Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.84041451
We conclude that HMGB 1 has the potential to induce a proinflammatory phenotype in Mphi , with RAGE as the major activation inducing receptor . . 0.84041451^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.90154046
We reported that RAGE ( receptor for advanced glycation end products ) , a multiligand receptor of the immunoglobulin superfamily expressed in myoblasts , when activated by its ligand amphoterin ( HMGB 1 ) , stimulates rat L 6 myoblast differentiation via a Cdc 42 Rac MKK 6 p38 mitogen activated protein kinase pathway , and that RAGE expression in skeletal muscle tissue is developmentally regulated . 0.90154046^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
One of these potentially amyloidogenic proteins is amphoterin ( also known as HMG 1 ) , involved in neuronal development and a ligand for the receptor for advanced glycation end products ( RAGE ) . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
The receptor for advanced glycation end products ( RAGE ) is expressed on endothelium and is a receptor for HMGB 1 . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
We measured levels of proinflammatory cytokines released by SFMs treated with HMGB 1 via enzyme linked immunosorbent assay and used soluble RAGE ( sRAGE ) to block the release of tumor necrosis factor alpha ( TNFalpha ) . ^^^ SFMs expressed RAGE and released TNFalpha , interleukin 1beta ( IL 1beta ) , and IL 6 upon stimulation with HMGB 1 . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
Besides its function as an architectural transcription factor HMGB 1 can also be secreted by certain cells and then acts as a ligand for the receptor for advanced glycation end products ( RAGE ) . ^^^ The binding of HMGB 1 to RAGE can activate key cell signaling pathways , such as p 38 ( MAPK ) , JNK , and p42 / p44 ( MAPK ) emphasizing the important role of HMGB 1 in inflammation and tumor metastasis . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
Receptor signal transduction of HMGB 1 occurs in part through the receptor for advanced glycation end products ( RAGE ) expressed on monocytes / macrophages , endothelial cells , neurons and smooth muscle cells . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
In several cell types the binding of extracellular high mobility group box protein 1 ( HMGB 1 ) with the receptor for advanced glycation end products ( RAGE ) induces cytoskeletal reorganization and cell motility . ^^^ To establish whether RAGE is also involved in murine erythroleukaemia ( MEL ) cell differentiation stimulated by HMGB 1 , we have demonstrated that these cells express a 51 kDa protein identified as RAGE , and then we have produced stable transfectants overexpressing wild type ( wt ) RAGE or a dominant negative ( dn ) RAGE mutant lacking the cytoplasmic domain to analyse the differentiation process in these cells . ^^^ This was also supported by the identical stimulatory effect exerted by HMGB 1 on both wt or dn RAGE transfectants . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
Although the receptor for advanced glycation end products ( RAGE ) has been shown to interact with HMGB 1 , other putative HMGB 1 receptors are known to exist but have not been characterized . ^^^ In the present experiments , we explored the role of RAGE , Toll like receptor ( TLR ) 2 , and TLR 4 , as well as associated kinases , in HMGB 1 induced cellular activation . ^^^ In contrast , RAGE played only a minor role in macrophage activation by HMGB 1 . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
Here , we show that extracellular HMGB 1 and its receptor for advanced glycation end products ( RAGE ) induce both migration and proliferation of vessel associated stem cells ( mesoangioblasts ) , and thus may play a role in muscle tissue regeneration . ^^^ Interestingly , alpha sarcoglycan null dystrophic muscle contains elevated levels of HMGB 1 ; however , mesoangioblasts migrate into dystrophic muscle even if their RAGE receptor is disabled . ^^^ This implies that the HMGB 1 RAGE interaction is sufficient , but not necessary , for mesoangioblast homing ; a different pathway might coexist . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
High mobility group B 1 ( HMGB 1 ) and its counter receptor , receptor for advanced glycation end products ( RAGE ) , represent suitable targets for investigation , integrating many aspects of modern biology , particularly that associated with chronic diseases involving inflammation , dysregulated cell death and cancer . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
Amphoterin ( HMGB 1 ) is a 30 kD heparin binding protein involved in process extension and migration of cells by a mechanism involving the receptor for advanced glycation end products ( RAGE ) . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
We show here that ( 1 ) RAGE is expressed in skeletal muscle tissue and its expression is developmentally regulated and ( 2 ) RAGE engagement by amphoterin ( HMGB 1 ) , a RAGE ligand , in rat L 6 myoblasts results in stimulation of myogenic differentiation via activation of p 38 mitogen activated protein kinase ( MAPK ) , up regulation of myogenin and myosin heavy chain expression , and induction of muscle creatine kinase . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
Therapeutic effect of anti HMGB 1 antibody and anti RAGE antibody on SIRS / sepsis ] . ^^^ In this study , we hypothesized whether treatment of anti HMGB 1 or anti RAGE antibody would block LPS lethality in septic mice . ^^^ LPS induced acute lung injury was almost disappeared by antibody treatment , because these antibodies were inhibited HMGB 1 and RAGE expression in lung . ^^^ Treatment of anti HMGB 1 or anti RAGE antibody seems to be valid therapy against SIRS / sepsis . . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
Expressions of RAGE and high mobility group box 1 ( HMGB 1 ) / amphoterin RAGE ligand were examined in 96 colorectal adenomas using immunohistochemistry and in situ hybridization , respectively . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
Requirement of HMGB 1 and RAGE for the maturation of human plasmacytoid dendritic cells . ^^^ We show that HMGB 1 leaves the nucleus of maturing PDC following TLR 9 activation , and that PDC express on the plasma membrane the best characterized receptor for HMGB 1 , RAGE . ^^^ These results reveal HMGB 1 and RAGE as the first known autocrine loop modulating the maturation of PDC , and suggest that antagonists of HMGB1 / RAGE might have therapeutic potential for the treatment of systemic human diseases . . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
Using neutralizing Abs and receptor for advanced glycation end product deficient ( RAGE ( / ) ) cells , we demonstrate that RAGE is required for the effect of HMGB 1 on dendritic cells . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
We found that the expression of HMGB 1 and its receptor for advanced glycation end products ( RAGE ) as well as that of other apoptosis / inflammation related proteins ( Bad , Bax , inducible nitric oxide synthase , and cyclooxygenase 2 ) was upregulated in the ileal mucosa of FFH newborn rats compared with BF animals . ^^^ Our results implicate HMGB 1 and RAGE as important mediators of enterocyte cell death and hypoxia induced injury in NEC and support the hypothesis that inhibitors such as semapimod might play a therapeutic role in chronic intestinal inflammation characterized by this animal model . . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
OBJECTIVE : The receptor for advanced glycation end products ( RAGE ) binds multiple ligands , including S 100 proteins , high mobility group box chromosomal protein 1 ( HMGB 1 ) , and AGEs , all of which are present in articular cartilage . ^^^ RAGE signaling was evaluated by stimulating chondrocytes with S100B and HMGB 1 and analyzing for activation of the ERK MAP kinase and NF kappaB . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
Although recent reports have indicated that the receptor for advanced glycation end products ( RAGE ) as well as Toll like receptor ( TLR ) 2 and TLR 4 are involved in cellular activation by HMGB 1 , there has been little evidence of direct association between HMGB 1 and these receptors . ^^^ To examine this issue , we used fluorescence resonance energy transfer ( FRET ) and immunoprecipitation to directly investigate cell surface interactions of HMGB 1 with TLR 2 , TLR 4 , and RAGE . ^^^ FRET images in RAW264 . 7 macrophages demonstrated association of HMGB 1 with TLR 2 and TLR 4 but not RAGE . ^^^ Transient transfections into human embryonic kidney 293 cells showed that HMGB 1 induced cellular activation and NF kappaB dependent transcription through TLR 2 or TLR 4 but not RAGE . ^^^ Coimmunoprecipitation also found interaction between HMGB 1 and TLR 2 as well as TLR 4 , but not with RAGE . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
Recently , the receptor for advanced glycation end products ( RAGE ) high mobility group B 1 ( HMGB 1 ) protein complex has been shown to have significant influence on invasiveness , growth and motility of tumour cells , which are essential characteristics required for metastatic behaviour . ^^^ However , complete characterisation of the protein complex is a precondition to a therapeutic approach based on the blocking of the RAGE HMGB 1 complex to spontaneously occurring tumours in dogs . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
HMGB 1 acts on a specific receptor , RAGE ( receptor for advanced glycation end products ) , and induces prolonged inflammation , organ failure , septicaemia and death . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
We sought to study the presence of the receptor for advanced glycation endproducts ( RAGE ) and its ligands , advanced glycation endproducts ( AGEs ) , S100 / calgranulins and amphoterin ( high mobility group box 1 protein ; HMGB 1 ) , in the vitreous cavity and epiretinal membranes ( ERMs ) of eyes of patients with proliferative diabetic retinopathy ( PDR ) and proliferative vitreoretinopathy ( PVR ) . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
A recent discovery reveals that DCs release the chromatin protein high mobility group box 1 ( HMGB 1 ) as a potent immunomodulatory cytokine mediating the interaction between DCs and T cells , via HMGB 1 binding to the membrane receptor for advanced glycation end products ( RAGE ) . ^^^ Our immunohistochemical and immunocytochemical analyses demonstrate HMGB 1 expression in primary osteoblasts and osteoclasts and that both cells express RAGE . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
Recent studies underscore the premise that RAGE interacts with pro inflammatory molecules , including S100 / calgranulins and amphoterin , the latter also known as high mobility group box 1 ( HMGB 1 ) . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
After binding to the receptor for advanced glycation end products ( RAGE ) , or Toll like receptor 4 ( TLR 4 ) , HMGB 1 activates macrophages / monocytes to express proinflammatory cytokines , chemokines , and adhesion molecules . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
In keeping with its in vitro properties , HMGB 1 stimulates neovascularization when applied in vivo on the top of the chicken embryo chorioallantoic membrane whose blood vessels express the HMGB 1 receptor for advanced glycation end products ( RAGE ) . ^^^ Accordingly , RAGE blockade by neutralizing Abs inhibits HMGB 1 induced neovascularization in vivo and endothelial cell proliferation and membrane ruffling in vitro . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
Induction of the three known receptors of HMGB 1 , namely RAGE , TLR 2 , and TLR 4 , by IL 1beta suggests that proinflammatory cytokines sensitize VSMCs to HMGB 1 . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
After binding to the receptor for advanced glycation end products ( RAGE ) or toll like receptor 4 ( TLR 4 ) , HMGB 1 activates vascular endothelial cells and macrophages / monocytes to express proinflammatory cytokines , chemokines and adhesion molecules . ^^^
Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
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Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
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Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
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Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
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Interacting proteins: Q15109 and P09429 Pubmed SVM Score :0.0
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