| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :1.0126177 |
| We showed that AdipoR 1 and AdipoR 2 serve as receptors for globular and full length adiponectin and mediate increased AMP activated protein kinase , peroxisome proliferator activated receptor alpha ligand activities , and glucose uptake and fatty acid oxidation by adiponectin . 1.0126177^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 ( AdipoR 1 and AdipoR 2 ) by expression cloning . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Very recently , the cloning of two adiponectin receptors AdipoR 1 and AdipoR 2 was reported . ^^^ Here we report the marked expression of mRNAs for the adiponectin receptors AdipoR 1 and AdipoR 2 in human and rat pancreatic beta cells , at levels similar to liver and greater than muscle . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , AdipoR 2 , one of the two recently identified receptors for adiponectin , an adipocyte specific secreted hormone with anti diabetic and anti atherogenic activities , was found to be induced by both PPARalpha and PPARgamma . ^^^ In conclusion , AdipoR 1 and AdipoR 2 are expressed in human atherosclerotic lesions and macrophages and can be modulated by PPAR and LXR ligands , thus identifying a mechanism of crosstalk between adiponectin and these nuclear receptor signaling pathways . . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Recently , two receptors of this adipose expressed protein called adiponectin receptor 1 ( AdipoR 1 ) and 2 ( AdipoR 2 ) have been cloned . ^^^ Taken together , our results suggest that AdipoR 2 expression is differentiation dependent and selectively regulated by GH implying a potential role of this hormone in adiponectin associated alterations of insulin sensitivity and energy homeostasis . . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| AIMS / HYPOTHESIS : The recent discovery of two adiponectin receptors ( AdipoR 1 and AdipoR 2 ) will improve our understanding of the molecular mechanisms underlying the insulin sensitising effect of adiponectin . ^^^ In the study subjects , the expression levels of AdipoR 1 ( p=0 . 004 ) and AdipoR 2 ( p=0 . 04 ) , as well as plasma adiponectin concentration ( p=0 . 03 ) were lower in people with a family history of Type 2 diabetes than in those with no family history of the disease . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Adiponectin receptors 1 ( AdipoR 1 ) and 2 ( AdipoR 2 ) are expressed ubiquitously in most organs , especially in skeletal muscle in AdipoR 1 , and liver in AdipoR 2 . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Recently adiponectin receptors AdipoR 1 and AdipoR 2 have been discovered by expression cloning . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Adiponectin acts by way of two receptors , ADIPOR 1 and ADIPOR 2 . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| The adiponectin receptors , AdipoR 1 and AdipoR 2 , are thought to transmit the insulin sensitizing , anti inflammatory , and atheroprotective effects of adiponectin . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| We report a link between adiponectin and bone homeostasis by demonstrating transcription , translation , and secretion of adiponectin , as well as expression of its receptors , AdipoR 1 and AdipoR 2 , in bone forming cells . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Recently , two receptors of this adipocyte secreted hormone , adiponectin receptor 1 ( AdipoR 1 ) and 2 ( AdipoR 2 ) , have been cloned . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| In rodent skeletal muscle , globular adiponectin ( gAD ) activates AMP kinase ( AMPK ) and stimulates fatty acid oxidation effects mediated through the adiponectin receptors , AdipoR 1 and AdipoR 2 . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Recent data show an induction of adiponectin receptor 2 ( AdipoR 2 ) by PPARalpha and PPARgamma agonists in human macrophages . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Furthermore , PRL increased adiponectin receptor 1 ( AdipoR 1 ) mRNA expression and GH decreased AdipoR 2 expression in the cultured human adipose tissue . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| We recently cloned the genes encoding two adiponectin receptors ( ADIPOR 1 and ADIPOR 2 ) . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Adiponectin receptors ( AdipoR 1 and AdipoR 2 ) were detected in both activated and quiescent HSCs , but only activated HSCs produced significant apoptosis after treatment with either globular or full length adiponectin . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Adiponectin exerts its function by interacting with membrane receptors , including AdipoR 1 and AdipoR 2 . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Adiponectin receptor 1 ( ADIPOR 1 ) and adiponectin receptor 2 ( ADIPOR 2 ) are newly identified receptors for adiponectin , an adipocytokine with anti inflammatory and insulin sensitizing properties . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| The adiponectin receptors AdipoR 1 and AdipoR 2 have been identified to mediate the insulin sensitizing effects of adiponectin . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Sequences of adiponectin , AdipoR 1 , and AdipoR 2 were determined and found to be highly homologous to those of the human and mouse . ^^^ The AA sequences predicted for the full length cDNA of porcine adiponectin , AdipoR 1 , and AdipoR 2 were similar to those of the human and mouse , ranging from 81 to 97 % homology , suggesting similar functions of these genes in pigs as in other species . ^^^ Fasting for 8 h did not have a significant effect on the expression of adiponectin and AdipoR 1 mRNA , but it increased ( P < 0 . 05 ) the AdipoR 2 mRNA in the s . c . adipose tissue of crossbred pigs . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| The following two adiponectin receptor types were recently identified : AdipoR 1 is abundantly expressed in muscle , whereas AdipoR 2 is predominantly expressed in the liver . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| In a separate cohort , liver samples belonging to healthy ( n = 11 ) , steatotic ( n = 12 ) , and NASH ( n = 12 ) patients were used to further explore the role of adiponectin by measuring the expression of adiponectin and adiponectin receptor ( AdipoR 2 ) mRNA . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Recently , the genes for mouse and human adiponectin receptor 1 ( ADIPOR 1 ) and 2 ( ADIPOR 2 ) have been cloned . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Importantly , Wy 14 , 643 treatment upregulated expression of the adiponectin receptor ( AdipoR ) 1 and AdipoR 2 in WAT , which was decreased in WAT of KKAy mice compared with that in nondiabetic control mice . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| We elucidated the role of the adiponectin receptors AdipoR 1 and AdipoR 2 in the effects of adiponectin on endothelin 1 ( ET 1 ) induced hypertrophy in cultured cardiomyocytes , and we examined the expression of adiponectin receptors in normal and infarcted mouse hearts . ^^^ Transfection of small interfering RNA ( siRNA ) specific for AdipoR 1 or AdipoR 2 reversed the suppressive effects of adiponectin on ET 1 induced cellular hypertrophy in cultured cardiomyocytes . ^^^ Adiponectin induced phosphorylation of AMP activated protein kinase ( AMPK ) and inhibited ET 1 induced ERK1 / 2 phosphorylation , which were also reversible by transfection of siRNA for AdipoR 1 or AdipoR 2 in cultured cardiomyocytes . ^^^ In conclusion , AdipoR 1 and AdipoR 2 mediate the suppressive effects of full length and globular adiponectin on ET 1 induced hypertrophy in cultured cardiomyocytes , and AMPK is involved in signal transduction through these receptors . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Expression of the adiponectin receptors AdipoR 1 and AdipoR 2 in lean rats and in obese Zucker rats . ^^^ The adiponectin receptors , AdipoR 1 and AdipoR 2 , are thought to transmit the insulin sensitizing effects of adiponectin , an adipokine secreted by adipocytes . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the presence and regulatory properties of the adiponectin receptors , AdipoR 1 and AdipoR 2 , in human adipose tissue ( AT ) and in isolated human adipocytes . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Two adiponectin receptors have been identified , and we investigated whether sequence variations in adiponectin receptor 1 ( ADIPOR 1 ) and adiponectin receptor 2 ( ADIPOR 2 ) genes could contribute to the genetic risk for type 2 diabetes in a case control study of 1 , 498 Caucasian subjects . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Adiponectin receptors ( adipoR 1 and adipoR 2 ) are recently found in mice which act as receptors for globular and full length adiponectin to mediate the fatty acid oxidation and glucose uptake in muscle and liver . ^^^ Radiation hybrid mapping demonstrated that porcine adiponectin , adipoR 1 and adipoR 2 were located to chromosome13q36 41 , 10p11 and 5q25 , in the regions that were syntenic to the homologs of human genes , respectively . ^^^ Semi quantitative RT PCR showed that porcine adiponectin mRNA was specifically expressed in adipose tissue and porcine adipoR 1 and adipoR 2 mRNA were ubiquitously expressed in many tissues except brain . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| The hepatic mRNA expression of the adiponectin receptors , AdipoR 1 and AdipoR 2 , displayed significant but opposite associations with phosphoenolpyruvate carboxykinase ( PEPCK ) gene expression , a substitute marker of hepatic insulin sensitivity . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Recently , two types of adiponectin receptors ( AdipoR 1 and AdipoR 2 ) were identified . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| We studied the effect of peroxisome proliferator activated receptor alpha ( PPAR alpha ) activation on serum concentrations and tissue expression of resistin , adiponectin , and adiponectin receptor 1 and 2 ( AdipoR 1 and AdipoR 2 ) mRNA in normal mice and mice with insulin resistance induced by lipogenic , simple carbohydrate diet ( LD ) . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The effects of adiponectin on glucose and lipid metabolism are mediated by the adiponectin receptors , adipoR 1 and adipoR 2 , which are mainly in liver and muscle . ^^^ AdipoR 1 and adiponectin expression was associated in lean ( r=0 . 943 , P < 0 . 005 ) and obese non diabetic patients ( r=0 . 74 , P < 0 . 01 ) , whereas a positive correlation between adipoR 2 and adiponectin expression was only found in the presence of diabetes ( r=0 . 883 , P < 0 . 002 ) . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Adiponectin binds to two types of receptors : 1 and 2 , encoded by two genes : AdipoR 1 , and AdipoR 2 , respectively . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| METHODS : Therefore , we investigated relative mRNA expression of selected adipocytokine genes ( leptin , leptin receptors ( LEPRA , LEPRB , LEPRC , LEPRD ) and adiponectin receptors ( ADIPOR 1 , ADIPOR 2 ) ) in placental tissues from women with pre eclampsia ( n = 6 ) or CHBP ( n = 8 ) . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : The physiological regulation of circulating adiponectin levels and mRNA expression of its receptors ( AdipoR 1 and AdipoR 2 ) in skeletal muscle remains to be fully elucidated . ^^^ CONCLUSIONS : Adiponectin , AdipoR 1 , and AdipoR 2 are all associated with body composition , insulin sensitivity , and metabolic parameters . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Adiponectin , a pleiotropic cytokine , exerts its effects via the specific receptors AdipoR 1 and AdipoR 2 . ^^^ In this study , we examined the expression of adiponectin receptors AdipoR 1 and AdipoR 2 in the human endometrium and assessed effects of adiponectin in endometrial cells . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Two seven transmembrane domain containing proteins , AdipoR 1 and AdipoR 2 , have recently been identified as adiponectin receptors , yet signalling events downstream of these receptors remain poorly defined . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Two adiponectin receptors , termed AdipoR 1 and AdipoR 2 , have been identified and these are ubiquitously expressed . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| These effects are assumed to be mediated by the recently discovered adiponectin receptors AdipoR 1 and AdipoR 2 . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| It mediates its insulin sensitising and anti atherogenic effects on target tissues through two known receptors , adiponectin receptors 1 and 2 ( ADIPOR 1 ; ADIPOR 2 ) , which are encoded by the genes ADIPOR 1 and ADIPOR 2 . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| Adiponectin downregulates its own production and the expression of its AdipoR 2 receptor in transgenic mice . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the mRNA expression of adiponectin , AdipoR 1 and AdipoR 2 , the two recently cloned adiponectin receptors and peroxisome proliferator activated receptor ( PPAR ) gamma 2 in adipose tissue of obese individuals before and during a very low calorie diet ( VLCD ) inducing weight loss . ^^^ Adiponectin , AdipoR 2 and PPARgamma 2 mRNA levels did not change during VLCD in any group . ^^^ In the IGT , but not in the NGT group , AdipoR 1 and AdipoR 2 expressions were positively related to that of PPARgamma 2 and , after VLCD , AdipoR 1 and AdipoR 2 expressions were positively related to each other and to that of adiponectin . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| The expression of adiponectin , adiponectin receptor 1 ( AdipoR 1 ) , and AdipoR 2 messenger RNA ( mRNA ) by SGECs was investigated by reverse transcription polymerase chain reaction . ^^^ All of the SGEC lines tested were shown to express adiponectin , AdipoR 1 , and AdipoR 2 mRNA , whereas adiponectin protein expression was detected by immunoblotting in SGECs from patients with primary SS but not in those from controls . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| The adiponectin receptors , AdipoR 1 and AdipoR 2 , which mediate the antidiabetic metabolic actions of adiponectin , have been cloned and are downregulated in obesity linked insulin resistance . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| The expression levels of adiponectin receptors AdipoR 1 and AdipoR 2 were examined in human OA tissues by RT PCR . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| We show that rat AP expresses AdipoR 1 and AdipoR 2 adiponectin receptor mRNA . ^^^ |
|
| Interacting proteins: Q15848 and Q86V24 |
Pubmed |
SVM Score :0.0 |
| AIM : To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR 1 on the mRNA and protein level and AdipoR 2 on the mRNA level . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :1.0126177 |
| We showed that AdipoR 1 and AdipoR 2 serve as receptors for globular and full length adiponectin and mediate increased AMP activated protein kinase , peroxisome proliferator activated receptor alpha ligand activities , and glucose uptake and fatty acid oxidation by adiponectin . 1.0126177^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 ( AdipoR 1 and AdipoR 2 ) by expression cloning . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Very recently , the cloning of two adiponectin receptors AdipoR 1 and AdipoR 2 was reported . ^^^ Here we report the marked expression of mRNAs for the adiponectin receptors AdipoR 1 and AdipoR 2 in human and rat pancreatic beta cells , at levels similar to liver and greater than muscle . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , AdipoR 2 , one of the two recently identified receptors for adiponectin , an adipocyte specific secreted hormone with anti diabetic and anti atherogenic activities , was found to be induced by both PPARalpha and PPARgamma . ^^^ In conclusion , AdipoR 1 and AdipoR 2 are expressed in human atherosclerotic lesions and macrophages and can be modulated by PPAR and LXR ligands , thus identifying a mechanism of crosstalk between adiponectin and these nuclear receptor signaling pathways . . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Recently , two receptors of this adipose expressed protein called adiponectin receptor 1 ( AdipoR 1 ) and 2 ( AdipoR 2 ) have been cloned . ^^^ Taken together , our results suggest that AdipoR 2 expression is differentiation dependent and selectively regulated by GH implying a potential role of this hormone in adiponectin associated alterations of insulin sensitivity and energy homeostasis . . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Adiponectin acts by way of two receptors , ADIPOR 1 and ADIPOR 2 . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| The adiponectin receptors , AdipoR 1 and AdipoR 2 , are thought to transmit the insulin sensitizing , anti inflammatory , and atheroprotective effects of adiponectin . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| We report a link between adiponectin and bone homeostasis by demonstrating transcription , translation , and secretion of adiponectin , as well as expression of its receptors , AdipoR 1 and AdipoR 2 , in bone forming cells . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Sequences of adiponectin , AdipoR 1 , and AdipoR 2 were determined and found to be highly homologous to those of the human and mouse . ^^^ The AA sequences predicted for the full length cDNA of porcine adiponectin , AdipoR 1 , and AdipoR 2 were similar to those of the human and mouse , ranging from 81 to 97 % homology , suggesting similar functions of these genes in pigs as in other species . ^^^ Fasting for 8 h did not have a significant effect on the expression of adiponectin and AdipoR 1 mRNA , but it increased ( P < 0 . 05 ) the AdipoR 2 mRNA in the s . c . adipose tissue of crossbred pigs . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| The following two adiponectin receptor types were recently identified : AdipoR 1 is abundantly expressed in muscle , whereas AdipoR 2 is predominantly expressed in the liver . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| In a separate cohort , liver samples belonging to healthy ( n = 11 ) , steatotic ( n = 12 ) , and NASH ( n = 12 ) patients were used to further explore the role of adiponectin by measuring the expression of adiponectin and adiponectin receptor ( AdipoR 2 ) mRNA . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| AIMS / HYPOTHESIS : The recent discovery of two adiponectin receptors ( AdipoR 1 and AdipoR 2 ) will improve our understanding of the molecular mechanisms underlying the insulin sensitising effect of adiponectin . ^^^ In the study subjects , the expression levels of AdipoR 1 ( p=0 . 004 ) and AdipoR 2 ( p=0 . 04 ) , as well as plasma adiponectin concentration ( p=0 . 03 ) were lower in people with a family history of Type 2 diabetes than in those with no family history of the disease . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Adiponectin receptors 1 ( AdipoR 1 ) and 2 ( AdipoR 2 ) are expressed ubiquitously in most organs , especially in skeletal muscle in AdipoR 1 , and liver in AdipoR 2 . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Recently adiponectin receptors AdipoR 1 and AdipoR 2 have been discovered by expression cloning . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Recently , two receptors of this adipocyte secreted hormone , adiponectin receptor 1 ( AdipoR 1 ) and 2 ( AdipoR 2 ) , have been cloned . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| In rodent skeletal muscle , globular adiponectin ( gAD ) activates AMP kinase ( AMPK ) and stimulates fatty acid oxidation effects mediated through the adiponectin receptors , AdipoR 1 and AdipoR 2 . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Recent data show an induction of adiponectin receptor 2 ( AdipoR 2 ) by PPARalpha and PPARgamma agonists in human macrophages . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Furthermore , PRL increased adiponectin receptor 1 ( AdipoR 1 ) mRNA expression and GH decreased AdipoR 2 expression in the cultured human adipose tissue . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| We recently cloned the genes encoding two adiponectin receptors ( ADIPOR 1 and ADIPOR 2 ) . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Adiponectin receptors ( AdipoR 1 and AdipoR 2 ) were detected in both activated and quiescent HSCs , but only activated HSCs produced significant apoptosis after treatment with either globular or full length adiponectin . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Adiponectin exerts its function by interacting with membrane receptors , including AdipoR 1 and AdipoR 2 . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Adiponectin receptor 1 ( ADIPOR 1 ) and adiponectin receptor 2 ( ADIPOR 2 ) are newly identified receptors for adiponectin , an adipocytokine with anti inflammatory and insulin sensitizing properties . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| The adiponectin receptors AdipoR 1 and AdipoR 2 have been identified to mediate the insulin sensitizing effects of adiponectin . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Adiponectin receptors ( adipoR 1 and adipoR 2 ) are recently found in mice which act as receptors for globular and full length adiponectin to mediate the fatty acid oxidation and glucose uptake in muscle and liver . ^^^ Radiation hybrid mapping demonstrated that porcine adiponectin , adipoR 1 and adipoR 2 were located to chromosome13q36 41 , 10p11 and 5q25 , in the regions that were syntenic to the homologs of human genes , respectively . ^^^ Semi quantitative RT PCR showed that porcine adiponectin mRNA was specifically expressed in adipose tissue and porcine adipoR 1 and adipoR 2 mRNA were ubiquitously expressed in many tissues except brain . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| The hepatic mRNA expression of the adiponectin receptors , AdipoR 1 and AdipoR 2 , displayed significant but opposite associations with phosphoenolpyruvate carboxykinase ( PEPCK ) gene expression , a substitute marker of hepatic insulin sensitivity . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Recently , the genes for mouse and human adiponectin receptor 1 ( ADIPOR 1 ) and 2 ( ADIPOR 2 ) have been cloned . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Importantly , Wy 14 , 643 treatment upregulated expression of the adiponectin receptor ( AdipoR ) 1 and AdipoR 2 in WAT , which was decreased in WAT of KKAy mice compared with that in nondiabetic control mice . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| We elucidated the role of the adiponectin receptors AdipoR 1 and AdipoR 2 in the effects of adiponectin on endothelin 1 ( ET 1 ) induced hypertrophy in cultured cardiomyocytes , and we examined the expression of adiponectin receptors in normal and infarcted mouse hearts . ^^^ Transfection of small interfering RNA ( siRNA ) specific for AdipoR 1 or AdipoR 2 reversed the suppressive effects of adiponectin on ET 1 induced cellular hypertrophy in cultured cardiomyocytes . ^^^ Adiponectin induced phosphorylation of AMP activated protein kinase ( AMPK ) and inhibited ET 1 induced ERK1 / 2 phosphorylation , which were also reversible by transfection of siRNA for AdipoR 1 or AdipoR 2 in cultured cardiomyocytes . ^^^ In conclusion , AdipoR 1 and AdipoR 2 mediate the suppressive effects of full length and globular adiponectin on ET 1 induced hypertrophy in cultured cardiomyocytes , and AMPK is involved in signal transduction through these receptors . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Expression of the adiponectin receptors AdipoR 1 and AdipoR 2 in lean rats and in obese Zucker rats . ^^^ The adiponectin receptors , AdipoR 1 and AdipoR 2 , are thought to transmit the insulin sensitizing effects of adiponectin , an adipokine secreted by adipocytes . ^^^ |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the presence and regulatory properties of the adiponectin receptors , AdipoR 1 and AdipoR 2 , in human adipose tissue ( AT ) and in isolated human adipocytes . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Two adiponectin receptors have been identified , and we investigated whether sequence variations in adiponectin receptor 1 ( ADIPOR 1 ) and adiponectin receptor 2 ( ADIPOR 2 ) genes could contribute to the genetic risk for type 2 diabetes in a case control study of 1 , 498 Caucasian subjects . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : The physiological regulation of circulating adiponectin levels and mRNA expression of its receptors ( AdipoR 1 and AdipoR 2 ) in skeletal muscle remains to be fully elucidated . ^^^ CONCLUSIONS : Adiponectin , AdipoR 1 , and AdipoR 2 are all associated with body composition , insulin sensitivity , and metabolic parameters . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Adiponectin , a pleiotropic cytokine , exerts its effects via the specific receptors AdipoR 1 and AdipoR 2 . ^^^ In this study , we examined the expression of adiponectin receptors AdipoR 1 and AdipoR 2 in the human endometrium and assessed effects of adiponectin in endometrial cells . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Two seven transmembrane domain containing proteins , AdipoR 1 and AdipoR 2 , have recently been identified as adiponectin receptors , yet signalling events downstream of these receptors remain poorly defined . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Two adiponectin receptors , termed AdipoR 1 and AdipoR 2 , have been identified and these are ubiquitously expressed . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| These effects are assumed to be mediated by the recently discovered adiponectin receptors AdipoR 1 and AdipoR 2 . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Adiponectin downregulates its own production and the expression of its AdipoR 2 receptor in transgenic mice . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Recently , two types of adiponectin receptors ( AdipoR 1 and AdipoR 2 ) were identified . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| We studied the effect of peroxisome proliferator activated receptor alpha ( PPAR alpha ) activation on serum concentrations and tissue expression of resistin , adiponectin , and adiponectin receptor 1 and 2 ( AdipoR 1 and AdipoR 2 ) mRNA in normal mice and mice with insulin resistance induced by lipogenic , simple carbohydrate diet ( LD ) . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The effects of adiponectin on glucose and lipid metabolism are mediated by the adiponectin receptors , adipoR 1 and adipoR 2 , which are mainly in liver and muscle . ^^^ AdipoR 1 and adiponectin expression was associated in lean ( r=0 . 943 , P < 0 . 005 ) and obese non diabetic patients ( r=0 . 74 , P < 0 . 01 ) , whereas a positive correlation between adipoR 2 and adiponectin expression was only found in the presence of diabetes ( r=0 . 883 , P < 0 . 002 ) . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| Adiponectin binds to two types of receptors : 1 and 2 , encoded by two genes : AdipoR 1 , and AdipoR 2 , respectively . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| METHODS : Therefore , we investigated relative mRNA expression of selected adipocytokine genes ( leptin , leptin receptors ( LEPRA , LEPRB , LEPRC , LEPRD ) and adiponectin receptors ( ADIPOR 1 , ADIPOR 2 ) ) in placental tissues from women with pre eclampsia ( n = 6 ) or CHBP ( n = 8 ) . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the mRNA expression of adiponectin , AdipoR 1 and AdipoR 2 , the two recently cloned adiponectin receptors and peroxisome proliferator activated receptor ( PPAR ) gamma 2 in adipose tissue of obese individuals before and during a very low calorie diet ( VLCD ) inducing weight loss . ^^^ Adiponectin , AdipoR 2 and PPARgamma 2 mRNA levels did not change during VLCD in any group . ^^^ In the IGT , but not in the NGT group , AdipoR 1 and AdipoR 2 expressions were positively related to that of PPARgamma 2 and , after VLCD , AdipoR 1 and AdipoR 2 expressions were positively related to each other and to that of adiponectin . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| The expression of adiponectin , adiponectin receptor 1 ( AdipoR 1 ) , and AdipoR 2 messenger RNA ( mRNA ) by SGECs was investigated by reverse transcription polymerase chain reaction . ^^^ All of the SGEC lines tested were shown to express adiponectin , AdipoR 1 , and AdipoR 2 mRNA , whereas adiponectin protein expression was detected by immunoblotting in SGECs from patients with primary SS but not in those from controls . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| It mediates its insulin sensitising and anti atherogenic effects on target tissues through two known receptors , adiponectin receptors 1 and 2 ( ADIPOR 1 ; ADIPOR 2 ) , which are encoded by the genes ADIPOR 1 and ADIPOR 2 . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| AIM : To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR 1 on the mRNA and protein level and AdipoR 2 on the mRNA level . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| The adiponectin receptors , AdipoR 1 and AdipoR 2 , which mediate the antidiabetic metabolic actions of adiponectin , have been cloned and are downregulated in obesity linked insulin resistance . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| The expression levels of adiponectin receptors AdipoR 1 and AdipoR 2 were examined in human OA tissues by RT PCR . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| We show that rat AP expresses AdipoR 1 and AdipoR 2 adiponectin receptor mRNA . ^^^ |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86V24 and Q15848 |
Pubmed |
SVM Score :0.0 |
| NA |
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