , tyrosine phosphorylation of IRS 1 , and association of IRS 1 with p 85 in response to leptin . ^^^ |
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| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| Once induced , SOCS 3 interacts with the insulin receptor , JAK 2 , IRS 1 , and IRS 2 . ^^^ |
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| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| The insulin like effects are mediated by the cytosolic tyrosine kinase Janus kinase 2 ( JAK 2 ) upon GH GH receptor interaction , resulting in tyrosine phosphorylation of downstream targets including the GH receptor itself and insulin receptor substrate 1 ( IRS 1 ) and IRS 2 . ^^^ |
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| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| Leptin stimulated activation of hypothalamic JAK 2 and phosphorylation of hypothalamic STAT 3 and IRS 2 were significantly impaired in SH 2 B ( / ) mice . ^^^ |
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| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| Here we show in various cell models that the adipose hormone leptin , a putative mediator in obesity related insulin resistance , promotes phosphorylation of Ser 318 in Irs 1 by a janus kinase 2 , Irs 2 , and PKC dependent pathway . ^^^ |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|