| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| To gain insight into pathways coupling GH receptor ( GHR ) to MAP kinase activation and signaling molecules that might interact with GHR and its associated tyrosine kinase JAK 2 , we examined whether SHC and Grb 2 proteins serve as signaling molecules for GH . ^^^ |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| Tyrosyl phosphorylation of GH receptor and JAK 2 recruits and activates signaling molecules such as Stat transcription factors , SHC , and insulin receptor substrates 1 and 2 that lead to the release of second messengers such as diacylglycerol , calcium , and nitric oxide and the activation of enzymes such as mitogen activated protein kinase , protein kinase C , phospholipase A 2 , and phosphatidylinositol 3 ' kinase . ^^^ |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| To examine pathways coupling GH receptor ( GHR ) to MAP kinase activation , we have determined the effects of GH on SHC growth factor receptor bound 2 son of Sevenless ( SHC Grb 2 SOS ) association and activation of Ras , Raf , and MAP ERK kinase ( MEK ) . ^^^ |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| Targeted mutations that affect components of this pathway , including the GH receptor , p66Shc , and the IGF 1 receptor ( IGF 1R ) , also extend life span ; mutations that affect IGF 1R or downstream components of the pathway decouple longevity effects from dwarfism . ^^^ |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| We briefly compare calorie restriction , GHRH R and Pit 1 mutants with knockout phenotypes of GH receptor , IGF 1 receptor and p66Shc , to make some general conclusions . ^^^ |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to investigate the interaction of Stat 5 with key effector proteins Erk 2 and Shc after activation by growth hormone ( GH ) , using Chinese Hamster Ovary ( CHO ) cells stably expressing the wild type rabbit growth hormone receptor ( GHR ) . ^^^ |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| The signaling molecules that are recruited and activated by the GHR JAK 2 complex include signal transducers and activators of transcription ( Stat ) factors , the adapter protein Shc , and the insulin receptor substrates ( IRSs ) 1 and 2 . ^^^ |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| We found that , in liver of GHR KO mice , the lack of GHR and GH eff . ects is associated with : ( 1 ) increased IR abundance , ( 2 ) increased insulin stimulated IR tyrosine phosphorylation , ( 3 ) normal efficiency of IRS 1 and Shc tyrosine phosphorylation and ( 4 ) normal activation of PI 3 kinase by insulin . ^^^ |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| After receptor binding , growth hormone ( GH ) induces GH receptors ( GHR ) dimerization and JAK 2 is activated after its association with a dimerized GHR , stimulating the tyrosyl phosphorylation of insulin receptor substrate 1 ( IRS 1 ) , IRS 2 and Shc proteins . ^^^ |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| Additionally , GH induced further accumulation of GHR , Grb 2 , and SHC proteins in the CM fraction . ^^^ |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| We found statistical evidence that C / EBP , MSRA , SHC 1 , growth hormone , GHR , PIT 1 , and PolgA may influence aging in mice . ^^^ |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|