| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.60093503 |
| Further insights into the consequences of the interaction of fibrillar TTR with RAGE may therefore provide a better understanding of neurodegeneration associated with FAP . . 0.60093503^^^ |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.79168593 |
| Here we show that TTR interaction with RAGE is conserved across mouse and human species and is not dependent on RAGE glycosylation . 0.79168593^^^ |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.0 |
| We have hypothesized that binding of TTR fibrils to the receptor for advanced glycation end products ( RAGE ) on critical cellular targets is associated with a destructive stress response underlying peripheral nerve dysfunction . ^^^ Studies on cultured neuronal like , Schwann , and endothelial cells incubated with TTR fibrils displayed RAGE dependent expression of cytokines and iNOS at early times ( 6 and 12 hr , respectively ) , followed by later ( 24 hr ) activation of caspase 3 and DNA fragmentation . ^^^ We propose that the interaction of TTR fibrils with RAGE may contribute to cellular stress and toxicity in FAP . ^^^ |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.0 |
| Transthyretin ( TTR ) amyloid fibrils have been shown to have affinity for RAGE and subsequently induce NF kappaB activation and apoptosis . ^^^ Transthyretin ( TTR ) amyloid fibrils have been shown to have affinity for RAGE and subsequently induce NF kappaB activation and apoptosis . ^^^ Sequential immunofluorescence staining revealed a clear relationship between TTR , AGE and RAGE . ^^^ We conclude that RAGE AGE or RAGE TTR interaction might play important roles for gastrointestinal dysfunction and amyloid toxicity , although not through NF kappaB activation and apoptosis . . ^^^ |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.0 |
| Using immunohistochemistry , AGEs , CML , and RAGE were found within amyloid deposits , more commonly in AA amyloid than in AL amyloid and not in ATTR amyloid . ^^^ |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.0 |
| How these TTR aggregates exert their effects is debatable ; interaction with cellular receptors , namely , the receptor for advanced glycation endproducts ( RAGE ) , is a probable candidate mechanism . ^^^ |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.0 |
| Cultured rat Schwannoma cell line treatment with TTR aggregates stimulated ERK1 / 2 activation , which was partially mediated by the receptor for advanced glycation end products ( RAGE ) . ^^^ |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15109 and P02766 |
Pubmed |
SVM Score :0.0 |
| NA |
|