Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: Q9BX66 and P55196 Pubmed SVM Score :0.0
Ponsin / SH3P12 : an l afadin and vinculin binding protein localized at cell cell and cell matrix adherens junctions . ^^^ To understand the molecular mechanism of the specific localization of l afadin at ZA in epithelial cells and at cell cell AJ in nonepithelial cells , we attempted here to identify an l afadin binding protein ( s ) and isolated a protein , named ponsin . ^^^ The third proline rich region of l afadin bound to the region of ponsin containing the second and third SH 3 domains . ^^^ The proline rich region bound to the region of ponsin containing the first and second SH 3 domains . l Afadin and vinculin bound to ponsin in a competitive manner and these three proteins hardly formed a ternary complex . ^^^ These results indicate that ponsin is an l afadin and vinculin binding protein localized at ZA in epithelial cells , at cell cell AJ in nonepithelial cells , and at cell matrix AJ in both types of cells . . ^^^
Interacting proteins: Q9BX66 and P55196 Pubmed SVM Score :0.0
Similar and differential behaviour between the nectin afadin ponsin and cadherin catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells . ^^^ The NAP system is composed of at least nectin , afadin and ponsin . ^^^ Ponsin is an afadin binding protein which furthermore binds to vinculin and provides a possible linkage of nectin afadin to cadherin catenin through vinculin . ^^^ Nectin , afadin , ponsin , cadherin and catenin were simultaneously recruited to these junctions . ^^^
Interacting proteins: Q9BX66 and P55196 Pubmed SVM Score :0.0
Ponsin is an afadin and vinculin binding protein that also localizes to AJs . ^^^ The nectin afadin complex has a potency to recruit the E cadherin beta catenin complex through alpha catenin in a manner independent of ponsin . ^^^ This recruitment of ZO 1 was dependent on afadin but independent of alpha catenin and ponsin . ^^^
Interacting proteins: Q9BX66 and P55196 Pubmed SVM Score :0.0
By immunoprecipitation , sGCbeta 1 was found to associate with occludin , JAM A , and ZO 1 , as well as with cadherin , catenin , nectin , afadin , ponsin , and espin , suggestive of its role in cell junction dynamics . ^^^