Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.51354888 |
Furthermore , we detected the association of CAP with the insulin receptor . 0.51354888^^^ |
|
Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
Insulin and antibodies against insulin receptor cap on the membrane of cultured human lymphocytes . ^^^ |
|
Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
Expression of CAP in NIH 3T3 cells overexpressing the insulin receptor induced the formation of stress fibers and focal adhesions . ^^^ |
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Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
Thiazolidinediones and insulin resistance : peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene . c Cbl associated protein ( CAP ) is a signaling protein that interacts with both c Cbl and the insulin receptor that may be involved in the specific insulin stimulated tyrosine phosphorylation of c Cbl . ^^^ |
|
Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
Cbl is recruited to the insulin receptor by interaction with the adapter protein CAP , through one of three adjacent SH 3 domains in the carboxy terminus of CAP . ^^^ Upon phosphorylation of Cbl , the CAP Cbl complex dissociates from the insulin receptor and moves to a caveolin enriched , triton insoluble membrane fraction . ^^^ |
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Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
We previously described a pathway involving the insulin stimulated tyrosine phosphorylation of Cbl , which is recruited to the insulin receptor by the adapter protein CAP . ^^^ |
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Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
On phosphorylation of Cbl , the c Cbl associated protein ( CAP ) / Cbl complex dissociates from the insulin receptor and translocates to a lipid raft membrane fraction to form a ternary complex with flotillin . ^^^ |
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Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
We also showed that SHIP 2 was able to coimmunoprecipitate with endogenous c Cbl protein in the absence of CAP and with the insulin receptor in CHO IR cell extracts . ^^^ |
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Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
Activation of both the insulin receptor substrates ( IRSs ) / Akt and the c Cbl associated protein ( CAP ) / c Cbl pathways are important in regulating insulin stimulated glucose transport . ^^^ |
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Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
In cells co expressing insulin receptor and CAP , without APS , no association of the insulin receptor and CAP could be detected and no insulin stimulated phosphorylation of Cbl was observed . ^^^ Insulin stimulated Cbl phosphorylation was reconstituted when APS was co expressed with insulin receptor , with or without CAP . ^^^ Taken together , these results indicate that APS plays a central role in recruiting both CAP and c Cbl to the insulin receptor after insulin stimulation and is necessary and sufficient for the insulin stimulated phosphorylation of c Cbl , whereas SH 2 Balpha may provide an alternative pathway for the recruitment of CAP . . ^^^ |
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Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
As some proteins implicated in insulin signaling , like insulin receptor , CAP , c Cbl or TC 10 , were reported to localize in lipid rafts , we addressed the same question for SHIP 2 . ^^^ |
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Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
The APS adapter protein plays a pivotal role in coupling the insulin receptor to CAP and c Cbl in the phosphatidylinositol 3 kinase independent pathway of insulin stimulated glucose transport . ^^^ |
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Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
The APS adapter protein is recruited to the autophosphorylated kinase domain of the insulin receptor and initiates the phosphatidylinositol 3 kinase ( PI3K ) independent pathway of insulin stimulated glucose transport by recruiting CAP and c Cbl . ^^^ |
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Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
In plasma membrane fractions , neither the high fat diet nor insulin altered the insulin receptor beta subunit ( IR beta ) , APS ( adaptor protein containing PH and SH 2 domains ) , c Cbl , or TC 10 protein concentration , but high fat feeding did decrease CAP protein concentration . ^^^ |
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Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
In human hepatoma Hep3B cells , SORBS 1 was partly dissociated from the insulin receptor complex and bound to c Abl protein upon insulin stimulation . ^^^ |
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Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: Q9BX66 and P06213 |
Pubmed |
SVM Score :0.0 |
NA |
|