| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| We hypothesized that NEP inhibition potentiates the natriuretic actions of exogenous ADM in anesthetized dogs ( n = 6 ) . ^^^ We therefore investigated renal function in which one kidney received intrarenal infusion of ADM ( 1 ng . kg 1 . min 1 ) while the contralateral kidney served as control before and during the systemic infusion of a NEP inhibitor ( Candoxatrilat , 8 microg . kg 1 . min 1 ; Pfizer ) . ^^^ In response to systemic NEP inhibition , UNaV and UV increased further in the ADM kidney . ^^^ Plasma ADM was unchanged during ADM infusion but increased during NEP inhibition . ^^^ In conclusion , the present investigation is the first to demonstrate that NEP inhibition potentiates the natriuretic and diuretic responses to intrarenal ADM . ^^^ |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| Neutral endopeptidase ( NEP ) is the major enzyme in ADM ' s degradation . ^^^ We observed the activity and distribution of NEP and the expression of its mRNA in the plasma , cardiac ventricle , aorta , jejunum and kidney of spontaneously hypertensive rats ( SHRs ) in order to study the possible role of NEP in elevating tissue ADM concentrations during hypertension . ^^^ ADM and NEP were diffuse in all tissues studied . ^^^ Plasma NEP activity , general NEP activity and the expression of NEP mRNA in the left ventricle , aorta and jejunum in SHRs was lower than that of controls , and the level of ADM was inversely correlated with NEP activity . ^^^ NEP activity and mRNA and protein expression in SHR kidneys were higher than in control kidneys ; moreover , the ADM content was positively correlated with NEP activity in the renal cortex . ^^^ |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| By inhibiting NEP , CGS 35601 also prevents the degradation of peptidic vasodilators such as bradykinin ( BK ) , natriuretic peptides ( NPs ) and adrenomedullin ( ADM ) and , hence , modulates the secondary release of other vasoactive mediators such as nitric oxide ( NO ) and prostaglandins . ^^^ |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| AIMS : To compare the haemodynamic responses of proadrenomedullin N terminal 20 peptide ( PAMP ) and adrenomedullin ( ADM ) in the forearm vascular bed of healthy male volunteers , and to investigate the role of neutral endopeptidase ( NEP ) in the metabolism of ADM . ^^^ In a second study , eight male subjects received the same doses of ADM , co infused with either the NEP inhibitor thiorphan ( 30 nmol 10 min ( 1 ) ) or the control vasoconstrictor noradrenaline ( 120 pmol 10 min ( 1 ) ) , on separate occasions . ^^^ In addition , NEP inhibition potentiates the haemodynamic effects of ADM . ^^^ However , in pathophysiological conditions such as hypertension and heart failure , NEP inhibition may exert a beneficial effect by increasing the biological activity of ADM . . ^^^ Adrenomedullin ( ADM ) in the human forearm vascular bed : effect of neutral endopeptidase inhibition and comparison with proadrenomedullin NH 2 terminal 20 peptide ( PAMP ) . ^^^ |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Omapatrilat ( OMA ) , a vasopeptidase inhibitor , simultaneously inhibits angiotensin converting enzyme ( ACE ) and neutral endopeptidase , which degrades vasodilatory factors ( eg , ADM ) and natriuretic peptides . ^^^ |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| ADM levels in plasma and tissues are regulated by the proteolysis of neutral endopeptidase ( NEP ) , the major enzyme of ADM degradation . ^^^ We observed the NEP activity in the plasma , the activity and distribution of NEP and its mRNA expression in the tissues of rats in septic shock to study the possible role of NEP in elevating tissue ADM concentration during sepsis . ^^^ The level of ADM was inversely correlated with NEP activity in the plasma , ventricle and aorta and positively correlated with NEP activity in the jejunum . ^^^ Thus , in sepsis , the local concentration and action of ADM in tissues may be differentially regulated by NEP . . ^^^ |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| The local effects of SCH 32615 , an inhibitor of enkephalinase ( EC 3 . 4 . 24 . 11 ) on the hot plate ( HP ) and tail flick ( TF ) responses were examined following unilateral intracerebral microinjection into the periaqueductal brain ( PAG ) , the medial ventral medulla ( VM ) and bilateral microinjection into the amygdala ( AM ) of the rat . ^^^ These data suggest that in the presence of a strong thermal stimulus , the behavioral response is subject to a tonically active or stimulus evoked modulation by the local release in the PAG , VM and AM of an agent , presumably an enkephalin peptide , the degradation of which is altered by enkephalinase inhibition . . ^^^ |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35318 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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