| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.7583541 |
| This signaling was inhibited in cells pretreated with soluble RAGE , and S100B was shown to bind to chondrocyte RAGE . 0.7583541^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| Here we show that two S 100 family proteins , S100B and S100A1 , activate RAGE in concert with amphoterin inducing neurite outgrowth and activation of transcription factor NF kappaB . ^^^ Furthermore , activation of RAGE by amphoterin and S100B promotes cell survival through increased expression of the anti apoptotic protein Bcl 2 . ^^^ However , whereas nanomolar concentrations of S100B induce trophic effects in RAGE expressing cells , micromolar concentrations of S100B induce apoptosis in an oxidant dependent manner . ^^^ We suggest that RAGE is a signal transducing receptor for both trophic and toxic effects of S100B . . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| A cell surface receptor , RAGE , has been identified on inflammatory cells and neurons for S100A12 and S100B , which transduces S100A12 and S100B effects . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| Extracellular S 100 proteins have been shown to exert regulatory effects on inflammatory cells , neurons , astrocytes , microglia , and endothelial and epithelial cells , and a cell surface receptor , RAGE , has been identified as a potential S100A12 and S100B receptor transducing the effects of these two proteins on inflammatory cells and neurons . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence was used to identify proliferating BrdU positive cells , and cells immunopositive for S100beta and its receptor receptor for advanced glycation end products ( RAGE ) . ^^^ On the other hand , we observed colocalization of RAGE receptors and BrdU immunoreactivities , suggesting that some proliferating cells express these receptors for S100beta . ^^^ RAGE expression by neuronal cells or neuronal precursors and its activation by S100beta may promote their survival . ^^^ LIMITATIONS : The anatomical localization of hippocampal S100beta , its receptor RAGE , and BrdU positive cells that we describe in this study is only indicative of a putative role for glia in antidepressant stimulated neurogenesis . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100B inhibits myogenic differentiation and myotube formation in a RAGE independent manner . ^^^ Although myoblasts express the multiligand receptor RAGE , which has been shown to transduce S100B effects on neurons , S100B produces identical effects on myoblasts overexpressing either full length RAGE or RAGE lacking the transducing domain . ^^^ This suggests that S100B affects myoblasts by interacting with another receptor and that RAGE is not the only receptor for S100B . ^^^ Our data suggest that S100B might participate in the regulation of muscle development and regeneration by inhibiting crucial steps of the myogenic program in a RAGE independent manner . . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the effect of AGEs and S100b , a specific RAGE ligand , on the expression of COX 2 and the molecular mechanisms involved in cultured THP 1 monocytes and human peripheral blood monocytes . ^^^ S100b induced COX 2 mRNA was blocked by an anti RAGE antibody and by inhibitors of NF kappa B ( Bay 11 7082 ) , oxidant stress , protein kinase C , ERK , and p 38 MAPKs . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| Divergent pathways of gene expression are activated by the RAGE ligands S100b and AGE BSA . ^^^ In contrast , the alternate RAGE ligand , S100b , triggered an increase in endothelial mRNA expression of a variety of immune related genes . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100B causes apoptosis in a myoblast cell line in a RAGE independent manner . ^^^ Astrocytes secrete S100B , and extracellular S100B exerts trophic and toxic effects on neurons depending on its concentration , in part by interacting with the receptor for advanced glycation end products ( RAGE ) . ^^^ Recently we reported that at picomolar to nanomolar doses S100B inhibits rat L 6 myoblast differentiation via inactivation of p 38 kinase in a RAGE independent manner . ^^^ We show here that at > or=5 nM in the absence of and at > 100 nM in the presence of serum S100B causes myoblast apoptosis via stimulation of reactive oxygen species ( ROS ) production and inhibition of the pro survival kinase , extracellular signal regulated kinase ( ERK ) 1 / 2 , again in a RAGE independent manner . ^^^ Our data also suggest that RAGE has no role in the transduction of S100B effects on myoblasts , implying that S100B can interact with more than one receptor to affect its target cells . . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| In contrast , the reported RAGE ligand S100b was confirmed to induce VCAM 1 expression on endothelial cells and TNF alpha secretion by PBMCs after 24 h of treatment . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE binding . ^^^ Moreover , amphoterin counteracted the antimyogenic activity of the Ca ( 2+ ) modulated protein S100B , which was reported to inhibit myogenic differentiation via inactivation of p 38 MAPK , and basic fibroblast growth factor ( bFGF ) , a known inhibitor of myogenic differentiation , in a manner that was inversely related to the S100B or bFGF concentration and directly related to the extent of RAGE expression . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| Further experiments suggest that 1 ) S100B activated expression of the receptor of advanced glycation products ( RAGE ) gene in neurons and 2 ) S100B induced a unique composition of the active NF kappaB complex consisting of the p 65 and c Rel subunits suggesting a novel mechanism for NF kappaB activation involved in S100B mediated neuroprotection . ^^^ Our data suggest that S100B secreted during the glial response to brain injury potently activates p65 / c Rel in a RAGE dependent manner and may exert neuroprotective and neuroregenerative effects in psychiatric disorders . . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| Cultured ARPE 19 cells were challenged with known ligands for RAGE , AGE , and S100B , to test for activation capacity . ^^^ Both AGE and S100B activated cultured RPE cells , as revealed by upregulated expression of RAGE , NFkappaB nuclear translocation , and apoptotic cell death . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100B protects LAN 5 neuroblastoma cells against Abeta amyloid induced neurotoxicity via RAGE engagement at low doses but increases Abeta amyloid neurotoxicity at high doses . ^^^ At the concentrations normally found in the brain extracellular space the glial derived protein , S100B , protects neurons against neurotoxic agents by interacting with the receptor for advanced glycation end products ( RAGE ) . ^^^ It is known that at relatively high concentrations S100B is neurotoxic causing neuronal death via excessive stimulation of RAGE . ^^^ This effect depends on S100B binding to RAGE because S100B is unable to contrast Abeta mediated neurotoxicity in neurons overexpressing a signaling deficient RAGE mutant lacking the cytosolic and transducing domain . ^^^ Our data suggest that at nanomolar doses S100B counteracts Abeta peptide neurotoxicity in a RAGE mediated manner . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100B , a Ca2+ binding protein , acts intracellularly as a Ca2+ signalling protein but is also secreted to the extracellular space , acting in a cytokine like manner through its receptor RAGE . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| Here we report that non receptor Src tyrosine kinase and the membrane protein caveolin 1 ( Cav 1 ) play a key role in the activation of RAGE by S100B in VSMCs . ^^^ Cholesterol depletion also inhibited S100B induced effects indicating the requirement for intact caveolae in RAGE specific signaling . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100B stimulated NO production by BV 2 microglia is independent of RAGE transducing activity but dependent on RAGE extracellular domain . ^^^ At the low levels normally found in the brain , extracellular S100B acts as a trophic factor , protecting neurons against oxidative stress and stimulating neurite outgrowth through its binding to the receptor for advanced glycation end products ( RAGE ) . ^^^ However , S100B stimulated NO production to the same extent in microglia overexpressing a transduction incompetent mutant of RAGE and in microglia overexpressing full length RAGE , with a significantly smaller effect in mock transfected microglia . ^^^ This suggests that the RAGE transducing activity has little or no role in S100B stimulated NO production by microglia , whereas RAGE extracellular domain is important , probably serving to concentrate S100B on the BV 2 cell surface . ^^^ On the other hand , S100B stimulated NF kappaB transcriptional activity in BV 2 microglia in a manner that was strictly dependent on RAGE transducing activity , pointing to additional , RAGE mediated effects of the protein on microglia that remain to be investigated . . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| Treatment of cultured human aortic endothelial cells with S100b induces the expression of MCP 1 and RAGE transcripts . ^^^ |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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