| Interacting proteins: Q9BX66 and P00519 |
Pubmed |
SVM Score :0.0 |
| We therefore propose that CAP , Ena and Abl act in concert to modulate the subcellular distribution of actin filaments in Drosophila . . ^^^ |
|
| Interacting proteins: Q9BX66 and P00519 |
Pubmed |
SVM Score :0.0 |
| This N terminal `` cap ' ' is required to achieve and maintain inhibition , and its loss turns c Abl into an oncogenic protein and contributes to deregulation of BCR Abl . . ^^^ |
|
| Interacting proteins: Q9BX66 and P00519 |
Pubmed |
SVM Score :0.0 |
| We present a crystal structure of a fragment of c Abl which reveals that a critical N terminal cap segment , not visualized in previous structures , buttresses the SH 3 SH2 substructure in the autoinhibited state and locks it onto the distal surface of the kinase domain . ^^^ Small angle 10 ray scattering ( SAXS ) analysis shows that a mutated form of c Abl , in which the N terminal cap and two other key contacts in the autoinhibited state are deleted , exists in an extended array of the SH 3 , SH 2 , and kinase domains . ^^^ |
|
| Interacting proteins: Q9BX66 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
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