Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
The NBS gene product , nibrin , is involved in DNA recombination repair , a function shared with known tumor suppressor genes like BRCA 1 and BRCA 2 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Nibrin confers new abilities to the nuclease complex , and can also bind to BRCA 1 ( one of the two proteins mutated in familial breast cancer ) . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
We analyzed 49 SNPs in BRCA 1 , BRCA 2 , ESR 1 , XRCC 1 , XRCC 2 , XRCC 3 , NBN , RAD 51 , RAD 52 , LIG 4 , ATM , BCL 2 , TGFB 1 , MSH 6 , ERCC 2 , XPF , NR3C1 , CYP1A1 , CYP2C9 , CYP2C19 , CYP3A5 , CYP2D6 , CYP11B2 , and CYP17A1 genes using the Pyrosequencing technique . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
SMC 1 associates with BRCA 1 and is phosphorylated in response to IR in an ATM and NBS 1 dependent manner . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
We also demonstrate that NBS 1 binding can occur in the absence of interaction with hMRE 11 or BRCA 1 . ^^^ NBS 1 has no DNA binding region but carries a combination of the fork head associated ( FHA ) and the BRCA 1 C terminal domains ( BRCT ) . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Expression of NBS 1 containing mutations in the forkhead associated or BRCA 1 COOH terminus domains did not correct the defects in radiation sensitivity or nuclear focus formation but did restore S phase checkpoint control in NBS cells . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Cells harbouring mutated NBS , hMRE 11 , BRCA 1 or MLH 1 were analysed . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Tumor cells often exhibit defects in these checkpoint proteins , which can lead to hypersensitivity ; proteins in this class include ataxia telangiectasia mutatated ( ATM ) , Meiotic recanbination 11 ( Mre 11 ) , Nijmegen breakage syndrome 1 ( Nbs 1 ) , breast cancer susceptibility genes 1 and 2 ( BRCA 1 ) , and ( BRCA 2 ) . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
For example , conventional deletion of ATR , Chk 1 , Mad 2 , NBS , Rad 50 , BRCA 1 , BRCA 2 , or Rad 51 leads to developmental arrest prior to gastrulation . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
NBS 1 , the product of the gene underlying the disease , contains three functional regions : the forkhead associated ( FHA ) domain and BRCA 1 C terminus ( BRCT ) domain at the N terminus , several SQ motifs ( consensus phosphorylation sites by ATM and ATR kinases ) at a central region and MRE 11 binding region at the C terminus . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Several newly identified tumor suppressor genes including ATM , NBS 1 , BRCA 1 and BRCA 2 are involved in DNA double strand break repair ( DSBR ) and DNA damage induced checkpoint activation . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
NBS 1 ( p 95 ) , the protein responsible for Nijmegen breakage syndrome , shows a weak homology to the yeast Xrs 2 protein at the N terminus region , known as the forkhead associated ( FHA ) domain and the BRCA 1 C terminus domain . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Our mutational study of the 75 MSI positive tumors revealed frequent mutations in hRAD 50 ( 23 cases , 31 % ) , BLM ( 16 cases , 21 % ) , and hMSH 6 ( 16 cases , 21 % ) ; rare mutations in BRCA 1 ( 1 case , 1 % ) and ATM ( 3 cases , 4 % ) ; and no mutation in NBS 1 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Here we show that Atm and Brca 1 are required for both the S phase and G ( 2 ) arrests induced by ionizing irradiation while Nbs 1 is required only for the S phase arrest . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
No mutations of hMLH 3 , ATM , BRCA 1 , or NBS 1 genes were detected . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
BRCA 1 forms a multi subunit protein complex referred to as the BRCA 1 associated genome surveillance complex ( BASC ) , which includes DNA damage repair proteins such as MSH 2 MSH6 and MLH 1 , as well as ATM , NBS 1 , MRE 11 , and BLM . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
G ( 2 ) / M accumulation after IR is not affected by the early G ( 2 ) / M checkpoint and is enhanced in cells lacking the IR induced S phase checkpoint , such as those lacking Nbs 1 or Brca 1 function , because of a prolonged G ( 2 ) arrest of cells that had been in S phase at the time of irradiation . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Optimal phosphorylation of these sites in Smc 1 after ionizing irradiation also requires the presence of the Atm substrates Nbs 1 and Brca 1 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
The combination of the highly conserved NBS 1 forkhead associated domain and BRCA 1 C terminus domain has a crucial role for recognition of damaged sites . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Seven FA associated genes have recently been cloned , and their products were found to interact with well known DNA damage response proteins , including BRCA 1 , ATM and NBS 1 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
The NH ( 2 ) terminus of NBS 1 , specifically the BRCA 1 COOH terminal domain , is required for this activity . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
We show here that BRCA 1 is required for ATM and ATR dependent phosphorylation of p 53 , c Jun , Nbs 1 and Chk 2 following exposure to ionizing or ultraviolet radiation , respectively , and is also required for ATM phosphorylation of CtIP . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Despite their initial recruitment to DSBs , numerous factors , including Nbs 1 , 53BP1 and Brca 1 , subsequently fail to form IRIF . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Interestingly , when H2AX transformed T98G cells were irradiated , Brca 1 and Nbs 1 were readily recruited in DNA double strand break ( DSB ) foci and showed the G2 / M phase arrest of the cell cycle . ^^^ Together with the evidence that H2AX transfection does not affect growth activities of non tumor cells under genotoxic stimuli , this suggests that H2AX gene transfer would provide a new modality for radio chemotherapy for glioblastomas , probably through overcoming the instability of the genome , and that Brca 1 and Nbs 1 might be crucial in this methodology . . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Bloom syndrome cells undergo p 53 dependent apoptosis and delayed assembly of BRCA 1 and NBS 1 repair complexes at stalled replication forks . ^^^ These BLM foci recruited BRCA 1 and NBS 1 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Damaged DNA in humans is detected by sensor proteins ( such as hHUS 1 , hRAD 1 , hRAD 9 , hRAD 17 , and hRAD 26 ) that transmit a signal via ATR to CHK 1 , or by another sensor complex ( that may include gammaH2AX , 53BP1 , BRCA 1 , NBS 1 , hMRE 11 , and hRAD 50 ) , the signal of which is relayed by ATM to CHK 2 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Here , we show that NBS 1 and BRCA 1 are required for the recruitment of previously activated ATM to the sites of DNA breaks after ionizing irradiation , and that this recruitment is required for the phosphorylation of SMC 1 by ATM . ^^^ Although these cells demonstrate normal phosphorylation and focus formation of ATM , NBS 1 , and BRCA 1 proteins after IR , they exhibit a defective S phase checkpoint , decreased survival , and increased chromosomal aberrations after DNA damage . ^^^ These observations suggest that many of the abnormal stress responses seen in cells lacking ATM , NBS 1 , or BRCA 1 result from a failure of ATM migration to sites of DNA breaks and a resultant lack of SMC 1 phosphorylation . . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
This function correlates with evidence that gamma H2AX regulates recruitment of several BRCA 1 carboxyl terminus domain containing proteins ( NBS 1 , 53BP1 , MDC1 / NFBD1 , and BRCA 1 ) in mammals . . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Molecular studies have established that a common pathway exists , both between the FA proteins and other proteins involved in DNA damage repair such as NBS 1 , ATM , BRCA 1 and BRCA 2 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
This response was strictly dependent on ATM ( ataxia telangiectasia mutated ) and 53BP1 , but not affected by diminished function of ATR ( ATM and Rad 3 related kinase ) , BRCA 1 , Chk 2 , Nbs 1 , and Mre 11 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
The serine / threonine protein kinase ATM signals to cell cycle and DNA repair components by phosphorylating downstream targets such as p 53 , CHK 2 , NBS 1 , and BRCA 1 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
The fork head associated ( FHA ) and the BRCA 1 C terminal domains ( BRCT ) of NBS 1 are essential for this physical interaction and focus formation of NBS 1 in response to DNA damage . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
The method was tested in the detection of cancer predisposing mutations in RET , hMSH 2 , hMLH 1 , BRCA 1 , BRCA 2 and NBS 1 genes . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Additionally , we summarized breast cancer risk associated with the following genetic factors : breast cancer susceptibility high penetrance genes ( BRCA 1 , BRCA 2 , p 53 , PTEN , ATM , NBS 1 or LKB 1 ) and low penetrance genes such as cytochrome P 450 genes ( CYP1A1 , CYP2D6 , CYP 19 ) , glutathione S transferase family ( GSTM 1 , GSTP 1 ) , alcohol and one carbon metabolism genes ( ADH1C and MTHFR ) , DNA repair genes ( XRCC 1 , XRCC 3 , ERCC4 / XPF ) and genes encoding cell signaling molecules ( PR , ER , TNFalpha or HSP 70 ) . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
We also show that STAT 1 is required for ATM dependent phosphorylation of NBS 1 and p 53 but not for BRCA 1 or H2AX phosphorylation following DNA damage . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Co localization of the majority of gammaH2AX foci with ataxia telangiectasia mutated , BRCA 1 , 53BP1 , and Nbs 1 foci in untreated melanoma cells indicated that the additional foci in melanoma cells were associated with a DNA change that the cells interpret as DNA dsb . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Key components of the homologous recombination and nonhomologous end joining repair pathways ( DNA PK , BRCA 1 , and NBS 1 ) underwent phosphorylation and formed nuclear foci . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Up to 1 , 600 cases and 4 , 241 controls from 4 separate genetic association studies from 3 countries were genotyped for 13 single nucleotide polymorphisms ( SNP ) in 6 genes ( BRCA 1 , NBS 1 , RAD 51 , RAD 52 , XRCC 2 and XRCC 3 ) involved in homologous recombination of DNA double strand breaks . ^^^ No association was detected between EOC risk and BRCA 1 Q356R , BRCA 1 P871L , RAD 51 g135c , RAD 51 g172t , RAD 52 c2259t , NBS 1 L34L , NBS 1 E185Q , NBS 1 A399A , NBS 1 P672P , XRCC 2 g4324c , XRCC 2 c41657t and XRCC 3 T241M . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
In Poland founder alleles of the BRCA 1 , CHEK 2 and NBS 1 genes have been associated with an increased risk of breast cancer , but the relative contribution of each of these alleles to the overall breast cancer burden has not yet been determined . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
The genes involved include the ATM , ATR , FA associated genes , NBS 1 and the cancer susceptibility genes BRCA 1 and BRCA 2 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
We will review the molecular interactions within the ATM Chk 2 pathway implicating the DNA damage sensor kinases ( ATM , ATR and DNA PK ) , the adaptor BRCT proteins ( Nbs 1 , Brca 1 , 53BP1 , MDC 1 ) and the effector kinases ( Chk 2 , Chk 1 , Plk 3 , JNK , p 38 ) . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
A clue towards understanding the molecular function of the FANC genes comes from the recently identified connection of FANC to the BRCA 1 , ATM , NBS 1 and ATR genes . ^^^ Taken together with the previously reported impaired DSB and DNA interstrand crosslinks repair in FA cells , the connection of FANC genes to the ATM , ATR , NBS 1 and BRCA 1 links the FANC genes function to the finely orchestrated network involved in the sensing , signalling and repair of DNA replication blocking lesions . . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Molecular studies have established that a common pathway exist , both between the FA proteins and other proteins involved in DNA repair such as NBS 1 , ATM , BRCA 1 and BRCA 2 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
The proteins involved in FA act coordinately in the cellular response to DNA cross links in a pathway that has been shown to interact physically or functionally with a variety of other proteins involved in DNA repair or cell cycle control , notably BRCA 1 , Rad 51 , ATM , ATR , and Nbs 1 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
BRIT 1 is also required for the expression of both BRCA 1 and the checkpoint kinase Chk 1 and phosphorylation of Nbs 1 . ^^^ Thus , the checkpoint defects in the absence of BRIT 1 are likely to result from its regulation of Nbs 1 , BRCA 1 , and Chk 1 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
Activated ATM phosphorylates other targets , including proteins p 53 , Mdm 2 , Chk 1 , Chk 2 , Brca 1 , Nbs 1 and cAb 1 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
The RAD 50 IVS3 1G > A splicing mutation leading to translational frameshift was observed in one patient , and the NBS 1 Leu150Phe missense mutation affecting a conserved residue in the functionally important BRCA 1 carboxy terminal ( BRCT ) domain in two patients , both being absent from 1000 controls . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
DNA damage by ICRF 193 was further demonstrated by formation of the nuclear foci of 53BP1 , NBS 1 , BRCA 1 , MDC 1 , and FANCD 2 and increased comet tail moment . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
FA proteins interact with various proteins involved in DNA damage response and cell cycle checkpoint regulation , such as : RAD 51 , BRCA 1 , BRCA 2 , ATM or NBS 1 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
We analyzed one or more single nucleotide polymorphisms ( SNPs ) in each of seven candidate genes ( WRN , TP 53 , NBS 1 , BRCA 1 , BRCA 2 , XRCC 3 and XRCC 4 ) in a study of 250 workers exposed to benzene and 140 controls in China . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
A major role for the NBS 1 and BRCA 1 proteins appears to be in the recruitment of an activated ATM kinase molecule to the sites of DNA breaks so that ATM can phosphorylate SMC 1 . ^^^
Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: O60934 and P38398	Pubmed	SVM Score :0.0
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