| Interacting proteins: P10912 and P29350 |
Pubmed |
SVM Score :0.0 |
| These results delineate a novel domain in the GH receptor that regulates the inactivation of the Jak / Stat pathway and appears to be modulated by SHP 1 . . ^^^ |
|
| Interacting proteins: P10912 and P29350 |
Pubmed |
SVM Score :0.0 |
| A reciprocal binding assay using IM 9 cells as a source of SHP 1 and SHP 2 revealed specific association of SHP 2 ( but not SHP 1 ) with a glutathione S transferase fusion incorporating GHR cytoplasmic domain residues 485 620 , but only if the fusion was first rendered tyrosine phosphorylated . ^^^ Finally , GH induced transactivation of a c Fos enhancer driven luciferase reporter in GHR and JAK 2 transfected COS 7 cells was significantly reduced when a catalytically inactive SHP 2 mutant ( but not wild type SHP 2 ) was coexpressed ; in contrast , expression of a catalytically inactive SHP 1 mutant allowed modestly enhanced GH induced transactivation of the reporter in comparison with that found with expression of wild type SHP 1 . ^^^ |
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