| Interacting proteins: P10912 and P23458 |
Pubmed |
SVM Score :0.84039355 |
| We conclude that the GHR associates with Jak 1 , Jak 2 and Tyk 2 in human liver . 0.84039355^^^ The growth hormone receptor associates with Jak 1 , Jak 2 and Tyk 2 in human liver . 0.76164245^^^ |
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| Interacting proteins: P10912 and P23458 |
Pubmed |
SVM Score :0.0 |
| Both JAK 1 and JAK 2 exhibit a nucleocytoplasmic distribution by immunocytochemistry in unstimulated serum deprived CHO cells stably transfected with rat GH receptor complementary DNA ( cDNA ) . ^^^ No change in the nuclear content of JAK 1 or JAK 2 was observed upon ligand stimulation of GH receptor cDNA transfected cells with 100 nM human GH for 5 , 10 , 15 , 30 , or 60 min . ^^^ |
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| Interacting proteins: P10912 and P23458 |
Pubmed |
SVM Score :0.0 |
| The growth hormone receptor ( GHR ) is believed to interact predominantly with Jak 2 , but studies on cell lines have shown that it may also induce phosphorylation of Jak 1 and Jak 3 . ^^^ |
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| Interacting proteins: P10912 and P23458 |
Pubmed |
SVM Score :0.0 |
| However , GH dependent phosphorylation of Stats 1 , 3 , and 5 was observed in cells expressing full length GHR in which tyrosines 333 and 338 are mutated to phenylalanine ( GHR 1 638Y333 , 338F ) GH , whose receptor lacks previously defined Stat 1 or Stat 3 binding sites , was found in 3T3 F442A fibroblasts and 2fTGH GHR cells to stimulate tyrosyl phosphorylation of JAK 2 to a substantially greater extent than , and JAK 1 to a similar extent as , leukemia inhibitory factor ( LIF ) and / or interferon gamma ( IFN gamma ) , ligands whose receptors contains Stat 3 and Stat 1 binding sites and activate Stat 3 and Stat 1 , respectively , better than GH . ^^^ These findings suggest that : 1 ) JAK 2 is required for GH dependent phosphorylation of Stats 1 , 3 , and 5 ; 2 ) tyrosines 333 and / or 338 are required for maximal tyrosyl phosphorylation of Stats 1 , 3 , and 5 ; 3 ) Stat 5 binds to a phosphorylated tyrosine ( s ) within amino acids 454 638 in addition to tyrosines 333 and / or 338 ; 4 ) GH stimulates tyrosyl phosphorylation of JAK 1 in addition to JAK 2 with JAK 2 having a much greater response ; 5 ) some Stat 3 and Stat 5 ( and possibly Stat 1 ) may bind to nonphosphorylated amino acids in GHR or to phosphorylated tyrosines in proteins that bind to GHR ( e . g . ^^^ |
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| Interacting proteins: P10912 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10912 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10912 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
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