Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: Q9UKG1 and P31751 Pubmed SVM Score :0.0
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Interacting proteins: Q9UKG1 and P31751 Pubmed SVM Score :0.0
Identification of a chromosome 3p14 . 3 21 . 1 gene , APPL , encoding an adaptor molecule that interacts with the oncoprotein serine / threonine kinase AKT 2 . ^^^ APPL is highly expressed in skeletal muscle , heart , ovary and pancreas , tissues in which AKT 2 mRNA is abundant . ^^^ APPL interacts with the inactive form of AKT 2 ; moreover , APPL binds to the PI3K catalytic subunit , p110alpha . ^^^ These data suggest that APPL is an adaptor that may tether inactive AKT 2 to p110alpha in the cytoplasm and thereby may expedite recruitment of AKT 2 and p110alpha to the cell membrane upon mitogenic stimulation . ^^^