| S100P stimulates cell proliferation and survival via receptor for activated glycation end products ( RAGE ) . ^^^ To determine the mechanisms involved in these effects , we tested the hypothesis that S100P activated RAGE ( receptor for activated glycation end products ) . ^^^ We found that S100P co immunoprecipitated with RAGE . ^^^ Furthermore , the effects of S100P on cell signaling , proliferation , and survival were blocked by agents that interfere with RAGE including administration of an amphoterin derived peptide known to antagonize RAGE activation , anti RAGE antibodies , and by expression of a dominant negative RAGE . ^^^ These data suggest that S100P can act in an autocrine manner via RAGE to stimulate cell proliferation and survival . . ^^^ |