| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| The ability of GH receptor ( GHR ) to transduce the signal for IRS 1 tyrosyl phosphorylation is mediated by the intracellular region of GHR between amino acids 295 and 380 by a mechanism not involving the two tyrosines in this region . ^^^ |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| Recent data suggest involvement of the Janus tyrosine kinase 2 ( JAK 2 ) in human GH induced tyrosine phosphorylation of the GH receptor and the insulin receptor substrates 1 and 2 ( IRS 1 and IRS 2 ) , leading to activation of the phosphatidylinositol 3 kinase and the acute insulin like effects in primary rat adipocytes . ^^^ |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| Interaction of GH with the cell surface GH receptor ( GHR ) causes activation of the GHR associated tyrosine kinase , JAK 2 , and consequent triggering of signaling cascades including the STAT , Ras / Raf / MEK1 / MAP kinase , and insulin receptor substrate 1 ( IRS 1 ) / PI3kinase pathways . ^^^ |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| We therefore tested the C2C12 myogenic cell line for its response to GH and demonstrate that C2C12 skeletal muscle cells rapidly respond to physiological levels of GH with increased tyrosine phosphorylation of the GH receptor , Janus kinase 2 , signal transducer and activator of transcription 5a and 5b , insulin receptor substrate 1 , and activation of MAPKs / ERKs and protein kinase B / Akt . ^^^ |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| The ability of GH to stimulate lipogenesis and tyrosine phosphorylation of the GH receptor ( GHR ) , Janus kinase 2 ( Jak 2 ) , insulin receptor substrate 1 ( IRS 1 ) and 2 ( IRS 2 ) was greatly reduced in refractory as compared to responsive primary rat adipocytes . ^^^ |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| The insulin like effects are mediated by the cytosolic tyrosine kinase Janus kinase 2 ( JAK 2 ) upon GH GH receptor interaction , resulting in tyrosine phosphorylation of downstream targets including the GH receptor itself and insulin receptor substrate 1 ( IRS 1 ) and IRS 2 . ^^^ |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| GH dependent tyrosine phosphorylation of SHP 2 was also observed in murine 32D cells ( which lack IRS 1 and 2 ) stably transfected with the GHR . ^^^ |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| To test for significance of IRS 1 with regard to GH signaling , IRS and GHR deficient 32D cells were stably reconstituted with the rabbit ( r ) GHR , either alone ( 32D rGHR ) or with IRS 1 ( 32D rGHR IRS 1 ) . ^^^ |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| We found that , in liver of GHR KO mice , the lack of GHR and GH eff . ects is associated with : ( 1 ) increased IR abundance , ( 2 ) increased insulin stimulated IR tyrosine phosphorylation , ( 3 ) normal efficiency of IRS 1 and Shc tyrosine phosphorylation and ( 4 ) normal activation of PI 3 kinase by insulin . ^^^ |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| After receptor binding , growth hormone ( GH ) induces GH receptors ( GHR ) dimerization and JAK 2 is activated after its association with a dimerized GHR , stimulating the tyrosyl phosphorylation of insulin receptor substrate 1 ( IRS 1 ) , IRS 2 and Shc proteins . ^^^ |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| Upon in vivo insulin stimulation , skeletal muscles of GHR ( / ) mice exhibit transient delayed responses in IR and IRS 1 phosphorylation but normal levels of p 85 association with IRS 1 . ^^^ |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P35568 |
Pubmed |
SVM Score :0.0 |
| NA |
|