Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.62225693
We report the relationship between serum IGF 1 , IGF 2 , their binding proteins IGFBP 1 and IGFBP 3 , and GH binding protein in 600 normal Spanish children who were divided into 5 groups according to Tanner stage : 1 , 150 males and 102 females ; 2 , 40 males and 42 females ; 3 , 45 males and 45 females ; 4 , 42 males and 55 females ; and 5 , 23 males and 56 females . 0.62225693^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.52824037
IGFBP 1 may regulate these effects by binding to and interaction with IGF 1 . . 0.52824037^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.6069388
The ratio between IGF 1 and IGFBP 1 decreased significantly after dialysis to 53 % of the ratio before dialysis ( P < 0 . 005 ) . 0.6069388^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.88121476
We propose that IGF 1 physically interacts with IGFBP 1 and that IGFBP 1 also binds to an integrin receptor , most likely the alpha5beta1 integrin . 0.88121476^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.53531414
There were significant inverse correlations between IGF 1 and both IGFBP 1 ( r = 0 . 45 ) and IGFBP 2 ( r = 0 . 62 ) . 0.53531414^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.68779335
However , the normal inverse relationship between free IGF 1 and IGFBP 1 was absent , and free IGF 1 changed in parallel with total IGF 1 and thus ALS and IGFBP 3 . 0.68779335^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.86620489
INTERPRETATION : These data show that circulating IGF 1 and its interaction with IGFBP 1 could be important determinants of glucose homoeostasis and provide further evidence for the possible protective role of IGF 1 against development of glucose intolerance . . 0.86620489^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Effect of insulin like growth factor type 1 ( IGF 1 ) and insulin on the secretion of sex hormone binding globulin and IGF 1 binding protein ( IBP 1 ) by human hepatoma cells . ^^^ Insulin , but not IGF 1 , was also found to inhibit the secretion of a low molecular weight IGF binding protein ( IBP 1 ) , which is also secreted by hepatoma cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
This low molecular weight insulin like growth factor ( IGF ) binding protein 1 ( IBP 1 ) is one of two distinct classes of IGF binding proteins which bind IGF 1 and IGF 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The negative influence might be explained in part by reduced levels of IGF 1 and elevated levels of IGF binding protein 1 in the diabetic sera . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In this study , we have mapped the expression of the genes for insulin like growth factors ( IGF 1 and 2 ) , the peptides they encode , and the IGF binding protein 1 ( IGF BP 1 ) during murine palatogenesis ( embryonic days ( E ) 12 15 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Anatomical relationships in the patterns of insulin like growth factor ( IGF ) 1 , IGF binding protein 1 , and IGF 1 receptor gene expression in the rat kidney . ^^^ In order to identify which renal structures produce IGF 1 and the functionally related IGF binding protein 1 ( IGFBP 1 ) , and which structures are potential sites of circulating or endogenous renal IGF action , we have employed in situ hybridization to localize IGF 1 , IGFBP 1 , and IGF 1 receptor messenger RNAs ( mRNAs ) in the rat kidney . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( BP 1 ) are critical cell regulators , with regulation and action in endocrine , paracrine , and autocrine modes . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and IGF binding protein 1 mRNAs are colocalized in the rat medullary thick ascending limbs of Henle ' s loops , but neither is detected in the human kidney . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Effect of recombinant IGF binding protein 1 on primary cultures of human keratinocytes and fibroblasts : selective enhancement of IGF 1 but not IGF 2 induced cell proliferation . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Since insulin like growth factor 1 ( IGF 1 ) has been shown to stimulate nerve regeneration , and IGF binding protein 1 is acutely regulated by plasma insulin we have investigated the relationships between plasma IGF 1 , IGFBP 1 , glucose and insulin in Type 1 ( insulin dependent ) diabetic patients with peripheral polyneuropathy . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Because opioid peptides are involved in the regulation of insulin secretion , we studied the effect of naloxone induced opiate receptor blockade on the circulating levels of insulin , IGF 1 , and IGF binding protein 1 ( IGFBP 1 ) in 13 nonobese and 7 obese PCOD patients and in 6 healthy subjects . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The effects of decidualization on uterine expression of insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) have been examined in the hypophysectomized ovariectomized ( hypox ovx ) rat and the pituitary intact ( ovx ) rat . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
A factor contained in plasma is required for IGF binding protein 1 to potentiate the effect of IGF 1 on smooth muscle cell DNA synthesis . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The role of insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) in the pathogenesis of polycystic ovary syndrome . ^^^ The objective of this study was to elucidate the relationship and role of insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) , insulin and luteinizing hormone ( LH ) in the pathogenesis of polycystic ovary syndrome ( PCOS ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 2 was measured after separation by gel chromatography at low pH and compared with IGF 1 levels in the same samples , whereas IGF binding protein 1 was measured in dialysed urine . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have examined the developmental pattern of IGF binding protein 1 ( IGFBP 1 ) , 2 , and 3 in serum by Western ligand blotting , the levels of IGFBP 3 , IGF 1 , and IGF 2 in serum by RIA , and the IGFBP mRNA levels of IGFBP 1 , 2 , and 3 in the livers of rhesus monkeys from fetal life through adulthood by Northern analysis . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Growth hormone ( GH ) , placental lactogen ( PL ) , prolactin ( PRL ) , insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) were determined in serum by radioimmunoassays ( RIAs ) in 12 women during pregnancy . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Short and long term effects of growth hormone on circulating levels of insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 , and insulin : a placebo controlled study . ^^^ The short and long term effects of GH on serum concentrations of insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) , and insulin were investigated in women participating in an in vitro fertilization program . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Inter relations between growth hormone , insulin , insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) and sex hormone binding globulin in acromegaly . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The pretreatment elevation of IGF binding protein 1 decreased by almost 50 % during GH therapy , while IGF binding protein 3 increased significantly in concentration , although this increase was significantly smaller than the GH induced increase in IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
A 10 to 20 fold increase in IGF binding protein 1 mRNA was seen 16 48 hr after exposure of the HepG 2 cells to insulin and IGF 1 , an increase abolished by cycloheximide . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To test the hypothesis that growth hormone ( GH ) insensitivity is responsible , amongst other mechanisms , for impaired growth in uraemic children , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 and IGFBP 3 were measured by radioimmunoassay in normal control children , in patients with end stage renal failure ( n = 51 ) and in patients with preterminal chronic renal failure ( n = 11 ) and the production rate of IGF was calculated . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In vivo actions of insulin like growth factor 1 ( IGF 1 ) on brain myelination : studies of IGF 1 and IGF binding protein 1 ( IGFBP 1 ) transgenic mice . ^^^ To study the effects and mechanisms of insulin like growth factor 1 ( IGF 1 ) on brain myelination in vivo , the morphology of myelinated axons and the expression of myelin specific protein genes have been examined in transgenic ( Tg ) mice that overexpress IGF 1 and that those ectopically express IGF binding protein 1 ( IGFBP 1 ) , a protein that inhibits IGF 1 actions when present in molar excess . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Differential regulation of insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 messenger ribonucleic acids by amino acid availability and growth hormone in rat hepatocyte primary culture . ^^^ To determine the mechanisms involved in the nutritional regulation of insulin like growth factor 1 ( IGF 1 ) production and action , we studied the regulation of IGF 1 and IGF Binding Protein 1 ( IGFBP 1 ) gene expression by GH and amino acid availability in rat hepatocyte primary culture . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The purpose of the present study was to investigate the regulation of plasma and tissue levels of insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 , 2 , and 3 ( IGFBP 1 , 2 , and 3 ) in rats injected with Escherichia coli lipopolysaccharide ( LPS ) , a component of the outer cell wall of gram negative bacteria . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Regulation of insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 gene transcription by hormones and provision of amino acids in rat hepatocytes . ^^^ Synthesis of insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) is altered in diabetes and malnutrition , but underlying processes are poorly understood . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Effect of growth hormone on steroidogenesis , insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 production and DNA synthesis in cultured human luteinized granulosa cells . ^^^ We have investigated the effect of GH alone and GH in combination with FSH on the secretion of oestradiol , progesterone , insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) and on [ 3H ] thymidine incorporation in cultured human luteinized granulosa cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) mRNAs are colocalized in the medullary thick ascending limb ( MTAL ) of the rat nephron , a segment that undergoes selective growth in response to elevated dietary protein . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
During each treatment period , concentrations of androgens , lipids , apolipoproteins , IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 3 , insulin sensitivity , percent body fat , libido , and sense of well being were measured . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have studied the effects of pirenzepine on plasma insulin , plasma glucose , growth hormone ( GH ) , androstenedione , testosterone , insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) responses to a mixed meal in obese clinically hyperandrogenic women with the polycystic ovary syndrome . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Spontaneous overnight and arginine stimulated GH secretion , insulin , IGF 1 , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , and IGFBP 3 levels were measured before , during , and after daily 10 h sc infusions of saline or IGF 1 ( 20 micrograms / kg . h ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 , IGF 2 , and IGF binding protein 1 ( IGFBP 1 ) , 2 , 3 , and 4 were identified in PF by immunoassays . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Type 1 diabetes mellitus is associated with decreased insulin like growth factor 1 ( IGF 1 ) levels , enhanced values of growth hormone ( GH ) and IGF binding protein 1 ( IGFBP 1 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum concentrations of insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) , 2 , and 3 are influenced by dietary intake in normal adults . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In addition , basal levels of serum insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) , IGF binding protein 3 ( IGFBP 3 ) , insulin , pro insulin , and blood glucose were measured during habitual energy intake as well as during the hypocaloric diet . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
After rhIGF 1 treatment , plasma IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , and IGFBP 2 all increased significantly , whereas IGFBP 3 did not change . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : Serum IGF 1 , IGF binding protein 1 ( IGFBP 1 ) and IGFBP 3 were measured at regular intervals throughout the study . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The liver is thought to be the major source of circulating insulin like growth factor ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) , whereas the primary production site of circulating IGFBP 3 remains unknown . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : To investigate the cyclic changes of serum insulin like growth factor ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) and IGFBP 3 levels during ovulatory menstrual cycle . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) enhances recovery from HgCl 2 induced acute renal failure : the effects on renal IGF 1 , IGF 1 receptor , and IGF binding protein 1 mRNA . ^^^ Solution hybridization RNAase protection assays showed that renal IGF 1 mRNA , IGF 1 receptor ( IGF 1R ) mRNA , and IGF binding protein 1 ( IGFBP 1 ) mRNA were unaffected by exogenous IGF 1 , but this treatment significantly increased renal IGF 1 in ARF rats compared with normal rats and ARF rats not receiving IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum levels of insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 were measured in 94 children with chronic renal failure ( CRF ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Differential regulation of IGF 1 and IGF binding protein 1 by dietary composition in humans . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) inhibits production of IGF binding protein 1 while stimulating estradiol secretion in granulosa cells from normal and polycystic human ovaries . ^^^ We have investigated the actions of FSH and insulin like growth factor 1 ( IGF 1 ) on the production of IGF binding protein 1 ( IGFBP 1 ) by granulosa cells from unstimulated normal and polycystic ( PCO ) human ovaries and related these effects to those on estradiol ( E 2 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Levels of growth hormone , insulin like growth factor 1 ( IGF 1 ) and 2 , IGF binding protein 1 and 3 , and cortisol in prednisone treated children with growth retardation after renal transplantation . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The transplants were treated with either a total of 300 ng truncated IGF 1 , two different IGF 1 polyclonal antisera , two different non immune sera , a total of 15 micrograms IGF binding protein 1 , or vehicle alone . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
An additional 125I IGF 1 protein complex of 43 , 000 daltons , corresponding to IGF binding protein 1 ( IGFBP 1 ) , was present in decidual membranes and appeared to increase as pregnancy proceeded . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 1 is not locally produced , but rather accumulates from circulating IGF 1 , trapped by increased levels of IGF binding proteins , particularly IGF binding protein 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The increase in IGF 1 levels was accompanied by a significant increase in IGF binding protein 2 levels , a slight reduction in IGF binding protein 3 levels , and an increase in levels of IGF binding protein 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The following significant changes in the peripheral IGF 1 system of these patients were found : low IGF 1 levels , and high IGF binding protein 1 ( BP 1 ) , and BP 3 affinity for IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Quantitative genetic analyses of insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 , and insulin levels in middle aged and elderly twins . ^^^ With the use of quantitative genetic models , the relative importance of genetic and environmental influences on serum levels of insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) , and insulin was evaluated in 248 pairs of middle aged and elderly Swedish twins reared apart and reared together . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MAIN OUTCOME MEASURES : Serum E 2 , FSH , GH , insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) , and IGFBP 3 concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Baseline evaluation of serum concentrations of luteinizing hormone ( LH ) , follicle stimulating hormone ( FSH ) , testosterone , fasting insulin , insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) and sex hormone binding globulin ( SHBG ) were performed before administering gonadotrophin releasing hormone agonist ( GnRHa ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Circulating levels of IGF 1 and IGF binding protein 1 throughout pregnancy : relation to birthweight and maternal weight . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum and follicular fluid levels of insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 and 3 during the normal menstrual cycle . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The effects of insulin like growth factor 1 ( IGF 1 ) on the initiation of myelination have been examined in the posterior portion of anterior commissure of the transgenic ( Tg ) mice that overexpress IGF 1 in brain , and those which exhibit ectopic brain expression of IGF binding protein 1 ( IGFBP 1 ) , an inhibitor of IGF actions . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum levels of insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 were measured in 54 children with end stage renal disease ( ESRD ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We compared some biobehavioral effects of ethanol in transgenic mice that overexpress insulin like growth factor 1 ( IGF 1 ) in brain and in those that exhibit ectopic : brain expression of IGF binding protein 1 with those in non transgenic littermate controls . ^^^ Ethanol induced sleep in IGF 1 transgenic mice was significantly shorter , and in IGF binding protein 1 transgenic mice significantly longer , than in controls . ^^^ In general , these data support the prediction made that chronically elevated exposure to IGF 1 in IGF 1 transgenic mice renders them less susceptible to the effects of ethanol than their non transgenic siblings , and that overexpression of IGF binding protein 1 has the opposite effect . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We also measured ultrafiltrated serum free IGF 1 and IGF 2 , total IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 3 , and insulin in a subgroup of 18 placebo treated and 20 lanreotide treated patients . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Transgenic ( Tg ) mice with brain IGF 1 overexpression and ectopic brain expression of IGF binding protein 1 ( IGFBP 1 ) , an inhibitor of IGF 1 actions , show changes in brain size and myelination . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Reduction in circulating IGF 1 and hepatic IGF 1 mRNA levels after caecal ligation and puncture are associated with differential regulation of hepatic IGF binding protein 1 , 2 and 3 mRNA levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Effect of marathon run on serum IGF 1 and IGF binding protein 1 and 3 levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 and 3 , and the acid labile subunit as serum markers of body composition during growth hormone ( GH ) therapy in adults with GH deficiency . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Sera were analyzed for soluble IL 2 Receptor ( sIL 2R ) levels , insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasmon resonance spectroscopy experiments revealed that all the high Mr isoforms and mature 7 . 5 kDa IGF 2 bound to immobilized recombinant soluble human IGF 1 receptor , recombinant human IGF binding protein 1 , and sIGF II / MPR with similar kinetics . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We compared levels of GH , IGF 1 , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , insulin , and C peptide in nondepressed CFS patients and normal controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Structural changes in insulin like growth factor ( IGF ) 1 mutant proteins affecting binding kinetic rates to IGF binding protein 1 and IGF 1 receptor . ^^^ Ligand binding properties of five single amino acid substituted variants ( V11A , D12A , Q15A , Q15E , and F16A ) of human insulin like growth factor 1 ( IGF 1 ) were analyzed with respect to their binding affinities and binding kinetics to recombinant IGF binding protein 1 ( IGFBP 1 ) and a soluble form of the IGF type 1 receptor ( sIGF 1 ( R ) ) , respectively . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Further , binding affinities to the IGF binding protein 1 and a soluble IGF type 1 receptor , respectively , were severely lowered in both disulfide mutant proteins compared to the native IGF 1 molecule . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Population based reference values for IGF 1 and IGF binding protein 1 : relations with metabolic and anthropometric variables . ^^^ Population based reference values for IGF 1 and IGF binding protein 1 ( IGFBP 1 ) have been established . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum concentrations of IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 3 , GH binding protein ( GHBP ) , lipids , and safety laboratory tests ( complete blood count and chemistry profile ) were measured in fasting samples ( 0800 0900 h ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
While antioestrogens such as tamoxifen and droloxifene reduce the expression of IGF IR in vitro and suppress plasma levels of IGF 1 but elevate IGF binding protein 1 in vivo , megestrol acetate may reduce the delivery of IGFs to the tissues by inhibition of IGFBP 3 protease activity . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Associations between insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 , insulin and other metabolic measures after controlling for genetic influences : results from middle aged and elderly monozygotic twins . ^^^ It has previously been shown that the serum levels of insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) , and insulin are influenced by genetic effects to various degrees . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 mRNA was diminished in potassium deficient rats within 4 days , whereas mRNA for IGF binding protein 1 ( IGFBP 1 ) , a collecting duct associated protein , was increased by day 7 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Free and total insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) , and IGFBP 3 and their relationships to the presence of diabetic retinopathy and glomerular hyperfiltration in insulin dependent diabetes mellitus . ^^^ Serum free and total IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , and IGFBP 3 levels were measured in 56 insulin treated IDDM patients and 52 healthy sex and age matched controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RNA expression of insulin like growth factor 1 ( IGF 1 ) is suppressed and those of IGF 2 and IGF binding protein 1 are constantly expressed in the endometrium during use of an intrauterine levonorgestrel system . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Binding affinities of insulin like growth factor 1 ( IGF 1 ) fusion proteins to IGF binding protein 1 and IGF 1 receptor are not correlated with mitogenic activity . ^^^ Binding kinetic properties of the three IGF 1 variants were analyzed using BIAcore kinetic interaction analysis testing for binding to both human IGF binding protein 1 ( IGFBP 1 ) and a soluble form of the human IGF type 1 receptor extracellular domains ( sIGF IR ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To evaluate whether insulin like growth factor 1 ( IGF 1 ) modulates neural activity in vivo , relative levels of brain [ 3H ] 2 deoxyglucose ( 2DG ) uptake were compared in adult behaving and anesthetized wild type ( wt ) mice , and transgenic ( Tg ) mice with either brain IGF 1 overexpression or ectopic brain expression of IGF binding protein 1 ( IGFBP 1 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : To establish the relation of insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) with 24 hour metabolic excursions in normal healthy women and in response to acute interruption of metabolic homeostasis by hypoinsulinemia . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Measurements were made of the GH secretory profile , insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 and 3 , and GH binding protein . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Alcohol withdrawal induced change in lipoprotein ( a ) : association with the growth hormone / insulin like growth factor 1 ( IGF 1 ) / IGF binding protein 1 ( IGFBP 1 ) axis . ^^^ Alcohol might also affect IGF binding protein 1 ( IGFBP 1 ) , which is an acute inhibitor of IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have examined the response of the renal insulin like growth factor ( IGF 1 ) axis to acute ischemic injury in the rat Key findings included a decrease in IGF 1 mRNA and peptide levels , a decrease in GH receptor gene plus protein expression and a decrease in the IGF binding proteins except for IGF binding protein 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We examined the ontogeny of mRNA levels of IGF 1 and 2 , IGF type 1 ( IGFI R ) and type 2 receptors ( IGFII R ) , IGF binding protein 1 and 3 ( IGFBP 1 and 3 ) , GH receptor ( GHR ) , and tissue concentrations of IGF and IGFBP in the pancreas of pigs . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and IGF binding protein 1 are related to cortisol in human cord blood . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : IGF 1 alone resulted in a significant dose dependent increase in medium estradiol ( E 2 ) ( p < 0 . 05 ) and progesterone ( P ) ( p < 0 . 001 ) and suppression of IGF binding protein 1 ( IGFBP 1 ) ( p < 0 . 001 ) , without any increase in [ 3H ] thymidine incorporation ( P=0 . 10 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Baseline levels of serum insulin like growth factor 1 ( IGF 1 ) was lower in older subjects , whereas circulating IGF binding protein 1 and lipid intermediates were lower in males than in females . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We studied 11 elderly male ( 50 78 years ) marathon runners and 10 age matched male ( 52 73 years ) sedentary controls to evaluate plasma concentrations of GH , total and free IGF 1 and IGF 2 and of IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , IGFBP 3 and insulin . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Differential expression of IGF 1 and IGF binding protein 1 and 2 in periportal and perivenous zones of rat liver . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
METHODS : Serum profiles of glucose , insulin , GH and IGF binding protein 1 ( IGFBP 1 ) were analysed in addition to IGF 1 in serum and nocturnal urinary excretion of GH . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NMR spectroscopy studies and biosensor interaction analysis of native and site directed mutants of insulin like growth factor 1 ( IGF 1 ) was applied to identify the involvement of individual residues in IGF 1 binding to IGF binding protein 1 ( IGFBP 1 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Developmental changes in serum levels of free and total insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 and 3 , and the acid labile subunit in rats . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin , insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 , growth hormone , and feeding in the newborn . ^^^ The relationship between GH , insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) , and insulin may be critical to the understanding of variation in early growth , especially in the small for gestational age ( SGA ) baby . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Using the in vitro nuclear run on transcription technique , we observed that fasting did not change IGF 1 gene transcription activity [ 76 + / 32 densitometric units ( DU ) for fasted vs . 58 + / 23 DU for control fed rats ; P = 0 . 1 ] , whereas IGF binding protein 1 ( IGFBP 1 ) gene transcription , a positive control , was increased more than 2 fold ( 729 + / 157 DU for fasted vs . 261 + / 56 DU for control fed rats ; P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Gene expression of IGF 1 , IGF 1 receptor ( IGF 1 R ) and IGF binding protein 1 ( IGFBP 1 ) was examined in renal tissue from normal DM animals and DM animals treated with Oc 10 , 20 and 100 microg / day . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To address this question , we performed a cross sectional study measuring serum levels of IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 3 , IGFBP 4 and IGFBP 5 by specific immunoassays in 52 adults with Type 1 ( n=27 ) and Type 2 ( n=25 ) diabetes mellitus and 100 age and sex matched healthy blood donors . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We studied the influence of 24 hour hypoxia ( 10 % oxygen ) , 48 hour hyperoxia ( 75 % oxygen ) , and relative hypoxia ( shifting from 48 hours in 75 % oxygen to 24 hours in room air ) on the gene expression of IGF 1 , IGF 1 receptor ( IGF IR ) , and IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 in retina using a solution hybridization RNase protection assay . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We evaluated the GH bioactivity ( GH BIO ) , GH serum level by immunofluorimetric assay ( GH IFMA ) , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 in 21 prepubertal obese children ( 13 boys and eight girls ) aged 5 . 7 to 9 . 4 years affected by simple obesity and in 32 ( 22 boys and 10 girls ) age and sex matched normal weight controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Other results were : IGF 1 , 3 11 ng / mL ( normal , 114 492 ) ; IGF 2 , 185 299 ng / mL ( normal , 358 854 ) ; IGF binding protein 1 ( IGFBP 1 ) , 12 200 ng / mL ( normal , 13 73 ) ; IGFBP 2 , 60 384 ng / mL ( normal , 55 480 ) ; and IGFBP 3 , 400 600 ng / mL ( normal , 2000 4000 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma insulin like growth factor 1 ( IGF 1 ) levels were higher in girls treated with CBZ and OXC than in the control girls , but AEDs did not affect fasting serum insulin , IGF binding protein 1 , or IGF binding protein 3 concentrations in girls on VPA , CBZ , or OXC medication during the period of exposure ( average 2 . 8 , 4 . 1 , and 1 . 9 years , respectively ) in this study . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) system , and cytokines , are involved in the fetal growth . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) ameliorates and IGF binding protein 1 ( IGFBP 1 ) exacerbates the effects of undernutrition on brain growth during early postnatal life : studies in IGF 1 and IGFBP 1 transgenic mice . ^^^ In transgenic ( Tg ) mice , IGF 1 overexpression stimulates postnatal brain growth , whereas decreased IGF 1 availability caused by ectopic brain expression of IGF binding protein 1 [ ( IGFBP 1 ) , an inhibitor of IGF 1 action ] retards postnatal brain growth . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Changes in other glucoregulators , such as insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) may also be related to alcohol abuse . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Leptin , insulin , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 were measured by specific immunoassays . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Free IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , and insulin were analyzed in 1 h samples , total IGF 1 in 2 h samples , and GH in 20 min samples . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The roles of insulin sensitivity , insulin like growth factor 1 ( IGF 1 ) , and IGF binding protein 1 and 3 in the hyperandrogenism of African American and Caribbean Hispanic girls with premature adrenarche . ^^^ Fasting levels of IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 3 , sex hormone binding globulin , and free testosterone ( T ) were also obtained . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum samples were analysed for ultrafiltered free IGF 1 ( fIGF 1 ) , total IGF 1 ( tIGF 1 ) , tIGF 2 and IGF binding protein 1 ( IGFBP 1 ) and 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Almost 90 per cent of haemangiopericytomas expressed IGF 1 receptor ( IGF IR ) mRNA ( 17 out of 19 ) , five ( 26 . 3 per cent ) expressed IGF binding protein 1 ( IGF BP 1 ) , three ( 15 . 8 per cent ) expressed IGF BP 2 , and four ( 21 per cent ) exhibited IGF BP 3 mRNA . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 , IGF 2 , IGF binding protein 1 , and C peptide in second trimester amniotic fluid are dependent on gestational age but do not predict weight at birth . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum steroids and gonadotropins were determined at 0 and 24 h and at 0 , 3 and 24 h after GnRH agonist challenge respectively , whereas IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 3 and sex hormone binding globulin were measured at baseline . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
With the use of a rat model , this study examined the interaction between AA input ( 1 . 27 and 0 . 62 g N . kg body wt ( 1 ) . 24 h ( 1 ) , AA and 1 / 2AA groups , respectively ) and recombinant human IGF 1 ( rhIGF 1 , 2 . 5 mg . kg body wt ( 1 ) . 24 h ( 1 ) ) infusion on the composition of the carcass and organs and on plasma insulin , IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , and acid labile subunit ( ALS ) concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Leptin , glucose , insulin , free IGF 1 , total IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , and IGFBP 3 levels were measured in the basal state after an overnight fast , and the acute insulin response to glucose ( AIRG ) was determined after intravenous glucose injection . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Differential effects of insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 on protein metabolism in human skeletal muscle cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Circulating levels of IGF 1 were reduced to a small but significant degree ( 6 . 4 + / 3 . 2 % , p < 0 . 05 ) , although IGF binding protein 1 ( known to inhibit IGF 1 ) was substantially increased ( 156 + / 40 % , p < 0 . 001 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We therefore measured IGF 1 , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , IGFBP 3 , and acid labile subunit ( ALS ) in 27 GHD subjects ( aged 5 82 yr ) from an extended kindred in Northeast Brazil with an identical GHRH receptor mutation and in 55 indigenous controls ( aged 5 80 yr ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In contrast there is a significant nocturnal decrease in free IGF 1 in healthy subjects , corresponding to the nocturnal increase in IGF binding protein 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Screening included serum assays for fasting insulin and glucose , insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 3 , free IGF 1 , inhibin B , leptin , and vascular endothelial growth factor . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Lack of T ( 24 ) phosphorylation is associated with the failure of IGF 1 to induce nuclear export of FKHR , and to inhibit expression of a reporter gene under the transcriptional control of the IGF binding protein 1 insulin response element . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor ( IGF ) 1 and IGF binding protein 1 concentrations in serum of normal subjects after alcohol ingestion : evidence for decreased IGF 1 bioavailability . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have extended the analysis of specimens to include measurements of GHBP , PGH , IGF 1 , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 and have related these to maternal characteristics , fetal growth , and glycemia . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We measured basal levels of serum insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 and IGFBP 3 together with 24 h urinary GH excretion . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Vitreous levels of IGF 1 , IGF binding protein 1 , and IGF binding protein 3 in proliferative diabetic retinopathy : a case control study . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
More importantly , they cause a decrease in circulating insulin like growth factor 1 ( IGF 1 ) activity , due to both a reduction in IGF 1 synthesis by the liver and an increase in IGF binding protein 1 level . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In order to investigate the cyclic changes of serum insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) and IGFBP 3 levels in menstrual cycles treated with or without antiestrogens ( clomiphene citrate and tamoxifen ) , we treated 24 young women having irregular menstrual cycles with either clomiphene citrate ( 100 mg / day ) ( n = 12 ) or tamoxifen ( 60 mg / day ) ( n = 12 ) from the 5th to the 9th day of the menstrual cycle . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Size at birth and cord blood levels of insulin , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 3 , and the soluble IGF II / mannose 6 phosphate receptor in term human infants . ^^^ We measured cord blood levels of IGF 2 , soluble IGF2R , insulin , IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , and IGFBP 3 and examined their relationships to weight , length , head circumference , ponderal index , and placental weight at birth in 199 normal term singletons . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Dietary restriction of single essential amino acids reduces plasma insulin like growth factor 1 ( IGF 1 ) but does not affect plasma IGF binding protein 1 in rats . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Highly structured , peptide antagonists of the interaction between insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) have recently been discovered by phage display of nave peptide libraries [ Lowman , H . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Addition of IGF binding protein 1 ( IGFBP 1 ) to normal sera ( n = 6 ) dose dependently decreased ultrafiltered free IGF 1 only ( P < 0 . 0007 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To determine the role of IGF binding proteins in mediating the direct effects of recombinant human IGF 1 on insulin requirements in type 1 ( insulin dependent ) diabetes mellitus , overnight changes in IGF 1 , IGF 2 , and IGF binding protein 1 , 2 , and 3 , collected under euglycemic conditions , were compared in nine subjects after double blind , randomized , sc administration of recombinant human IGF 1 ( 40 microg / kg ) or placebo at 1800 h . ^^^ Yet despite reduced free insulin levels ( 8 . 5 + / 1 . 5 ; placebo , 12 . 2 + / 1 . 2 mU / liter ; P = 0 . 03 ) , IGF binding protein 1 levels were reduced after recombinant human IGF 1 administration ( 53 . 7 + / 6 . 8 ; placebo , 82 . 2 + / 11 . 8 ng / ml ; P = 0 . 008 ) . ^^^ Taken together , these data are consistent with the hypothesis that transcapillary movement of IGF 1 ( perhaps mediated by IGF binding protein 1 ) , out of the circulation facilitates altered insulin sensitivity . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
No differences were noted in GH pulse frequency , GH pulse amplitude , IGF 1 , IGF binding protein 1 , and IGF binding protein 3 before and after treatment . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Therapeutic serum levels of octreotide along with a reduction of insulin like growth factor 1 ( IGF 1 ) ( P < . 01 ) and an increase of IGF binding protein 1 ( P < . 05 ) were demonstrated . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aim of this study was to compare concentrations of IGF 1 , IGF binding protein 1 ( IGF BP 1 ) , and IGF BP 3 in patients with breast cancer ( n = 14 ) with those seen in control subjects ( n = 23 ) and to assess the effect of tamoxifen on IGF status in these patients . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We examined fitness and the response to brief exercise of interleukin 6 ( IL 6 ) , tumor necrosis factor alpha ( TNF alpha ) , insulinlike growth factor 1 ( IGF 1 ) , and IGF binding protein 1 ( IGFBP 1 ) in 14 subjects with CF ( 10 . 5 + / 0 . 8 yr of age ) , 9 of whom were treated with ibuprofen , and 14 healthy control subjects ( 11 . 6 + / 0 . 5 yr of age , NS ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Development and clinical evaluation of a novel immunoassay for the binary complex of IGF 1 and IGF binding protein 1 in human serum . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We determined the association between fetal nutrition and the insulin IGF axis by measuring the plasma concentrations of amino acids , insulin , IGF 1 and IGF binding protein 1 ( IGFBP 1 ) in maternal and cord blood from gestational age matched dichorionic ( DC ) twins with ( n = 10 ) and without discordant birth weights ( n = 10 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Hyperinsulinemia , elevated total IGF 1 , and decreased IGF binding protein 1 ( IGFBP 1 ) have also been reported in PA . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
AIMS / HYPOTHESIS : The aim of this study was to investigate the role of insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) and IGFBP 3 gene variants on the metabolic changes observed in response to a 100 day overfeeding protocol conducted with 12 pairs of monozygotic twins . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We examined whether the concentrations of estrone , E 2 , IGF 1 , IGF 2 , and IGF binding protein 1 ( IGFBP 1 ) , 2 , and 3 in umbilical cord blood plasma differed in female neonates of three racial / ethnic groups with contrasting breast cancer risk . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
METHODS : Effects of fasting on the expression of insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) genes were analyzed by Northern blotting technique in rats . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : Serum concentrations of leptin , insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) , insulin , cortisol , testosterone , ethanol and plasma glucose were determined . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
A longitudinal analysis of maternal serum insulin like growth factor 1 ( IGF 1 ) and total and nonphosphorylated IGF binding protein 1 in human pregnancies complicated by intrauterine growth restriction . ^^^ In cord blood and late gestation maternal serum , IGF 1 is positively correlated with birth weight , whereas IGF binding protein 1 ( IGFBP 1 ) is inversely correlated with birth weight . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , and IGFBP 3 were measured at rest . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Placental GH , IGF 1 , IGF binding protein 1 , and leptin during a glucose challenge test in pregnant women : relation with maternal body weight , glucose tolerance , and birth weight . ^^^ We measured body weight ( BW ) and plasma levels of placental GH ( PGH ) , IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , and leptin at the time of the glucose challenge test ( GCT ) in 289 women , who were pregnant with a single fetus , between 24 and 29 wk gestational age ( GA ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
From these results , we conclude that the reduced plasma IGF 1 in IGF binding protein 1 transgenic mice may result from insufficient GH production by the depressed number of somatotrophs , possibly associated with functional alteration of hypothalamic control . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 3 , cholesterol , triglycerides , HDL cholesterol , LDL cholesterol , apolipoprotein B ( apoB ) , lipoprotein ( a ) ( Lp ( a ) ) , glucose , HbA ( 1c ) , and C peptide were measured in fasting samples . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Remarkable increases were found in proinflammatory cytokines IL 6 ( 795 + / 156 % ) , TNF alpha ( 30 + / 12 % ) , and IL 1beta ( 286 + / 129 % ) and in IGF binding protein 1 ( 835 + / 234 % ) , which itself is stimulated by inflammatory cytokines and is known to inhibit IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : On univariate analysis significant increases and not decreases in IGF 1 , IGF binding protein 1 and 3 were observed after prostatectomy . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Fasting levels of glucose , insulin , proinsulin ( P ( 0 ) ) , hemoglobin A1c , testosterone , SHBG , delta 4 androstenedione , dehydroepiandrosterone sulfate , LH , FSH , IGF 1 , IGF binding protein 1 , IGF binding protein 3 , free IGF 1 , and lipids were measured . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Kidney IGF 1 and IGF binding protein 1 ( IGFBP 1 ) mRNA expression increased after 10 and 30 days of diabetes . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The objective of this present paper was to analyse the dosages of insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 and 3 ( IGFBP 1 and IGFBP 3 ) in the follicular fluid environment of infertile patients with endometriosis . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In a subgroup of diabetic patients ( n =21 ) and non diabetic patients ( n =13 ) , vitreous and serum total IGF 1 , IGF binding protein 1 ( IGFBP 1 ) and IGFBP 3 were also determined . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In later life , IGF 1 and IGF binding protein 1 ( IGFBP 1 ) have been implicated in the pathogenesis of arteriosclerosis . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Fasting IGF 1 , IGF 2 and IGF binding protein 1 ( IGFBP 1 ) concentrations were determined and their relationship to specific dietary constituents was analysed . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Embolisation decreased fetal plasma IGF 1 concentrations ( 48 % , P < 0 . 001 ) and increased IGF binding protein 1 ( IGFBP 1 ) concentrations ( 737 % , P < 0 . 002 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 modulate prostate cancer cell growth and apoptosis : possible mediators for the effects of diet and exercise on cancer cell survival . ^^^ DE also decreased serum IGF 1 and increased serum IGF binding protein 1 ( IGFBP 1 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In contrast , Psammomys with hypoinsulinaemic hyperglycaemia induced either by streptozotocin injection or by pancreas exhaustion brought on by a long term caloric excess diet , had significant increases in kidney / body weight ratio which were associated with elevated renal IGF 1 and mRNA and protein levels of kidney IGF binding protein 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The role of mitogen activated protein kinase in insulin and insulin like growth factor 1 ( IGF 1 ) signaling cascades for progesterone and IGF binding protein 1 production in human granulosa cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Further , the impact on collagen , IGF 1 and IGF binding protein 1 ( IGFBP 1 ) formation was studied . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
This study examined whether the acute elevation of IGF binding protein 1 ( IGFBP 1 ) decreases the plasma free IGF 1 concentration and alters in vivo rates of muscle protein synthesis and glucose uptake . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 ( free and total ) , insulin , and IGF binding protein 1 were measured before , during , and 1 wk after the training . ^^^ Finally , within 7 days of the cessation of the diet and training regimen , IGF 1 and IGF binding protein 1 in the UF group returned to preintervention levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Low insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) concentrations are closely associated with insulin resistance . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESEARCH DESIGN AND METHODS : Blood samples collected annually from subjects recruited at diagnosis of type 1 diabetes and followed prospectively through puberty ( median follow up 9 . 3 years , range 4 . 7 12 . 8 ) were analyzed for total and free IGF 1 , IGF binding protein 1 , testosterone , sex hormone binding globulin , and HbA ( 1c ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Fasting levels of glucose , insulin , proinsulin , hemoglobin A1c , testosterone , SHBG , Delta 4 androstenedione ( Delta 4 A ) , dehydroepiandrosterone sulfate ( DHEAS ) , LH , FSH , IGF 1 , IGF binding protein 1 , free IGF 1 , and lipids were measured . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma IGF binding protein 1 and IGF binding protein 2 , but not IGF 1 , levels of prenatally T treated females were elevated in the first month of life , a period when the prenatally T treated females were not exhibiting catch up growth . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 and 3 ( IGFPB 1 , IGFPB 3 ) are expressed in normal and neoplastic endometrium . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
At baseline the activity of the GH insulin like growth factor 1 ( IGF 1 ) system was impaired with low GH values , low total IGF 1 and in relation to the obesity low levels of free IGF 1 and non suppressed IGF binding protein 1 ( IGFBP 1 ) . 2 / 3 were hypogonadal . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The prospective association of serum insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 levels with all cause and cardiovascular disease mortality in older adults : the Rancho Bernardo Study . ^^^ The prospective association of serum IGF 1 and IGF binding protein 1 ( IGFBP 1 ) with all cause , ischemic heart disease ( IHD ) , and non IHD CVD mortality was examined in 633 men and 552 nonestrogen using postmenopausal women , aged 51 98 yr ( mean , 74 yr ) in 1988 1992 , who were followed through July 2001 ( 96 % follow up ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum profiles of glucose , insulin , GH and IGF binding protein 1 ( IGFBP 1 ) were analysed in addition to IGF 1 and HbA1c . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF binding protein 1 ( IGFBP 1 ) is believed to modify this feedback through its effects on free IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum insulin like growth factor 1 ( IGF 1 ) , acid labile subunit ( ALS ) and IGF binding protein 1 ( IGFBP 1 ) levels were determined by specific radioimmunoassay methods . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
BACKGROUND / AIMS : To investigate changes in free insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) complexed IGF 1 during human pregnancy . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In PWS patients , no correlation was found between adiponectin and anthropometrical parameters or measures of insulin sensitivity ( e . g . fasting insulin and insulin sensitivity as estimated by the homeostasis model assessment ) , or between adiponectin and IGF binding protein 1 or IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Growth hormone ( GH ) , insulin like growth factor 1 ( IGF 1 ) , and IGF binding protein 1 ( IGFBP 1 ) were measured in 19 patients ( 10 female ; mean age = 31 . 1 years [ SD = 5 . 8 ] ; 9 black British / African , 10 white British ) before and after a mean of 2 . 5 ( SD = 0 . 9 ) months of clozapine treatment . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
No differences in 24 h mean GH , cortisol , IGF binding protein 1 , and IGF 1 were observed between the groups . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The results also revealed that arginine deficiency produced an opposite effect in the expression of IGF 1 and IGF binding protein 1 in the liver and kidney . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Fasting glucose , insulin , IGF 1 , and glucagon were higher on Pred vs . placebo , whereas IGF 2 and IGF binding protein 1 and 2 were lower . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
It has been suggested that IGF 1 is trapped in the kidney by IGF binding protein 1 ( IGFBP 1 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Testosterone and estradiol regulate free insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) , and dimeric IGF I / IGFBP 1 concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Early developmental changes in IGF 1 , IGF 2 , IGF binding protein 1 , and IGF binding protein 3 concentration in the cerebrospinal fluid of children . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aim of this study was to examine the effects of prenatal asphyxia and cerebral hypothermia on changes in IGF 1 and 2 , IGF binding protein 1 ( IGFBP 1 ) , and insulin levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The circulating levels of IGF 1 , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , and IGFBP 3 did not differ between patients and controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
INTRODUCTION : Alcohol induces disturbances in insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Measures at baseline , 6 and 12 months included body weight , height , body fat , lean mass , body fat % , and waist circumference , as well as fasting glucose , insulin , insulin resistance , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 , IGFBP 2 , and IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Before and after intervention , levels of fasting insulin , GH , total IGF 1 , free IGF 1 , IGF binding protein 1 , IGF 2 , free fatty acids , testosterone , and SHBG were measured . ^^^ Levels of IGF binding protein 1 significantly increased , whereas no significant differences were measured in total IGF 1 and free IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
AIMS / HYPOTHESIS : To find out whether the levels of insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 1 ( IGFBP 1 ) , highly phosphorylated IGFBP 1 ( hpIGFBP 1 ) , and IGF binding protein 3 ( IGFBP 3 ) are related to the progression of diabetic retinopathy ( DR ) during pregnancy and postpartum . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
GH and LH secretion burst amplitude ( approximately 50 % ) and overnight pulsatile secretion ( approximately 50 % ) , IGF binding protein 1 ( +67 % ) , and free fatty acids ( +33 % ) increased , whereas leptin ( 47 % ) , total ( 27 % ) and free IGF 1 ( 32 % ) , total ( 24 % ) and free testosterone ( 30 % ) , and IGF binding protein 3 ( 6 % ) decreased . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
A number of biochemical endpoints were assessed including urinary phytoestrogen metabolites , lipids , antioxidant status , DNA damage and insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) and 3 ( IGFBP 3 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : Insulin like growth factor 1 ( IGF 1 ) and IGF binding protein 1 ( IGFBP 1 ) may be important determinants of glucose homeostasis . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
One of these two SNPs was the nonsynonymous mutation in exon 4 , lying close to the integrin binding RGD motif , which is thought to affect tissue delivery of IGF 1 by IGF binding protein 1 ( IGFBP 1 ) , possibly suggesting a `` reno protective ' ' effect via altered IGFBP 1 binding . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Hence , our objective is to examine relationships between IGF 1 levels ; body mass index ( BMI ) ; fasting insulin level ; IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 levels ; and an array of traditional cardiovascular risk factors . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MAIN OUTCOME MEASURES : Pubertal growth , body composition by absorptiometry , uterine ovarian size by ultrasound , fasting insulin , glucose , lipids , leptin , IGF 1 , and IGF binding protein 1 were assessed . ^^^ Metformin was also associated with lower insulin resistance and leptin and IGF 1 levels and higher SHBG and IGF binding protein 1 levels and with a more favorable lipid profile . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MAIN OUTCOME MEASURES : Pubertal staging , age at menarche , body composition by absorptiometry , fasting insulin , glucose , lipids , leptin , IGF 1 , IGF binding protein 1 , testosterone , dehydroepiandrosterone sulfate , and SHBG were the main outcome measures . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Changes in bioactive IGF 1 and IGF binding protein 1 during an oral glucose tolerance test in patients with liver cirrhosis . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In situ hybridization was used to map patterns of gene expression for components of the insulin like growth factor ( IGF ) system , including IGF 1 and 2 , IGF binding proteins 1 5 ( IGFBP 1 5 ) , the IGF 1 receptor , and GH in the rat pituitary . ^^^ Neither IGF 1 nor IGFBP 1 5 were detected in the IL . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum levels of insulin like growth factors ( IGF 1 and IGF 2 ) , insulin , insulin like growth factor binding protein 1 ( IGFBP 1 ) , growth hormone ( GH ) and growth hormone binding protein ( GH BP ) activity were assessed in a group of healthy newborns and reevaluated at one and three months of life in six of them . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Intravenous ( N = 10 ) or subcutaneous ( N = 9 ) administration of IGF 1 ( 75 micrograms . kg 1 and 150 micrograms . kg 1 , respectively ) in LTD children resulted in a rapid 50 60 % fall in serum insulin ( p < 0 . 02 ) , a decline in blood glucose and a concomitant 40 60 % rise of IGFBP 1 levels ( p < 0 . 05 ) . ^^^ Treatment for seven days with IGF 1 ( 150 micrograms . kg 1 10 d 1 ) resulted in a decrease by 34 % and 44 % of serum IGFBP 1 level in two out of three children with LTD . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We tested whether IGFBP 1 , a modulator of IGF 1 action , would play a role in the pathogenesis of growth failure and metabolic picture of Turner syndrome . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 1 , a nonglycosylated peptide , competes with the IGF 1 receptor for ligand binding and also regulates IGF action . ^^^ As IGFBP 1 regulates the action of IGF 1 , octreotide stimulation of IGFBPs may represent an additional pharmacological mechanism for attenuating the GH IGF 1 axis . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum IGF 1 , IGF 2 , IGF binding proteins ( IGFBP 1 , IGFBP 3 ) , GH and insulin were measured by radioimmunoassay . ^^^ Mean levels of IGFBP 1 and IGFBP 3 , IGF 2 and GH were unaffected by IGF 1 administration . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Both IGFBP 1 and IGFBP 3 produced a dose related inhibition of IGF 1 stimulated oestradiol accumulation in granulosa cell conditioned medium with complete reversal of the effects of IGF 1 in the presence of a molar excess of binding protein . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Binding of [ 125I ] IGF 1 to IGFBP 3 , IGFBP 2 , and IGFBP 1 , measured by ligand blotting , was not statistically different in the 2 groups , but binding intensities for the serum 24 / 25 kDa IGFBP were approximately 2 . 5 times greater in fracture women than control women ( P less than 0 . 0005 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum concentrations of IGFBP 1 , but not those of IGFBP 2 , were increased ( approximately 4 fold ) in the DXM treated fetuses , as quantified by [ 125I ] IGF 1 ligand blotting and IGFBP 2 immunoblotting . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and IGFBP 1 mRNAs are not expressed in either NMU tumors or in normal breast . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In the IGF 1 treated group , IGFBP 1 showed a transient increase ( P less than 0 . 05 ) at day 3 but was similar in both groups at day 55 of treatment . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) were measured in amniotic fluid , extraembryonic coelomic fluid and maternal serum from 23 women with apparently normal first trimester pregnancies prior to termination . ^^^ The levels of IGF 1 and IGFBP 1 were significantly higher in coelomic fluid than amniotic fluid ( IGF 1 , P = 0 . 006 ; IGFBP 1 , P = 0 . 0008 ( paired t test ) ) . ^^^ There was a significant relation between levels of IGF 1 and IGFBP 1 in amniotic fluid ( r = 0 . 43 ; P = 0 . 04 ) and in coelomic fluid ( r = 0 . 81 ; P less than 0 . 001 ) but not in maternal serum . ^^^ The finding that both the absolute levels of IGFBP 1 and the ratio to IGF 1 were low in amniotic fluid implies that there is a very high level of unbound , biologically active IGF 1 in this compartment in the first trimester . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In contrast to plasma IGFBP 1 , IGF 1 concentrations did not vary during hyper and hypoinsulinemic infusion periods and were not significantly different between groups . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Perfused IGFBP 1 , 2 , 3 , and IGF 1 also crossed the capillary boundary but in contrast to IGFBP 4 , preferentially localized in cardiac muscle with a connective tissue / muscle ratio of approximately 1 : 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 2 has a higher affinity for IGF 2 than for IGF 1 and its affinity for both forms of IGF is greater than for human IGFBP 1 . ^^^ Like IGFBP 1 the protein can enhance the DNA synthesis response of porcine aortic smooth muscle cells to IGF 1 ; however , IGFBP 2 was much less potent . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The affinity of each of the IGFs for individual BPs and the regions of the IGF 1 molecule that are required for this high affinity binding have been defined only for IGFBP 1 and IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
That EGF stimulates secretion is supported by the finding that IGF 1 and IGFBP 1 mRNA levels are increased after EGF supplementation . ^^^ This non growth hormone dependent regulation of IGF 1 and IGFBP 1 production by adult rat hepatocytes in culture indicates an important autocrine / paracrine role for IGF 1 , particularly during liver regeneration after extensive organ mass loss . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 treatment increased IGFBP 1 from 78 + / 46 ng / mL ( mean pretreatment ) to 137 + / 64 ng / mL ( P less than 0 . 001 ; mean for the last 4 days of IGF 1 ) . ^^^ The results show significant increases in IGFBP 1 and 2 during IGF 1 infusion . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
PURPOSE : We conducted this study to fully characterize the expression and hormonal regulation of IGF binding protein expression in human MCF 7 breast cancer cells and to test the ability of purified IGFBP 1 to inhibit IGF 1 action . ^^^ The effect of IGF 1 , IGFBP 1 , and 17 beta estradiol on serum free cell growth was also studied . ^^^ In contrast , exogenous addition of IGFBP 1 could block IGF 1 induced mitogenesis ; this effect was reversible by excess IGF 1 . ^^^ Furthermore , the exogenous addition of the IGFBP 1 blocked IGF 1 action and potentially could be used as a pharmacologic inhibitor of IGF action . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The binding proteins IGFBP 1 and IGFBP 3 did not cross react , but both IGF 1 and IGF 2 markedly inhibited IGFBP 6 tracer binding to antiserum . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma levels of insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) were measured in fasting blood samples obtained from 16 postmenopausal breast cancer patients before and during tamoxifen treatment for 1 to 6 months . ^^^ Tamoxifen suppressed total plasma IGF 1 by a mean of 28 . 5 % ( P less than 0 . 001 ) but elevated plasma IGFBP 1 by a mean value of 78 % ( P less than 0 . 001 ) . ^^^ These findings suggest that tamoxifen exerts its influence on plasma IGF 1 and IGFBP 1 by mechanisms other than those known to regulate the plasma levels of these peptides , primarily growth hormone and insulin , respectively . ^^^ A dual effect suppressing plasma IGF 1 and elevating plasma IGFBP 1 suggests that tamoxifen may have a significant influence on endocrine and possibly paracrine delivery of IGF 1 to breast cancer cells in vivo . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We studied the relationship of serum insulin like growth factor 1 ( IGF 1 ) , IGF 2 , the IGF binding proteins IGFBP 1 , IGFBP 2 , and IGFBP 3 , and GH binding protein ( GHBP ; which is postulated to be derived from the extracellular portion of the GH receptor ) in normal volunteers and patients with anorexia nervosa before and after a refeeding program . ^^^ Both serum IGF 1 and IGF 2 were positively correlated with serum IGFBP 3 and negatively correlated with serum IGFBP 1 and IGFBP 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Both insulin like growth factor 1 ( IGF 1 ) and follicle stimulating hormone ( FSH ) exerted a dual effect on granulosa cells : while estradiol ( E 2 ) production was increased by both stimulants , the addition of either of the two hormones led to a reduction in IGFBP 1 secretion by more than 50 % . ^^^ Inhibition of IGFBP 1 production in response to IGF 1 was dose dependent , with the highest effect observed at 5 nM IGF 1 . ^^^ A significant correlation was found between the increase in E 2 and inhibition of IGFBP 1 secretion in response to IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In umbilical cord serum , by contrast , most IGF 1 was present in the 40 kDa binding proteins ( consisting of IGFBP 1 and IGFBP 2 ) . ^^^ In the fetal circulation IGFBP 1 and IGFBP 2 appear to be the major binding proteins for IGF 1 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
As IGF binding proteins ( IGFBPs ) can modulate the biological effects of IGF 1 , plasma IGFBP 1 levels were also measured . ^^^ Treatment with Tamoxifen for 2 weeks resulted in a small , but significant , decrease in IGF 1 levels , but increase in the plasma concentration of IGFBP 1 . ^^^ In contrast , treatment with MPA increased levels of IGF 1 , but significantly reduced plasma IGFBP 1 concentrations . ^^^ Treatment with 4 OHA had no significant overall effect on plasma IGF 1 or IGFBP 1 levels , although changes were detected for some subjects . ^^^ It is concluded that although treatment with Tamoxifen or MPA produced significant changes in plasma IGF 1 concentrations , any physiological effects of such changes are likely to be modulated by the corresponding alterations in plasma IGFBP 1 concentrations . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Elevated levels of maternal IGF 1 and IGF binding proteins IGFBP 1 are regulated by placental hormones rather than pituitary control during pregnancy . ^^^ Maternal IGF 1 promotes fetal growth by stimulating nutrient transfer to fetus through placenta and IGFBP 1 suppresses fetal growth by inhibiting IGF 1 binding to receptors in placenta . ^^^ Since IGF 1 and IGFBP 1 are produced in placenta and decidua , respectively , fetal growth is regulated by these substances in the locally formed paracrine system . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Dex enhanced the secretion of IGFBP 1 as measured by ligand blot analysis but did not show any prominent effect on immunoreactive IGF 1 secretion . ^^^ The content of IGFBP 1 mRNA in the cells increased greatly in the presence of Dex but the IGF 1 mRNA content did not change significantly under the same conditions . ^^^ These results show that the gene expression of IGF 1 and IGFBP 1 is differently regulated by glucocorticoids and insulin in primary cultures of rat hepatocytes . ^^^ The results most possibly explain the in vivo effects of glucocorticoids and insulin in regulation of IGF 1 and IGFBP 1 production by liver . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
As the somatostatin analog octreotide suppresses pituitary GH secretion and circulating IGF 1 levels , we examined its effects on human hepatoma ( hep G 2 ) cells which selectively express IGFBP 1 . ^^^ As IGFBP 1 may regulate peripheral IGF 1 action , induction of IGFBP 1 represents a novel pituitary independent mechanism for octreotide action . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin also augments the bioactive concentrations of IGF 1 and androgens through regulation of the synthesis of their respective binding proteins insulin like growth factor 1 binding protein ( IGFBP 1 ) and sex hormone binding globulin ( SHBG ) in the liver . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MAIN OUTCOME MEASURES : Serum concentrations of IGFBP 1 , insulin like growth factor 1 ( IGF 1 ) , insulin and sex hormone binding globulin were measured before and 2 hours after glucose administration . ^^^ On both occasions glucose induced hyperinsulinemia caused a significant decrease in the circulating IGFBP 1 levels , whereas the IGF 1 levels remained unchanged . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Evidence of clinical correlation exists regarding GH status , IGF 1 levels , and the IGFBPs particularly IGFBP 1 and IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum concentrations of insulin like growth factors 1 and 2 ( IGF 1 and IGF 2 ) , the low molecular weight form of IGF binding protein ( IGFBP 1 ) , insulin , C peptide and GH were determined in six healthy subjects and four patients with GH deficiency during 30 min of moderate physical exercise on the cycle ergometer . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The stimulation of IGFBP 1 release by ( Bu ) 2cAMP was completely inhibited by simultaneous exposure to insulin ( 100 ng / ml ) and / or IGF 1 ( 100 ng / ml ) ( day 5 control = 35 ng / ml , ( Bu ) 2cAMP alone = 248 ng / ml , insulin + ( Bu ) 2cAMP = 36 ng / ml , or IGF 1 + ( Bu ) 2cAMP = 10 . 1 ng / ml ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
If IGFBP 1 functions to decrease the bioavailability of IGF 1 in vivo the enhanced expression of IGFBP 1 may be an additional mechanism whereby glucocorticoid excess results in growth retardation . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Ligand blotting with [ 125I ] IGF 1 revealed that serum levels of IGFBP 1 ( 32 K ) were greater in SGA than shams , while immunoblotting with specific antiserum demonstrated that levels of IGFBP 2 ( 34 K ) , the major fetal rat IGF BP , were similar in serum from SGA and shams litters . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have examined the possible relationship between fasting insulin , SHBG , testosterone , IGF 1 , IGFBP 1 and fat distribution in 25 extremely obese , menstruating women ( mean weight 107 + / 3 kg ) with normal glucose tolerance . ^^^ The obese women showed an elevated fasting insulin ( mean + / SEM ; 21 + / 2 mumol / l ) , a normal IGF 1 , but reduced IGFBP 1 ( 14 . 6 + / 2 micrograms / l ) ; in 15 women IGFBP 1 levels were undetectable by the present assay . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin measurements were compared with basal gonadotrophins , androgens , insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) . ^^^ In addition , serum insulin concentrations in lean women with PCOS correlated positively with serum IGF 1 and negatively with serum IGFBP 1 concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
An increase in circulating IGFBP 1 in sera from fasted rats was demonstrated by immunoblotting , and an increased abundance of a 30 kDa IGFBP in sera from fasted rats was apparent when [ 125I ] IGF 1 was used in ligand blotting experiments . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In this way , IGFBP 1 and IGF 1 could act in a paracrine and / or autocrine fashion in maintaining normal liver architecture during regeneration . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The objective of this study was to investigate the effect of oral contraceptives ( OCs ) , administered for 3 months , on serum gonadotropin , androgen , IGF 1 , and IGFBP 1 concentrations , and glucose tolerance in 7 women with polycystic ovarian disease ( PCOD ) and in 5 healthy subjects . ^^^ The combination of decreased total IGF 1 concentration and increased IGFBP 1 concentration induced by OCs may decrease ovarian androgen production in PCOD . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The two cell lines which secreted immunoreactive IGFBP 1 also had IGF 1 receptors , whereas the cell lines RL 952 and AN3CA , not producing IGFBP 1 , had no saturable IGF membrane binding sites . ^^^ IGF 1 receptor binding to HEC 1B and KLE cells was inhibited in the presence of purified IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The addition of increasing concentrations of unlabeled IGF 1 in the presence of each IGFBP showed that either IGFBP 1 or IGFBP 3 , but not IGFBP 2 , resulted in a paradoxical increase in [ 125I ] IGF 1 binding to the cell surface . ^^^ In a physiological salt solution , the order of affinity of the IGFBPs for IGF 1 was IGFBP 3 greater than IGFBP 1 greater than IGFBP 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Among 13 octreotide responders , mean pre treatment basal GH , IGF 1 , and IGFBP 1 levels were 19 + / 5 micrograms / L , 1021 + / 168 micrograms / L , and 36 + / 8 micrograms / L respectively . ^^^ IGFBP 1 may be another useful marker in evaluating the response of acromegaly to octreotide treatment in patients who experience clinical benefit but equivocal GH and IGF 1 attenuation . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In this report we have examined the effects of streptozotocin induced ( STZ ) diabetes on expression of insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) in various tissues . ^^^ In contrast to the decrease in IGF 1 mRNA , IGFBP 1 mRNA was significantly increased in the liver and kidney of diabetic rats . ^^^ In diabetic rats , a highly significant correlation ( R = 0 . 75 , p less than 0 . 001 ) between hepatic IGFBP 1 mRNA and glucose was observed whereas there was no significant correlation between serum glucose and hepatic IGF 1 mRNA abundance ( R = 0 . 24 , p = NS ) . ^^^ Treatment of diabetic rats with insulin resulted in a small , non significant increase in hepatic and renal IGF 1 mRNA and a significant decrease in renal IGFBP 1 mRNA abundance . ^^^ The observations reported here are consistent with the hypothesis that diminished IGF 1 expression and inhibition of available IGF 1 by increased levels of IGFBP 1 may explain the impaired growth seen in diabetic animals . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Des ( 1 3 ) IGF 1 failed to bind to the CSF BPs , but bound to IGFBP 1 , although with a 40 fold weaker affinity than IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
These studies were undertaken to determine which forms of IGFBP are secreted by endometrial carcinoma ( HEC 1B ) and breast carcinoma ( MDA 231 ) cells , to characterize variables that control IGFBP secretion , and to study the effect of IGFBP 1 and IGFBP 2 on IGF 1 stimulated cell proliferation . ^^^ IGF 1 stimulated the secretion of IGFBP 3 from both cell types and IGFBP 2 from HEC 1B cells but either decreased or caused no change in secretion of IGFBP 1 and a 24 , 000 Mr form . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Binding studies showed that the phosphorylated IGFBP 1 secreted by HepG 2 cells has a 6 fold higher affinity for IGF 1 than it does after dephosphorylation . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have determined the consequences of insulin like growth factor binding protein 1 ( IGFBP 1 ) administration alone and in combination with insulin like growth factor 1 ( IGF 1 ) . ^^^ Co infusion of equimolar concentrations of human IGFBP 1 abolished the IGF 1 induced fall ( P less than 0 . 001 ) . ^^^ The half life of human IGFBP 1 , measured using a primate specific RIA , was 12 . 5 + / 0 . 7 min and was not influenced by the co infusion of IGF 1 . ^^^ This study demonstrates that , in the rat , human IGFBP 1 blocks the hypoglycemic response to intravenous IGF 1 and increases blood glucose levels when administered alone . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 1 from diabetic adolescents has been shown to inhibit IGF 1 bioactivity . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
This study was undertaken to investigate the presence of IGF 1 and IGF 2 , as well as that of their binding proteins ( BP ) , IGFBP 1 and IGFBP 3 in human serum and follicular fluid ( FF ) . ^^^ The IGFBP 1 level was found to be significantly higher ( P less than 0 . 01 ) in FF than in serum , whereas IGF 1 and IGFBP 3 values remained markedly lower ( P less than 0 . 01 ) in FF . ^^^ It is concluded that IGFBP 1 is produced locally , whereas the serum may possibly be the major source of IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The present results demonstrate that these changes in the GH IGF 1 axis are associated with insulin resistance with respect to blood glucose and high levels of IGFBP 1 when patients are fasted . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In order to study the effects of insulin like growth factor ( IGF 1 ) and insulin like growth factor binding protein ( IGFBP 1 ) on human granulosa cell proliferation after in vitro fertilization , cells were obtained after oocyte retrieval and cultured in the presence or absence of graded amounts of recombinant IGF 1 , purified IGFBP 1 and [ 3H ] thymidine . ^^^ Half maximal stimulation of [ 3H ] thymidine incorporation was obtained with 10 ng / ml exogenous IGF 1 , which was chosen for suppression experiments with graded amounts of purified IGFBP 1 . ^^^ The same concentration of IGFBP 1 also markedly inhibited binding of [ 125I ] iodotyrosyl IGF 1 to the cells . ^^^ It is concluded that : ( 1 ) after a refractory period , granulosa cells from hyperstimulated follicles retained their mitogenic activity ; ( 2 ) IGF 1 is capable of stimulating DNA amplification in granulosa cells ; and ( 3 ) IGFBP 1 inhibits the IGF 1 stimulated proliferation in these cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In the fetus , IGF 1 and 2 are complexed with two specific binding proteins ( IGFBP 1 and 2 ) , which are thought to modulate the actions of the IGFs in target tissues . ^^^ We examined regulation of the genes for IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 2 in fetal rat liver in an experimental model for intrauterine growth retardation caused by maternal fasting on days 17 21 of gestation . ^^^ Changes in fetal insulin and glucose may be related to changes in expression of the IGF 1 and IGFBP 1 genes in the growth retarded fetuses . ^^^ The decreased expression of IGF 1 and 2 and increased expression of the IGFBP 1 gene may contribute to the fetal growth retardation observed in this model system . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In the same cells IGFBP 1 inhibited DNA synthesis stimulated by IGF 1 . ^^^ We demonstrated that the same protein IGFBP 1 is able to inhibit DNA synthesis stimulated by serum and by IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum levels of insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) have been determined by radioimmunoassay in the maternal circulation ( n = 91 ) and in the umbilical artery ( n = 56 ) and vein ( n = 90 ) of man . ^^^ These findings suggest that IGFBP 1 might inhibit the action of IGF 1 in both the maternal and the fetal compartments and that the rise in IGFBP 1 could be a primary factor in retardation of fetal growth . ^^^ Alternatively , circulating IGF 1 and IGFBP 1 levels may only be a secondary reflection of local tissue events involved in fetal growth . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In monolayer cultures of fetal skin fibroblasts both forms of IGFBP 1 inhibited binding of [ 125I ] IGF 1 onto the cells , but amplified the IGF 1 stimulated [ 3H ] thymidine incorporation into the same cells . ^^^ Recently we found that the same IGFBP 1 preparation inhibits IGF 1 stimulated [ 3H ] thymidine incorporation into human hyperstimulated granulosa cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
LPS also decreased the IGF 1 content in liver and skeletal muscle and increased plasma , liver , and muscle concentrations of IGFBP 1 . ^^^ Pretreatment with anti TNF Ab attenuated the LPS induced reduction in IGF 1 and the increased IGFBP 1 in plasma and liver and completely prevented the decrease in IGF 1 observed in muscle . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The addition of IGF 1 to the culture medium had no effect on the migration of cells expressing IGFBP 1 or vector alone . ^^^ The effect of IGFBP 1 on migration is independent of IGF 1 and is probably mediated through the alpha 5 beta 1 integrin . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The effects of IGF 1 and IGF 2 on IGFBP 1 secretion were biphasic , with initial stimulation ( 200 250 % ) that peaked at 1 and 10 ng / ml , respectively , followed by inhibition at higher concentrations ( half maximal inhibition at 3 ng / ml and 30 ng / ml , respectively ) . ^^^ The decrease in IGFBP 1 levels in decidualized stromal cultures was associated with the induction of mitogenesis by IGF 1 and IGF 2 , while IGF effects on prolactin secretion paralleled those of IGFBP 1 secretion , with stimulation ( 243 324 % ) in the low concentration range followed by inhibition at higher concentrations . ^^^ These data indicate that endometrial stromal cell IGFBP 1 is regulated by insulin , at concentrations that are compatible with insulin acting via its own receptor , while the effects of IGF 1 and IGF 2 on IGFBP 1 secretion , are suggestive of their acting probably through the type 1 IGF receptor . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In serum and other biological fluids , IGF 1 and IGF 2 are reversibly bound to six molecular species of specific binding proteins ( IGFBP 1 to 6 ) which regulate their transport to target cells as well as their biological activities . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The regulation of insulin like growth factor binding protein 1 ( IGFBP 1 ) by its ligands , IGF 1 and IGF 2 , was studied in continuous cultures of HepG 2 human hepatoma cells . ^^^ Both IGF 1 and IGF 2 in concentrations as low as 1 10 nmol / l caused significant suppression of IGFBP 1 protein levels . ^^^ This suppression was accompanied by decreased IGFBP 1 mRNA levels occurring within 2 4 h of exposure to IGF 1 or IGF 2 , and by a significant decrease in IGFBP 1 promoter activity . ^^^ IGF 1 and IGF 2 were equipotent in suppressing basal levels of IGFBP 1 protein , mRNA and promoter activity . ^^^ IGF 1 , IGF 2 , and IGF analogs with low IGFBP 1 affinity , ( des 1 3 ) IGF 1 and long R3IGF 1 , all potently suppressed the previously characterized increase in IGFBP 1 protein levels and promoter activity induced by cAMP and theophylline . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Cord sera were obtained from 44 term , human infants exhibiting various patterns of intrauterine growth and were assayed for IGF 1 , IGF 2 , and IGFBP 1 , 2 , and 3 by specific RIAs . ^^^ By contrast , IGF 1 correlated with the reciprocal of both IGFBP 1 and IGFBP 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Islets enriched in beta cells following a 5 day preincubation regime were maintained in various concentrations of glucose ( 1 . 4 16 . 7 mmol / l ) or amino acids ( x 1 x 3 total concentrations ) , with or without exogenous IGF 1 , 2 , IGFBP 1 or IGFBP 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factors 1 ( IGF 1 ) and 2 ( IGF 2 ) and their binding proteins ( IGFBP 1 , IGFBP 2 and IGFBP 3 ) were measured by radioimmunoassay in plasma and milk samples collected throughout the study . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
These results may indicate hitherto unnoticed interactions of somatostatin and insulin on IGFBP 1 release with possible impact on IGF 1 action at the cellular level . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Sex steroids , insulin like growth factor 1 ( IGF 1 ) and IGFBP 1 were measured by radioimmunoassay . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Critically ill , septic patients have high basal levels of GH , low levels of IGF 1 and its carrier binding protein IGFBP 3 , high levels of an inhibitory binding protein , IGFBP 1 , and increased serum protease activity which reduces the affinity of IGFBP 3 for IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Ligand blotting with IGF 1 demonstrated a 31 kDa protein in both membranes , identified by immunostaining as IGF binding protein 5 ( IGFBP 5 ) , not IGFBP 1 or IGFBP 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In this report , insulin like growth factor 1 ( IGF 1 ) and the combination of IGF 1 plus insulin like growth factor binding protein ( IGFBP 1 ) were applied directly to linear incisions made through dorsal rat skin , and histologic analysis of breaking strength and hydroxyproline quantification were performed . ^^^ However , the combination of IGF 1 plus IGFBP 1 significantly increased wound breaking strength . ^^^ This increase in wound breaking strength induced by the combination of IGF 1 and dephosphorylated IGFBP 1 was accompanied by an 67 % increase in wound hydroxyproline content , whereas the combination of IGF 1 and the phosphorylated form of IGFBP 1 had no effect . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We recently demonstrated that circulating insulin like growth factor binding protein 1 and 2 ( IGFBP 1 and 2 ) are induced in these deficiencies , and that removal of IGFBP 1 and 2 from serum of such animals by specific antibodies reverses inhibition of cellular IGF 1 dependent functions , including collagen and DNA synthesis . ^^^ The ability of fasted or scorbutic guinea pig sera to inhibit IGF 1 action in cells increased in parallel with IGFBP activity ( [ 125I ] IGF 1 binding ) , which , in turn , mainly reflected the concentration of IGFBP 1 in sera . ^^^ The overall results taken together with our recent findings from cell culture experiments are compatible with circulating IGFBP 1 and 2 acting as inhibitors of collagen gene expression by blocking IGF 1 action during fasting and phase 2 of vitamin C deficiency . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
For example , depending on experimental conditions , IGFBP 1 has been shown to both enhance and inhibit IGF 1 mediated mitogenesis . ^^^ We have previously shown that excess exogenous IGFBP 1 inhibited IGF 1 mediated growth of MCF 7 cells . ^^^ In this study , we examined whether or not endogenously expressed IGFBP 1 could interfere with IGF 1 mediated growth of MCF 7 cells . ^^^ Type 1 IGF receptor could not be phosphorylated by IGF 1 in cells expressing IGFBP 1 ; however , an IGF 1 analogue ( Arg 3 IGF 1 ) , which can not complex with IGFBPs , stimulated receptor phosphorylation . ^^^ IGF 1 did not stimulate cell growth in IGFBP 1 expressing cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have previously shown that IGF 1 administration increases IGFBP 1 and 2 and reduces IGFBP 3 in normal subjects . ^^^ IGFBP 1 was suppressed by 32 % after oral glucose alone , whereas an injection of IGF 1 plus oral glucose were associated with a more marked fall of 53 % ( despite suppression of C peptide ) . ^^^ These changes in IGFBP 1 , 2 , and 3 could alter the distribution of IGF 1 among the various IGFBPs in the circulation . ^^^ In a substrate sufficient state , e . g . after oral glucose , IGFBP 1 and 2 show opposite acute responses to IGF 1 , and IGF 1 has an apparent acute insulin like effect on IGFBP 1 concentrations that differs from its longer term effect . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The present study was designed to investigate whether , in addition to the mean levels , the overnight pattern of GH , IGF 1 , IGFBP 1 and SHBG differed in obese women with polycystic ovaries as compared to that observed in the non obese PCOD patients . ^^^ Twenty four samples were collected from each patient and examined in one batch for GH , IGF 1 , IGFBP 1 , SHBG and insulin . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and type 1 and type 2 IGF receptor mRNAs were equally expressed in both HFA and HAA . 12 O tetradecanoyl phorbol 13 acetate ( TPA ) , a protein kinase regulator , upregulated IGFBP 1 in HFA cultures as determined by RIA , but ACTH was without effect . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Following administration of an oral glucose load , serum IGFBP 1 concentrations were decreased within 2 h in men and in pregnant women while IGF 1 levels remained constant . ^^^ These results suggested that IGFBP 1 regulates IGF 1 activity in pregnancy in a similar manner to that in the non pregnant state . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin resistant NIDDM patients , with high basal glucose and insulin , normal IGFBP 1 , and low GH , had decreased prefasting serum IGF 1 concentrations , similar to the values in fasted body mass index and age matched OB subjects . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Treatment of these MDGCs with IGF 1 dramatically stimulated the production ( to a detectable level ) of a 30 kDa IGFBP that was identified by immunoblotting with antiserum to IGFBP 5 but not antisera to IGFBP 1 , 2 , 3 , 4 , or 6 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We studied basal and insulin stimulated serum levels of IGF 1 and 2 and IGFBP 1 , 2 , and 3 in six acromegalic patients before and 2 months after successful adenomectomy compared with a group of sex and age matched healthy , untreated subjects . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
More than 95 % of IGF 1 circulates bound to binding proteins ( IGFBPs ) ; of these IGFBP 1 is of particular interest as it is inversely regulated by insulin and is thought to inhibit the action of IGF 1 and IGF 2 . ^^^ Elevated IGFBP 1 levels have been associated with an inhibition of serum IGF 1 bioactivity in children with insulin dependent diabetes . ^^^ IGFBP 1 also appears to inhibit IGF 1 hexose stimulated uptake . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
After each treatment period ( 4 weeks ) , serum profiles of GH , IGF 1 , IGF binding proteins 1 and 3 ( IGFBP 1 and IGFBP 3 ) , glucose , insulin , non esterified fatty acids ( NEFA ) , glycerol , 3 hydroxybutyrate , alanine , lactate and glucagon were measured for 37 hours after GH injection ( 3 IU / m2 at 1900 hour ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Human sera were incubated with [ 125I ] IGF 1 for 2 h followed by non denaturing PAGE . [ 125I ] IGF I / IGFBP 1 complexes from serum co migrated with a pure p4IGFBP 1 standard . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Further , the quality of embryos , development of the endometrium , rate of clinical pregnancy , and serum and follicular fluid ( FF ) concentrations of insulin like growth factor 1 ( IGF 1 ) , insulin like growth factor binding protein 1 ( IGFBP 1 ) , and IGFBP 3 were estimated . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
There is a growing body of evidence that the insulin like growth factors ( IGF 1 and IGF 2 ) are dynamically involved in the regulation of glucose homeostasis , with one of their binding proteins , IGFBP 1 , playing a counterregulatory role . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Response of insulin like growth factor ( IGF ) binding protein 1 ( IGFBP 1 ) and IGFBP 3 to IGF 1 treatment in severe insulin resistance . ^^^ IGFBP 1 concentrations did not significantly change during the infusion but those of IGFBP 3 increased from 1655 + / 127 to 2197 + / 334 micrograms / l ( P = 0 . 002 ) , despite a significant fall in GH concentrations from 10 . 7 + / 2 . 6 to 4 . 1 + / 1 . 1 mU / l ( P = 0 . 007 ) , suggesting that IGFBP 3 regulation is also IGF 1 dependent . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Our results showed that IGF 1 , IGF 2 , IGFBP 2 and 3 mRNAs were expressed in uterine fibroids , and that IGFBP 1 mRNA or protein was not detected in fibroids . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma concentrations of IGF 1 , IGFBP 1 , and IGFBP 3 were compared between 40 postmenopausal breast cancer patients receiving long term tamoxifen therapy and 39 breast cancer patients receiving no hormonal treatment . ^^^ In an additional group of seven patients , serum levels of IGF 1 and IGFBP 1 were determined before and during treatment at 6 and 12 months . ^^^ There were no significant differences in the mean concentrations ( + / standard error of the mean ) of IGF 1 ( 10 . 0 + / 0 . 4 nmol / l and 11 . 2 + / 0 . 5 nmol / l , respectively ) and IGFBP 3 ( 3 . 2 + / 0 . 1 mg / l and 3 . 1 + / 0 . 1 mg / l , respectively ) , whereas the mean value of IGFBP 1 was significantly higher in the tamoxifen group ( 6 . 0 + / 0 . 6 micrograms / l versus 2 . 8 + / 0 . 3 micrograms / L , P = 0 . 0001 ) . ^^^ The tamoxifen induced increase in IGFBP 1 plasma levels may be an important mechanism modulating IGF 1 action at the tissue level . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
During food restriction , plasma IGF binding protein 3 ( IGFBP 3 ) and to a lesser extent IGFBP 1 were decreased , and IGFBP 2 was increased ; after switching to ad libitum feeding , plasma levels of IGFBP 2 normalized , but levels of IGFBP 1 and IGFBP 3 remained low in the face of normalized plasma IGF 1 levels . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In all subjects a single blood sample was drawn for IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 and GH measurements by specific RIAs . ^^^ As IGF 2 is normal and IGFBP 1 and IGFBP 2 are inversely correlated to the serum GH levels in the acromegalic patients , we speculate that the molar ratio between IGF 1 and IGFBP 3 reflects free ( biologically active ) IGF 1 and is dependent on GH levels . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 3 complex ; however , it did not inhibit formation of complexes between IGF 1 and IGFBP 1 , 2 , or 4 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The results of this study suggest that the transient accumulation of IGF 1 in the kidney of the postpubertal diabetic rat may not be due to an increase in the local synthesis of IGF 1 , but rather to an increase in IGF 1 uptake from the circulation due to non membrane associated IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The observations were consistent with IGFBP 1 representing a secretory product of the glandular epithelium and could either play a role in development of the trophoblastic component of the conceptus during the pre placental period of anti mesometrial implantation or in the endometrium acting as an inhibitor of local IGF 1 action and in either case by transporting IGF 1 from the stromal to the glandular luminal environment . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Thereafter , blood samples for determination of serum glucose , insulin , insulin like growth factor binding protein 1 ( IGFBP 1 ) , GH , and insulin like growth factor 1 ( IGF 1 ) concentrations were collected for 180 min . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 1 abolished IGF 1 stimulated estradiol production by luteinizing granulosa cells in a dose dependent manner with a 50 % inhibitory concentration ( IC 50 ) of 0 . 27 nM . ^^^ Similarly , IGFBP 1 inhibited 125I IGF 1 binding to granulosa cells . ^^^ Immunoreactive IGFBP 1 released into the medium was inhibited by both IGF 1 and follicle stimulating hormone dose dependently with an IC 50 of 0 . 14 and 0 . 13 nM , respectively , while human chorionic gonadotropin stimulated IGFBP 1 release with a 50 % effective dose ( ED 50 ) of 0 . 6 nM . ^^^ These results suggest that IGFBP 1 is involved in follicular development and granulosa cell differentiation in the human ovary and that gonadotropins may influence IGF 1 action by modifying IGFBP 1 levels within the ovary . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In contrast , IGFBP 1 inhibits both 125I IGF 1 binding to placental membrane and 3H glycine uptake of trophoblast cells by IGF 1 in a dose dependent manner . ^^^ Moreover , fetal growth and the transfer of 3H AIB to fetus are accelerated when IGFBP 1 is neutralized by polyclonal antibody , suggesting that maternal IGFBP 1 inhibits fetal growth by inhibiting IGF 1 action on the placenta . ^^^ IGF 1 and four IGFBPs including IGFBP 1 , 2 , 3 , and 4 are localized in cytotrophoblast of term placenta . ^^^ Similarly IGFBP 1 , 2 , and 4 are detected in medium conditioned by term decidua cells by Western ligand blot in which release of IGFBP 1 and 4 are diminished by IGF 1 and all three IGFBPs are increased by progesterone . ^^^ Fetal levels of IGF 1 and IGFBP 1 are positively and negatively correlate with fetal weight , respectively . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVES : Insulin is believed to be the prime regulator of insulin like growth factor binding protein 1 ( IGFBP 1 ) secretion , and in normal subjects acute insulin induced hypoglycaemia exerts a rapid effect on concentrations of IGFBP 1 , and may also influence insulin like growth factor 1 ( IGF 1 ) concentrations . ^^^ MEASUREMENTS : Serum levels of IGFBP 1 , insulin , glucose , and IGF 1 were measured at regular intervals during the insulin tolerance test . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Effect of insulin on the hepatic production of insulin like growth factor binding protein 1 ( IGFBP 1 ) , IGFBP 3 , and IGF 1 in insulin dependent diabetes . ^^^ The main source of circulating IGF 1 and IGFBP 1 is considered to be the liver , but that of circulating IGFBP 3 is not known . ^^^ IGF 1 and IGFBP 3 are GH dependent , whereas IGFBP 1 is insulin regulated . ^^^ The aim of the present study was to examine the effect of insulin on the hepatic secretion of IGFBP 1 , IGFBP 3 , and IGF 1 . ^^^ Basal splanchnic IGFBP 1 production was 18 + / 7 micrograms / min , whereas no basal net exchanges of IGF 1 or IGFBP 3 were observed across the splanchnic area . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Histological examination shows that IGF 1 stimulates efficient reepithelialisation of the wounds both alone and in the presence of recombinant IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In the endometrium , IGFBP 1 gene expression is stimulated by progesterone and inhibited by insulin , while IGFBP 1 inhibits the mitogenic action of IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
These observations provide support for significant opposite roles for the pancreatic hormones , insulin and glucagon , in the regulation of liver IGF 1 and IGFBP 1 production . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have therefore examined the effects of recombinant human IGF 1 ( rhIGF 1 ) administration on the levels of IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 and IGF bioactivity in a group of 9 late pubertal adolescents with IDDM . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The hepatic expressions of mRNA encoding IGF 1 and IGFBP 3 were reduced and IGFBP 1 mRNA was elevated in the SDR . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
CONCLUSIONS : Twice daily GH injections , apart from producing a more physiological serum GH profile , were superior to one injection in increasing serum IGF 1 and decreasing IGFBP 1 levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have investigated whether this inverse relation also exists in acromegaly , before and during treatment with octreotide , and whether changes in IGFBP 1 levels relate to GH and IGF 1 levels . ^^^ There was no significant correlation between IGFBP 1 levels and levels of GH and IGF 1 , either before or during treatment . ^^^ CONCLUSIONS : Octreotide treatment , in addition to reducing GH , IGF 1 and insulin levels , is associated with an increase in IGFBP 1 concentrations in patients with acromegaly , and it is suggested that the rise in serum IGFBP 1 is a consequence of the decrease in insulin secretion . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
A rhIGFBP 1 dose of 9 . 8 micrograms / injection ( an IGFBP 1 / IGF 1 molar ratio of 0 . 04 : 1 ) caused no significant effect on rhIGF 1 stimulated growth parameters , whereas a rhIGFBP 1 dose of 1200 micrograms / injection ( IGFBP 1 / IGF 1 molar ratio of 5 : 1 ) resulted in 78 % or greater inhibition of rhIGF 1 stimulated growth ( P < 0 . 05 ) . rhIGFBP 1 doses of 48 and 240 micrograms / injection ( IGFBP 1 / IGF 1 molar ratios of 0 . 2 : 1 and 1 : 1 , respectively ) had intermediate inhibitory effects . ^^^ The results suggest that in addition to its proposed role in glucose homeostasis , IGFBP 1 may play a role in inhibiting somatic growth and other physiological functions stimulated by IGF 1 and GH . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : To evaluate interrelationships between levels of insulin like growth factor 1 ( IGF 1 ) , insulin like growth factor binding protein ( IGFBP 1 ) , and ovarian steroids in late preovulatory follicular fluid ( FF ) after pituitary desensitization with GnRH agonist and controlled ovarian hyperstimulation . ^^^ MAIN OUTCOME MEASURES : Levels of IGF 1 , IGFBP 1 , E 2 , P 4 ( representative of follicular maturity ) , T , and A in FF and the volume of this fluid were determined . ^^^ CONCLUSION : Decreased levels of FF IGF 1 with unaltered levels of FF IGFBP 1 in larger follicles may favor a shift toward diminished action of IGF 1 at the time of immediate preovulation . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In conclusion , measurements of early metabolic changes in GHD adults during the first 15 days after the start of GH replacement indicate that IGF 1 values reach maximal levels only after 8 12 days , that the measurements of changes in IGFBP 1 and IGFBP 3 levels probably do not contribute to a determination of the optimal GH replacement dose , that maximal N retaining effects occur within 2 5 days , after which adaptation occurs , that massive sodium retention occurs during this period , which spontaneously levels off , and that cumulative sodium retention closely correlates during this period with changes in BIA . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Thus , we examined the effects of 8 weeks of endurance training on changes in IGF 1 , IGF 1 binding protein 1 ( IGFBP 1 ) , IGFBP 3 , and maximal aerobic power ( VO2max ) in 18 older individuals ( aged 66 . 1 + / 1 . 4 years , 10 men and eight women ) . ^^^ Although no mean group change in IGFBP 1 or IGFBP 3 was noted , the individual changes between IGF 1 and IGFBP 3 showed a tendency to be related in men ( r = . 48 , P = . 15 ) , but not in women ( . 21 , NS ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The present study investigates the effects of the insulin like growth factors ( IGF 1 , IGF 2 ) on decidualization in vitro , as indicated by a P dependent growth response and by the secretion of PRL and IGFBP 1 . ^^^ Stimulation of IGFBP 1 ( 200 250 % ) and PRL ( 243 324 % ) peaked at 1 ng / ml for IGF 1 , and 10 ng / ml for IGF 2 , followed by inhibition at higher peptide concentrations ( ED50s 3 and 30 ng / ml , respectively ) . ^^^ Maximal physiological doses ( 100 ng / ml ) of IGF 1 and IGF 2 virtually abolished IGFBP 1 secretion ( 1 % and 2 % of basal levels , respectively ) , but did not cause total suppression of PRL secretion ( 8 % and 22 % of basal levels ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Furthermore , alteration of IGFBP by antiestrogens such as a marked increase of IGFBP 1 production have been shown to inhibit the proliferative effect of IGF 1 on ER positive , but stimulate this effect , on ER negative cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma levels of glucose , insulin , the insulin like growth factor ( IGF 1 and 2 ) and IGFBP 1 were determined in four young healthy males performing cycle exercise to fatigue while being fed either placebo ( trial C ) or glucose polymer solution ( trial G ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
When IGF 1 binding protein ( IGFBP ) mRNA levels were studied under these conditions , we found that IGFBP 1 mRNA was not detected in spleen ; IGFBP 2 mRNA levels were reduced in Hx rats ( 67 . 9 + / 7 . 4 % of control values , P < 0 . 05 ) and bGH treatment prevented this reduction ( 95 . 5 + / 12 . 2 % , NS ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Conversely , purified rat IGFBPs 1 and 2 inhibited DNA and collagen synthesis in cells cultured in normal guinea pig serum or IGF 1 stimulated DNA synthesis , with IGFBP 1 being more potent . ^^^ Thus , IGFBP 1 and , to a lesser extent IGFBP 2 , cause inhibition of IGF 1 action by sera from fasted and scorbutic guinea pigs and may inhibit collagen gene expression in vivo . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Autoradiography and immunostaining of 2 D Western blots of culture media proteins demonstrated that implantation site and not non implantation site tissue synthesized and released immunoreactive IGFBP 1 into the culture medium . 125Insulin like growth factor 1 ( IGF 1 ) specifically bound to this protein on 1 D Western ligand blots . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The formation in serum of binary complexes between IGF 1 or 2 and either of six IGF binding proteins ( IGFBP 1 to 6 ) and , in particular , of long lived ternary complexes between IGF 1 or 2 , IGFBP 3 , and acid labile subunit is thought to regulate IGF 1 bioavailability by increasing its serum half life . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Using the ligand binding technique , 125I IGF 1 visualizes 5 different protein bands corresponding to those previously reported for IGFBP 1 to 4 with apparent sizes of 23 42 kd in serum samples prepared from severely burned patients and healthy individuals . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In contrast , IGF 1 , IGFBP 1 , and IGFBP 6 mRNAs were expressed at low levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We aimed to assess the direct effects of liver dysfunction on serum levels of IGF 1 and its major binding proteins by measuring fasting levels of growth hormone , IGF 1 , IGFBP 1 , IGFBP 3 , insulin , C peptide , and glucose in 35 patients with cirrhosis and during an oral glucose tolerance test in 16 of those patients . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aim of the present study was to characterize the effect of 44 h of hyperglycaemia on diurnal levels of insulin like growth factor binding protein 1 ( IGFBP 1 ) , insulin like growth factor 1 ( IGF 1 ) , growth hormone ( GH ) and glucagon in 7 well controlled subjects with insulin dependent diabetes mellitus ( IDDM ) . ^^^ Glucose levels per se do not influence either total IGF 1 or IGFBP 1 concentrations in well insulinised diabetic patients . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aim of this study was to examine relations between sex hormones , IGF 1 and insulin like growth factor binding protein 1 ( IGFBP 1 ) in post menopausal women with breast cancer . ^^^ DESIGN : To measure plasma sex steroids , sex hormone binding globulin ( SHBG ) , IGF 1 , IGFBP 1 , insulin and urinary oestrogen metabolites in post menopausal women with breast cancer not receiving any endocrine therapy . ^^^ RESULTS : SHBG correlated negatively with plasma androstenedione ( P < 0 . 001 ) , insulin ( P < 0 . 001 ) , IGF 1 , height and plasma oestrone sulphate ( P < 0 . 025 for all ) , but positively with plasma IGFBP 1 ( P < 0 . 025 ) . ^^^ IGFBP 1 correlated negatively with IGF 1 ( P < 0 . 001 ) and the testosterone / SHBG ratio ( P < 0 . 05 ) . ^^^ Neither IGF 1 nor IGFBP 1 correlated with any of the plasma or urinary sex hormones or with the oestrone / androstenedione and oestradiol / testosterone ratios . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MAIN OUTCOME MEASURES : Seminal plasma and serum levels of IGF 1 , IGFBP 1 , and IGFBP 3 were determined by commercially available assays , furthermore , samples were subjected to Western ligand blotting . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 2 expression did not vary with IGF 1 or dexamethasone treatment in these cells ; IGFBP 1 mRNA was not detectable , and IGFBP 6 mRNA was low and inconsistent . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The purposes of this study were to explore whether serum levels of insulin , insulin like growth factor 1 ( IGF 1 ) , insulin like growth factor binding protein 1 ( IGFBP 1 ) and IGFBP 3 in both maternal and fetal compartments were affected by the stress of labor , and to investigate the relationship between the fetal birthweight and serum levels of insulin , IGF 1 and IGFBPs . ^^^ Serum concentrations of insulin , IGF 1 , IGFBP 1 and IGFBP 3 were determined by radioimmunoassays ( insulin , IGFBP 1 and IGFBP 3 ) and immunoradiometric assay ( IGF 1 ) . ^^^ As for all measurements ( insulin , IGF 1 , IGFBP 1 and IGFBP 3 ) , serum levels in pregnant women ( from both NSD and CS ) were strikingly higher than those in the fetus . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In this review we present evidence to indicate that growth factor receptors for insulin like growth factor 1 ( IGF 1 ) and epidermal growth factor ( EGF ) , and secretory proteins , insulin like growth factor binding protein 1 ( IGFBP 1 ) and retinol binding protein ( RBP ) , which are present in the glandular epithelium during the menstrual cycle , undergo cell specific changes in gene expression at the implantation site during pregnancy . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 1 is antagonistic to the insulin like and growth promoting effects of IGF 1 , and IGFBP 3 holds IGFs in the circulation by associating with IGFs and an acid labile subunit to form a ternary complex . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In the present study , serum levels of IGF 1 and IGF 2 and IGFBP 1 , 2 , and 3 were measured in 58 patients ( age , 0 . 8 17 yr ) with treated ( 51 subjects ) or untreated ( 7 subjects ) insulin dependent diabetes mellitus ( IDDM ) and were compared with the levels in normal subjects . ^^^ Regression analysis revealed a negative correlation between hemoglobin ( Hb ) A1c and standard deviation scores ( SDS ) of IGF 1 and a positive association between HbA1c and IGFBP 1 SDS or IGFBP 2 SDS . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Before insulin therapy , serum IGF 1 , IGF 2 , IGF binding protein 3 ( IGFBP 3 ) , and GH binding protein ( GHBP ) levels were significantly decreased , whereas IGFBP 1 and cortisol were significantly increased in diabetic children compared to those in an age , sex , and stage of puberty matched control group . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To investigate the time course and the precise cellular distribution of changes in IGFBP expression , we used quantitative in situ hybridization to analyze renal IGF 1 and IGFBP 1 to 5 messenger RNA ( mRNA ) localization and levels from 2 days to 6 months after the onset of streptozotocin induced diabetes . ^^^ In summary , streptozotocin induced diabetes is associated with very prominent and complex alterations in renal IGF system gene expression , including robust increases in cortical IGFBP 1 and profound decreases in cortical IG FBP 5 mRNA and medullary IGF 1 mRNA levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Blood , collected from a cohort ( n = 3 ) of these patients within 24 h of their discharge from the hospital , indicated that IGF 1 and IGF 2 were still reduced ( 30 % ) and that the decrease in IGFBP 3 and the elevation in IGFBP 1 were still evident at this time . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In normal term FCS , the following levels ( + / SE ) were present : IGF 1 , 76 + / 16 ; IGF 2 , 401 + / 38 ; IGFBP 3 , 700 + / 112 ; IGFBP 1 , 77 + / 10 ng / mL ; and insulin , 3 . 8 + / 1 . 6 microU / mL . ^^^ In IUGR FCS , IGF 1 , IGF 2 , and IGFBP 3 were significantly reduced , and IGFBP 1 was 7 fold higher than in FCS from normal weight fetuses . ^^^ In LGA FCS , IGF 1 , insulin , and IGFBP 3 were significantly increased , whereas IGFBP 1 was significantly decreased . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In control cultures , MC3T3 E 1 cells expressed the mRNAs for IGF 1 , IGF 2 , and IGFBP 2 , 4 , 5 , and 6 but not IGFBP 1 or 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We examined six different stromal phenotypes for IGFBP protein and IGFBP 1 to 6 mRNA expression . [ 125I ] IGF 1 ligand blot analysis of conditioned medium demonstrate different patterns of IGFBP secretion by each cell type . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In a double blind , crossover design we studied the impact of 5 weeks of placebo or GH administration ( 0 . 03 mg . kg 1 body wt . day 1 ) in nine obese women ( mean + / SEM : age 30 . 4 + / 2 . 4 years ; body mass index 37 . 0 + / 2 . 8 kg / m2 ) on IGF 1 , IGF 2 , IGFBP 1 and 3 and GHBP . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum levels of insulin like growth factor ( IGF ) binding protein 3 ( IGFBP 3 ) in healthy infants , children , and adolescents : the relation to IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , age , sex , body mass index , and pubertal maturation . ^^^ Therefore , we measured IGFBP 3 , IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 2 levels by RIA in 907 healthy children to establish well characterized normative data on IGFBP 3 according to age , sex , and pubertal stage and to study the complex relationship between IGFs and their BPs in puberty . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To study the effects of advice on diet , exercise and their combination on oral glucose tolerance ( OGTT ) , insulin secretion , insulin like growth factor 1 ( IGF 1 ) and its binding protein , IGFBP 1 . ^^^ An OGTT , insulin secretion , IGF 1 and its binding protein , IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The supposed inhibitory effect of IGFBP 1 on the biological effect of IGF 1 might result in an additional clinical benefit in acromegalic patients as compared to treatment directed at the pituitary level . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
As IGFBPs are synthesized and secreted by smooth muscle cells and bind to IGFs with high affinity , this study was undertaken to determine the ability of IGFBP 1 and 2 to modulate cellular migration in response to IGF 1 and 2 . ^^^ The addition of IGFBP 1 caused a 19 21 % inhibition of IGF 1 or IGF 2 stimulated migration , whereas the addition of IGFBP 2 inhibited the effect of both by greater than 60 % . ^^^ In contrast , [ Trp 221 ] IGFBP 1 in which the RGD sequence was changed to WGD , thus eliminating its capacity to bind to the alpha 5 beta 1 integrin , inhibited IGF 1 stimulated migration by 67 + / 17 % . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The validity of the IGFBP 5 RIA was established from the following data : 1 ) recombinant human IGFBP 5 and purified human bone derived IGFBP 5 inhibited the binding of tracer to the antisera in an identical manner ; 2 ) the immunoreactive IGFBP 5 in serum co migrated with recombinant human IGFBP 5 in both sodium dodecyl sulfate polyacrylamide gel electrophoresis and high performance gel filtration chromatography ; 3 ) none of the other known IGFBPs ( IGFBP 1 , 2 , 3 , 4 , and 6 ) exhibited significant cross reactivity ; 4 ) the addition of IGF 1 or IGF 2 to the samples did not affect the recovery of IGFBP 5 ; and 5 ) the recovery of the exogenously added IGFBP 5 to serum was greater than 90 % . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Moreover , in GH deficient patients , the diurnal mean levels of IGFBP 1 were inversely correlated to IGF 1 ( r = 0 . 477 ; P < 0 . 05 ) and body mass index ( r = 0 . 450 ; P < 0 . 05 ) . ^^^ When insulin was taken into account , a tendency for a negative correlation between IGFBP 1 and IGF 1 ( P = 0 . 054 ) remained , whereas the relationship to body mass index disappeared . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVES : The aim of this study was to examine ( 1 ) the diurnal variation in SHBG and ( 2 ) the inter relationships of insulin , IGF 1 , SHBG and IGFBP 1 over 24 hours in 10 women with anovulatory PCOS and compare them with weight matched ovulatory controls . ^^^ Serum samples were taken at two hourly intervals for 24 hours and stored for measurement of SHBG , IGFBP 1 , insulin and IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The GH insulin like growth factor 1 ( IGF 1 ) binding protein ( BP ) 3 axis , insulin sensitivity , and insulin IGFBP 1 / insulin sex hormone binding globulin axes were evaluated in 13 adolescent girls ( ages 11 18 yr ) with mild to moderate signs of hyperandrogenism ( HA ) and 28 age matched normal girls . ^^^ Twenty four hour blood samples were obtained at 10 min intervals and were used to determine GH pulsatility ( 20 min samples ) , IGFBP 3 levels ( 0800 0900 h ) , and fluctuations of insulin , IGFBP 1 , and IGF 1 ( hourly samples ) during feeding and fasting phases of the day . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Third trimester fetal growth and umbilical venous blood concentrations of IGF 1 , IGFBP 1 , and growth hormone at term . ^^^ Insulin like growth factor 1 ( IGF 1 ) , insulin like growth factor binding protein 1 ( IGFBP 1 ) and growth hormone ( GH ) concentrations were measured in umbilical venous blood after delivery of 78 term newborn infants . ^^^ These observations indicate that umbilical blood concentrations at birth of IGF 1 , but not IGFBP 1 or GH , relate to both fetal size and fetal growth during the third trimester of pregnancies reaching term . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have studied the time course for IGF 1 and IGFBP 1 after burn injury and their relations to circulating levels of other anabolic and catabolic hormones . ^^^ RESULTS : On admission , plasma levels of glucagon , IGFBP 1 and GH were elevated while levels of IGF 1 were low . ^^^ Three weeks after the burn injury , IGF 1 levels were increased but still markedly below normal , while IGFBP 1 levels remained unchanged . ^^^ During the most catabolic phase in the first week after the burn ( TPN period ) there was an inverse relation between IGF 1 and IGFBP 1 and glucagon ( r = 0 . 83 , P < 0 . 05 ) . ^^^ Uncoupling of the GH IGF 1 axis , and the attenuation of the inhibitory effects of insulin on IGFBP 1 , both contribute to the reduction in IGF 1 levels and bioavailability , factors which may play an important role in post injury metabolism . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
DESIGN : Baseline IGF 1 , insulin like growth factor binding protein 1 ( IGFBP 1 ) , IGFBP 3 , GH response to the exercise propranolol test , and insulin responses to a standard oral glucose tolerance test were compared among patients with functional ovarian hyperandrogenism , hyperandrogenic nonfunctional ovarian hyperandrogenism patients , and age matched controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma IGF 1 , IGFBP 1 and 3 , and tibial growth were equal among 0 , 30 , and 65 STZ Ax rats that did not receive corticosterone . ^^^ In the 0 STZ Ax rats , plasma IGF 1 and IGFBP 3 increased in proportion to the corticosterone implant dose , but IGFBP 1 was unaffected . ^^^ By contrast , IGF 1 and IGFBP 3 were unaltered by corticosterone in the 30 STZ Ax rats , and IGFBP 1 increased in proportion with the dose of corticosterone . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Concentrations of serum insulin like growth factor 1 ( IGF 1 ) , IGF 1 binding protein 1 ( IGFBP 1 ) , and IGFBP 3 were related to specific measures of basal or pulsatile GH release . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In addition , in type 1 diabetes significant increase in a circulating molecule that binds IGF 1 , IGF 1 binding protein 1 ( IGFBP 1 ) , occurs along with reduced IGF 1 , when neuropathic complications are prominent . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serine phosphorylation of insulin like growth factor binding protein 1 ( IGFBP 1 ) has been shown to alter its affinity for the insulin like growth factors ( IGF 1 and IGF 2 ) and to modify its capacity to modulate cellular responses to the IGFs . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
However , adult levels of IGF 1 were maintained in lit / + mice to at least 52 weeks of age , as were levels of IGFBP 1 and 4 , while IGFBP 3 and 2 declined with age . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have characterized the affinities of IGFBP 1 4 for IGF 1 and 2 by employing 1 ) purified IGFBP preparations , 2 ) both [ 125I ] IGF 1 and [ 125I ] IGF 2 as radioligands , and 3 ) multiple IGF analogs designed to have altered affinities for IGFBPs . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Des ( 1 3 ) insulin like growth factor 1 ( IGF 1 ) is an IGF analogue lacking aminoacid 1 to 3 which displays reduced binding to insulin like growth factor binding protein 1 ( IGFBP 1 ) . ^^^ A greater inhibition of immunoreactive IGFBP 1 was obtained with des ( 1 3 ) IGF 1 ( 10 ng / ml ) in Hep G 2 medium when incubated in Eagle ' s Modified Essential Medium ( EMEM ) without phenolred compared to EMEM with phenolred ; EMEM without phenolred was chosen for further experiments . ^^^ Des ( 1 3 ) IGF 1 decreases dose dependently the concentration of IGFBP 1 , with a maximal effect at 3 10 micrograms / l when incubated for 24 h ; 10 micrograms / l of des ( 1 3 ) IGF 1 caused a small but significant inhibition of IGFBP 1 after 8 h incubation and this inhibition was 41 % and 33 % of controls after 14 and 19 h incubation . ^^^ The relative potencies at 16 h of incubation of IGF 1 and insulin in suppressing IGFBP 1 in comparison to des ( 1 3 ) IGF 1 were 0 . 41 ( 0 . 25 0 . 78 ) and 0 . 08 ( 0 . 01 0 . 26 ) , respectively . ^^^ A dose dependent decrease of IGFBP 1 mRNA to 30 % of control was observed after 4 h incubation with 0 . 1 10 micrograms / l des ( 1 3 ) IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
This study examines responses of IGFBP 1 and the IGFBP 3 complex to recombinant human IGF 1 . ^^^ However , after the seventh IGF 1 injection , a 3 . 5 fold greater IGFBP 1 response to the same IGF 1 dose was seen . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have studied the effects of hypothyroidism ( n = 22 ) and hyperthyroidism ( n = 17 ) on levels of serum immunoreactive IGF 1 and 2 , IGF binding proteins ( IGFBP 1 and 3 ) , and IGF bioactivity before and during treatment . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The median effective dose ( ED 50 ) of IGFBP 1 to cause inhibitory effects on IGF activated glucose consumption was 100 200 micrograms / l and was similar for both IGF 1 and IGF 2 at a concentration of 1 . 0 microgram IGF / l . ^^^ Therefore , at IGF concentrations of comparable activity , the inhibitory effects of IGFBP 1 were greater for IGF 1 than for IGF 2 , because of the higher activity of IGF 1 in this assay . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Interactive effects of nutrients and hormones on the expression of insulin like growth factor binding protein 1 ( IGFBP 1 ) mRNA and peptide , and IGF 1 release from isolated adult rat hepatocytes . ^^^ The results show that isolated adult rat hepatocytes release IGF 1 and IGFBP 1 under the interactive control of nutrients and hormones involved in metabolic homeostasis . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Since we have shown that the nonphosphorylated form of IGFBP 1 has a lower affinity for IGF 1 compared to phosphorylated forms and a greater potentiating effect of IGF 1 actions , we determined which serine residues in human IGFBP 1 are phosphorylated . ^^^ The [ Ala 98 , 101 ] IGFBP 1 purified from the conditioned media of these cells had the following characteristics : 1 ) when labelled with [ 32P ] orthophosphate , it contained 63 % less radioactivity than wild type IGFBP 1 ; 2 ) when analyzed by nondenaturing gel electrophoresis , it contained none of the most rapidly migrating and most rapidly migrating and most highly phosphorylated isoform , more of the nonphosphorylated isoform , and more of the most slowly migrating phosphorylated isoform ; and 3 ) its affinity for IGF 1 was reduced 2 . 5 fold and was midway between wild type IGFBP 1 from transfected CHO cells and dephosphorylated IGFBP 1 . ^^^ We conclude that Ser 101 represents the major site of phosphorylation of IGFBP 1 and that while phosphorylation of Ser 101 increases affinity of IGFBP 1 for IGF 1 , phosphorylation of Ser 169 and / or Ser 119 also contributes to the high affinity of fully phosphorylated IGFBP 1 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Oestrogen stimulates the expression of IGF 1 and IGF 1 receptor mRNAs , whereas progesterone induces the major endometrial IGFBP , IGFBP 1 , which is proposed to act as an inhibitor of IGF actions in normal endometrium . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Substitution of Phe 26 with Ser or Leu , which decreased binding to the IGF 1 and insulin receptors , reduced binding to IGFBP 1 and 6 up to 80 fold , but had lesser effects on the other IGFBPs . [ Leu 27 ] IGF 2 and [ Leu 43 ] IGF 2 , which had a more markedly reduced affinity for the IGF 1 and insulin receptors than did [ Ser 26 ] IGF 2 , were bound by the IGFBPs with relatively unchanged affinity compared with IGF 2 . ^^^ IGFBP 1 and IGFBP 6 are most sensitive to changes in IGF 2 structure , although IGFBP 1 binds IGF 1 and IGF 2 with equal affinity , whereas IGFBP 6 has a marked preferential binding affinity for IGF 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have examined the presence of mRNA encoding both IGF 1 and IGF 2 and IGFBP 1 , 2 , and 3 in fibroids and corresponding myometrium from 20 women undergoing hysterectomy for symptomatic uterine fibroids . ^^^ Northern blots of total cellular RNA were probed with oligonucleotides for IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 and a human IGFBP 1 cDNA . ^^^ The data showed that in fibroids compared to myometrium , 1 ) the relative abundance of IGF 1 mRNA was not different , but there was an increase in the relative abundance of IGF 2 mRNA ( P < 0 . 001 ) ; 2 ) IGFBP 1 mRNA was undetectable in fibroids and detectable in only 1 specimen of myometrium ; 3 ) there was no difference in the relative abundance of IGFBP 2 mRNA , but there was an increase in the relative abundance of IGFBP 3 mRNA in myometrium ( P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
It is concluded that in athyreotic patients receiving T 4 , withdrawal of the drug decreases serum IGFBP 1 and SHBG concentrations and IGF 1 levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : Serum samples were assayed for GH by immunoradiometric assay and IGF 1 , IGFBP 1 and insulin by radioimmunoassay . ^^^ IGFBP 1 levels increased overnight both before and during IGF 1 therapy , rising from 24 to 83 and 22 to 110 micrograms / l before therapy and 13 to 60 and 13 to 71 micrograms / l during therapy . ^^^ This rise in IGFBP 1 appeared to be inversely related to the fall in serum insulin levels overnight and appeared not to be affected by IGF 1 therapy . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : To study the serum levels of insulin , insulin like growth factor 1 ( IGF 1 ) , and insulin like growth factor binding protein 1 ( IGFBP 1 ) in relation to clomiphene citrate ( CC ) responsiveness in women with polycystic ovarian disease ( PCOD ) . ^^^ INTERVENTIONS : Blood samples were taken at fasting state and during oral glucose tolerance test ( OGTT ) for the determination of insulin , IGF 1 , and IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : To investigate the relationship between preterm delivery and maternal serum insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) levels . ^^^ MAIN OUTCOME MEASURES : Serum IGF 1 and IGFBP 1 levels were determined by radioimmunoassay . ^^^ In the third trimester , serum IGF 1 levels in singleton preterm deliveries were lower than those in normal pregnancies , and IGFBP 1 concentrations were higher than those in normal pregnancies . ^^^ CONCLUSIONS : Neither IGF 1 nor IGFBP 1 appears to play a significant role in preterm delivery since maternal serum IGF 1 and IGFBP 1 levels are similar in preterm and term deliveries . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 1 was inversely correlated to the IGF 1 concentration ( p < 0 . 001 ) and to the 24 h urinary cortisol excretion ( p < 0 . 005 ) with a combined R squared value of 0 . 58 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : Serum IGFBP 1 , sex hormone binding globulin , free T 3 and free T 4 , TSH and IGF 1 levels were measured after an overnight fast before treatment , and at the end of each 3 month period . ^^^ CONCLUSIONS : Oral thyroxine produces a rise in serum IGFBP 1 levels without a change in serum IGF 1 concentration . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Twenty nine children with Crohn ' s disease were studied before and after treatment with steroids or an elemental diet to assess the effect of disease activity and treatment on serum insulin like growth factor 1 ( IGF 1 ) , insulin like growth factor binding protein ( IGFBP 1 ) , and insulin concentrations . ^^^ The median serum IGF 1 concentration was lower in patients with active disease than in matched controls , and lower in stunted than well grown patients , but insulin and IGFBP 1 concentrations were not significantly different between any group . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
A large part of IGF 1 was associated with its binding proteins ( IGFBPs ) in the circulation and one of IGFBPs , IGFBP 1 inhibited 3H glycine uptake by IGF 1 in a dose dependent manner . ^^^ These results indicate that EGF and IGF 1 regulate fetal growth and maturation independently and that IGF 1 and IGFBP 1 influence fetal development in a counter regulatory system . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 1 is a hepatic protein which is acutely and inversely regulated by insulin , and is thought to modulate the peripheral actions of IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Stimulation of brain cell growth by fetal plasma is reduced when levels of IGF 1 are low and IGFBP 1 are high . 2 . ^^^ Increased levels of IGFBP 1 and reduced availability of IGF 1 may contribute to reduced brain growth when maternal nutrition is impaired . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In the patients with GHIS , chronic IGF 1 treatment , with twice daily injections for 6 months , caused a significant steady decline of IGF 2 and an increase in IGFBP 2 , but had no effect on IGFBP 1 and IGFBP 3 levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : Serum levels of IGFBP 1 , insulin , GH , glucose , IGF 1 and cortisol were measured at varying intervals during the fast and both glucose meal studies . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
DESIGN : In situ hybridization histochemistry was used to localize messenger ribonucleic acids ( mRNAs ) for IGF 1 and IGF 2 , the IGF 1 and IGF 2 receptors and IGFBP 1 to 6 in fresh frozen testis sections from healthy young men who died of trauma . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have recently shown that IGFBP 1 purified from human amniotic fluid neutralizes IGF 1 dependent growth of MCF 7 cells . ^^^ In this study we examined the effects of recombinant IGFBP 1 ( rBP 1 ) on IGF 1 , estradiol ( E 2 ) , and serum induced monolayer and anchorage independent growth ( AIG ) of MCF 7 cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum [ 125I ] IGF 1 binding activity was increased 4 fold ( P < 0 . 01 ) , and Western ligand and immunoblotting demonstrated that levels of IGFBP 1 were high in intact STZ diabetic animals . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding proteins ( IGFBP 1 , 2 , and 3 ) , and IGF binding capacity ( IGF BC ) were evaluated in samples collected at 7 : 00 AM , 3 : 00 PM , and 11 : 00 PM . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and IGFBP 1 were diffusely present in all different thyroid tissues as well . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In CRF circulating levels of GH are elevated , serum IGF 1 is normal and circulating IGFBP 1 , 2 , and 3 are elevated . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
A fasting blood sample was obtained from subjects with Type 1 diabetes for the measurement of ovarian and adrenal sex hormones , LH and FSH , glucose and insulin , insulin like growth factor 1 ( IGF 1 ) , and insulin like growth factor binding protein 1 ( IGFBP 1 ) ; and an ovarian ultrasound scan was performed . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Northern analysis for RNAs of the insulin like growth factor ( IGF ) regulatory system indicates that RNAs for IGF 1 , IGF 1 receptor , and IGF binding proteins ( IGFBP ) 2 6 , but not IGFBP 1 , are expressed in MDG2 . 1 cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Blood was sampled for measurement of serum estradiol , IGF 1 , IGF 2 , and IGFBP 1 , 2 and 3 at various times during estradiol treatment . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Circulating levels of insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) in Taiwanese women during normal pregnancy were investigated . ^^^ Serum concentrations of IGF 1 and IGFBP 1 were determined by immunoradiometric assay ( IRMA ) and radioimmunoassay ( RIA ) . ^^^ It is concluded that serum IGF 1 levels during pregnancy may be regulated by various classes of IGF binding proteins other than IGFBP 1 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To gain insight into the role of the insulin like growth factors ( IGFs ) in regulating lung development , we have used in situ hybridization histochemistry ( ISHH ) to examine the ontogeny and sites of expression of IGF 1 and IGF 2 , IGF binding proteins ( IGFBP 1 to IGFBP 6 ) , and IGF cell surface receptors in fetal rat lung from 15 to 21 days of gestation . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : GH was assayed every 20 minutes , IGFBP 1 , glucose and free insulin every hour and IGF 1 at 0700 h . ^^^ GH , IGFBP 1 , IGF 1 and free insulin were measured by radioimmunoassay . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In pathological states , the increased IGF 1 concentrations were accompanied by an increase in IGFBP 1 concentrations were accompanied by an increase in IGFBP 3 levels in synovial fluid . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum IGF 1 , IGFBP 1 , and insulin were measured by RIA , and IGFBP 3 was determined by immunoradiometric assay in 26 children with ESLD ( mean of 3 . 7 samples pre OLT and 4 . 2 samples post OLT per patient ) and 30 age matched controls . ^^^ In conclusion , IGF 1 and IGFBP 3 are reduced , and IGFBP 1 and IGFBP 2 are increased in children with ESLD . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aim of this study was to identify production of IGF 1 and 2 and IGFBP 1 to 4 by unstimulated normal and polycystic ovaries . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Nitrogen balance , urinary 3 methyl histidine excretion plasma growth hormone ( GH ) , serum cortisol , IGF 1 binding proteins ( IGFBP 1 , 3 ) , glomerular filtration rate , plasma amino acid concentrations and whole body energy expenditures were measured as effector variables during days 1 5 post operatively . ^^^ Serum and plasma concentrations of IGFBP 1 , 3 cortisol , blood glucose and amino acids were not significantly influenced by rhIGF 1 administration , while plasma GH levels decreased significantly as expected . rhIGF 1 had no effect on either nitrogen balance or protein breakdown ( 3 methylhistidine excretion ) in post operative patients on dextrose supplementation only , although plasma concentrations of IGF 1 increased from 130 140 ng mL 1 to a range of 300 450 ng mL 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 1 inhibited IGF 1 induced and spontaneous SMC proliferation dose dependently . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
CONCLUSIONS : FSH enhances the action of IGF 1 in human granulosa cells by inhibiting the secretion of IGFBP 1 and the binding activity of IGFBP 3 by stimulating the proteolysis of IGFBP 3 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The system involves a network of molecules that includes the IGFs themselves ( IGF 1 and 2 ) , IGF receptors ( types 1 and 2 ) , IGF binding proteins ( IGFBP 1 through 6 ) , and IGFBP proteases . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In biological media , IGF 1 and IGF 2 are reversibly associated with specific high affinity ( 10 ( 9 ) 10 ( 11 ) M 1 ) binding proteins ( IGFBP 1 to 6 ) differing in expression according to tissue of origin and playing a variety of roles in IGF transport and half lives , delivery of IGFs to their target cells and modulation of IGF interactions with their receptors . ^^^ In the case of IGFBP 1 , whose hepatic synthesis is negatively regulated by insulin , plasma concentrations are subject to extensive nycthemeral variation , rising with fasting and dropping after feeding , which may be involved in controlling the access of free IGF 1 to its cellular receptors and hence IGF 1 regulated glucose and amino acid uptake . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Because of the physiologic importance of IGF 1 and its potential therapeutic properties , the renal sites of mRNA synthesis for IGF 1 , IGF IR , and IGFBP 1 through IGFBP 5 were characterized in rat kidney by in situ hybridization . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Because IGFBP 1 has been shown to stimulate cell migration and has previously been localized to the distal nephron , the site of greatest injury in the folic acid model , these data are compatible with the notion that this protein may function either directly to affect cellular repair or act as a reservoir for IGF 1 under conditions of cellular damage . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In the ovine fetus , insulin like growth factor 1 ( IGF 1 ) is bound mainly to the low molecular weight insulin like growth factor binding proteins ( IGFBP ) , IGFBP 1 and IGFBP 2 , with little binding to IGFBP 3 until near term at 147 days gestation . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Levels of messenger RNA ( mRNA ) encoding insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF 1 receptor , and IGF binding proteins ( IGFBP 1 to 6 ) were determined after OP 1 treatment . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Here , we examined the effects of 17 beta estradiol ( E 2 ) , epidermal growth factor ( EGF ) , and IGF 1 on DNA synthesis in the uterus of ovariectomized ( ovex ) transgenic mice ( Tg ) , which overexpress rat insulin like growth factor binding protein 1 ( IGFBP 1 ) . ^^^ The data reported here together with previous reports of E 2 regulation of IGF 1 and IGFBP 1 expression in uterus support the hypothesis that the IGF 1 is a mediator of estrogen action in the uterus . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We examined regulation of IGFBP 1 production in human granulosa cells by insulin and IGF 1 . ^^^ After 48 h incubation with insulin or IGF 1 , the medium was collected and IGFBP 1 and progesterone concentrations were measured , using kits from Diagnostic Systems Laboratories , Webster , TX . ^^^ Incubation with 100 ng / mL of insulin reduced IGFBP 1 culture medium concentration to 1 . 6 + / 0 . 3 ng / mL ( P < 0 . 01 , compared with controls ) . 1 , 10 , and 100 ng / mL of IGF 1 inhibited IGFBP 1 concentrations in the conditioned culture medium to 1 . 3 + / 0 . 3 ng / mL , 0 . 4 + / 0 . 1 ng / mL and 0 . 3 + / 0 . 1 ng / mL , respectively ( P < 0 . 01 , compared with controls ) . ^^^ Preincubation with antiinsulin receptor antibody IR 47 9 alleviated inhibitory effect of insulin , but not of IGF 1 on IGFBP 1 production . ^^^ For cells preincubated with IR 47 9 and then incubated with 1 , 10 , or 100 ng / mL of IGF 1 , the IGFBP 1 conditioned culture medium concentrations were 1 . 7 + / 0 . 1 ng / mL , 0 . 5 + / 0 . 2 ng / mL , and 0 . 3 + / 0 . 1 ng / mL , respectively . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
All effects of combined GH and oxandrolone therapy on endocrine parameters such as insulin , SHBG , IGFBP 1 and IGF 1 mimic the endocrine pattern normally observed during the pubertal growth spurt . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We examined cardiovascular risk factors , IGF 1 , IGF 2 and IGFBP 1 in 74 NIDDM patients analysed as a whole group and according to treatment type . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
These results provide evidence for the role of IL 1 as an endogenous mediator of the sepsis induced changes in IGF 1 and IGFBP 1 and suggest that the accompanying changes in muscle protein synthesis are partially mediated via changes in IGF I . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
METHODS . cDNA sequences for IGF 1 , IGF IR , and IGFBP 1 to IGFBP 6 were used to synthesize 35S CTP labeled antisense and sense probes for in situ hybridization on 5 microns sections of the rat eye , including the retina , choroid , sclera , ciliary body , and cornea . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In group 2 we observed a 42 % decrease in IGF 1 during treatment ( P < 0 . 025 ) , while the level of IGFBP 1 increased by a mean value of 70 % ( P < 0 . 025 ) . ^^^ As IGF 1 is a potent mitogen for breast cancer cells in vitro , a decrease in the plasma level of this growth factor with an increase in the concentration of IGFBP 1 may contribute to the anti tumour effects of droloxifene . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In this study , we examined the effect of fetal exposure to alcohol IGF 1 and on IGF 2 and IGFBP 1 and IGFBP 2 mRNA in placenta and fetal lung tissue . ^^^ At G 20 , dams were killed , and we examined placenta and fetal lung for the steady state levels of mRNA for IGF 1 and IGF 2 and for IGFBP 1 and IGFBP 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In hepatocytes , synthesis of IGFBP 1 , 2 , and 4 was observed ; insulin and IGF 1 decreased that of IGFBP 1 , and 2 while increasing that of IGFBP 4 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
During the basal period , burn patients demonstrated a significant reduction in the venous concentration of IGF 1 and an increase in both IGFBP 1 and 2 compared to control values . ^^^ Insulin produced a significant 15 % increase in the IGF 1 concentration in burn patients , but decreased the circulating levels of IGFBP 1 by 50 % . ^^^ The IGF 1 and IGFBP 1 concentrations at the end of the insulin period were still significantly different from those in control subjects . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 stimulated TC 1 DNA synthesis in a dose dependent manner and this effect was inhibited by recombinant IGFBP 1 and 4 . ^^^ The local effects of IGF 1 , however , may be blocked by IGFBP 1 or 4 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Expression of IGFBP 1 to 6 by MC suggests that these proteins may modulate IGF 1 bioavailability in the glomerulus . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : Serum IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 , insulin and C peptide were measured by radioimmunoassay . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The cirrhotic patients had high growth hormone ( GH ) and low insulin like growth factor 1 ( IGF 1 ) levels , with low insulin like growth factor binding protein ( IGFBP ) 3 levels , but surprisingly high IGFBP 1 levels ( 26 . 8 + / 8 . 4 microgH vs . 3 . 2 + / 0 . 2 microm / L , P < . 001 ) . ^^^ GH , IGF 1 , and IGFBP 3 levels were now similar in the two groups ; IGFBP 1 levels decreased in the cirrhotic patients but remained fivefold higher than the comparison value ( 10 . 6 + / 3 . 7 vs . 2 . 1 + / 0 . 4 , P < . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have studied steady state levels of mRNA for the genes in the IGF 1 axis in normal and cirrhotic human liver , localised the most highly expressed gene , IGFBP 1 , and measured circulating IGFBP 3 by radioimmunoassay ( RIA ) , IGFBP 2 and IGFBP 3 by Western ligand blot ( WLB ) , and protease activity for IGFBP 3 in cirrhotic patients . ^^^ Messenger RNA for IGF 1 , IGFBP 1 , IGFBP 2 , and IGFBP 3 was detectable by Northern blotting in normal and cirrhotic liver although there was considerable variation in expression . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
At our clinic we follow the development of MSA of specific binding proteins ( BP ) , trying to introduce or modify the described techniques f . e . the analyses of BP of GH ( GHBP ) , BP for IGF 1 ( IGFBP 3 , IGFBP 1 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Free IGF 1 was inversely correlated ( r = 0 . 49 , P < 0 . 05 ) with IGFBP 1 and / or IGFBP 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Our studies demonstrate that IGF 1 may now be added to the list of regulatory peptides which alpha 2M may bind and that , in rat decidua , DAP may represent the functional homolog of decidual IGFBP 1 in the human and regulate growth factor function during placental development . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We report data for IGF 1 , IGFBP 1 , and 3 , and GHBP in 92 Spanish children with IDDM , separated according to pubertal stage : prepubertal ( n = 49 ) ; pubertal onset ( n = 17 ) ; mid puberty ( n = 17 ) , and complete puberty ( n = 9 ) , as well as to metabolic control ( HbA 1 < 9 % or > or = 9 % ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : Serum levels of GH and IGF 1 were measured by radioimmunoassay , IGF 2 was measured by radioreceptor assay , and IGFBP 1 was measured by an enzyme linked immunoassay . ^^^ IGFBP 1 was present as a free phosphoprotein in AIDS patients with low levels of IGF 1 and in a bound form when serum IGF 1 levels were normal . ^^^ CONCLUSIONS : AIDS wasting is associated with a GH resistant state that results in low levels of serum IGF 1 , IGF 2 and IGFBP 3 , elevated levels of phosphorylated IGFBP 1 , and a reduced ability to form the IGFBP 3 ternary complex . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In addition , total serum IGF 1 , IGFBP 1 and IGFBP 3 levels as well as IGFBP 3 protease activity were determined . ^^^ RESULTS : Free ( dissociable and ultrafiltrated ) IGF 1 concentrations were significantly higher in pubertal boys than in prepubertal children and correlated significantly with the molar ratio between IGF 1 and IGFBP 3 ( r = 0 . 69 , P < 0 . 0001 and r = 0 . 54 , P = 0 . 0008 , respectively ) and inversely with IGFBP 1 ( r = 0 . 47 , P < 0 . 0001 and r = 0 . 43 , P = 0 . 0003 , respectively ) . ^^^ Multiple regression analysis suggested that IGFBP 3 level , and not IGFBP 1 , was the major determinant of the free IGF 1 serum level in normal boys . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Diabetic hypersomatotrophinemia may be due to hepatic resistance to GH and increased hepatic production of IGF 1 binding protein 1 ( IGFBP 1 ) , leading to reduced levels of circulating IGF 1 and further stimulation of GH production . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Also , changes in liver mRNA expression of IGF 1 and 2 and IGFBP 1 and 2 were restored in refed undernourished and IGF 1 and IGFBP 1 levels recovered in insulin treated diabetic rats . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Whereas the enhanced endogenous production of glucocorticoids appears to mediate the IL 1 beta induced decrease in IGF 1 synthesis in liver , the changes in IGF 1 content observed in other tissues and the increase in IGFBP 1 and IGFBP 2 appear to be largely glucocorticoid independent . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 2 ( IGF 2 ) inhibits insulin like growth factor binding protein 1 ( IGFBP 1 ) production in luteinized human granulosa cells with a potency similar to insulin like growth factor 1 ( IGF 1 ) and higher than insulin . ^^^ Production of IGFBP 1 in human granulosa cells is under inhibitory control of insulin and insulin like growth factor 1 ( IGF 1 ) . ^^^ We examined the effect of IGF 2 on IGFBP 1 production in human granulosa cells and compared this effect of IGF 2 to similar effects of insulin and IGF 1 . ^^^ After 24 h of incubation with insulin , IGF 1 , or IGF 2 , the medium was removed and frozen at 20 C until assayed for IGFBP 1 . ^^^ Concentration of IGFBP 1 in the medium collected from cells incubated with hormones was statistically lower than that for control cells starting at 10 ( 3 ) ng / mL of insulin ( P < 0 . 05 ) , 0 . 5 ng / mL of IGF 1 ( P < 0 . 05 ) and 1 ng / mL of IGF 2 ( P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Effect of exogenous gamma aminobutyric acid ( GABA ) on hepatic insulin like growth factor 1 ( IGF 1 ) and IGF 1 binding protein ( IGFBP 1 ) mRNA abundance following partial hepatectomy in rats . ^^^ Insulin like growth factor 1 ( IGF 1 ) and IGF 1 binding protein ( IGFBP 1 ) are highly expressed in the liver and may play an important role in enhancing hepatic regeneration following partial hepatectomy in rats . ^^^ Since hepatic levels of these growth factors are influenced by pituitary growth hormone release , which in turn is regulated by systemic serum gamma aminobutyric acid ( GABA ) concentrations , we chose to examine the effects of elevated serum GABA concentrations on hepatic IGF 1 and IGFBP 1 mRNA abundance following partial hepatectomy in the rat . ^^^ The results of our experiments revealed that at serum GABA concentrations similar to those associated with liver failure , peak hepatic IGF 1 and IGFBP 1 mRNA levels were significantly lower in GABA treated rats compared with saline treated controls ( p < 0 . 05 and 0 . 01 , respectively ) . ^^^ To exclude a direct effect of GABA on hepatocyte IGF 1 and IGFBP 1 mRNA expression , suspensions of isolated hepatocytes were incubated in the presence and absence of exogenous GABA . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma levels of IGF 1 , IGFBP 1 and IGFBP 3 were measured before and during treatment with tamoxifen up to 19+ months in 34 post menopausal patients with advanced breast cancer . ^^^ These findings confirm and extend previous observations regarding the effects of treatment with tamoxifen on IGF 1 and IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In addition , radioimmuno assays for insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 3 ( IGFBP 3 ) , acid labile subunit ( ALS ) and IGFBP 1 were performed . ^^^ IGFBP 1 , seen on immunoblot clearly before transplant , disappeared after the transplant . rhGH successfully improved growth in these children , in association with a fourfold increase in IGF 1 levels , which was maintained following transplantation . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The phosphorylation of insulin like growth factor binding protein 1 ( IGFBP 1 ) alters its binding affinity for insulin like growth factor 1 ( IGF 1 ) and thus regulates the bioavailability of IGF 1 for binding to the IGF 1 receptor . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The biological action of IGF 1 is thought to be influenced by binding proteins , one of which is insulin like growth factor binding protein 1 ( IGFBP 1 ) , which is not only a carrier protein but also actively regulates the cellular actions of IGF 1 . ^^^ These observations suggest associations between IGF 1 , IGFBP 1 , testosterone and SHBG in serum . ^^^ DESIGN AND PATIENTS : The associations between the serum levels of IGF 1 and IGFBP 1 on one hand , and testosterone and SHBG on the other were investigated in 38 normal healthy young and middle aged men . ^^^ CONCLUSION : The present study suggests that among healthy young and middle aged men , there is an association between serum levels of free testosterone and SHBG on the one hand , and serum IGF 1 and IGFBP 1 on the other . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Periconceptual undernutrition resets plasma IGFBP levels and alters the response of IGFBP 1 , IGFBP 3 and IGF 1 to subsequent maternal undernutrition in fetal sheep . ^^^ Levels of IGFBP 1 were increased and IGFBP 3 , IGFBP 4 , IGF 1 , glucose and insulin were reduced at day 115 after undernutrition . ^^^ The degree of change in IGFBP 1 , IGFBP 3 and IGF 1 between day 105 and day 115 was greater in fetuses receiving low periconceptual nutrition . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 2 and IGFBP 1 both inhibit this IGF 1 receptor mediated stimulation . ^^^ These studies demonstrate that the stimulation of cell migration by IGFBP 1 and IGF 1 involves signaling by members of the integrin family of receptors . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Recent studies demonstrate that IGF 2 in FFe is higher than in FFa ' whereas IGF 1 , IGFBP 3 and IGFBP 1 levels do not differ , underscoring the importance of local IGF 2 production by the granulosa and the importance of IGFBP 4 and IGFBP 2 in regulation of IGF 2 action within the follicle during its developmental pathway as an E 2 or A dominant follicle . ^^^ In the androgen treated female to male transsexual ( TSX ) model for PCOS , IGF 1 , IGF 2 , IGFBP 3 and IGFBP 1 levels do not differ . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Low circulating levels of the insulin like growth factors ( IGF 1 and 2 ) have been shown to be associated with changes in the IGF binding proteins ( IGFBP 1 to 6 ) that may significantly impact on IGF bioactivity . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
These data suggest that overexpression of IGFBP 1 attenuates the hypoglycemic effect of endogenous IGF 1 , which is initially compensated for by enhanced pancreatic insulin production . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 1 significantly inhibited cell division stimulated by IGF 1 ( P < 0 . 001 ) and IGF 2 ( P < 0 . 001 ) , but not that stimulated by the analogue , LR3IGF 1 , which has low affinity for IGFBPs . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In this study , we have measured PSA , IGF 1 , IGF 2 , IGFBP 1 and IGFBP 3 in tumour tissue cytosols from 200 women with primary breast cancer , and have examined relationships between IGFs or IGFBPs and PSA along with other markers , including p 53 protein , steroid hormone receptors ( oestrogen and progesterone ) , cathepsin D , epidermal growth factor receptor , Her 2 / neu protein , S phase fraction and DNA ploidy . ^^^ Correlations or associations between PSA and IGF 1 , IGF 2 , IGFBP 1 or IGFBP 3 were not observed . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The study protocol included blood samples collection during a 24 h period for measurement of glucose , glycated hemoglobin , GH IGF 1 and IGFBP 1 levels under two situations : on poor glycemic control and after 2 3 months on better control through systematic diet , low in carbohydrates and increase in insulin dosage . ^^^ IGFBP 1 values were significantly reduced and IGF 1 levels significantly higher after better glycemic control ; 4 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We measured levels of maternal and cord serum IGF 1 , IGF 2 , C peptide , IGFBP 1 , IGFBP 2 and IGFBP 3 in 8 White Class B insulin dependent DP and 8 non diabetic pregnancies ( NP ) . ^^^ No significant differences were found between DP and NP with respect to cord serum IGF 2 , maternal serum IGF 1 , IGF 2 , C peptide , IGFBP 1 , IGFBP 2 and IGFBP 3 , and the concentration and affinity of TR for IN , IGF 1 and IGF 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In biological media , IGF 1 and IGF 2 are reversibly associated with specific , high affinity binding proteins . ( IGFBP 1 to 6 ) whose expression varies with tissue of origin , stage of development , and hormonal and nutritional status . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
High IGFBP 1 levels may also contribute towards limiting the availability of IGF 1 to its target cells . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The normal values of insulin like growth factor 1 ( IGF 1 ) , IGF binding proteins 1 and 3 ( IGFBP 1 and IGFBP 3 ) , and the high affinity growth hormone binding protein ( GHBP ) are not well established in large series of healthy fullterm newborns . ^^^ We report the normative data for IGF 1 , IGFBP 1 , IGFBP 3 , and GHBP in 271 normal Spanish full term newborns , born between 37 and 42 weeks of gestation , and compare these results with the same parameters studied in 39 premature infants . ^^^ When the group of premature newborns was divided into infants born before or after 32 weeks of gestation , we found higher levels of IGF 1 and IGFBP 3 ( p < 0 . 01 and p < 0 . 05 , respectively , by Student ' s test ) in the group with the higher gestational age ; however , the IGFBP 1 level was lower in this group ( p < 0 . 001 by Student ' s t test ) , with no differences seen in serum GHBP concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
As previously described , there were significant decreases in circulating levels of IGF 1 and IGFBP 3 ( 38 42 kDa band ) , and an increase in the 30 kDa IGFBP ( likely corresponding to IGFBP 1 ) in poorly controlled diabetic animals . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Cord sera were obtained from term , Chilean newborns exhibiting various patterns of intrauterine growth and assayed for IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , and IGFBP 3 by specific radioimmunoassays ( RIA ) . ^^^ By contrast , circulating IGFBP 1 and IGFBP 2 were inversely related to IGF 1 levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To determine the developmental pattern of expression of IGF 1 , IGF 2 , IGF 1 R and IGFBP 1 6 mRNAs in the rhesus monkey placenta , in situ hybridization histochemistry was performed in placentae and fetal membranes from 65 days until term ( 165 + / 5 days ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Blood samples were taken on days 15 , 29 , 43 , 55 , 90 , 120 , 150 , 180 for GH , IGF 1 , IGFBP 3 , IGFBP 1 and insulin measurements . ^^^ Insulin levels were elevated and positively correlated with those of GH but not with those of IGF 1 and IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum levels of progesterone , IGFBP 1 , insulin like growth factor 1 ( IGF 1 ) and insulin were determined on day 8 after hCG administration ( day 0 indicates the day of hCG administration ; progesterone supplementation group ) or on day 21 of the menstrual cycle ( controls ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
GH , GH binding protein ( GHBP ) , IGF 1 , and IGF binding proteins 1 5 ( IGFBP 1 through 5 ) ] in adolescent females ( age range , 15 17 yr ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
A combination of IGF 1 and IGFBP 1 at 1 ng / ml of each reagent , a concentration at which gel contraction was not observed when each of the reagents was tested individually , produced a 14 % gel contraction ( P < 0 . 001 ) , whereas combinations of des ( 1 3 ) IGF 1 with IGFBP 1 at the same concentrations did not promote gel contraction . ^^^ The increased IGFBP 1 doses in combination with 1 ng / ml IGF 1 tended to enhance the gel contraction . ^^^ IGF 1 and IGFBP 1 induced gel contraction was prominent during the initial 12 h incubation period . ^^^ When anti IGF 1 , anti IGFBP 1 , or anti IGF 1 receptor antibody was added to the assay medium before the addition of IGF 1 and IGFBP 1 , the IGF 1 and IGFBP 1 induced gel contraction was significantly suppressed ( P < 0 . 001 ) . ^^^ Endothelin 1 , a vasoconstrictor peptide that is known to promote fibroblast embedded collagen gel contraction , appeared to be partially involved in the IGF 1 and IGFBP 1 induced gel contraction , because the addition of an endothelin receptor antagonist ( Bosentan or BE 18257B at 1 microg / ml ) moderately suppressed the IGF 1 and IGFBP 1 induced gel contraction ( P < 0 . 01 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 1 , 3 , 4 , or 5 did not have increased heparin binding in the presence of IGF 1 or IGF 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Genetic and environmental components of interindividual variation in circulating levels of IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 3 . ^^^ We assessed the magnitude of the genetic component in the variation of circulating levels of insulin like growth factors 1 and 2 ( IGF 1 and IGF 2 ) , and their binding proteins IGFBP 1 and IGFBP 3 by measuring their serum concentrations in 32 monozygotic and 47 dizygotic adult twin pairs of the same sex . ^^^ Our results show that , in adults , there is a substantial genetic contribution responsible for interindividual variation of the circulating levels of IGF 1 , IGF 2 , and IGFBP 3 , but not for the IGFBP 1 levels . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : Maternal serum GH , IGF 1 , IGFBP 1 and 3 were determined , and fetal weight and umbilical artery pulsatility index ( PI ) was estimated by ultrasonography and Doppler ultrasound at 33 weeks gestational age . ^^^ RESULTS : Serum IGF 1 was lower in the SGA group ( 246 vs 297 micrograms / l , P = 0 . 03 ) but GH and IGFBP 1 and 3 did not differ between the groups . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In seven subjects with IDDM , where serum IGFBP 1 and IGFBP 3 concentrations , and IGFBP 3 protease activity had also been measured in a previous study , the relationship between these variables and circulating free IGF 1 concentrations were examined by linear regression analysis . ^^^ Free IGF 1 concentrations correlated positively with total IGF 1 and negatively with IGFBP 1 concentrations . ^^^ An inverse correlation between free IGF 1 and IGFBP 1 supports the hypothesis that IGFBP 1 plays an important role in the acute modulation of free IGF 1 levels . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : Fasting measurements of glucose , insulin , IGF 1 , IGF 2 , IGFBP 1 and IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Although levels of IGF 1 and IGFBP 3 did not differ in either CA or AA , the 2 to 4 fold higher levels of IGFBP 1 in AA than in CA and CS resulted in a 3 fold reduced ratio of IGF I / IGFBP 1 in AA , which may decrease the bioactivity and hypoglycemic effect of IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In the present study , we examined whether a short term fast ( approximately 12 h ) alters the serum concentration of free / dissociable IGF 1 , and whether these changes are associated with alterations in IGFBP 1 and the proteolysis status of IGFBP 3 . ^^^ The results indicate that a physiologically relevant short term overnight fast does not alter the circulating levels of free / dissociable IGF 1 despite a marked elevation in IGFBP 1 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : ( 1 ) Compared to 100 normal weight girls of same age the obese subjects had increased levels of IGF 1 , IGFBP 1 , IGFBP 2 , and IGFBP 3 and normal levels of IGF 2 . ( 2 ) After weight loss ( 8 . 1 + / 2 . 0 kg ) IGF 2 and IGFBP 2 increased and IGF 1 , IGFBP 1 , IGFBP 3 and the ratio IGF I / IGFBP 3 decreased significantly . ( 3 ) Correlation analysis revealed that fasting insulin levels of the patients were positively correlated with IGF 1 but inversely with IGFBP 1 and IGFBP 2 . ^^^ The main conclusion is that obesity has to be considered for interpretation of serum concentrations of IGF 1 , IGFBP 1 , IGFBP 2 , and IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 receptor , and five IGF binding proteins ( IGFBPs ) , IGFBP 1 , IGFBP 2 , IGFBP 3 , IGFBP 4 , and IGFBP 5 in smooth muscle cells ( SMCs ) using colloidal gold immunocytochemistry . ^^^ Quantitative reverse transcription polymerase chain reaction ( QRT PCR ) performed on de novo atherectomy specimens identified mRNA for IGF 1 , IGF 1 receptor , IGFBP 1 , IGFBP 2 , IGFBP 4 , IGFBP 5 levels and detected mRNA for IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We report maternal serum levels of IGF 1 , IGF 2 , and IGFBP 1 , 2 , and 3 ; IGFBP 1 phosphorylation ; and IGFBP 3 proteolysis in pregnancies ( n = 139 ) complicated by trisomy 18 or trisomy 21 compared with those in normal controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In contrast , Tg mice that exhibit ectopic brain expression of IGFBP 1 , an inhibitor of IGF action when present in molar excess , manifest postnatal brain growth retardation , and mice with ablated IGF 1 gene expression , accomplished by homologous recombination , have brains that are 60 % of normal size as adults . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In conclusion , we report that EGF treatment for 4 weeks in Goettingen minipigs reduces circulating IGF 1 and IGFBP 3 , increases circulating IGFBP 1 , IGFBP 2 and IGFBP 4 , and induces a slight hyperthyroidism as judged from increased circulating levels of T3 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Hormone profiles ( IGF 1 , IGFBP 1 , IGFBP 3 , cortisol , insulin , glucagon , triiodothyronine [ T 3 ] , levothyroxine [ T 4 ] , and thyroxine binding globulin ) were taken . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Ontogeny of mRNA levels of IGFs , IGF type 1 and type 2 receptors ( IGFI R and IGFII R ) , IGFBP 1 and 3 ( IGFBPs ) and growth hormone receptor ( GHR ) were also examined by Northern blot analysis in liver , kidney and skeletal muscle of pig . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
DNA synthesis appears to be in reciprocal relationship with hepatic expression of IGF 1 , IGFBP 1 , IGFBP 2 and IGFBP 4 , suggesting that IGF I / IGFBPs system is not involved in liver growth . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
As expected , human recombinant IGFBP 1 ( 80 nM ) completely inhibited IGF 1 mediated activation of ER , however , IGFBP 1 also caused a significant decrease in E 2 mediated activation . ^^^ This study confirmed that IGF 1 can cause transcriptional activation of endogenous ER in human breast cancel cells , and inhibition of ER action by IGFBP 1 suggests that IGF 1 signaling may be necessary for maximal ER activation . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To evaluate the role of insulin like growth factors ( IGFs ) and IGF binding proteins ( IGFBPs ) in excessive fetal growth ( macrosomia ) in diabetic pregnancy , 84 insulin treated diabetic mothers and their infants were tested for serum concentrations of IGF 1 , IFG 2 , and IGFBP 1 , 2 and 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 1 , insulin like growth factor 1 ( IGF 1 ) and growth hormone levels were measured before and during the FSIGT . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 , oestradiol and norethisterone were analysed by radioimmuno assays . ^^^ CONCLUSIONS : Treatment with oral hormone replacement therapy significantly suppresses plasma IGF 1 levels and increases plasma IGFBP 1 while transdermal treatment had no influence . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : In JRA patients , IGF 1 , IGFBP 3 , and osteocalcin levels were significantly lower and insulin levels significantly higher than those in controls , but there was no significant difference in the level of IGFBP 1 . ^^^ With rHuGH treatment , height velocity and mean levels of IGF 1 , osteocalcin , and insulin increased significantly , while mean levels of IGFBP 1 fell significantly . ^^^ The height velocity correlated positively with IGF 1 and osteocalcin , and negatively with IGFBP 1 . ^^^ Levels of IGFBP 1 were inversely related to those of insulin and IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
An IGF 1 domain has been identified that remains exposed after IGF 1 binding to IGFBP 1 or to IGFBP 3 , which is recognized by 6 different mAb . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The imbalance between reduced hepatic IGF 1 production and increased hepatic IGFBP 1 and 2 production is likely to play a pathogenic role for catabolism and growth failure in CRF . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In binding to IGF 1 , the plasma phosphoform of IGFBP 1 was found to have a higher affinity ( 2 . 3 + / 1 . 1 10 10 ( 10 ) M 1 ) than nonphosphorylated IGFBP 1 ( 2 . 5 + / 1 . 7 10 10 ( 9 ) M 1 , P < 0 . 002 ) . ^^^ Therefore , in the circulation , IGF 1 has a considerably higher affinity than IGF 2 for IGFBP 1 ( P < 0 . 02 ) . ^^^ The affinity of phosphorylated IGFBP 1 from plasma ( 2 . 3 + / 1 . 1 10 10 ( 10 ) M 1 ) also was significantly higher than the affinity of IGFBP 3 for IGF 1 ( 5 . 6 + / 4 . 2 10 10 ( 9 ) M 1 , P < 0 . 005 ) . ^^^ These data suggest that the highly phosphorylated IGFBP 1 in the normal circulation will preferentially bind IGF 1 rather than IGF 2 , whereas in pregnancy , the affinity of IGFBP 1 for IGF 1 will be reduced because of the appearance of non and lesser phosphorylated forms . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Fetal hepatic IGFBP 1 mRNA levels increased in 4 of 6 nephrectomized fetuses , while those of IGF 1 , IGF 2 , IGFBP 2 were unchanged . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Early follicular , late follicular , midluteal phase , and samples taken at ovulation were also assayed for IGF 1 and IGFBP 1 and IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In the present study of GH , administered in double blind , placebo controlled , cross over fashion to regularly cycling women undergoing in vitro fertilization , we found that follicular fluid levels of IGFBP 1 , 3 , and 4 and serum levels of IGFBP 3 , as well as follicular fluid and serum IGF 1 , were significantly increased in the GH treated cycles , when compared with the placebo cycle of the same patient . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Patients with insulin dependent diabetes mellitus ( IDDM ) exhibit abnormalities in the GH / insulin like growth factor ( IGF ) axis , including GH hypersecretion , low serum IGF 1 and IGF binding protein 3 ( IGFBP 3 ) levels , and elevated IGFBP 1 levels . ^^^ Forty three pediatric IDDM patients were randomly assigned to groups receiving daily , fasting subcutaneous injections of placebo or rhIGF 1 ( 80 micrograms . kg . day ) for 28 days , while continuing to receive splitmix insulin therapy and intensive outpatient management . rhIGF 1 therapy corrected IGF 1 deficiency , suppressed IGFBP 1 levels ( P < 0 . 01 ) , and induced a trend toward lower circulating GH levels throughout the study . rhIGF 1 therapy also induced an approximate 50 % decrease in IGF 2 levels ( P < 0 . 001 ) and an approximate 70 % increase in IGFBP 2 levels ( P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor binding protein 1 ( IGFBP 1 ) modulates the mitogenic actions of IGF 1 and IGF 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We determined the circulating levels of IGF 1 and two of its key binding proteins , IGFBP 1 and IGFBP 3 . ^^^ The levels of IGFBP 1 in patients with PV ( 37 . 80 + / 4 . 33 microg / L ) were more than fourfold higher than in normals ( 9 . 34 + / 1 . 34 microg / L ) or patients with secondary erythrocytosis ( 9 . 47 + / 1 . 96 microg / L ) , whereas the plasma concentrations of IGFBP 3 and IGF 1 in these patients were similar to those of normal subjects . ^^^ The substantial increase in concentration of IGFBP 1 was confirmed on ligand blots performed with ( 125 ) 1 IGF 1 . ^^^ IGFBP 1 can be either inhibitory or stimulatory to the action of IGF 1 under different conditions . ^^^ We reasoned that if IGFBP 1 were stimulatory for erythropoiesis , an elevated IGFBP 1 level could help to explain the increased sensitivity to IGF 1 observed in PV . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum IGFBP 3 levels fell while IGFBP 1 and 2 levels rose during treatment , changes that likely affect the bioavailability of IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In summary , renal hypertrophy in non obese diabetic mice is associated with a persistent accumulation of renal IGF 1 and , IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To explore this question further we measured the concentrations of IGF 1 and 2 and their binding proteins ( IGFBP 1 and 3 ) in adrenal and ovarian vein samples of severely hyperandrogenic women ( serum testosterone > 5 nmol / l ) collected as part of their diagnostic work up . ^^^ The concentration of IGFBP 1 was negatively correlated ( r = 0 . 60 , P > 0 . 05 ) with insulin and IGFBP 3 showed a strong positive correlation with IGF 1 ( r = 0 . 90 , P > 0 . 01 ) . ^^^ Hyperinsulinaemia is associated with low circulating IGFBP 1 concentrations and IGFBP 3 seems to be an excellent indicator of the peripheral IGF 1 concentration . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 1 and IGFBP 3 , but not an N terminal fragment of IGFBP 3 , could effectively block binding of both IGF 1 and IGF 2 to the solid phase IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 levels were reduced by 33 % in elders ( P < 0 . 001 ) and correlated with IGFBP 1 levels among old ( r = 0 . 40 ; P < 0 . 01 ) , but not young , men , indicating that low GH secretion and / or IGF 1 production may contribute to the elevation of IGFBP 1 levels in aging . ^^^ Serum levels of IGFBP 1 ( but not IGF 1 or 2 or IGFBP 3 ) correlated with body mass index and upper arm fat and muscle areas in elders . ^^^ We conclude that insulin remains an important determinant of IGFBP 1 levels in elders , that the fasting glucose level is also a significant determinant of IGFBP 1 in both old and young subjects , and that reduced secretion of GH may contribute to impaired anabolism in aging through multiple mechanisms , including reduced production of IGF 1 and alterations in circulating levels of both IGFBP 1 and 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Following a five day maternal fast , both IGF 1 and IGF 2 levels were decreased in the maternal and fetal circulation ( P < 0 . 05 ) , accompanied by a decrease in fetal hepatic IGF 1 mRNA levels , but the IGFBP 2 level was increased and the IGFBP 3 level was decreased in maternal circulation , whereas the IGFBP 1 level was increased in fetal circulation . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENT : Total IGF 1 , free IGF 1 , IGFBP 1 , IGFBP 2 , IGFBP 3 , and insulin were measured in obese subjects and normal control subjects . ^^^ Using multiple linear regression analysis , total IGF 1 and insulin concentrations were positively correlated ( r = 0 . 58 , P = 0 . 001 ) and free IGF 1 and IGFBP 1 concentrations were negatively correlated ( r = 0 . 57 , P = 0 . 001 ) . ^^^ It seems likely that overnutrition and chronic hyperinsulinaemia in obesity may alter this regulated growth response by insulin stimulation of IGF 1 production and suppression of hepatic IGFBP 1 and IGFBP 2 production , which may inhibit IGF 1 bioactivity . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We examined whether insulin like growth factor 1 ( IGF 1 ) and one of its binding proteins ( IGFBP 1 ) in fetal serum obtained by cordocentesis is correlated with intrauterine growth retardation ( IUGR ) and weight estimation by ultrasound . ^^^ Cordocentesis sera from 27 fetuses suspected of having IUGR were analysed for IGF 1 and IGFBP 1 by radioimmunoassay . ^^^ IGFBP 1 was inversely correlated with birth weight ( P < 0 . 006 ) and concentrations of IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
After 12 months of study , the 30 children receiving rhGH showed : ( 1 ) greater increase in height ( 9 . 1 + / 2 . 8 vs . 5 . 5 + / 1 . 9 cm , P < 0 . 0001 ) ; ( 2 ) increases in serum levels of IGF 1 , IGF 2 , free IGF 1 , IGFBP 3 and acid labile subunit ( ALS ) ; ( 3 ) a greater decrease in serum IGFBP 1 levels ; and ( 4 ) no significant difference in serum IGFBP 2 levels , when compared to the 14 control patients . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In heterozygous and homozygous adults , there was a negative correlation between IGF 1 and IGFBP 1 concentrations ( r = 0 . 8 , P < 0 . 0001 ) , suggesting a link between transgene expression and IGF 1 levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Within penetrant cerebral wounds in the acute phase of the response ( 1 7 days post lesion ; dpl ) , increased levels of IGF 1 , IGFBP 1 , 2 , 3 , 6 , and IGF 1R protein were localized to injury responsive astrocytes , neurons and cells of the monocyte lineage . ^^^ IGF 1 , IGFBP 1 , and IGFBP 3 protein were also associated with the microvascular endothelium , which was accompanied by increased levels of IGFBP 3 mRNA . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Spontaneous GH secretion , IGF 1 , free IGF 1 ( fIGF 1 ) , IGF 2 , their binding proteins ( IGFBP 1 , IGFBP 2 , and IGFBP 3 ) , and GH binding protein ( GHBP ) values at the time of clinical diagnosis ( n = 65 ) , after a 25 % decrease in the body mass index ( BMI ) expressed as the SD score ( BMI SD score ; n = 29 ) , and after a diminution of at least 50 % of the initial BMI SD score ( n = 9 ) are reported . ^^^ IGFBP 1 was negatively correlated with IGF 1 and fIGF 1 in all groups . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We report their spontaneous GH secretion and IGF 1 , free IGF 1 ( fIGF 1 ) , IGF 2 , the IGF binding proteins ( IGFBP 1 , IGFBP 2 , and IGFBP 3 ) , and GH binding protein ( GHBP ) levels at the time of the clinical diagnosis ( n = 50 ) and after recuperation of between 6 8 % ( n = 42 ) and 10 % or less of the initial weight ( n = 20 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In this study , we examined the effects of acute changes in serum insulin on free IGF 1 , total IGF 1 , IGFBP 1 , and IGFBP 3 in 11 healthy subjects . ^^^ In the fasting state , free IGF 1 was positively correlated with SI ( r = 0 . 52 ; P < 0 . 005 ) and inversely correlated with glucose ( r = 0 . 51 ; P < 0 . 005 ) and IGFBP 1 ( r = 0 . 65 ; P < 0 . 001 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum IGFBP 1 levels are lower in PCOS , likely because of hyperinsulinemia , and serum free IGF 1 levels are raised . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Levels of insulin , glucose , lactate , insulin like growth factor ( IGF 1 ) , IGFBP 1 , human placental lactogen ( hPL ) and beta human chorionic gonadotropin ( beta hCG ) were measured at 30 minute intervals during perfusion . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In FGR cases , maternal IGF 1 was low ( P = 0 . 0001 ) and IGFBP 1 was high ( P = 0 . 03 ) and maternal IGF 2 was low in SGA ( P = 0 . 005 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Fasting levels of IGF 1 , free IGF 1 , IGF 2 , IGFBP 3 , and insulin increased significantly within 3 months of GH treatment , whereas IGFBP 1 , IGFBP 2 , and IGFBP 6 showed no change . ^^^ Free IGF 1 paralleled total IGF 1 except during fasting , when it varied inversely with IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Differential role of glucocorticoids in mediating endotoxin induced changes in IGF 1 and IGFBP 1 . ^^^ These data suggest that glucocorticoids play a major role in regulating IGF 1 mRNA and peptide content in tissues in response to LPS , but the increased IGFBP 1 in blood and tissues induced by LPS appears largely glucocorticoid independent . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : The serum IGF 1 values increased up to Tanner stage 4 and thereafter decreased , whereas IGFBP 1 showed the inverse pattern . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
This increase in IGF 1 could be caused by the increase in kidney IGFBP 1 gene and protein expression and the decrease in kidney IGF 1 degrading activity noted in K deficiency . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To evaluate the effects of exogenous recombinant human IGF 1 on circulating concentrations of IGF 1 binding protein 1 ( IGFBP 1 ) , IGF 1 binding protein 3 ( IGFBP 3 ) , and growth hormone in the critically ill patient ; to assess the safety of the subcutaneous administration of 40 microg / kg of recombinant human IGF 1 in these patients ; and to investigate any effect this dose might have on nitrogen balance , creatinine clearance , and serum electrolyte and lipid concentrations . ^^^ Serum concentrations of IGF 1 , IGFBP 1 , IGFBP 3 , growth hormone , and insulin were measured by radioimmunoassay . ^^^ There was marked between patient variability in changes in circulating IGF 1 , and IGFBP 1 , and IGFBP 3 concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In both GHD and controls , free IGF 1 correlated significantly ( P < 0 . 05 ) with total IGF 1 ( GHD r = 0 . 78 ; controls r = 0 . 42 ) , IGFBP 1 ( GHD r = 0 . 67 ; controls r = 0 . 46 ) and the molar ratio of total IGF 1 over IGFBP 3 ( GHD r = 0 . 58 ; controls r = 0 . 62 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In contrast , in kidney , K depletion increased IGFBP 1 and 2 mRNA expression with no additional effect of IGF 1 infusion . ^^^ In liver of K depleted animals , IGFBP 1 mRNA expression was increased whereas increased IGFBP 1 and 2 mRNA expression was observed when these animals were infused with IGF 1 . ^^^ In kidney increased IGFBP 1 and 2 mRNA expression may enhance IGF 1 bioavailability with subsequent kidney growth . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Our purpose was to compare circulating levels of IGF 1 and IGFBP 1 in women with and without endometrial cancer . ^^^ We assessed circulating levels of IGF 1 and IGFBP 1 and IGFBP 3 in 23 patients with endometrial cancer , 11 patients with uterine cervical cancer and 27 healthy control women . ^^^ There were no significant differences in the serum levels of IGF 1 and IGFBP 1 in the patients with cervical cancer and the control group . ^^^ In conclusion , an increased circulating concentration of IGF 1 and a decreased circulating concentration of IGFBP 1 are associated with endometrial cancer especially in postmenopausal women . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The free fraction of IGF 1 modulated by acute changes in IGFBP 1 may play a direct role . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Our recent observations of significant inverse correlations between free IGF 1 and IGFBP 1 in cross sectionally collected fasting serum samples support a possible physiological association between the peptides . ^^^ IGFBP 1 was inversely correlated to free IGF 1 at baseline ( r = 0 . 57 ; P < 0 . 05 ) , as well as during the OGTT ( r = 0 . 66 ; P < 0 . 0001 ) . ^^^ These results extend our previous findings of an inverse correlation between free IGF 1 and IGFBP 1 in cross sectional studies to include longitudinal observations , and thus further substantiates the hypothesis that IGFBP 1 is an important determinant of free IGF 1 in vivo . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Concomitantly , levels of IGFBP 1 decreased gradually from baseline to 4 . 1 + / 2 . 3 micrograms / l ( saline ; P < 0 . 0005 ) and to 4 . 6 + / 1 . 8 micrograms / l ( IGF 1 ; P < 0 . 0001 ) . ^^^ Noteworthily , in both situations a further twofold increase in free IGF 1 was observed during the hyperinsulinemic clamp , concomitant with a decrease in IGFBP 1 . ^^^ This supports the hypothesis that IGFBP 1 is important in the short term regulation of free IGF 1 in vivo . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To elucidate the physiological role of human stromelysin 3 ( hST 3 ) in tumor progression and / or wound healing , insulin like growth factor binding protein 1 ( IGFBP 1 ) was analyzed as a potential physiological substrate . hST 3 proteolysis generates two fragments of 16 and 9 kDa that react with IGFBP 1 monoclonal antibody , although they do not bind insulin like growth factor 1 ( IGF 1 ) in ligand blot . ^^^ We show that IGFBP 1 inhibits IGF 1 induced survival and proliferation of BAF / 3 cells , as well as IGF 1 mediated activation of phosphatidylinositol 3 kinase ( PI 3 K ) . ^^^ IGFBP 1 complex with hST 3 restores IGF 1 induced proliferation and PI 3 K kinase activity in these cells . ^^^ IGFBP 1 complex compared with that obtained using IGF 1 alone . ^^^ To produce this enhanced proliferation , IGF 1 must bind to IGFBP 1 before hST 3 proteolysis , demonstrated using an IGF 1 variant that does not bind IGFBP . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factors ( IGF 1 and IGF 2 ) in biological fluids bind to high affinity binding proteins ( IGFBP 1 to 6 ) , which transport them and regulate their activities . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and IGF 2 also have specific inhibitory effects on IGFBP 1 expression . ^^^ Moreover , IGFBP 1 appears to be a primary determinant of free IGF 1 levels in serum . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The levels of IGF 1 receptor and IGFBP 1 , 2 , 4 , and 6 mRNAs were extremely low and / or were not altered by any of the treatments . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Follicle stimulating hormone , luteinizing hormone ( LH ) , oestradiol , progesterone , IGF 1 , IGFBP 3 , sex hormone binding globulin , dihydroepiandrosterone sulphate and GH were determined in all samples , whereas insulin and IGFBP 1 were determined in fasted samples only . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
A 520 bases human IGF 1 , a 556 bases human IGF 2 , a 480 bases human IGF 1 receptor and a 250 human IGF II / mannose 6 phosphate ( M6P ) receptor probe were radiolabelled as were human IGFBP 1 , 2 , 3 , 4 , 5 and 6 probes . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The temporal variations in endometrial expression of mRNA encoding insulin like growth factor 1 ( IGF 1 ) and IGF 2 , and insulin like growth factor binding protein 1 ( IGFBP 1 ) and IGFBP 2 were investigated between oestrus and day 20 of pregnancy in ewes . ^^^ Northern blot analysis of endometrial total RNA revealed major transcripts for IGF 1 ( 7 . 1 kb ) , IGF 2 ( 5 . 8 kb ) , IGFBP 1 ( 1 . 3 kb ) and IGFBP 2 ( 1 . 7 kb ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
However , the rather limited data have been inconclusive so far and plasma concentrations of both insulin like growth factor 1 ( IGF 1 ) and binding proteins ( IGFBP 1 to IGFBP 6 ) have not been measured simultaneously in depressed patients . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The present study was undertaken to establish the therapeutic effect of recombinant human growth hormone ( r hGH ) on the nutritional state and clarify the usefulness of the insulin like growth factor 1 ( IGF 1 ) insulin like growth factor binding protein 1 ( IGFBP 1 ) ratio as nutritional indices for prediction of the clinical response in uremic patients on hemodialysis . ^^^ Blood samples were collected for measurement of the following plasma biochemical and hematological indices : serum IGF 1 , IGFBP 1 , growth hormone , total protein ( TP ) , prealbumin , transferrin , albumin , serum urea nitrogen ( SUN ) , creatinine , hematocrit , and amino acids . ^^^ Serum IGF 1 increased markedly from 193 + / 49 to 321 + / 81 ng / ml , whereas serum IGFBP 1 decreased from 139 + / 13 to 81 + / 19 micrograms / l ( p < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
At 10 nM , IGFBP 1 was ineffective where IGFBP 3 provoked 90 % displacement of 125I des ( 1 3 ) IGF 1 , but it was equally potent in displacing 125I IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum IGF 1 , IGFBP 1 , and IGFBP 2 levels were measured by radioimmunoassay , and IGFBP 3 by immunoradiometric assay . ^^^ In both groups , growth hormone receptor mRNA expression was examined by quantitative reverse transcription polymerase chain reaction , IGF 1 mRNA expression by ribonuclease protection assay , and IGFBP 1 to 4 mRNA expression by Northern analysis . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum levels of IGF 1 , IGFBP 1 , IGFBP 3 , and insulin were measured by specific immunoassays . ^^^ RESULTS : Compared with the controls , patients with PCOS had significantly higher insulin levels , similar IGF 1 and IGFBP 3 levels , and significantly lower IGFBP 1 . ^^^ Insulin did not change serum IGF 1 levels in either group , although a significant decrease in IGFBP 1 levels occurred in normal women but not in patients with PCOS . ^^^ Octreotide treatment also did not change serum IGF 1 levels in either group , but serum insulin levels decreased significantly and IGFBP 1 levels increased significantly in both groups ; this response was significantly greater in controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Decreased insulin sensitivity and insulin like growth factor 1 ( IGF 1 ) bioavalibility , as measured by the serum IGF I / insulin like growth factor binding protein 1 ( IGFBP 1 ) ratio , was found after fasting , whereas no metabolic changes were found after bed rest . ^^^ After brief hypocaloric nutrition , insulin sensitivity is reduced , whereas IGF 1 bioavalibility is reduced by an increase in levels of IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Although levels of IGF 1 and IGFBP 3 did not differ , the elevation of IGFBP 1 levels in FHA resulted in a reduced ( P < 0 . 01 ) ratio of IGF I / IGFBP 1 , which may decrease the bioactivity and hypoglycemic effect of IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In aging , there are marked decreases in IGF 1 and 2 , normal levels of IGFBP 3 , and marked increases in IGFBP 1 in serum . ^^^ In these conditions , serum levels of IGF 1 and 2 are markedly diminished , IGFBP 3 levels are also decreased , and IGFBP 1 levels are markedly increased . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum IGF 1 and IGF 2 were quantified by radioimmunoassay ( RIA ) , IGFBP 3 by immunoradiometric assay ( IRMA ) , and changes in IGFBP 1 , 2 , 3 , and 4 were estimated by Western ligand blotting ( WLB ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In a cross sectional study of 218 healthy persons ( 103 men , 115 women ) aged 55 to 80 years , fasting serum ( total and free ) IGF 1 and IGFBP 1 levels , lipid profile , insulin , and glucose were measured . ^^^ High fasting serum free IGF 1 levels are associated with a decreased presence of atherosclerotic plaques and coronary artery disease and lower serum triglycerides , whereas high fasting IGFBP 1 levels are associated with a more favorable cardiovascular risk profile . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aim of our study was to determine the serum levels of IGF 1 , IGF 2 , and their binding proteins IGFBP 1 and IGFBP 3 in young children 3 months to 2 years of age with nonorganic failure to thrive ( NOFTT ) . 29 children with NOFTT and 32 normal controls were recruited and studied for auxologic and hormonal parameters . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 production may be diminished and the serum concentration of IGF binding proteins ( IGFBP 1 and 3 ) is increased . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
There were no statistically significant differences between cases and controls for IGF 1 and IGFBP 1 levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The effect of an intravenous infusion of IGF 1 and insulin on IGFBP 1 , IGFBP 3 , acid labile subunit , free and bound IGF 1 , catecholamines and potassium in normal volunteers during an amino acid and glucose clamp . ^^^ MEASUREMENTS : Circulating levels of total IGF 1 , free and bound IGF 1 , Insulin , IGFBP 1 , IGFBP 3 , ALS , catecholamines and potassium were measured . ^^^ There was a significant ( P < 0 . 05 ) fall in IGFBP 1 levels from 27 . 1 + / 4 . 1 8 . 06 + / 1 . 6 micrograms / l during the insulin infusion and a significant ( P < 0 . 05 ) rise during the first 120 min of IGF 1 infusion from 28 . 6 + / 6 . 3 67 . 9 + / 10 . 6 micrograms / l . ^^^ IGF 1 and insulin under conditions of adequate substrate supply have acute effects on IGFBP 1 and potassium physiology , but have little effect on IGFBP 3 , ALS or catecholamines . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum IGF 1 and IGFBP 1 levels did not significantly change over time or between groups . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
GH and IGF 1 basal concentrations were significantly higher in pre menopausal than in post menopausal women , while IGF 2 , IGFBP 1 and IGFBP 3 concentrations did not vary significantly . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma levels of IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 , estradiol and progesterone were measured by radioimmunoassay ( RIA ) in each sample . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In this study , the relationships between intra and extracellular amino acid ( AA ) levels and IGF 1 and / or IGFBP 1 levels were studied in 30 adult patients ( aged 24 70 years ) on haemodialysis who had no clinical signs of malnutrition . ^^^ Blood samples ( n = 30 ) and muscle biopsies ( n = 13 ) were collected for determination of free AA in erythrocytes ( RBC ) , plasma and muscle by reverse phase HPLC while IGFBP 1 , IGF 1 and insulin plasma levels were determined by radioimmunoassay The patients on haemodialysis had elevated glutamate concentrations in RBC and plasma compared with healthy controls ( 524 + / 26 vs 448 + / 17 mumol / l , P < 0 . 05 and 45 + / 4 vs 32 + / 4 mumol / l , P < 0 . 01 respectively ) , although glutamate levels in muscle were within the normal range . ^^^ No plasma AA level displayed a significant correlation with IGF 1 , IGFBP 1 or insulin levels . ^^^ However , glutamate concentrations in RBC were positively correlated to IGFBP 1 ( r = 0 . 51 , P < 0 . 01 ) and inversely correlated to IGF 1 ( r = 0 . 46 . ^^^ Muscle glutamate , which was inversely related to RBC glutamate , displayed an opposite pattern with an inverse relation to IGFBP 1 levels ( r = 0 . 73 , P < 0 . 01 ) and a positive correlation to IGF 1 levels ( r = 0 . 64 , P < 0 . 02 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
As GH and IGF 1 normally increase during adolescence , we investigated the effects of obesity on circulating total and free IGF 1 levels and IGFBP 1 , 2 , and 3 in 19 obese adolescents [ 14 + / 1 yr old ; body mass index ( BMI ) , 34 + / 3 ] , 20 lean adolescents ( 14 + / 1 yr old ; BMI , 23 + / 0 . 5 ) , and 10 lean adults ( 22 + / 0 . 7 yr ; BMI , 22 + / 0 . 7 ) . ^^^ Low IGFBP 1 levels were associated with normal to increased free IGF 1 levels in obese adolescents , even though total IGF 1 values were lower than those in lean adolescents . ^^^ These data suggest that the compensatory hyperinsulinemia that characterizes adolescent obesity chronically suppresses levels of IGFBP 1 , and low IGFBP 1 concentrations may serve to increase the bioavailability of free IGF 1 , which may , in turn , contribute to lower circulating GH , total IGF 1 , and IGFBP 3 concentrations . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We conclude that the well known inhibitory effect of octreotide on the early increase in renal IGF 1 concentration and renal size in diabetes may be mediated through a direct effect on renal IGFBP 1 levels . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 1 and 2 were negatively correlated to weight gain and food conversion efficiency in the ad libitum fed group , while IGF 1 , 2 , IGFBP 1 , 3 and 4 were positively correlated to body weight , weight gain and food conversion efficiency in the food restricted group . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
An inverse relationship was also found between IGFBP 1 levels and body mass index ( r = 0 . 46 , P < 0 . 0001 ) and with IGF 1 levels ( girls only , r = 0 . 41 , P < 0 . 003 ) . ^^^ Consequently , insulin sensitivity , obesity , and IGF 1 are important predictors of IGFBP 1 levels in pubertal children . ^^^ It is possible that insulin mediated suppression of IGFBP 1 in obese children may increase free IGF 1 levels and thus contribute to somatic growth . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We measured serum levels of free IGF 1 and free IGF 2 , total IGF 1 , total IGF 2 , big IGF 2 and IGFBP 1 , IGFBP 2 and IGFBP 3 in patients with NICTH before ( n=14 ) and after surgical removal of the tumour ( n=3 ) . ^^^ In accordance with earlier observations levels of total IGF 1 , total IGF 2 , and IGFBP 3 were decreased , whereas IGFBP 1 and IGFBP 2 were increased in NICTH ( all p values < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum free IGF 1 , total IGF 1 , IGFBP 1 and IGFBP 3 levels in an elderly population : relation to age and sex steroid levels . ^^^ MEASUREMENTS : In a cross sectional study of 218 healthy people ( 103 men , 115 women ) aged 55 80 years we measured serum total and free IGF 1 , IGFBP 1 and IGFBP 3 levels and sex steroids . ^^^ In women only , free IGF 1 was related positively with DHEAS while IGFBP 1 was inversely correlated with DHEAS . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 correlated positively with lean body mass ( DEXA ) and negatively with TBF and IGFBP 1 in both groups . ^^^ Multiple regression analysis revealed that age and IGFBP 1 were the only significant predictors of IGF 1 in CON , whereas IGFBP 3 and , to a lesser extent TBF , were the only independent predictors of IGF 1 in GHDAs . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : To determine the effects of hMG and highly purified FSH on follicular production of the ovarian growth factors transforming growth factor beta 1 ( TGF beta 1 ) , insulin like growth factors 1 and 2 ( IGF 1 and IGF 2 ) , and insulin like growth factor binding proteins 1 and 3 ( IGFBP 1 and IGFBP 3 ) . ^^^ RESULT ( S ) : Compared with highly purified FSH , ovarian hyperstimulation with hMG produced lower levels of TGF beta 1 and IGF 1 and higher levels of IGFBP 1 . ^^^ CONCLUSION ( S ) : In patients undergoing IVF , the follicular expression of TGF beta 1 , IGF 1 , and IGFBP 1 was regulated differently by highly purified FSH compared with a preparation containing FSH and LH in a 1 : 1 ratio ( hMG ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma concentrations of growth hormone , insulin , insulin like growth factors 1 and 2 ( IGF 1 and 2 ) and their binding proteins IGFBP 1 and 3 were measured before and after rhGH , and their relationship with rates of whole body protein turnover was determined in the morning in the postabsorptive state by using L [ 1 13C ] leucine . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The present results show that ovarian hormones and dietary protein content affect the plasma concentrations of IGF 1 , IGFBP 3 and IGFBP 4 and hepatic mRNA of IGF 1 , IGFBP 1 , IGFBP 2 , IGFBP 3 and IGFBP 4 in different manners . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
This is the first study to give a complete overview of the mRNA expression patterns of Igf 1 , Igf 2 , type 1 Igf receptor ( Igf1r ) and six Igf binding proteins ( IGFBP 1 6 ) in embryonic mouse limbs , at various stages of development , by whole mount in situ hybridization ( ISH ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
No relationship was found between the serum levels of insulin and IGF 1 , IGFBP 1 , or IGFBP 3 in obese subjects . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
AIM : To evaluate insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) in borderline hypertension ( BHT ) in relation to plasma lipoprotein and insulin levels , anthropometric variables and 24 h ambulatory blood pressure ( BP ) . ^^^ RESULTS : There was no difference in IGF 1 or IGFBP 1 between BHT and NT men . ^^^ However , subjects with insulin resistance ( IR ) had decreased levels of IGF 1 ( 145 + / 36 vs 153 + / 28 microg / L , p < 0 . 05 ) and IGFBP 1 ( 41 + / 15 vs 52 + / 20 microg / L , p < 0 . 01 ) compared to those without IR . ^^^ CONCLUSION : While there are no differences between BHT and NT men in IGF 1 and IGFBP 1 , both are significantly decreased in IR subjects . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In contrast , no changes in the plasma concentrations of IGFBP 2 , 3 , or 4 were detected in alcohol fed rats at this time point Previous studies have indicated that elevations in glucocorticoids or decreases in insulin or growth hormone might be responsible for the decrease in IGF 1 and / or the increase in IGFBP 1 in other catabolic conditions . ^^^ These data indicate that chronic alcohol feeding in rats decreases IGF 1 and increases IGFBP 1 in the circulation and in skeletal muscle and that these changes appear to be independent of changes in classical hormonal regulators of the IGF system . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Our data show that leucine limitation strongly induces IGFBP 1 without affecting IGF 1 and IGF 2 expression in human HepG 2 cells and in isolated rat hepatocytes . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
DESIGN : In a cross sectional population based study of 218 healthy elderly subjects ( age 55 80 yrs ) fasting free and total insulin like growth factor ( IGF 1 ) , insulin like growth factor binding protein 1 ( IGFBP 1 ) and insulin like growth factor binding protein 3 ( IGFBP 3 ) levels were measured . ^^^ Free and total IGF 1 , IGFBP 1 and IGFBP 3 levels , were not different in subjects with the lowest and the highest Disability Index Score . ^^^ CONCLUSION : Low free IGF 1 and high IGFBP 1 levels are associated with a decreased self reported quality of health , but are not related to physical disability in the elderly . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We measured IGF 1 , IGFBP 1 , GHBP and other factors to clarify the hormonal relation between the nutrition and the linear growth in SO and compared these factors with children with normal short stature ( NS ) . ^^^ Hyperinsulinemia also may increase free IGF 1 by lowering IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : The evaluation included two standard GH provocative tests , GHRH test , night time GH secretion , GHBP ; and IGF 1 , IGFBP 3 and IGFBP 1 before and after 0 . 1 and 0 . 3 U / kg / day of rhGH given i . m . , for 4 days . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Human IGFBP 1 is phosphorylated on serine residues , which increases its affinity for IGF 1 . ^^^ An acidic , presumably phosphorylated , form of human IGFBP 1 inhibits IGF 1 stimulated DNA synthesis in cultured cells , while a less acidic , unphosphorylated form potentiates this function . ^^^ Dephosphorylation of purified phosphorylated rat IGFBP 1 did not affect its affinity for IGF 1 or its specific binding activity , and the dephosphorylated form inhibited DNA synthesis in 3T3 cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
GH , IGF 1 , IGF binding protein ( BP ) 3 , IGFBP 1 , and C peptide were measured at birth and at 2 mo . ^^^ At birth IUGR newborns showed levels of GH and IGFBP 1 significantly higher , and IGF 1 , IGFBP 3 , and C peptide significantly lower than control subjects . ^^^ At 2 mo GH and IGFBP 1 levels decreased , whereas IGF 1 , IGFBP 3 , and C peptide rose , attaining the concentrations found in control subjects at birth . ^^^ These results suggest that : 1 ) the IGF related growth promoting mechanism is impaired in IUGR children at birth but is fully restored at 2 mo ; 2 ) the cord blood levels of GH , IGF 1 , IGFBP 3 , IGFBP 1 , and C peptide are not predictive of the weight and length gain during the first 3 mo of life ; 3 ) IUGR children have at least two different IGFBP 3 proteases , one cation dependent protease that is present at birth and able to yield the major approximately 29 kD IGFBP 3 fragment and a second one , with a different activation timing , which exhibits cation independence and induces the formation of a approximately 18 kD IGFBP 3 form . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Dialysate / serum ratios for IGF 1 , IGF 2 , and IGFBP 1 , 2 , and 3 were significantly increased at 2 h and increased further at 4 h , at which time values averaged 1 . 3+ / 0 . 2 % , 3 . 1+ / 0 . 5 % , 6 . 2+ / 1 . 0 % , 2 . 4+ / 0 . 2 % , and 1 . 3+ / 0 . 2 % of serum levels , respectively . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Neutral gel filtration of serum showed that almost all IGF 1 activity was in the 35 to 45 kDa complex , coincident with IGFBP 1 peak , while the 150 kDa complex was absent , although the acid labile subunit was normally represented . ^^^ IGFBP 1 was reduced ( 216 ng / mL ) , although still in the high range , whereas IGF 1 ( 71 ng / mL ) , IGFBP 3 ( 0 . 62 microg / mL ) , and IGF 2 ( 111 ng / mL ) were only slightly increased . ^^^ In conclusion , we speculate that the increased IGFBP 1 values found in this patient produce 1 ) inhibition of IGF 1 biological activity and , therefore , a resistance to IGF 1 not due to a receptor defect for this hormone ; 2 ) inhibition of formation of the circulating 150 kDa ternary complex and , therefore , an accelerated clearance rate of IGF peptides ; 3 ) inhibition of the feedback action on GH , leading to increased GH levels , which could suggest the diagnosis of GH insensitivity syndrome ; and 4 ) inhibition of body growth . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Proliferation of serum starved EVT cells was stimulated by addition of serum but unaffected by a wide range of IGF 1 , IGF 2 , and IGFBP 1 concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aim of our study was to evaluate concentration of IGF 1 and binding proteins : IGFBP 1 and IGFBP 3 in postmenopausal period . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factors , IGF 1 , IGF 2 , and IGF binding protein ( IGFBP 1 ) appear to play major roles in endometrial development during the menstrual cycle and in the process of implantation . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Chronic LPS administration ( 250 microg / kg daily for 8 days ) significantly decreased body weight , serum levels of IGF 1 and pituitary GH content , whereas it increased circulating IGFBP 3 ( 47 kDa band ) , IGFBP 1 and IGFBP 2 ( 33 kDa band ) and the 24 kDa band ( which possibly corresponds to IGFBP 4 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : To study the influence of type 2 diabetes on the insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) serum levels in an area based population of type 2 patients previously described . ^^^ There was a positive correlation between IGF 1 and insulin levels and also an inverse correlation between IGF 1 and IGFBP 1 levels . ^^^ In multiple stepwise correlation analysis , 37 % of the variability in IGFBP 1 could be explained by BMI , IGF 1 SD score , age , IGF 1 , and fasting blood glucose . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The preferential and site specific increase in IGFBP 1 , 3 , and 5 suggest that these IGFBPs may regulate the local autocrine and / or paracrine actions of IGF 1 and contribute to the pathogenesis of the early manifestations of diabetic nephropathy . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : The mean follicular fluid concentrations of IGF 1 and IGFBP 1 were significantly lower in the `` decreased ' ' ovarian reserve group compared with the `` normal ' ' ovarian reserve group , with no change in estradiol or IGF 2 levels . ^^^ This resulted in a decreased molar IGF 1 : BP ratio and an increased molar IGF 2 : IGFBP 1 ratio . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
After oestrus , the overall means of both groups of ewes showed lower ULF IGF 1 content ( Days 3 and 12 ) , lower plasma IGF 1 concentrations ( Days 3 16 ) , higher endometrial expression of mRNA encoding IGFBP 1 ( Days 12 16 ) and lower endometrial expression of mRNA encoding IGFBP 2 ( Day 8 ) . ^^^ Between Days 0 and 16 after oestrus , the pregnant ewes had lower plasma IGF 1 concentrations and higher endometrial expression of IGFBP 1 mRNA than did the cyclic ewes . ^^^ The concomitant endometrial expression of mRNA encoding IGFBP 1 and IGFBP 2 suggests a role of these binding proteins in the regulation of IGF 1 bioavailability in the uterine environment of the ewe . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
When transplant recipients with and without posttransplant erythrocytosis were compared , similar levels of IGF 1 were found ; however , the group with erythrocytosis had significantly elevated IGFBP 1 and IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To better understand how estradiol and IGF 1 affect the IGF 1 axis , a series of three studies was conducted to examine how estradiol and GH interact to affect the IGF 1 axis and how IGF 1 regulates IGFBP 1 and 3 during GH inhibition or receptor antagonism in adult female rhesus monkeys . ^^^ However , changes in serum insulin in response to the feeding patterns during the acute treatment with IGF 1 , predicted changes in serum IGFBP 1 . ^^^ Although overall serum concentrations of IGFBP 1 are elevated by estradiol and may be differentially affected by IGF 1 treatment , acute changes in IGFBP 1 are more a consequence of changes in serum insulin in response to food intake . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
SHBG , DHEAS , testosterone , free androgen index ( FAI ) and plasma concentrations of IGF 1 and IGFBP 1 were determined in 3 basal samples , before and after therapy . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The effects of GH on renal IGF 1 and IGFBP 1 , 2 , 3 , 4 , and 5 following Nx were examined in spontaneous dwarf rats ( SDRs ) which have a complete and specific lack of GH among pituitary hormones . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Therefore , we examined in 25 healthy athletes the effects of three different durations of three types of exercise incremental ergometer cycling exercise ( ICE ) , long distance Nordic ski race ( NSR ) and a treadmill simulated soccer game ( TSG ) lasting 20 min , 3 h , and 2 10 45 min separated by a 15 min half time rest respectively , on plasma concentrations of growth hormone ( [ GH ] ) , insulin like growth factor 1 ( [ IGF 1 ] ) and its binding proteins 1 and 3 ( [ IGFBP 1 ] , [ IGFBP 3 ] ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : We determined the effects of continuous combined nonoral and oral estrogen progestin therapy on plasma levels of insulin like growth factor 1 ( IGF 1 ) and its binding proteins 1 ( IGFBP 1 ) and 3 ( IGFBP 3 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum DHEA , DS , sex steroids , IGF 1 , IGFBP 1 , IGFBP 3 , growth hormone binding protein ( GHBP ) levels and lipid profiles as well as body composition ( by DEXA ) and muscle strength ( by MedX testing ) were measured at baseline and after each treatment . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
METHODS : In four females known with congenital partial lipodystrophy , hyperinsulinaemia with acromegaloid features , the number and affinity of the IGF 1 receptors on peripheral blood mononuclear cells ( PBMCs ) , and the concentration of circulating insulin , total and free IGF 1 , IGFBP 1 and IGFBP 3 levels were measured in the fasting and the fed state . ^^^ Total IGF 1 , free IGF 1 and IGFBP 3 levels did not differ but serum IGFBP 1 levels were lower in lipodystrophy subjects than in healthy controls . ^^^ The effects of IGF 1 stimulation on thymidine uptake by PBMCs of lipodystrophy subjects in the absence of IGFBP 1 were not different from healthy controls cultures in vitro . ^^^ When a combination of IGFBP 1 ( in a concentration comparable to the fasting serum IGFBP 1 levels in lipodystrophy patients found in our study ) and IGF 1 was added to PBMC cultures from lipodystrophy patients no decrease in thymidine uptake by PBMCs was found . ^^^ CONCLUSIONS : In the four subjects with lipodystrophy hyperinsulinaemia , lowered free IGF 1 and IGFBP 1 levels , but increased free IGF I / IGBP 1 ratios were observed . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Biosynthesis of IGFBP 3 was stimulated dose dependently by IGF 1 and 2 , while IGFBP 1 , 2 and 4 were not affected . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Between 1 7 days post lesion ( dpl ) , in the acute phase following a penetrant wound to the CNS , IGF 2 and IGF IIR protein , but not messenger RNA , were colocalized , with IGF 1 , IGF IR , and IGFBP 1 , 2 , 3 , and 6 , to neurons , macrophages , astrocytes , and microglia within the damaged tissue . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MAIN OUTCOME MEASURE ( S ) : Levels of GH , IGF 1 , IGFBP 1 , IGFBP 3 , insulin , and C peptide . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In addition to a direct stimulation of IGF 1 and ALS expression , GH inhibits IGFBP 1 serum levels and IGFBP 2 expression in an indirect manner , possibly facilitating enhanced IGF bioavailability to target tissues . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) is a peptide growth factor , and its activity is modulated by interaction with the family of IGF binding proteins ( IGFBP 1 to 6 ) . ^^^ With insulin treatment , the levels of IGF 1 , IGFBP 1 and 4 were normalized and glomerular hypertrophy was prevented . ^^^ Initial glomerular hypertrophy of diabetic nephropathy is a related IGF 1 action , which may be modulated by IGFBP 1 and 4 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 1 inhibits the receptor binding and biological actions of IGF 1 in the endometrium and in cultured human trophoblastic cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
However , addition of dephosphorylated IGFBP 1 , derived from in vivo dephosphorylation of the phosphorylated form , stimulated the growth of both cell lines , independent of interaction with IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Women with PCOS exhibited elevations of all androgens as well as unbound oestradiol , insulin and non IGFBP 1 bound IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
As for the peripheral limb of the GH insulin like growth factor 1 ( IGF 1 ) axis , high free IGF 1 , low IGF binding proteins 1 ( IGFBP 1 ) and 2 ( IGFBP 2 ) , normal or high IGFBP 3 and increased GH binding protein ( GHBP ) circulating levels have been described in obesity . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The goals of this study were to determine whether the long term training regimens experienced by competitive collegiate swimmers would result in altered levels of total and free serum insulin like growth factor 1 ( IGF 1 ) as well as IGF binding proteins ( BP ) IGFBP 1 and 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In AN , the levels of GH binding protein , free and total IGF 1 , free IGF 2 , and IGFBP 3 were significantly reduced ; total IGF 2 , IGFBP 2 , and IGFBP 4 levels were unchanged ; and IGFBP 1 was increased . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In conclusion , a suppressive effect of GH on IGFBP 1 appears to be unmasked in the presence of low or suppressed insulin levels , making GH a potential regulator of IGF 1 bioactivity in a hitherto unrecognized way . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Expression of insulin like growth factor binding protein 1 ( IGFBP 1 ) is up regulated following partial hepatectomy and IGFBP 1 can modulate both the metabolic and mitogenic effects of insulin like growth factor 1 ( IGF 1 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and IGFBP 1 mRNAs were expressed in all uterine tissues throughout this period . ^^^ Our results suggest that coordinated temporal and spatial expression of IGF 1 and its binding proteins ( IGFBP 1 , 3 , 4 , 5 , and 6 ) could play important roles in perinatal rodent uterine development . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To study this phenomenon we have investigated the endocrine status , including IGF 1 and its binding proteins IGFBP 1 and IGFBP 3 , in children referred for follow up at various time intervals after surgery . ^^^ IGF 1 , IGFBP 3 , IGFBP 1 and prolactin serum concentrations were evaluated in fasting samples . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Because IGFBP 1 inhibits many anabolic actions of IGF 1 , increases in IGFBP 1 may be partly responsible for the decrease in lean body mass observed in catabolic / inflammatory conditions . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Chronic liver disease was characterised by low serum IGF 1 , IGF 2 , IGFBP 3 and ALS levels with raised IGFBP 1 and 2 levels . ^^^ Growth post OLT correlated positively with serum IGF 1 and negatively with IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The liver is an important endocrine organ producing potent anabolic growth factors such as IGF 1 ( insulin like growth factor 1 ) and its major binding proteins , called IGFBP 1 , 2 and 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Different inhibitory actions of IGFBP 1 , 2 and 4 on IGF 1 effects in vascular smooth muscle cells . ^^^ We have studied how IGFBP 1 , 2 and 4 modulate IGF 1 induced DNA and protein synthesis in cultured rat VSMCs . ^^^ IGFBP 1 and IGFBP 4 acted in an inhibitory manner on IGF 1 induced DNA synthesis with calculated IC 50 values of 1 . 6 nM and 6 . 2 nM respectively . ^^^ IGFBP 1 , 2 and 4 inhibited IGF 1 induced protein synthesis in a similar way . ^^^ In conclusion , IGFBP 1 , 2 and 4 , of which IGFBP 2 and 4 may be locally derived , act as inhibitors with different potencies on IGF 1 effects in VSMCs . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Compared to normal subjects , free IGF 1 and IGFBP 3 were significantly elevated , and IGFBP 1 was decreased upon AMI . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
A significant increase in IGFBP 1 levels was observed during treatment with 80 microg / kg 10 day IGF 1 , reflecting the inhibitory effect of rhIGF 1 on insulin secretion . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Total alanine scanning mutagenesis of insulin like growth factor 1 ( IGF 1 ) identifies differential binding epitopes for IGFBP 1 and IGFBP 3 . ^^^ We have systematically investigated the binding contribution of each IGF 1 amino acid side chain toward IGFBP 1 and IGFBP 3 , combining alanine scanning mutagenesis and monovalent phage display . ^^^ In contrast , binding of IGFBP 1 was more sensitive to alanine substitutions in IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) , a polypeptide known to affect bone metabolism , and two of its binding proteins ( IGFBP 1 , IGFBP 3 ) were measured preoperatively and after 6 months . ^^^ We found consistently lower levels of IGF 1 and IGFBP 3 and a tendency to higher levels of IGFBP 1 in the patients with hip fractures , who also had a lower total body mass , lower fat mass and bone mineral density than the coxarthrosis group , indicating a more catabolic state in the patients with hip fracture , even 6 months after the trauma . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum was collected at baseline and at intervals throughout the study for the measurement of total IGF 1 , IGF 2 , IGFBP 1 , 2 , 3 , free insulin and growth hormone ( GH ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : Serum IGF 1 and IGF 2 were measured by RIA while IGFBP 1 3 were measured by Western ligand blot ( WLB ) and compared with determinations by specific immunoassays . ^^^ Stepwise ( backwards ) multiple regression analyses showed that the changes in IGF 1 and IGF 2 , and age correlated with the change in serum IGFBP 1 . ^^^ CONCLUSION : GH significantly increased serum IGF 1 , IGF 2 , IGFBP 3 , and IGFBP 4 and decreased serum IGFBP 1 and IGFBP 2 in post menopausal women . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The autocrine release of IGF 1 , IGF 2 and IGFBP 1 through 3 was determined by specific RIAs and western ligand blotting . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In contrast , IGF 1 or IGF 2 ( 6 . 5 nM ) preferentially induced the accumulation of IGFBP 3 ( 1 . 9 fold ) and to a lesser extent of IGFBP 4 , but did not show any effect on IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : IGFBP 1 and insulin were measured in samples drawn every 4 h over the 24 h period while IGF 1 , IGF 2 , IGFBP 2 and IGFBP 3 were determined in samples collected at the end of the study . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We investigated serum IGF 1 , free IGF 1 , IGFBP 1 , IGFBP 3 and insulin levels in 36 obese and 39 non obese healthy children . ^^^ IGF 1 , free IGF 1 , free IGF I / IGF 1 and IGFBP 1 levels in the obese children were not significantly different from those in the control group . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
DESIGN : Cross sectional analysis of the relationship between insulin resistance syndrome variables and concentrations of IGF 1 , IGF 2 , IGFBP 1 and IGFBP 3 in 80 subjects with NIDDM . ^^^ Concentrations of IGF 1 are linked to HDL cholesterol , and this is not explained by levels of IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma insulin , glucose , growth hormone , glucagon , IGF 1 , free IGF 1 , IGFBP 1 , 2 , 3 and leptin were measured . ^^^ During insulin withdrawal , IGFBP 1 increased by more than 6 fold ( from 32+ / 8 to 205+ / 17 ng / mL , P < 0 . 001 ) , IGFBP 3 increased significantly ( from 2631+ / 118 to 3053+ / 101 ng / mL , P < 0 . 001 ) , and total IGF 1 levels declined modestly ( from 226+ / 33 to 182+ / 26 ng / mL , P < 0 . 001 ) . ^^^ Within 2 h of insulin replacement , the changes in circulating concentrations of IGFBP 1 and IGFBP 3 were partially reversed , and free IGF 1 levels rebounded to 0 . 54+ / 0 . 22 ng / mL ( P < 0 . 1 vs . insulin withdrawal ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In active MS lesions , the expression of IGF 1 , insulin and IGFBP 1 was detected in hypertrophic astrocytes while that of IGF 2 and IGFBP 2 and 3 was confined to foamy macrophages within lesions and activated microglia in adjacent white matter . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVES AND METHODS : Our goal was to describe nutritional homeostasis in healthy exclusively breastfed infants ( n = 175 ) during their first 5 d , by cross sectional measurements of body weight , blood glucose , plasma insulin , insulin like growth factor 1 ( IGF 1 ) , insulin like growth factor binding protein 1 ( IGFBP 1 ) , free fatty acids ( FFA ) , glycerol , ketone ( 3 OH butyric acid ) and lactate . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
CONCLUSIONS : The results of this study suggest that , while overexpression of IGFBP 1 attenuates IGF 1 action in vitro , it enhances thyroid growth in vivo , presumably as a result of perturbations in thyroid function at multiple levels . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Oxytocin treated food restricted females had more body fat and lower plasma levels of IGF 1 , IGFBP 1 and IGFBP 3 compared with saline treated counterparts . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : Serum levels of IGF 1 , free IGF 1 , IGFBP 3 and IGFBP 1 were measured by immunoradiometric assay . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Northern blot analysis of total mRNA isolated from the tumour demonstrated high expression of the IGF 2 gene and abundant 1 . 1 kb IGFBP 6 transcript , while the genes encoding IGFBP 3 , 4 and 5 were only weakly expressed and mRNA of IGFBP 1 , 2 and IGF 1 could not be detected . mRNAs for the IGF type 2 receptor could be easily demonstrated , whereas those for the insulin and IGF type 1 receptor were hardly detectable . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
DESIGN , PATIENTS AND MEASUREMENTS : Serum IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 , osteocalcin ( OST ) , bone specific alkaline phosphatase ( BAP ) , urinary deoxypyridinoline ( DPYD ) and N telopeptide of type 1 collagen ( NTX ) were measured in 31 premenopausal women aged 31 43 and 65 postmenopausal women aged 47 60 : this latter group comprised 30 normal healthy women and 35 osteoporotic women . ^^^ RESULTS : Compared with premenopausal women or normal postmenopausal women , serum IGF 1 and IGFBP 3 levels were significantly lower in osteoporotic postmenopausal women while no significant differences in serum levels of IGF 2 , IGFBP 1 and IGFBP 2 were observed . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Splanchnic exchange of insulin like growth factor binding protein 1 ( IGFBP 1 ) , IGF 1 and acid labile subunit ( ALS ) during normo and hyper insulinaemia in healthy subjects . ^^^ OBJECTIVE : The main source of circulating IGF 1 , insulin like growth factor binding protein 1 ( IGFBP 1 ) and acid labile subunit ( ALS ) is considered to be the liver , but their production rates have not been determined in healthy individuals . ^^^ Thus , the splanchnic exchange of IGFBP 1 , IGF 1 , ALS and glucose were studied . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Clinical studies suggest that circulating concentrations of insulin like growth factor binding protein 3 ( IGFBP 3 ) are decreased or unaffected by IGF 1 administration , whereas acute increases in IGF 1 may increase serum IGFBP 1 . ^^^ In addition , serum IGF 1 and IGFBP 3 appeared to be regulated diurnally , even during IGF 1 infusion , whereas IGFBP 1 and insulin were affected by the timing of food intake . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : The African American girls were older and sexually more mature and had higher fat mass , higher serum insulin and free IGF 1 concentrations , higher serum free IGF 1 to total IGF 1 ratio , but lower serum IGFBP 1 concentrations than the white girls . ^^^ CONCLUSIONS : Higher serum insulin concentrations in the African American girls are associated with lower serum IGFBP 1 concentrations and increased bioavailability of free IGF 1 , which may contribute to their accelerated growth compared with their white counterparts . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum levels of free IGF 1 ( fIGF 1 ) were elevated ( 5 . 9 + / 0 . 3 vs . 2 . 7 + / 0 . 3 ng / mL ; P < 0 . 001 ) in inverse relation with IGFBP 1 ( r = 0 . 31 ; P = 0 . 046 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
CONCLUSIONS : These results demonstrate that CD patients show significant changes in serum IGF 1 , in younger children , and IGFBPs ( particularly IGFBP 1 ) , in older children and adolescents , correlating with clinical course and response to dietary treatments . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Effect of protein intake on plasma and erythrocyte free amino acids and serum IGF 1 and IGFBP 1 levels in rats . ^^^ Free AA in plasma and RBC were determined by reversed phase high pressure liquid chromotography , and IGF 1 , IGFBP 1 , and insulin plasma levels were determined by RIA . ^^^ Rats fed the low protein ( 6 % ) diet were growth retarded and had lower serum IGF 1 levels and higher serum IGFBP 1 levels than the other two groups ( P < 0 . 0001 ) . ^^^ When the groups were combined , both RBC and plasma EAA to NEAA ratios were positively correlated to IGF 1 ( r = 0 . 76 and 0 . 80 , respectively ; P < 0 . 0001 ) and inversely correlated to IGFBP 1 levels ( r = 0 . 67 , P < 0 . 001 and r = 0 . 78 , P < 0 . 0001 , respectively ) . ^^^ A significant inverse correlation was found between RBC glutamate and IGF 1 ( r = 0 . 85 , P < 0 . 0001 , n = 25 ) and insulin ( r = 0 . 72 , P < 0 . 001 , n = 21 ) , and a positive correlation was found for IGFBP 1 ( r = 0 . 78 , P < 0 . 0001 , n = 24 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Reference values for IGF 1 , IGFBP 1 , IGFBP 3 and osteocalcin in healthy children in Zaragoza ] . ^^^ Immunoradiometric assays were used to determine basal serum IGF 1 , IGFBP 1 , IGFBP 3 and osteocalcin concentrations . ^^^ IGF 1 , IGFBP 1 , IGFBP 3 and osteocalcin concentrations differ during the pubertal period according to age . ^^^ Sex did not influence IGF 1 or IGFBP 1 concentrations and there were punctual differences in IGFBP 3 and osteocalcin levels between girls and boys . ^^^ CONCLUSIONS : Sincere there are differences in IGF 1 , IGFBP 1 , IGFBP 3 and osteocalcin reference values according to age , sex , pubertal stage and immunoassays , it is necessary to establish the reference values for each population and laboratory in accordance with these parameters . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In addition to measuring IGF 1 , IGF 2 and IGFBP 3 , serum IGFBP 1 , 2 , 4 and 5 were measured . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Testosterone was administered to peripubertal rats and the responses of mRNA of GH receptor , IGF 1 , IGF 1 receptor and IGF binding proteins 1 and 3 ( IGFBP 1 and IGFBP 3 ) as well as circulating IGF 1 were evaluated in two time related models : over 12 h after a single injection ( short term study ) and 10 days after continuous administration ( long term study ) . ^^^ These data suggest that the effect of testosterone on growth ( as assessed by weight gain ) is small and is not mediated by changes in hepatic gene expression of IGF 1 , IGF 1 receptor , IGFBP 1 , IGFBP 3 or circulating IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Associations of IGF 1 , IGFBP 1 and IGFBP 3 on intrauterine growth and early catch up growth . ^^^ Fetal cord blood IGF 1 , IGFBP 1 and IGFBP 3 levels of appropriate for gestational age ( AGA ) and intrauterine growth retardation ( IUGR ) babies are studied and followed up for 6 9 months , reevaluated for anthropometric measures and the effects of IGF 1 , IGFBP 1 and IGFBP 3 on fetal growth and early catch up growth is investigated . 23 AGA and 21 IUGR babies , totally 44 newborns , were included in the study protocol . ^^^ IGF 1 and IGFBP 3 levels were found to be high in AGAs with respect to IUGR babies and IGFBP 1 is found to be high in IUGR with respect to AGAs . ^^^ A good correlation was found between birth weight , postnatal weight and postnatal height and IGF 1 and IGFBP 3 levels ( p < 0 . 05 ) but not with IGFBP 1 levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In summary , 1 ) acute exercise transiently increased all components of the IGF 1 ternary complex , possibly due to mobilization of preformed intact complexes ; 2 ) GH pretreatment augmented the exercise induced changes in ternary complexes ; 3 ) postexercise IGFBP 1 increments may protect against delayed onset hypoglycemia ; 4 ) serum total IGF 1 , IGFBP 3 , and ALS may be suitable markers of GH abuse ; and 5 ) differences in disappearance times altered the sensitivity of each marker for detecting GH abuse . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : Compared with controls , estrogen treated monkeys had 2 fold higher SF levels of IGF 1 ( P < 0 . 001 ) , 1 . 7 fold higher IGF 2 ( P < 0 . 006 ) , 5 . 9 fold higher IGFBP 1 ( P < 0 . 02 ) , and 2 . 5 fold higher IGFBP 3 ( P < 0 . 001 ) . ^^^ Estrogen plus progesterone treated monkeys had SF levels of IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 3 that were intermediate between the levels in the control and estrogen groups , except that the level of IGFBP 3 was significantly greater than that in the control group ( P < 0 . 001 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Because the anatomical distribution of IGFBPs is likely to dictate IGF bioavailability , we determined the cellular distribution and expression of IGF 1 , IGF 2 , and IGFBP 1 to IGFBP 6 in epiphyseal growth plates of the fetal sheep , using immunocytochemistry and in situ hybridization . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
METHODS : Nutritional status was assessed in 42 women ( 80+ / 7 years old ) using the body mass index ( BMI ) , triceps skin fold , arm muscle circumference and serum levels of insulin like growth factor ( IGF 1 ) and its binding protein ( BP ) IGFBP 1 . ^^^ RESULTS : Low BMI ( < == 20 ) and reduced IGF 1 and IGFBP 1 levels were detected in 50 % of the patients . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : Non diabetic obese subjects had increased free IGF 1 and 2 , total IGF 2 , IGFBP 3 and GHBP , reduced IGFBP 1 and 2 ( p < 0 . 05 ) , but normal total IGF 1 , when compared to lean subjects . ^^^ Also IGFBP 1 and total IGF 1 were normal in obese Type 2 diabetics , whereas free and total IGF 2 and IGFBP 3 remained elevated to a similar extent as in simple obesity ( p < 0 . 05 ) . ^^^ In contrast , free IGF 1 and 2 and GHBP were markedly reduced , whereas IGFBP 1 and 2 were increased ( p < 0 . 05 ) . ^^^ However , some changes became accentuated ( GHBP and IGFBP 2 ) , while others ( free IGF 1 and IGFBP 1 ) were no longer present . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Fasting serum levels of IGFBP 1 , IGFBP 2 , IGFBP 3 , IGF 1 and free IGF 1 were determined using appropriate immunoenzymatic , radioimmuno or immunoradiometric assays . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
PATIENTS AND DESIGN : We measured serum levels of insulin , IGF 1 , IGFBP 1 , IGFBP 3 and IGF bioactivity in 77 fasting subjects ( 43 male ) mean age 9 . 6 years ( range 2 . 99 17 . 98 years ) . ^^^ Insulin levels were also low and correlated with IGF 1 and IGFBP 3 ( r = 0 . 42 , P = 0 . 0004 , and r = 0 . 45 , P = 0 . 0002 , respectively ) whereas levels of IGFBP 1 were inversely related to those of IGF 1 and insulin ( r = 0 . 43 , P = 0 . 0004 , r = 0 . 52 , P < 0 . 0001 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : The patients had reduced serum free IGF 1 ( 53 % ) and increased levels of total IGF 2 ( 40 % ) , IGFBP 1 ( 546 % ) , and IGFBP 2 ( 270 % , P < 0 . 05 ) . ^^^ In patients , free IGF 1 levels correlated positively with CCr ( r 2 = 0 . 38 , P < 0 . 002 ) and inversely with IGFBP 1 ( r 2 = 0 . 69 , P < 0 . 0001 ) and IGFBP 2 ( r 2 = 0 . 41 , P < 0 . 0007 ) , whereas CCr was inversely correlated with levels of IGFBP 1 ( r 2 = 0 . 48 , P < 0 . 0001 ) and IGFBP 2 ( r 2 = 0 . 63 , P < 0 . 0001 ) . ^^^ CONCLUSIONS : These data strongly support the hypothesis that CRF related growth failure and tissue catabolism are caused by an increased concentration of circulating IGFBP 1 and 2 , resulting in low serum levels of free IGF 1 and thus IGF 1 bioactivity . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We also measured the serum levels of insulin , total and free IGF 1 , and IGFBP 3 to investigate their relationships to the IGFBP 1 phosphorylation status in obese subjects . ^^^ A stepwise regression analysis of the combined group revealed that only the total IGFBP 1 level was an independent predictor of the free IGF 1 concentration ( P < 0 . 001 ) . ^^^ CONCLUSION : The present study shows that both total and nonphosphorylated IGFBP 1 concentrations are decreased in obese children and the increased free IGF 1 level in obese children is related to the reduced total IGFBP 1 level , but unrelated to the change in the IGFBP 1 phosphorylation status . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Thus , we postulate that the insulin resistance of puberty induces compensatory hyperinsulinaemia , which in turn suppresses circulating levels of IGFBP 1 , which in turn leads to increased levels of free IGF 1 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Poor glycaemic control in type 1 diabetes is associated with elevated serum IGFBP 1 levels and reduced rather than elevated serum IGF 1 levels . ^^^ IGFBP 1 has been proposed as one of the IGF 1 inhibitors in the serum of diabetics . ^^^ Lowered IGF 1 and increased IGFBP 1 levels in the blood may thus result in decreased IGF 1 bioavailability at the tissue level . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Blood was drawn , after an overnight fast , for the determination of serum IGF 1 and IGFBP 1 levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The IGF 1 , IGFBP 1 , and 3 content was evaluated by specific immunoassays and / or immunoblotting with anti IGFBP specific antiserum . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Baseline serum IGF 1 and IGFBP 3 were low , while IGFBP 1 and IGFBP 2 were raised . ^^^ IGF 1 and IGFBP 1 did not change with feeding . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Levels of serum total IGF 1 , total IGF 2 , IGFBP 1 , IGFBP 2 and IGFBP 3 were determined experimentally , while those of IGFBP 4 , IGFBP 5 and IGFPB 6 , as well as the 12 affinity constants of association of the two IGFs with the six IGFBPs , were taken from published values . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Its increase in FGR could be the cause or consequence of impaired placental perfusion , but high IGFBP 1 concentrations might further reduce the availability of maternal IGF 1 to the placenta . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Acting on hepatocytes , glucagon promotes ( and insulin inhibits ) cAMP dependent mechanisms that down regulate lipogenic enzymes and cholesterol synthesis , while up regulating hepatic LDL receptors and production of the IGF 1 antagonist IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Expression of mRNA for IGF 1 , IGF 2 , type 1 IGF receptor , IGFBP 1 , oestrogen receptor ( ER ) and progesterone receptor ( PR ) in the endometrium was explored by a semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ In conclusion , up regulation of IGFBP 1 collaboratively with down regulation of IGF 1 may account for the protective effect of progesterone in HRT on the endometrium . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aim of our study was to determine the effects of 36 h fasting on 8 h diurnal GH , insulin and glucose levels as well as on basal IGF 1 , IGFBP 3 , acid labile subunit ( ALS ) , IGFBP 1 , GHBP and free fatty acid ( FFA ) levels . ^^^ STUDY DESIGN : In all subjects we studied the effects of 36 h fasting on 8 h daytime GH , insulin and glucose levels ( assay every 30 min from 0800 h to 1600 h ) as well as on basal IGF 1 , IGFBP 3 , ALS , IGFBP 1 , GHBP and FFA levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In patients with renal osteodystrophy , an elevation of some IGF binding proteins ( IGFBPs ) has been described , but there is no study measuring serum levels of both IGF 1 and IGF 2 as well as IGFBP 1 to 6 in different forms of renal osteodystrophy and hyperparathyroidism . ^^^ Serum levels of total and free IGF 1 , IGF 2 , IGFBP 1 to 6 , and biochemical bone markers including intact parathyroid hormone ( PTH ) , bone alkaline phosphatase ( B ALP ) , and osteocalcin ( OSC ) were measured by specific immunometric assays . ^^^ In all subjects , free and total IGF 1 levels showed significant negative correlations with IGFBP 1 , IGFBP 2 , and IGFBP 4 ( that is , inhibitory IGF system components ) and significant positive correlations with IGFBP 3 and IGFBP 5 ( that is , stimulatory IGF system components ) . ^^^ CONCLUSION : Patients with primary and secondary hyperparathyroidism showed lower levels of the putative stimulatory IGFBP 5 but higher levels of IGFBP 1 , 2 , 3 , and 6 , whereas total IGF 1 and IGF 2 levels were not or only moderately increased . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : Diabetes was associated with increased renal expression of IGFBP 1 mRNA ( diabetes 824+ / 236 vs control 264+ / 76 arbitrary units , P < 0 . 01 ) and decreased expression of mRNAs for IGF 1 ( diabetes 39+ / 7 vs control 185+ / 23 arbitrary units , P < 0 . 001 ) and IGFBP 4 ( diabetes 139+ / 25 vs control 383+ / 54 arbitrary units , P < 0 . 001 ) . ^^^ Aminoguanidine treatment inhibited the effects of diabetes on renal expression of mRNA for IGF 1 , IGFBP 1 and IGFBP 4 . ^^^ The changes in IGF 1 and IGFBP 1 mRNA levels were reflected in altered peptide levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Moderately decreased IGF 1 and increased IGFBP 1 plasma levels contrasted with the sustained increase in GH secretion that we recently described , thereby suggesting that endotoxin causes a state of resistance to GH . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor binding protein 1 ( IGFBP 1 ) and IGF 1 during oral and transdermal estrogen replacement therapy : relation to lipoprotein ( a ) levels . ^^^ Plasma IGFBP 1 , insulin like growth factor 1 ( IGF 1 ) and lipoprotein ( a ) ( Lp ( a ) ) were determined at baseline , 3 and 6 months . ^^^ The baseline levels of estrone ( E 1 ) , E 2 , IGFBP 1 , IGF 1 and Lp ( a ) did not differ between the groups . ^^^ During oral ERT , IGFBP 1 levels increased by 104 % ( P < 0 . 001 ) , whereas IGF 1 levels decreased by 13 % ( mean , P < 0 . 05 ) . ^^^ IGF 1 and IGFBP 1 levels remained unchanged in the transdermal group . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 levels were significantly lower ( P < 0 . 05 ) , and insulin like growth factor binding proteins 1 and 3 ( IGFBP 1 and IGFBP 3 ) significantly higher than an age matched healthy normal group . ^^^ Resting IGF 1 levels were significantly ( P < 0 . 05 ) elevated ( 70 % ) by the resistance training whereas no significant changes occurred in IGFBP 1 and IGFBP 3 levels . ^^^ IGFBP 1 / IGF 1 and IGFBP 3 / IGF 1 ratios were significantly decreased ( approximately 50 % ) as a result of resistance training ( P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Therefore , we studied the effects of IGFBP 1 on IGF 1 induced somatic and organ growth in pituitary deficient Snell dwarf mice . ^^^ Human GH , IGF 1 , IGFBP 1 , and a preequilibrated combination of equimolar amounts of IGF 1 and IGFBP 1 were administered sc during 4 weeks . ^^^ Coadministration of IGF 1 with IGFBP 1 neutralized the stimulating effects of IGF 1 on body length and weight as well as on the femoral muscles and testes . ^^^ The effect of IGFBP 1 plus IGF 1 on kidney weight was not significantly greater than the effect of IGFBP 1 alone . ^^^ Western ligand blotting showed induction of the IGFBP 3 doublet as well as IGFBPs with molecular masses of 24 kDa , most probably IGFBP 4 , by human GH , IGF 1 alone , and IGF 1 in combination with IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Also , serum IGF 1 and the 30 kDa IGFBPs ( IGFBP 1 and 2 ) were significantly increased in these groups . ^^^ Serum IGFBP 3 levels increased in the IGF 1 group along with increased hepatic IGFBP 1 and 3 mRNA levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma concentrations of LH , FSH , estradiol , free testosterone , IGF 1 , IGFBP 1 , sex hormone binding globulin , and insulin were evaluated . ^^^ A nonsignificant increase in plasma IGF 1 levels was observed after metformin ( 276 + / 48 vs . 291 + / 71 mcg / L ) , with a significant increase in plasma IGFBP 1 levels ( 0 . 56 + / 0 . 2 vs . 0 . 98 + / 0 . 38 mcg / L ; P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Using RNAase protection analysis ( RPA ) , we examined the gene expression for IGF 1 , IGF 2 , IGF1R , M6P / IGF2R , IGFBP 1 and IGFBP 2 in a series of hepatoblastomas with corresponding normal liver from the same individuals . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and IGFBP 3 levels were lower and those of IGFBP 1 higher in nonsuppressor than in suppressor cases and in healthy controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : To examine ethnic differences in adrenal androgen production , IGF 1 , and IGFBP 1 and 3 in relation to bone age , insulin , and body composition in healthy prepubertal girls . ^^^ METHODS : Serum levels of DHEA S , androstenedione , IGF 1 , and IGFBP 1 and 3 were examined in relation to bone age , insulin , and body composition ( determined by dual energy 10 ray absorptiometry ) in 47 ( 19 Caucasian , 9 African American , 19 Mexican American ) healthy prepubertal girls aged 7 . 5 9 . 0 years . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The IGF peptides ( IGF 1 and 2 ) mediate their effects through the type 1 IGF receptor ( IGF 1R ) , while the IGF binding proteins ( IGFBP 1 to 6 ) modulate their interaction with the receptor . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In females , IGF 1 and IGFBP 1 , 2 , 3 , and 4 levels did not differ significantly among heterozygous , homozygous , and wild type animals . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The liver is the major source of IGF 1 and at least two IGFBPs ( IGFBP 1 and IGFBP 3 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Blood samples were obtained for the measurement of BG at 0200 , 0400 and 0700 , and of insulin , total IGF 1 ( tIGF 1 ) , fIGF 1 , IGFBP 1 and IGFBP 3 at 0700 . ^^^ The morning increase in BG ( deltaBG ( 4 7 ) ) correlated significantly with fIGF 1 SDS ( r= 0 . 352 , p=0 . 0152 ) and IGFBP 1 SDS ( r=0 . 438 , p=0 . 0021 ) , but did not correlate significantly with the fIGF 1 level itself or the ratio of fIGF 1 to tIGF 1 ( f / t IGF 1 ratio ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The concentrations of IGF 1 , IGFBP 1 , SHBG , LH , FSH , testosterone , cortisol , PRL , estradiol , were estimated . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
GH treated CRF children show catch up growth that correlates positively with a rise in each component of the 150 kDa serum ternary complex ( IGF 1 or II / IGFBP 3 or 5 / acid labile subunit ) ; IGFBP 1 , 2 and 6 levels do not rise , but serum IGF bioactivity does . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
There was a positive correlation between IGFBP 4 and IGFBP 2 ( r=0 . 46 , P < 0 . 001 ) ; IGFBP 5 was positively correlated with IGF 1 ( r=0 . 59 , P < 0 . 001 ) , IGF 2 ( r=0 . 42 , P < 0 . 001 ) and IGFBP 3 ( r=0 . 47 , P < 0 . 001 ) and inversely correlated with IGFBP 1 ( r= 0 . 41 , P < 0 . 001 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In the present study , serum and urine IGFBP ( IGFBP 1 , 2 , and 3 ) and serum IGF 1 and 2 levels were measured by radioimmunoassay ( RIA ) in 27 patients with type 1 diabetes aged 9 to 48 years compared with 9 healthy subjects aged 10 to 28 years . ^^^ The macroalbuminuria group ( > 500 mg / 24 h ) had elevated serum IGFBP 1 and 2 and decreased IGF 1 levels ( P < . 01 5 normal controls ) . ^^^ The changes in serum IGFBP concentrations ( eg , increases in IGFBP 1 and IGFBP 2 ) may lead to alterations in the availability of IGF 1 to peripheral tissues . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum IGF 1 and IGFBP 3 increased with rHGH treatment , whereas serum IGFBP 1 decreased compared with placebo ( p < . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The changes are potentially related to a decrease in IGF 1 availability and / or to an IGF 1 independent role of IGFBP 1 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and 2 , and IGFBP 1 , 2 , 4 , 5 , and 6 did not interfere . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In conclusion , secretion of IGFBP 1 is increased during luteolysis , and may inhibit the steroidogenic effects of insulin like growth factor 1 ( IGF 1 ) , but no evidence was found to implicate IGFBP 1 in the embryotoxic effect of regressing CL . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
By late pregnancy , a 25 % reduction in maternal IGF 1 concentration and a two to threefold increase in maternal IGFBP 1 concentration ( P < 0 . 05 ) associated with shearing were observed . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 , IGFBP 1 and IGFBP 2 mRNAs were not detected in PT and PD . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Moreover , the increased IGFBP 1 levels might curtail the negative IGF 1 feedback in AN . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MATERIALS AND METHODS : This study searched for the mRNA expression patterns of components of the IGF system : IGF 1 and IGF 2 , IGF receptors 1 and 2 ( IGF 1R , IGF 2R ) , IGF binding proteins 1 6 ( IGFBP 1 6 ) ) in the most frequent human gastroenteropancreatic neuroendocrine tumours ( gastrinomas , insulinomas , tumours associated with carcinoid syndrome and functionally inactive tumours ) employing reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ In addition , 12 pairs of significantly coexpressed IGF system components were detected ( IGF 1 < > IGF 1R , IGF 1 < > IGF 2R , IGF 1 < > IGFBP 3 , IGF 1 < > IGFBP 6 , IGFBP 3 < > IGF 1R , IGFBP 6 < > IGF 1R , IGFBP 1 < > IGF 2R , IGFBP 3 < > IGF 2R , IGFBP 5 < > IGF 2R , IGFBP 3 < > IGFBP 5 , IGFBP 3 < > IGFBP 6 , IGFBP 5 < > IGFBP 6 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor ( IGF ) binding protein 1 ( IGFBP 1 ) is a 28 kDa plasma protein that binds to IGF 1 and IGF 2 with high affinity . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aim of this study was to clarify the relationship between insulin like growth factor 1 ( IGF 1 ) , the serum levels of which are influenced by nutrition and which by itself promotes amino acid uptake , and insulin like growth factor binding protein 1 ( IGFBP 1 ) , known to regulate serum ( s ) IGF 1 and protein intake , in end stage renal disease patients . ^^^ Methods : Thirty hemodialysis patients were studied , and s IGF 1 and s IGFBP 1 levels were measured by radioimmunoassay . ^^^ The s albumin was inversely correlated with log s IGFBP 1 ( r = 0 . 38 , p < 0 . 01 ) and positively with the s IGF I / s IGFBP 1 ratio ( r = 0 . 36 , p < 0 . 007 ) but not with s IGF 1 ( p < 0 . 13 ) . ^^^ CONCLUSIONS : The s IGF 1 and the s IGF I / s IGFBP 1 ratio were correlated with estimates of protein intake of the patients calculated from urea kinetics ( PCRn ) but not with direct estimates by the dietitian . ^^^ The s IGF 1 SD score and the ratio s IGF I / s IGFBP 1 might be a tool to monitor anabolic status and to select hemodialysis patients for therapeutic intervention with recombinant human IGF 1 and / or recombinant human growth hormone to counteract catabolism . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
No significant changes were observed in plasma IGF 1 and 2 concentrations or IGFBP 1 , 2 , 3 or 4 levels throughout the 4 day study at either gestational age . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To examine the hypothesis that anthropometric measures and physical fitness influence circulating insulin like growth factor 1 ( IGF 1 ) during puberty , we measured IGF 1 , free IGF 1 , IGFBP 1 , and IGFBP 3 concentrations in 156 healthy girls ( 9 16 years old ) characterized by aerobic capacity ( VO2max ) , fat free mass ( FFM ) , percent fat mass and pubertal development . ^^^ IGF 1 , free IGF 1 and IGFBP 3 increased with pubertal development while IGFBP 1 declined . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 , IGFBP 1 and IGFBP 3 were low , while insulin , C peptide and GH were undetectable . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In marked contrast , AM precursor peripheral blood monocytes , do not express neuropeptides or IGF 1 and only express IGFBP 1 , 4 and 6 and IGFBP rP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The levels of immunoreactivity for IGF 1 receptor and for four IGFBPs ( IGFBP 1 , 2 , 3 and 5 ) were significantly increased in diabetic HREC cultures . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To determine if in vitro secretion of the decidual peptides insulin like growth factor 1 ( IGF 1 ) , prolactin or insulin like growth factor binding protein 1 ( IGFBP 1 ) correlates with infant birthweight in uncomplicated , term human pregnancies , decidua from 45 pregnancies with normally distributed birthweights was cultured in defined medium for 24 h . ^^^ IGF 1 , prolactin and IGFBP 1 concentrations in the culture medium were measured by radioimmunoassay . ^^^ Neither infant birthweight nor a normalized measure of infant birthweight ( birthweight z score ) correlated with the quantity of IGF 1 , prolactin or IGFBP 1 secreted by the decidua from that pregnancy . ^^^ IGF 1 and IGFBP 1 secretion also correlated positively in individual samples . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor 1 receptors on blood cells : their relationship to circulating total and `` free ' ' IGF 1 , IGFBP 1 , IGFBP 3 and insulin levels in healthy subjects . ^^^ Total IGF 1 , insulin and IGFBP 1 levels showed no relation to the IGF 1 receptor on erythrocytes and PBMCs in the fasting state . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Phosphorylated insulin like growth factor ( IGF ) binding protein 1 ( IGFBP 1 ) inhibits while non phosphorylated IGFBP 1 stimulates IGF 1 induced amino acid uptake by cultured trophoblast cells . ^^^ The effects of phosphorylated insulin like growth factor binding protein ( pIGFBP 1 ) and non phosphorylated ( npIGFBP 1 ) IGFBP 1 on amino acid uptake induced by IGF 1 were studied using cultured trophoblast cells . ^^^ Thus , it is suggested that IGFBP 1 phosphoisoforms are also involved in fetal growth by modulating IGF 1 action in the placenta . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
No significant relationships were found between absolute levels or changes in nu LH concentrations and leptin , IGF 1 , IGFBP 3 , or IGFBP 1 concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Northern blot analysis , in situ hybridization , and immunohistochemical studies of these `` early ' ' lesions demonstrated increased expressions of IGF 1 and IGF binding protein 4 ( IGFBP 4 ) in altered parenchymal cells , and a decreased expression of IGFBP 1 . ^^^ HCC arising in this model had decreased expressions of IGF 1 and IGFBP 4 but IGFBP 1 expression was not significantly altered . ^^^ The altered gene expression in glycogen storing preneoplastic hepatic foci , especially the up regulation of IGF 1 and IGFBP 4 with the down regulation of IGFBP 1 , resemble the insulin dependent regulation of these components in normal rat hepatocytes . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
BACKGROUND : The insulin like growth factor ( IGF ) system , which is composed of two ligands ( IGF 1 and IGF 2 ) , two receptors ( IGFR 1 and IGFR 2 ) and six binding proteins ( IGFBP 1 to 6 ) , plays an important role in cell biology . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 mRNA is suppressed and mRNA encoding IGF 2 and IGFBP 1 are consistently up regulated in decidualized endometrium in women treated with the intrauterine levonorgestrel system ( LNG IUS ) . ^^^ The latter findings suggest that suppression of IGF 1 action by IGFBP 1 may be one of the molecular mechanisms accounting for progestagenic and anti oestrogenic effects of LNG IUS in the endometrium . ^^^ Consequently , examination of local IGF 1 , IGF 2 and IGFBP 1 expression might provide additional information when evaluating the effect of different progestins on the endometrium at the molecular level . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Similar anomalies have been reported in mice with disruption of the igf 1 gene and in a model of transgenic mice over expressing IGFBP 1 in all tissues , including the brain . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Significant correlations ( p < 0 . 001 ) were seen between total and free ALS concentrations and IGF 1 ( r = 0 . 50 and 0 . 60 , respectively ) , free IGF 1 ( r = 0 . 37 and 0 . 36 ) , IGF 2 ( r = 0 . 37 and 0 . 27 ) , IGFBP 1 ( r = 0 . 48 and 0 . 49 ) , IGFBP 2 ( r = 0 . 44 and 0 . 51 ) and IGFBP 3 ( r = 0 . 67 and 0 . 59 ) at all Tanner stages . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma concentrations of IGF 1 decreased by 31 . 5 % ( 434 + / 84 versus 297 + / 71 ng / ml ; P : < 0 . 05 ) after 5 days of clomiphene therapy , whereas plasma concentrations of IGFBP 1 increased by approximately 28 . 1 % ( 26 . 3 + / 4 versus 36 . 6 + / 7 ng / ml ; P : < 0 . 05 ) . ^^^ This gave a 56 . 5 % reduction in the IGF 1 : IGFBP 1 ratio ( 21 . 9 versus 9 . 53 ) . ^^^ The present results show that clomiphene does not cause changes in insulin resistance associated with PCOS but reduces plasma concentrations of IGF 1 and increases those of IGFBP 1 , with a consequent marked reduction in the IGF 1 : IGFBP 1 ratio . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Furthermore , the presence of mRNAs of IGF 2 and of receptors for IGF 1 ( IGF IR ) , growth hormone ( GHR ) and insulin ( IR ) , as well as mRNAs of IGF binding proteins ( IGFBP 1 , 2 and 3 ) were assessed by RT PCR . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aim of the present study was to investigate whether the diurnal variability of B Glucose is dependent on GH , IGF 1 and IGFBP 1 levels , apart from insulin , and if there is any difference between Tanner stages 3 and 5 . ^^^ S Insulin , S GH , S IGF 1 and S IGFBP 1 were analysed . ^^^ CONCLUSION : We have demonstrated in type 1 diabetes adolescent boys a relationship between simultaneously measured blood glucose and IGFBP 1 levels independent of the insulin and GH levels , suggesting that the free fraction of IGF 1 influences the glucose metabolism . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and IGFBP 1 were elevated . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Because growth is regulated by the GH insulin like growth factor ( IGF ) system , which may be altered in catabolic states , we studied serum IGF 1 , free IGF 1 , IGF 2 , the IGF binding proteins ( IGFBP 1 to 3 ) , and total and free acid labile subunit ( ALS ) levels in 26 prepubertal children with ALL at diagnosis ( n = 26 ) and 6 ( n = 21 ) , 12 ( n = 21 ) , 18 ( n = 21 ) , 24 ( n = 20 ) , 30 ( n = 16 ) , and 36 months ( n = 16 ) after beginning treatment to investigate the effects of disease and therapy on this system and its relationship with growth in these patients . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To examine the response of the IGF / IGFBP system of neonatal kidney to diabetes , renal IGF 1 and 2 and IGFBP 1 , 2 , and 3 concentration and mRNA expression were determined in streptozotocin induced diabetic rat neonates . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and its binding proteins IGFBP 1 and 3 as nutritional markers in prepubertal children . ^^^ OBJECTIVE : To assess the validity of the use of IGF 1 , IGFBP 1 and IGFBP 3 as biochemical markers of nutritional status in prepubertal healthy children . ^^^ RESULTS : Overweight children were found to have higher serum levels of IGF 1 ( 306+ / 162 . 2 vs . 209+ / 71 . 2 ng / ml , p < 0 . 001 ) and IGFBP 3 ( 3 . 3+ / 1 . 0 vs . 2 . 9+ / 0 . 5 mg / l , p < 0 . 01 ) and lower serum levels of IGFBP 1 ( 4 . 3+ / 3 . 9 vs . 13 . 8+ / 7 . 4 microg / l , p < 0 . 01 ) . ^^^ There was a positive correlation with BMI , for IGF 1 and IGFBP 3 , and negative correlation for IGFBP 1 . ^^^ CONCLUSION : IGF 1 , IGFBP 1 and IGFBP 3 clearly classify over and underweight prepubertal children , showing a good correlation with BMI . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Both types of patients have increased serum IGF 1 and IGFBP 2 levels , and decreased serum IGFBP 1 levels , while only AT patients have high serum insulin levels . ^^^ In these three models , serum insulin levels are significantly decreased , serum IGF 1 and IGFBP 1 , 2 , and 3 are decreased in diabetic and neurotoxin injected rats , while serum IGFBP 1 is increased in hereditary ataxic rats . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
At baseline , we determined fasting blood levels of free and total IGF 1 , IGFBP 1 , and IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Both nephron segments immunostained strongly for IGF 1 and IGFBP 1 , but only the nonhyperplastic enlarged thick ascending Henle limb cells immunostained for TGF beta , which was strongly positive . ^^^ CONCLUSIONS : These findings are consistent with a sustained role for IGF 1 in promoting the exaggerated renal growth of KD and appear to be mediated through local trapping of IGF 1 by the overexpressed IGFBP 1 , which together with IGF 1 can promote renal growth . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We engineered two IGFBP selective variants that demonstrated 700 and 80 , 000 fold apparent reductions in affinity for IGFBP 1 while preserving low nanomolar affinity for IGFBP 3 , the major carrier of IGF 1 in plasma . ^^^ These IGF 1 variants may potentially be useful for treating disease conditions associated with up regulated IGFBP 1 levels , such as chronic or acute renal and hepatic failure or uncontrolled diabetes . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
These data suggest that uptake of circulating IGF 1 into CSF is independent of the type 1 or 2 IGF receptors as well as IGF sequestration to IGFBP 1 , 3 , 4 , or 5 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Sepsis and bacterial lipopolysaccharide ( LPS ) injection decrease circulating concentrations of insulin like growth factor ( IGF ) 1 and induce an increase in IGFBP 1 and IGFBP 4 that may have impact upon IGF 1 anabolic actions . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Human IGFBP 1 undergoes serine phosphorylation , and this enhances both its affinity for IGF 1 by six to eightfold and its capacity to inhibit IGF 1 actions . ^^^ Scatchard analysis showed that the affinity of phosphorylated rat IGFBP 1 for IGF 1 was 3 . 9 fold higher than that of nonphosphorylated human IGFBP 1 . ^^^ The phosphorylation state of human IGFBP 1 may account for part of the phenotypic differences noted in the two studies of transgenic mice , and it is an important determinant of the capacity of human IGFBP 1 to inhibit IGF 1 actions in vivo . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aims of our study were to investigate : ( 1 ) the developmental pattern of the serum IGFBP 2 concentration at birth and during childhood and adolescence ; ( 2 ) whether the serum IGFBP 2 level could be a marker for the diagnosis and evolution of diseases where the growth hormone ( GH ) IGF axis is altered , and ( 3 ) whether this binding protein shows a relationship with IGF 1 , its free fraction , IGFBP 1 and 3 . ^^^ IGFBP 2 correlated positively with IGFBP 1 and negatively with IGF 1 and IGFBP 3 in normal subjects and at diagnosis of the pathologies studied . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
A stepwise regression analysis for all subjects revealed that IGFBP 1 is the only independent predictor of log free IGF 1 ( R 2 = 0 . 23 , P < 0 . 01 ) . ^^^ The high IGFBP 1 may contribute to growth retardation in a subgroup of idiopathic short stature through a decrease in free IGF 1 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In poorly growing children , especially in ESRD children and to a lesser extent in RT children , high concentrations of IGF 1 and IGFBP 1 , 2 , 3 and 6 , suggest a resistance mainly by a sequestration mechanism . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : To investigate the effects of insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) on development of ovarian follicles during gonadotropin stimulation in in vitro fertilization ( IVF ) program . ^^^ METHODS : Enzyme linked immunosorbent assay ( ELISA ) and radioimmunoassay were used to determine the levels of IGF 1 , IGFBP 1 and estradiol ( E 2 ) in serum and follicular fluid obtained during oocyte pick up ( OPU ) in 32 IVF embryo transfer cycles . ^^^ However changes of serum IGFBP 1 levels may play a complementary role in regulation of follicular development by altering free IGF 1 levels . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We measured levels of IGF 1 , IGFBP 1 , IGFBP 2 , IGFBP 3 , and insulin in plasma samples from 149 men who had a diagnosis of prostate cancer between 1 month and 10 years after blood collection and among 298 control men . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Treatment with insulin lispro changes the insulin profile but does not affect the plasma concentrations of IGF 1 and IGFBP 1 in type 1 diabetes . ^^^ Our aim was to examine whether the plasma insulin profile obtained by treatment with the insulin analogue lispro has a different effect on plasma concentrations of IGF 1 and IGFBP 1 than that seen during treatment with conventional human insulin ( regular insulin ) . ^^^ IGF 1 and IGFBP 1 levels were measured at the end of 6 weeks treatment with each insulin being administered by a continuous subcutaneous insulin infusion . ^^^ IGF 1 was measured fasting while IGFBP 1 , free insulin and blood glucose were measured fasting and repeatedly after a morning meal preceded by an insulin bolus dose . ^^^ CONCLUSIONS : Our results indicate that the effect of lispro on IGF 1 and IGFBP 1 in patients with type 1 diabetes does not differ from that of human regular insulin . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
However , as a likely consequence of intraportal insulin deficiency , patients with type 1 DM also exhibit abnormalities of the growth hormone ( GH ) / IGF / IGF binding protein ( IGFBP ) axis , including GH hypersecretion , reduced circulating levels of insulin like growth factor 1 ( IGF 1 ) and IGFBP 3 , and elevated levels of IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Renal extractable IGF 1 protein and IGFBP 1 mRNA were increased in the D group and normalized in the DS group . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The insulin like growth factor ( IGF ) system includes IGF 1 and IGF 2 , the type 1 and type 2 IGF receptors , and specific IGF binding proteins ( IGFBP 1 to IGFBP 6 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
STUDY DESIGN : We studied the effects of 36 h fasting on 8 h diurnal mean GH , insulin and glucose concentrations ( mGHc , mINSc and mGLUc ; assay every 30 min from 8 . 00 am to 4 . 00 pm ) as well as on IGF 1 , IGFBP 3 , ALS , IGFBP 1 , GHBP and free fatty acid ( FFA ) levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The role of the IGF axis in IGFBP 1 and IGF 1 induced renal enlargement in Snell dwarf mice . ^^^ In contrast , IGFBP 1 has been reported to interact with cell surfaces and enhance IGF 1 action locally in some tissues . ^^^ To test whether IGFBP 1 is a renotropic factor , IGFBP 1 was administered alone or in combination with IGF 1 to Snell dwarf mice , an in vivo model without compensatory feedback effects on growth hormone ( GH ) secretion . ^^^ Administration of IGF 1 , alone or in combination with IGFBP 1 , tended to increase glomerular volume , while no changes were seen in the other groups . ^^^ Administration of IGFBP 1 or IGFBP 1+IGF 1 both caused dilatation of the thin limbs of Henle ' s loop , while GH or IGF 1 administration had no visible effect . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In rats with CRF induced by partial renal ablation , 7 days of GH treatment had a diminished effect on weight gain and hepatic IGF 1 and IGFBP 1 mRNA levels , compared with sham operated pair fed controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Long term alcohol abuse may therefore not only cause considerable IGF 1 and IGFBP 1 production changes , but also changes in IGF 1 bioavailability , which at least in part is determined by the IGF I / IGFBP 1 ratio . ^^^ Serum concentrations of insulin , GH , IGF 1 , and IGFBP 1 were determined in the morning in all participants , and the IGF I / IGFBP 1 ratios were calculated . ^^^ Patients in group C had low IGF 1 levels , high IGFBP 1 levels , and low IGF 1 bioavailability as reflected by the IGF I / IGFBP 1 ratios , which were several fold reduced compared with subjects in group N ( 0 . 6+ / 0 . 2 vs 10 . 2+ / 2 . 3 ; p < 0 . 001 ) . ^^^ It is concluded that alcohol abuse lowers the hepatic production of IGF 1 and increases the production of IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : To measure circulating concentration of growth hormone ( GH ) , insulin like growth factors 1 ( IGF 1 ) , and it ' s binding protein 1 ( IGFBP 1 ) and binding protein 3 ( IGFBP 3 ) in patients with sever hepatitis , and to survey the clinical significance of GH IGFS axis . ^^^ Serum concentration of GH , IGF 1 , IGFBP 1 and IGFBP 3 was determined by ELISA . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We measured IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 by immunoassays , IGFBP 3 by Western ligand blotting ( WLB ) and finally in vitro IGFBP 3 proteolysis by a ( 125 ) 1 IGFBP 3 degradation assay . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : IGF 1 , ICGF 2 , IGF 1R , IGFBP 1 , IGFBP 2 , IGFBP 4 , IGFBP 5 , and IGFBP 6 were expressed by LAM cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Surface plasmon resonance analysis indicated that alpha ( 2 ) M preferentially associates with the phosphorylated isoform of IGFBP 1 and that when complexed to alpha ( 2 ) M , IGFBP 1 can still bind IGF 1 . ^^^ These findings have functional significance since alpha ( 2 ) M protects IGFBP 1 from proteolysis and abrogates the inhibitory effect of phosphorylated IGFBP 1 on IGF 1 stimulated 3T3 L 1 cell proliferation . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Classical and atypical GHIS groups were compared in terms of ( 1 ) phenotypic features , including high pitched voice , sparse hair , blue sclera , hypoglycaemia , microphallus , ( 2 ) birth length , height SDS , and ( 3 ) basal IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 , GHBP and increase in IGF 1 on IGF 1 generation testing . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We measured the serum levels of IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Both nephron segments stained strongly for IGF 1 and IGFBP 1 . ^^^ These findings are consistent with a sustained role for IGF 1 in promoting the renal hypertrophy of KD and appear to be caused by local trapping of IGF 1 by the over expressed IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Biophysical and biochemical data show that the detergent binds to IGF 1 specifically and blocks binding of IGFBP 1 and IGFBP 3 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Can hormonal contraceptives affect plasma levels of IGF 1 and IGFBP 1 in slim women with polycystic ovary syndrome ? ] . ^^^ IGF 1 serum levels were not influenced ( 230 + / 70 vs . 235 + / 112 pg . ml 1 , n . s . ) , IGFBP 1 serum concentration significantly increased ( 46 . 3 + / 24 . 1 vs . 75 . 6 + / 24 . 0 pg . ml 1 , p < 0 . 001 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In contrast , intravenous infusion of recombinant human IGF 1 ( rhIGF 1 ) enhanced hepatic IGFBP 1 gene expression . ^^^ The responses of IGFBP 1 and IGFBP 3 to increased plasma IGF 1 and insulin may serve to protect the fetus from exaggerated anabolic effects and to blunt the hypoglycemic potential of circulating IGFs and insulin . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Effects of an endurance cycling competition on resting serum insulin like growth factor 1 ( IGF 1 ) and its binding proteins IGFBP 1 and IGFBP 3 . ^^^ Serum levels of both total and free IGF 1 and IGF binding proteins 1 and 3 ( IGFBP 1 and IGFBP 3 ) were measured in each of the samples . ^^^ CONCLUSIONS : It would appear that the increase in circulating levels of both IGF 1 and its binding protein IGFBP 1 is a short term ( one week ) endocrine adaptation to endurance exercise . ^^^ After three weeks of training , total IGF 1 and IGFBP 1 remained stable , whereas free IGF 1 fell below starting levels . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
This study was undertaken to evaluate the effects of acute changes in plasma glucose and insulin levels on free IGF 1 and IGFBP 1 in obese and non obese subjects . ^^^ Free IGF 1 and IGFBP 1 were determined at 0 , 19 , 22 , 50 , 100 , and 180 minutes . ^^^ RESULTS : Basal free IGF 1 levels tended to be higher and IGFBP 1 lower in obese than in lean subjects . ^^^ To determine the effects of insulin on the availability of free IGF 1 and IGFBP 1 , changes in their plasma concentrations were measured during a frequently sampled intravenous glucose tolerance test . ^^^ DISCUSSION : These data suggest that the concentrations of free IGF 1 and IGFBP 1 are differentially regulated by obesity . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
CONCLUSIONS : The alterations of IGF 1 , IGFBP 1 and 4 observed in catabolism correlate with the effects of IL 6 on the biosynthesis of these components in primary rat liver cells , while a neutral IGFBP 3 protease was not detectable . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 , IGF binding proteins 1 , 2 and 3 ( IGFBP 1 , 2 , 3 ) and insulin were measured in serum samples from all subjects and cotinine in 186 samples . ^^^ Anthropometric measures , such as body mass index ( BMI ) or waist to hip ratio ( WHR ) do not seem to influence total IGF 1 concentrations in peripheral blood , but may modulate IGF 1 bioavailability through insulin dependent changes in IGFBP 1 and 2 concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serial serum measurements of total insulin like growth factor 1 ( IGF 1 ) , free IGF 1 , IGF binding proteins 1 , 2 , 3 and 4 ( IGFBP 1 to 4 ) were performed . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : To determine whether preeclampsia influences insulin like growth factor 1 ( IGF 1 ) , insulin like growth factor binding protein 1 ( IGFBP 1 ) , and insulin like growth factor binding protein 3 ( IGFBP 3 ) , independent of its effect on birth weight . ^^^ IGF 1 , IGFBP 1 , and IGFBP 3 were measured in umbilical plasma . ^^^ RESULTS : Between mild preeclampsia and controls , there were no differences in IGF 1 , IGFBP 1 , and IGFBP 3 . ^^^ In severe and early onset preeclampsia , umbilical cord plasma IGF 1 was approximately 50 % lower , and IGFBP 1 was more than twice as high as in controls ( both P < . 01 ) . ^^^ At each birth weight level , IGF 1 was lower and IGFBP 1 was higher in severe or early preeclampsia than among controls of similar weight . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Fifteen IUGR and 12 normal short prepubertal subjects had a 90 min frequently sampled 4 glucose tolerance test performed to measure plasma glucose , insulin , IGF 1 , IGF 2 , IGFBP 3 , and IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma concentrations of IGF 1 , IGFBP 1 , IGFBP 2 , IGFBP 3 , and C peptide were determined . ^^^ RESULTS : Mean concentrations of plasma IGF 1 , IGFBP 1 , IGFBP 2 , IGFBP 3 , and C peptide were 156 . 1 , 14 . 3 , 434 . 4 , 3062 , and 2 . 86 ng / ml , respectively . ^^^ Women in the highest tertile for physical activity had lower plasma concentrations of IGF 1 , IGFBP 3 , and C peptide , and higher concentrations of IGFBP 1 and IGFBP 2 , as compared to women in the lowest tertile . ^^^ We did confirm that a lean body shape is associated with higher concentrations of IGFBP 1 and IGFBP 2 , and possibly also with lower concentrations of IGF 1 and IGFBP 3 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
SGA children also had lower levels of IGFBP 1 ( 87 . 0 vs 133 . 8 , p = 0 . 04 ) , but similar IGF 1 levels ( IGF 1 SDS : 1 . 1 vs 1 . 7 , p = 0 . 4 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To provide further insight into the effect of tamoxifen at low doses on the IGF system , we have correlated the drug serum levels attained after 2 months of either placebo ( n = 32 ) , tamoxifen 20 mg / day ( n = 26 ) , 10 mg / day ( n = 23 ) or 10 mg / every other day ( n = 29 ) with the changes in IGF 1 , Insulin like Growth Factor 2 ( IGF 2 ) , Insulin like Growth Factor Binding Protein 1 ( IGFBP 1 ) , Insulin like Growth Factor Binding Protein 3 ( IGFBP 3 ) , and IGF I / IGFBP 3 ratio . ^^^ Compared with placebo , tamoxifen induced a mean + / standard error ( SE ) reduction of IGF 1 of 16 . 9 + / 7 . 8 % , p < 0 . 05 , a non significant increase of 22 . 9 + / 12 . 2 % in IGF 2 , an increase in IGFBP 1 of 49 . 3 + / 22 . 7 % , p < 0 . 05 , and a non significant change of IGFBP 3 ( 4 . 0 % + / 9 . 2 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Our aim was to evaluate serum concentrations of IGF 1 , IGFBP 1 , and IGFBP 3 in patients with thyroid dysfunction before and after normalization of thyroid function . ^^^ Serum growth hormone ( GH ) , insulin , IGF 1 , IGFBP 1 , and IGFBP 3 were measured in all patients before and after normalizing serum thyroid hormone concentrations . ^^^ Hypothyroidism is associated with significant reductions of IGF 1 and IGFBP 3 , and IGFBP 1 is elevated in both hypothyroidism and hyperthyroidism . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
CONCLUSIONS : The present study indicates that moderate preeclampsia is associated with low newborn birth weight , IGF 1 , IGFBP 3 , and high IGFBP 1 without significant changes in zinc and leptin levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
They examined : serum concentrations of total IGF 1 , free IGF 1 , IGFBP 1 , 2 , 3 , and 6 , total cholesterol , HDL cholesterol , LDL cholesterol and triglycerides as well as the intimomedial thickness of the common carotid arteries and parameters of blood flow in the microcirculation , evaluated by a laser Doppler examination . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The relationship between ovarian structure and serum insulin , insulin like growth factor 1 ( IGF 1 ) and its binding protein ( IGFBP 1 and IGFBP 3 ) levels in premature pubarche . ^^^ The aim of this study was to determine serum insulin , insulin like growth factor 1 ( IGF 1 ) and its binding proteins ( IGFBP 1 and IGFBP 3 ) levels and their relationship with androgen levels and ovarian structure in 23 girls with premature pubarche ( PP ) . ^^^ Fasting levels of testosterone , dehydroepiandrosterone ( DHEA ) and its sulfate ( DHEAS ) , androstenedione ( delta4A ) , sex hormone binding globulin ( SHBG ) , glucose ( G ) , insulin ( 1 ) , IGF 1 , IGFBP 1 , IGFBP 3 were measured . ^^^ The androgens , SHBG , G , 1 , FIGR , IGF 1 and IGFBP 1 levels were similar among the groups ( PPc 1 vs PPc 2 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Before weight gain , leptin , IGF 1 , and IGFBP 3 were significantly lower and IGFBP 1 was elevated in the malnourished group compared with the control group . ^^^ Among PEM patients , after 10 % weight gains , the levels of leptin , IGF 1 , and IGFBP 3 were significantly higher and IGFBP 1 significantly lower compared with the control group . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
A synthetic peptide ( bp 1 01 ) has been shown to have a high affinity and specificity for human IGFBP 1 and to inhibit IGF 1 binding . ^^^ IGFBP 1 complexes , anabolic and insulin like effects of IGF 1 could be detected in human hepatoma ( HepG 2 ) cell cultures and to determine the receptor subtype ( s ) through which these effects were mediated . ^^^ In conclusion , bp 1 01 competes with IGF 1 for binding to IGFBP 1 , which leads to release of free IGF 1 from IGF I . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The present clinical study compares the impact of low and high dose parenteral testosterone ( T ) supplementation on daily GH secretory patterns and serum IGF 1 , IGFBP 1 , and IGFBP 3 concentrations in healthy older ( 60 82 yr ) and young ( 20 40 yr ) men . ^^^ To monitor somatotropic axis responses , blood was sampled every 10 min for 24 h for later chemiluminescence based assay of serum GH , RIA of serum IGF 1 , and immunoradiometric assay of serum IGFBP 1 and IGFBP 3 concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Intact PTH , osteocalcin , 1 , 25 ( OH ) ( 2 ) D ( 3 ) , 25 OH D ( 3 ) , IGF 1 , procollagen type 1 carboxy terminal extension peptide ( PICP ) and procollagen type 1 cross linked carboxy terminal telopeptide ( ICTP ) were studied by RIA , whereas IGFBP 1 and IGFBP 3 concentrations were assayed by IRMA . ^^^ In rHuEPO treated CAPD subjects IGF 1 and IGFBP 1 correlated positively with serum CrossLaps ( r = 0 . 61 , p < 0 . 05 and r = 0 . 64 , p < 0 . 05 , respectively ) , whereas in hemodialyzed patients without rHuEPO a significant negative correlation between IGFBP 3 and serum CrossLaps was found ( r = 0 . 69 , p < 0 . 001 ) as well as between IGFBP 3 and aluminium ( r = 0 . 51 , p < 0 . 05 ) , IGF 1 and ICTP ( r = 0 . 43 , p < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The multiple activities of IGF 1 and 2 are modulated by a family of IGF binding proteins ( IGFBP 1 to 6 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and 2 and IGFBP 1 and 3 were measured in the culture media by specific immunoassays . ^^^ The results showed that IGF 1 and 2 , IGFBP 1 to 6 and IGF IR were detected in the human corpus luteum throughout the luteal phase . ^^^ Moreover , the expression and production of IGF 1 and IGFBP 1 increased progressively from corpora lutea from the early to late luteal phases ( P < 0 . 05 ) , whereas the expression and production of IGFBP 2 , 4 and 5 were significantly higher in corpora lutea from the mid luteal phase ( P < 0 . 05 ) . ^^^ However , functional studies showed that nitric oxide donors elicited a stimulatory action on production of IGF 1 in corpora lutea from the early luteal phase ( 80 % ) and on production of IGFBP 1 in corpora lutea from the late luteal phase ( 50 % ) ( P < 0 . 05 ) , whereas production of IGF 2 and IGFBP 3 was not affected by nitric oxide . ^^^ Nitric oxide regulates IGF 1 and IGFBP 1 production , indicating that the growth factors may serve , at least in part , as mediators of the action of nitric oxide in the human corpus luteum . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
BMD in total body , distal and UD radius , and femoral neck was positively correlated with serum IGF 1 ( r = 0 . 31 to 0 . 49 ) , IGF 2 ( r = 0 . 32 to 0 . 48 ) , IGFBP 3 ( r = 0 . 37 to 0 . 53 ) , and free androgen index ( FAI ) ( r = 0 . 32 to 0 . 40 ) , and negatively with IGFBP 1 ( r = 0 . 37 to 0 . 41 ) and IGFBP 2 ( r = 0 . 29 to 0 . 41 ) levels . ^^^ Age correlated negatively with serum IGF 1 , IGF 2 , IGFBP 3 , FAI , estradiol / SHBG ratio , and BMD in total body , distal and UD radius , and femoral neck , and positively with IGFBP 1 , IGFBP 2 , and SHBG levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Radioimmunoassays were used to analyse IGF 1 , free IGF 1 ( fIGF 1 ) and IGFBP 1 3 . ^^^ In spite of the significant changes of IGF 1 , IGFBP 2 , total IGFBP 3 and IGFBP 3 ( 29 kDa proteolytic fragment ) after rhGH administration to patients with malnutrition , maintained on parenteral nutrition , the increase of nitrogen balance was seen only in patients who decreased their IGFBP 1 and increased bioavailable IGF 1 as reflected by measurement of fIGF 1 . ^^^ The levels of IGFBP 1 may provide a useful marker of IGF 1 bioavailability in monitoring the efficiency of the rhGH therapy in malnourished patients . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The proliferative action of insulin like growth factors ( IGF 1 and 2 ) is mediated via the type 1 IGF receptor ( IGF IR ) and is modulated by their association with high affinity binding proteins , IGFBP 1 to 6 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Overall , these data indicate that reduced fertility in transgenic female mice overexpressing human IGFBP 1 are mainly due to an alteration of terminal follicular growth leading to a decrease in natural and induced ovulation rate , likely due to an impairment of IGF 1 action on follicular cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
METHODS : Umbilical cord blood was collected in 12 804 consecutive deliveries , and cord plasma from 585 singleton infants born at term after uncomplicated pregnancies was analyzed for leptin , IGF 1 , and 2 IGF binding proteins ( IGFBP 1 and IGFBP 3 ) . ^^^ If intrauterine growth is related to the risk of developing adult diseases , IGF 1 , IGFBP 1 , and leptin may be involved in the underlying processes . 1131 1135 insulin like growth factors , leptin , umbilical cord plasma , birth weight . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In this review , we will summarize our previous observations on progestin regulated gene expression , estrogen metabolic enzymes , nitric oxide synthase , aromatase , IGF 1 and 2 , IGFBP 1 , prolactin and glycodelin . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Blood was sampled at baseline and at 6 h intervals for glucose , IGFBP 1 , free and total IGF 1 , and insulin . ^^^ Levels of free IGF 1 were inversely associated with IGFBP 1 over the course of fasting ( P = 0 . 002 ) . ^^^ Similarly , total IGF 1 was negatively associated with IGFBP 1 ( P = 0 . 01 ) . ^^^ This decline in free IGF 1 appears to be the result of the steady rise in IGFBP 1 that occurs as insulin declines . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Clinical data were recorded at the time of bone density measurement , concomitant with blood sample extraction for study of IGF 1 , IGF binding protein 3 ( IGFBP 3 ) , IGFBP 1 , estradiol , sex hormone binding globulin , dehydroepiandrosterone sulfate , prealbumin , amino terminal propeptide of procollagen 3 , osteocalcin , bone alkaline phosphatase , carboxy terminal propeptide of procollagen 1 , amino terminal propeptide of procollagen 1 , carboxy terminal telopeptide of collagen 1 , 25 OH vitamin D , 1 , 25 ( OH ) ( 2 ) vitamin D , and parathormone . ^^^ IGF 1 , estradiol , and biochemical bone formation markers were higher and IGFBP 1 , sex hormone binding globulin , and biochemical bone resorption markers were lower in the weight recovered stages ( stages 2 and 3 ) compared with the active phase ( stage 1 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Function of insulin like growth factor ( IGF 1 ) and its binding protein ( IGFBP 1 ) in pathological proliferation of endometrium . ^^^ The purpose of this project was the investigation of insulin , IGF 1 and IGFBP 1 concentrations in the serum of patients with pathological changes in endometrium . ^^^ IGF 1 and its binding protein ( IGFBP 1 ) stimulate cell growth and differentiation of the normal and neoplastic endometrium . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Free IGF 1 had a negative correlation with IGFBP 1 ( R= 0 . 64 , p=0 . 01 ) . ^^^ The authors found no correlations between IGF 1 , IGFBP 3 , free IGF 1 , IGFBP 1 and HbA1c in the study . ^^^ It was , therefore , postulated that a near normal free IGF 1 level in diabetic children resulted from a balance of interaction between IGFBP 1 and IGFBP 3 to total IGF 1 in order to keep the normal metabolic status as much as possible . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : Birth weight ( BW ) , birth length ( BL ) , ponderal index , head circumference ( HC ) , and cord serum levels of albumin , prealbumin , retinol binding protein ( RBP ) , total and free IGF 1 , IGF 2 , IGFBP 3 , acid labile subunit ( ALS ) , and leptin were significantly lower , whereas levels of IGFBP 1 , IGFBP 2 , and IL 6 were significantly higher in preterm than in term neonates ( P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 bioactivity is regulated in part by its six binding proteins ( IGFBP 1 to IGFBP 6 ) ; insulin inhibits the production of IGFBP 1 and perhaps IGFBP 2 . ^^^ As a result , chronically elevated fasting and postprandial insulin levels may lead to a decrease in circulating IGFBP 1 and IGFBP 2 concentrations and , consequently , an increase in IGF 1 bioavailability . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Fetal IGF 1 concentrations decreased during cortisol infusion and fetal IGFBP 1 concentrations were negatively correlated with fetal weight ( r= 0 . 76 , P=0 . 02 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Significant differences were found between nonsurvivors and survivors for the levels of total IGF 1 ( 2 . 6 vs . 5 . 6 nmol / liter ) , free IGF 1 ( 0 . 003 vs . 0 . 012 nmol / liter ) , IGFBP 1 ( 44 . 3 vs . 8 . 9 nmol / liter ) , IGFBP 3 protease activity ( 61 vs . 32 % ) , IL 6 ( 1200 vs . 50 ng / ml ) , and TNFalpha ( 34 vs . 5 . 3 pg / ml ; P < 0 . 01 ) . ^^^ The pediatric risk of mortality score correlated significantly with levels of IGFBP 1 , IGFBP 3 protease activity , IL 6 , and TNFalpha ( r = +0 . 45 to +0 . 69 ) and with levels of total IGF 1 and free IGF 1 ( r = 0 . 44 and 0 . 55 , respectively ) . ^^^ Follow up after 48 h in survivors showed an increased number of GH peaks , increased free IGF 1 and IGFBP 3 levels , and lower IGFBP 1 levels compared with admission values . ^^^ GH levels and IGFBP 1 levels were extremely elevated in nonsurvivors , whereas total and free IGF 1 levels were markedly decreased and were accompanied by high levels of the cytokines IL 6 and TNFalpha . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Blood samples were obtained before insulin injection and breakfast to test for plasma glucose ( PG ) , IGF 1 , IGFBP 1 , IGFBP 3 , total and complex GHBP ( tGHBP and cGHBP ) , and HbA1c . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Such a powerful increase was correlated by a small enhancement in insulin like growth factor binding protein 3 ( IGFBP 3 ) plasma levels , while treatment with IGF 1 alone affected very significantly both IGFBP 1 and IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
They underwent clinical examination and assessment of plasma or serum levels of ghrelin leptin , soluble leptin receptor , IGF 1 , IGFBP 1 and IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum IGF 1 and 2 , IGFBP 1 , 2 and 3 , GH and GHBP levels were studied on day 1 , 3 , 5 and 7 after ICU admission , during comparable artificial nutrition in SEP and TRA and basally in AS . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
METHODS : Plasma levels of IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 3 were determined from the fasting bloods of 206 BPH cases admitted for treatment and 306 randomly selected population controls in Shanghai , China . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The data reveal that IGFBP 1 and 2 reduced O2A cell survival in the absence and presence of exogenously added IGF 1 . ^^^ The effects of IGFBP 1 on cell survival in the presence of exogenously added IGF 1 were IGF 1 dependent , whereas IGFBP 2 displayed both IGF 1 dependent and IGF 1 independent effects . ^^^ Furthermore , IGFBP 1 and 2 inhibited O2A cell differentiation in the presence of IGF 1 as reflected by decreased expression levels of two myelin proteins , CNPase ( 2 ' , 3 ' cyclic nucleotide 3 ' phosphohydrolase ) and MAG ( myelin associated glycoprotein ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Exercise in noninfused 50 % fasted rats , compared with the normally fed rats , resulted in significantly lower blood glucose ( minute 70 ) and insulin levels , significantly lower liver glycogen content , no change in IGF 1 , and significantly higher increases in free fatty acid , glycerol , beta hydroxybutyrate , and IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum levels of IGF 1 and IGFBPs ( IGFBP 1 and 3 ) were compared between groups . ^^^ The findings suggest that circulating levels of IGF 1 and IGFBP 1 are related to the extent of myocardial injury in patients with HCM . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Posttranslational phosphorylation of IGFBP 1 significantly increases its affinity for IGF 1 and therefore represents a further mechanism for controlling IGF bioavailability . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We found significant linear positive correlations between leptin and body weight , BMI , LH , peptide C , insulin , IGF 1 values and negative correlations with cortisol and IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In this study , we show that neutralization of IGF action by a type 1 IGF receptor ( IGFR 1 ) blocking antibody or neutralization of IGF 1 by IGFBP 1 reduced cell motility . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The effect of tibolone on endometrial IGF 1 and IGFBP 1 levels in ovariectomized rats . ^^^ OBJECTIVE : The goal of this study was to search the effects of two different doses of tibolone on endometrial IGF 1 and IGFBP 1 levels in ovariectomized rats . ^^^ No significant difference was noted between each treatment group for both IGF 1 and IGFBP 1 . ^^^ CONCLUSION : Tibolone caused histological changes in endometrium and stimulated IGF 1 and IGFBP 1 staining . ^^^ Both low and high dose treatments led to moderate and strong staining intensities for IGF 1 and IGFBP 1 , respectively . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGFBP 2 to 6 were expressed in the chondrocytes , IGFBP 1 was absent and both IGF 1 and IGF 2 , and the type 1 and type 2 IGF receptors were expressed . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : All four GH doses increased IGF 1 , IGFBP 3 and IGF 1 / IGFBP 3 ratio , and decreased IGFBP 1 from day 3 onwards ( P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To test the hypothesis that the relative insulin resistance of puberty is associated with changes in IGF 1 levels , we compared IGF 1 , IGF binding protein 3 ( IGFBP 3 ) , and IGFBP 1 levels to insulin resistance [ M ( lbm ) , milligrams glucose used per kilogram of lean body mass ( LBM ) per minute ] measured during euglycemic , hyperinsulinemic clamp studies in 342 children and adolescents . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In all subjects , we evaluated basal levels of anterior pituitary hormones , IGF 1 , insulin like growth factor binding protein ( IGFBP ) 3 , and IGFBP 1 , as well as the GH responses to intravenous ( 4 ) infusion of growth hormone releasing hormone ( GHRH ) alone , GHRH plus arginine ( ARG ) , and the GH release evoked by somatostatin ( SRIH ) infusion withdrawal , which is related to endogenous GHRH tone . ^^^ Basal plasma concentrations of GH , IGF 1 , IGFBP 3 , and IGFBP 1 did not significantly differ between CHI patients and controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : Intact IGFBP 1 , IGFBP 2 and IGFBP 6 inhibited in equimolar concentration the IGF 1 and IGF 2 stimulated DNA synthesis and cell proliferation , whereas the biological activity of IGFBP 3 was complex . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Basal GH , IGF 1 , and IGFBP 1 and 3 were higher in Tr ( P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The actions of GCs are thought to be mediated in part by impaired action of the insulin like growth factors ( IGF 1 and IGF 2 ) and their binding proteins ( IGFBP 1 to 6 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Fasting serum samples were analyzed for total and free IGF 1 and 2 , for IGFBP 1 to 4 , as well as for IGFBP 3 proteolysis . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
These mice present a liver phenotype illustrated by a 12 fold increase in liver insulin like growth factor binding protein 1 ( IGFBP 1 ) mRNA and a 50 % decrease in liver insulin like growth factor 1 ( IGF 1 ) mRNA correlated with a 50 % decrease in circulating IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
There was also a correlation between serum levels of IGF 1 and IGFBP 3 and an inverse correlation between the serum level of IGF 1 and serum levels of IGFBP 1 and IGFBP 2 in the ANS group . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
These data suggest that a plant based diet is associated with lower circulating levels of total IGF 1 and higher levels of IGFBP 1 and IGFBP 2 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Hyperinsulinaemia has been shown to have a direct effect on the live , suppressing the production of sex hormone binding globulin ( SHBG ) and insulin like growth factor binding proteins 1 and 2 ( IGFBP 1 , 2 ) while stimulating the production of insulin like growth factor 1 ( IGF 1 ) . ^^^ Men adopting a low fat diet and daily exercise reduced their levels of serum insulin and IGF 1 , while increasing their levels of IGFBP 1 and sex hormone binding globulin ( SHBG ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
DESIGN : Serum samples for analysis of haemoglobin A1c and IGF 1 were obtained in addition to serum profiles of GH , insulin and IGFBP 1 before and after 3 weeks of PZP treatment . ^^^ Concordantly , the IGF 1 levels were statistically unchanged , as were IGFBP 1 concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Concentrations of IGF 1 , insulin , glucose , and IGFBP 1 , IGFBP 2 , and IGFBP 3 in serum drawn at least 2 years before diagnosis ( mean times of 10 . 5 and 15 . 8 years for pre and postmenopausal cases , respectively ) were compared using conditional logistic regression analysis . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum concentrations of testosterone ; estrone ; estradiol ; dehydroepiandrosterone and dehydroepiandrosterone sulfate ; insulin like growth factor 1 ( IGF 1 ) ( total and free ) and its binding proteins IGFBP 1 , IGFBP 2 , and IGFBP 3 ; and leptin were measured . ^^^ Serum estradiol ; dehydroepiandrosterone sulfate ; total IGF 1 , IGFBP 1 , IGFBP 2 , and IGFBP 3 ; and leptin showed no association . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Late in pregnancy , food restriction reduced the ratio of maternal circulating IGF 1 to IGFBP 1 by 52 per cent ( P=0 . 011 ) and increased the ratio of IGF 1 to IGFBP 3 in maternal plasma by 10 per cent ( P=0 . 011 ) . ^^^ In mid pregnancy , the volume density of the maternal blood space in the placental labyrinth correlated positively with both maternal plasma IGF 1 and IGFBP 3 , while maternal blood space volume correlated negatively with maternal plasma IGFBP 1 . ^^^ Concomitantly , placental weight , placental diameter , placental volume , volume density and weight of syncytiotrophoblast , weight of foetal capillaries , syncytiotrophoblast surface density and total syncytiotrophoblast surface area in the placental labyrinth , each correlated positively with the ratio of IGF 1 to IGFBP 1 in maternal plasma , while syncytiotrophoblast thickness correlated negatively with this ratio . ^^^ In late pregnancy therefore , increased trophoblast abundance and placental vascularity , and a reduced barrier to diffusion between maternal and foetal blood , occurs in association with increased abundance of IGF 1 and its major carrier , IGFBP 3 , and a reduction in that of IGFBP 1 in maternal blood in the guinea pig . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Effect of diet and exercise on serum insulin , IGF 1 , and IGFBP 1 levels and growth of LNCaP cells in vitro ( United States ) . ^^^ Insulin , IGF 1 , IGFBP 1 , and IGFBP 3 were measured by ELISA , and serum was used to stimulate LNCaP cell growth in vitro . ^^^ RESULTS : Serum IGF 1 levels decreased by 20 % while IGFBP 1 increased by 53 % after 11 day DE . ^^^ In the long term group , IGF 1 was 55 % lower , while IGFBP 1 was 150 % higher relative to baseline . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum IGF 1 , IGFBP 3 and IGFBP 1 concentrations were measured by IRMA . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
These results show that expression of the IGFBP 1 transgene leads to a marked inhibition of hepatic preneoplasia , possibly by decreasing the mitogenic activity of IGF 1 and / or IGF 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
There was no statistically significant correlation of T levels with free IGF 1 , IGFBP 1 , glucose , DHEAS , or estriol . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
METHODS : Cross sectional study : urinary leptin , measured in the first morning urine voided and expressed as ng excreted overnight , and serum concentrations of leptin , IGF 1 , IGF 2 , IGFBP 3 and IGFBP 1 were determined in a cohort of 188 healthy schoolchildren aged 5 19 years ( 88 males , 100 females ) . ^^^ In the cross sectional study urinary leptin correlated significantly with serum IGF 1 ( r = +0 . 41 , P = 0 . 001 ) , IGF 2 ( r = +0 . 19 , P = 0 . 05 ) , IGFBP 3 ( r = +0 . 29 , P = 0 . 001 ) and IGFBP 1 ( r = 0 . 25 , P = 0 . 001 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum T and F IGF 1 and IGF 2 were determined using noncompetitive time resolved monoclonal immunofluorometric assays , IGFBP 1 was determined by an in house RIA , IGFBP 2 by a novel in house time resolved immunofluorometric assay , whereas IGFBP 3 by an immunoradiometric assay . ^^^ Our results show that T and F IGF 1 , 2 , and IGFBP 1 , 2 , and 3 levels in patients were similar to controls and did not show any significant difference . ^^^ Specifically , mean T IGF 1 for patients group was 131 ( 61 ) , F IGF 1 was 0 . 47 ( 0 . 16 ) , T IGF 2 was 1056 ( 300 ) , F IGF 2 was 1 . 45 ( 0 . 54 ) , IGFBP 1 was 33 ( 14 ) , IGFBP 2 was 848 ( 377 ) , and finally IGFBP 3 was 3953 ( 1422 ) . ^^^ For controls , mean T IGF 1 was 146 ( 51 ) , F IGF 1 was 0 . 85 ( 0 . 43 ) , T IGF 2 was 939 ( 197 ) , F IGF 2 was 1 . 53 ( 0 . 53 ) , IGFBP 1 was 44 ( 24 ) , IGFBP 2 was 764 ( 316 ) and finally IGFBP 3 was 3721 ( 1017 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 , IGFBP 1 , IGFBP 3 , IGF I / IGFBP 1 , IGF I / IGFBP 3 , and hGH were comparable among the different categories of cycles . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Authors investigated serum levels of insulin like growth factor 1 ( IGF 1 ) , insulin like growth factor binding protein 1 ( IGFBP 1 ) , insulin like growth factor binding protein 3 ( IGFBP 3 ) , sex hormone binding globulin ( SHBG ) and levels of insulin during oral glucose tolerance test in 34 girls with premature adrenarche in 38 age and BMI matched healthy controls . ^^^ It has been shown that hyperinsulinaemia , decrease in IGFBP 1 and increase IGF 1 levels may be present in some affected prepubertal patients . ^^^ In the pubertal group , in addition to hyprinsulinaemia , decreased IGFBP 1 and increased IGF 1 levels an attenuated SHBG level was observed . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
This was associated with a significant increase in renal IGFBP 1 , and dissociated from IGF 1 changes . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In contrast , serum from patients with pancreatitis did not show significant increases in IGF 1 and IGFBP 3 levels , however , significant increases in IGFBP 1 level ( 2 . 5 fold ) . ^^^ Pancreatic cancer tissue and serum of patients with pancreatic cancer showed significant increases in IGF 1 , IGFBP 3 and IGFBP 1 content , accompanied by dramatic increases in IGF 1 tissue receptor expression , compared to controls . ^^^ The data suggest that disturbances in tissue collagen metabolism during pancreatic diseases may result from deregulation of IGF 1 homeostasis and that elevated serum levels of IGF 1 , IGFBP 3 and IGFBP 1 may serve as markers of pancreatic cancer . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Quantification of RT PCR products revealed significantly less expression of IGFBP 1 , IGF 1 , and 5alpha reductase type 1 in Sertoli cell tumors and seminomas . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Effect of dexamethasone treatment on serum GH , IGF 1 , and the binding proteins IGFBP 1 and 3 in ventilated very preterm infants . ^^^ Ventilation score and nutritional intake did not significantly correlate with serum GH , IGF 1 , or IGFBP 1 or 3 levels , either before or after the start of DEXA . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The blood was also analyzed for fasting metabolic parameters which included total cholesterol ( TC ) , high density lipoprotein ( HDL ) , low density lipoprotein ( LDL ) , insulin , glycosylated hemoglobin ( HbA1C ) , insulin like growth factor 1 ( IGF 1 ) , insulin like growth factor binding protein 1 ( IGFBP 1 ) , fasting blood glucose and morning leptin . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
On the other hand , in malnutri tion , the circulating level of insulin like growth factor 1 ( IGF 1 ) falls while the level of insulin like growth factor binding protein 1 ( IGFBP 1 ) is remarkably increased . ^^^ It has been recognized that IGF 1 and IGFBP 1 are indicators reflecting the initiation of a malnutritional state in patients with chronic renal failure , although there are many indicators such as albumin , prealbumin , and anthropometric measurement for nutritional assessment . ^^^ The serum IGF 1 / IGFBP 1 ratio is useful not only as a nutritional parameter but also as a predicting index of responsiveness to r hGH . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
However , in previous studies we showed that in the skin of fasted rats IGF 1 as well as IGFBP 1 and IGFBP 2 expressions were not different , compared to control rat skin , although collagen content was significantly decreased . ^^^ In the present study we show that fasted rat skin contains similar amounts of IGF 1 , IGFBP 3 and IGFBP 1 , although extract from fasted rat skin induced inhibition of collagen biosynthesis in cultured fibroblasts , compared to control rat skin extract . ^^^ We suggest that there is an increased level of IGFBP 1 phosphoisoform in fasted rat skin , associated with increased affinity for IGF 1 . ^^^ The increase of phosphorylated IGFBP 1 in fasted rat skin tissue may augment IGF 1 binding affinity for IGF and decrease its bioavailability for receptor interaction . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We investigated the effects of short term transdermal estradiol on basal and exercise stimulated serum GH , IGF 1 , and associated binding proteins ( IGFBP 1 and IGFBP 3 ) in seven weight stable female amenorrheic athletes with percentage body fats greater that 12 % . ^^^ Serum samples for GH , IGF 1 , IGFBP 1 , and IGFBP 3 were obtained at baseline ( t 1 ) , 72 hr ( t 2 ) , 144 hr ( t 3 ) , and during three 90 minute trials of aerobic exercise . ^^^ Basal , and exercise GH , IGF 1 , and IGFBP 1 were not different between trials . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The insulin like growth factor ( IGF ) axis is a complex system composed of 2 mitogenic ligands , IGF 1 and 2 , 2 receptors , IGF 1R and IGF 2R , and 6 binding proteins , IGFBP 1 to 6 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum was analysed for free and total IGF 1 and 2 , free plus dissociable IGF 1 , IGFBP 1 , 2 and 3 , IGFBP 1 bound IGF 1 as well as IGFBP 3 proteolysis . ^^^ RESULTS : When compared with controls , diabetic patients ( n = 58 ) showed reduced ( P < 0 . 0005 ) levels of free and total IGFs , free plus dissociable IGF 1 and IGFBP 3 , whereas levels of IGFBP 1 , IGFBP 1 bound IGF 1 and IGFBP 2 were elevated . ^^^ When comparing diabetic patients with different degrees of retinopathy , IGFBP 2 and IGFBP 1 bound IGF 1 were the only parameters that differed significantly . ^^^ Patients with retinopathy ( non PDR as well as PDR ) had elevated IGFBP 2 ( P < 0 . 03 ) and reduced IGFBP 1 bound IGF 1 ( P < 0 . 03 ) , when compared with patients without retinopathy . ^^^ CONCLUSION : Our study gives no evidence of a direct role of circulating free IGF 1 in the development of PDR , whereas IGFBP 2 and IGFBP 1 bound IGF 1 showed a relationship with the degree of retinopathy . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Blood was collected for IGF 1 , IGFBP 1 , and IGFBP 2 at 9 , 25 , and 35 wk gestation and in cord blood at delivery . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To this end , we evaluated the behavior not only of IGF 1 but also of IGF 2 , IGF binding protein ( IGFBP ) 3 , and acid labile subunit , the subunits that constitute the main IGF complex in circulation ( 150 kDa complex ) , as well as of IGFBP 1 and IGFBP 2 , which are negatively regulated by GH and , like IGFBP 3 , able to influence the bioavailability of the IGFs . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The genotypes and plasma IGF 1 and IGFBP 1 concentrations of 1031 subjects were analysed . ^^^ In addition , the 51Gln allele was a risk factor for hypertension ( OR=2 . 63 , CI : 1 . 37 5 . 08 , p=0 . 003 ) . 51Gln carriers had lower concentrations of IGF 1 and higher concentrations of IGFBP 1 compared to non carriers . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum samples were also used to measure insulin , IGF 1 , IGFBP 1 . ^^^ RESULTS : The Diet and Exercise and the Exercise alone groups had lower serum insulin and IGF 1 but higher IGFBP 1 compared to Controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
With respect to the gene expression of other IGF system components , VA deficiency caused a twofold induction of IGF 1 receptor ( IGF IR ) mRNA in the heart and a twofold reduction in IGFBP 6 mRNA in the lungs , but did not alter the expression of IGF 2 , IGFBP 1 , IGFBP 3 , IGFBP 4 or IGFBP 5 in all tissues examined . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The influence of insulin on secretion of IGF 1 and IGFBP 1 in cultures of human endometrial stromal cells . ^^^ OBJECTIVES : To study the influence of insulin on IGF 1 and IGFBP 1 secretion of the human endometrial stromal cells . ^^^ After 24 h of culturing , the mediums were collected for either IGF 1 or IGFBP 1 assays . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aim of the present study was to determine whether 4 months of intensified training would result in modified plasma insulin like growth factor 1 ( IGF 1 ) , insulin like growth factor binding protein 1 ( IGFBP 1 ) or IGFBP 3 in eight competitive cyclists and eight sedentary individuals and to define the relationships of these factors with glucose disposal . ^^^ IGF 1 was negatively correlated with insulin sensitivity before and after training ( r = 0 . 66 and 0 . 67 , respectively ; P < 0 . 05 ) and IGFBP 1 was negatively correlated with glucose effectiveness before andafter training ( r = 0 . 68 and 0 . 77 , respectively ; P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : Age was a strong determinant of both IGF 1 and IGFBP levels ; women aged 65 70 years had significantly lower IGF 1 and IGFBP 3 concentrations and significantly higher IGFBP 1 and IGFBP 2 concentrations than women aged 20 24 years . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
High affinity interactions between insulin like growth factors ( IGF 1 and IGF 2 ) and insulin like growth factor binding proteins ( IGFBP 1 , 2 , 3 , 4 , 5 and 6 ) antagonize the binding of IGF to the type 1 IGF receptor . ^^^ Proteases found in a variety of biological fluids can degrade IGFBP 1 6 into fragments that have a greatly reduced affinity for IGF 1 and IGF 2 , increasing the concentration of free IGFs at the cell surface and allowing IGFs to bind to and activate the IGF receptor . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE AND DESIGN : It has been suggested that circulating free IGF 1 participates in glucose homeostasis and that IGFBP 1 reflects changes in insulin sensitivity . ^^^ However , despite the reduction in IGFBP 1 , glucose infusion did not increase free IGF 1 over the control level , and free IGF 2 was slightly reduced ( P < 0 . 02 ) . ^^^ However , we can not preclude that the observed changes in circulating IGFBP 1 may affect the glucose lowering effect of IGF 1 and 2 at the local tissue level . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma levels of IGF 1 , IGFBP 1 , 2 , 3 and C peptide were measured by radioimmunoassays . ^^^ For IGF 1 , the adjusted OR ( 95 % CI ) of the top vs . bottom quartile was 1 . 1 ( 0 . 6 ; 2 . 1 ) ; for IGFBP 1 it was 0 . 7 ( 0 . 3 ; 1 . 3 ) ; for IGFBP 2 , 1 . 1 ( 0 . 5 ; 2 . 4 ) ; for IGFBP 3 , 1 . 6 ( 0 . 7 ; 3 . 5 ) , for C peptide , 1 . 3 ( 0 . 7 ; 2 . 7 ) and for IGF I / IGFBP 3 ratio , 1 . 0 ( 0 . 5 ; 1 . 8 ) . ^^^ Our data do not support an association between postmenopausal circulating levels of IGF 1 , IGFBP 1 , 2 , 3 , C peptide and postmenopausal breast cancer . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
PURPOSE : To perform a retrospective analysis of 62 age matched IVF treated women in order to investigate whether levels of inhibin B , IGF 1 , and IGFBP 1 in serum 2 days before oocyte retrieval and in follicular fluid at the day of oocyte retrieval might be useful as indicators of the ovarian ability to produce oocytes ( ovarian reserve ) . ^^^ Levels of inhibin B , IGF 1 , and IGFBP 1 in follicular fluid and in serum obtained 2 days before oocyte retrieval were analyzed and correlated to clinical parameters including estradiol levels , progesterone levels , follicle size , follicle number , and oocyte number . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
After binding with IGFBP 1 , IGFBP 2 and IGFBP 6 , IGF 1 passes through epithelium and reaches the target cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We performed clinical examination and estimation of serum concentrations of IGF 1 , free IGF 1 , IGFBP 1 , 2 , 3 and 6 , insulin , C peptide and fasting glucose . ^^^ Patients with obesity featured by decreased IGF 1 ( p < 0 . 05 ) , free IGF 1 ( p < 0 . 05 ) , IGFBP 1 ( p < 0 . 01 ) and IGFBP 3 ( p < 0 . 05 ) serum levels . ^^^ Type 1 diabetes was characterised by typical decrease in IGF 1 ( p < 0 . 05 ) , free IGF 1 ( p < 0 . 01 ) and IGFBP 3 ( p < 0 . 01 ) serum levels as well as by increase in IGFBP 1 ( p < 0 . 01 ) serum levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The reduction in free IGF 1 was paralleled by an increase in IGFBP 1 , an increase in the complex formation of IGFBP 1 and IGF 1 , and a modest reduction in IGFBP 3 proteolysis . ^^^ GH replacement increased free and total IGF 1 to levels similar to those observed during plain fasting and decreased IGFBP 1 , however , without affecting IGFBP 1 bound IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
LF mice had significantly lower levels of serum insulin , tumor IGF 1 mRNA expression , and tumor IGFBP 2 immunostaining and higher levels of serum IGFBP 1 ( by Western ligand blot ) relative to the HF mice . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
These data suggest that ( 1 ) endurance training increases SI , Sg , and IGFBP 1 and 3 in men and , for SI and IGFBP 1 , this increase becomes more pronounced with age ; ( 2 ) endurance training may attenuate the aged related decline in SI and IGF 1 ; and ( 3 ) IGFBP 1 may protect against the risk of hypoglycemia by counteracting the hypoglycemic effect of IGF 1 in such situations of high SI . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Enalapril decreased medullary expression of IGF 1 and increased renal expression of IGFBP 1 , changes that were not affected by concomitant GH treatment . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma IGF 1 , IGFBP 1 , and 3 were measured by radioimmunoassay and Western blot analysis . ^^^ IGF 1 , acid labile subunit ( ALS ) , IGFBP 1 and 3 mRNA levels were determined by Northern blot analysis . ^^^ The sepsis induced decrease in hepatic IGF 1 mRNA and circulating IGF 1 ( 26 % ) , as well as the 4 fold increase in plasma IGFBP 1 and hepatic IGFBP 1 mRNA were prevented by capsaicin . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Components of the IGF 1 system ( total and free IGF 1 ; IGFBP 1 , 3 , and ALS ; nonternary IGF 1 and IGFBP 3 ) , biomarkers of metabolic and nutritional status ( transferrin , ferritin , prealbumin , glucose , free fatty acids , glycerol , beta hydroxybutyrate ) , and body composition were measured in 12 men ( 22 + / 3 yr , 87 + / 8 kg , 183 + / 7 cm , 20 + / 5 % body fat ) on days 1 , 3 , and 4 during a control and experimental ( Exp ) period . ^^^ Exp produced losses in body mass ( 3 . 0 % ) , lowered total IGF 1 ( 24 % ) , free IGF 1 ( 42 % ) , IGFBP 3 ( 6 % ) , nonternary IGF 1 ( 27 % ) , and IGFBP 3 ( 16 % ) , and increased IGFBP 1 ( 256 % ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
End points included changes in fasting insulin , glucose , insulin resistance , IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 , and IGF 1 : IGFBP 3 molar ratio between baseline and week 15 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 and IGFBP 6 were examined by specific assays . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : The aim of this study is to evaluate the influence of three different HRT regimens on serum levels of SHBG , IGF 1 , IGFBP 1 and IGFBP 3 in postmenopausal women . ^^^ Levels of SHBG , IGF 1 , IGFBP 1 and IGFBP 3 in the serum were measured by means of a specific immunoassay . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : IGF 1 levels were reduced in trichinellosis ( p=0 . 016 ) , with the increased relative amounts of IGFBP 1 , 2 and 4 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
A low protein intake decreased the circulating levels of IGF 1 , IGFBP 3 , GH and insulin whereas the serum levels of IGFBP 1 were increased . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
CONCLUSION : Low total IGF 1 and , in relation to the obesity , low free IGF 1 , low total IGF 2 and non suppressed IGFBP 1 are consistent with the concept that PWS patients have a partial GH deficiency , which can be corrected by GH replacement . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and IGF binding protein 3 ( IGFBP 3 ) levels were significantly reduced , but by different degrees , in both mouse lines , but IGFBP 1 and 4 levels were reduced and IGFBP 2 levels increased in GHR / mice but unaltered in GHA mice . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Estrogen agonists / antagonists may down regulate growth hormone signaling in hepatocytes an explanation for their impact on IGF 1 , IGFBP 1 , and lipoprotein ( a ) . ^^^ These effects include reduced synthesis of IGF 1 and apolipoprotein ( a ) , and increased synthesis of IGFBP 1 shifts which arguably could decrease risk for vascular disease and certain cancers . ^^^ These effects are diametrically opposite to those of growth hormone ( GH ) , which boosts hepatic production of IGF 1 and apolipoprotein ( a ) , while suppressing that of IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The influence of glucose insulin potassium ( GIK ) on the GH / IGF 1 / IGFBP 1 axis during elective coronary artery bypass surgery . ^^^ Conclusions The authors conclude that GIK blunts the rise of IGFBP 1 and thereby increases the bioavailability of IGF 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 / IGFBP 1 increases blastocyst formation and total blastocyst cell number in mouse embryo culture and facilitates the establishment of a stem cell line . ^^^ We hypothesize that IGF 1 and its dephosphorylated binding protein ( IGFBP 1 ) may be able to improve embryo culture with an associated reduced cell death , and that the resultant increase in the total cell number of the embryo could increase the chances of establishing an embryonic stem cell line . ^^^ RESULTS : In vivo fertilized zygotes were cultured in medium containing supplementary IGF 1 , or IGFBP 1 / IGF 1 . ^^^ The establishment of embryonic stem cell lines was performed using the hatching blastocysts that were cultured in the presence of IGF 1 or IGFBP 1 / IGF 1 . ^^^ The results show that the rate of blastocyst formation in a tissue culture system in the presence of IGF 1 was 88 . 7 % and IGFBP 1 / IGF 1 it was 94 . 6 % , respectively , and that it was significantly greater than the figure for the control group ( 81 . 9 % ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We compared the regulation of IGFBP 1 and SHBG production by insulin and insulin like growth factors ( IGF 1 and IGF 2 ) in human hepatoma cell cultures . ^^^ IGF 1 and IGF 2 also inhibited the IGFBP 1 and SHBG levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
DESIGN : Cross sectional study in 121 healthy children ( 65 male , 56 female ) aged 5 18 years , in whom height , weight , body mass index ( BMI ) , pubertal status and measurements of IGF 1 , IGFBP 3 , IGFBP 1 and leptin were available . ^^^ In stepwise multiple regression , 30 % of the variability in ghrelin through childhood could be accounted for by log IGF 1 ( 24 % ) and log IGFBP 1 ( 6 % ) . ^^^ However in view of the negative relationship with IGF 1 and the positive relationship with IGFBP 1 , this fall in ghrelin could facilitate growth acceleration over puberty . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We investigated for the first time in a prospective study the association of pre diagnostic blood concentrations of C peptide ( a marker of pancreatic insulin production ) , IGF 1 , IGFBP 1 , 2 and 3 with endometrial cancer risk . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Real time RT PCR using SYBR Green 1 detection was employed to determine mRNA expressions of the following factors : ubiquitin ( UBQ ) , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF receptor type 1 ( IGFR 1 ) , growth hormone receptor ( GH R ) and IGF binding proteins 1 6 ( IGFBP 1 6 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Dexamethasone treatment decreased ( P < 0 . 05 ) plasma IGF binding protein ( IGFBP ) 1 on days 7 and 14 , but increased ( P < 0 . 05 ) plasma IGFBP 1 , decreased ( P < 0 . 05 ) plasma IGF 1 and IGFBP 3 , and decreased hepatic mRNA for growth hormone receptor ( GHR ) and IGF 1 on day 42 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Thus , IGF 1 , IGFBP 3 and the phosphorylation status of IGFBP 1 in circulation are likely to be involved in growth regulation during the postnatal period in VLBW infants . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Anthropometric data as well as fasting serum samples of plasma B glucose , serum lipids , insulin , insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) levels were determined . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In a group of 87 postmenopausal women , we found that childhood exposure to the 1944 1945 Dutch famine was associated with increased plasma levels of IGF 1 and IGFBP 3 , whereas IGFBP 1 and 2 levels were weakly decreased . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : To assess the effect of pegvisomant induced serum insulin like growth factor 1 ( IGF 1 ) normalization on IGF binding proteins 1 , 2 , 3 ( IGFBP 1 , IGFBP 2 and IGFBP 3 ) , total , non bound ( 45 kDa ) and 150 kDa ternary complex associated IGFBP 3 , and in vivo IGFBP 3 proteolysis in patients with active acromegaly . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We therefore examined metabolic and anthropometric influences on circulating levels of insulin like growth factor 1 ( IGF 1 ) , insulin like growth factor binding protein 1 ( IGFBP 1 ) , and the IGF 1 : IGFBP 1 ratio in a middle aged population of 349 men and 492 women . ^^^ However , we found that low IGFBP 1 levels and an increased IGF 1 : IGFBP 1 ratio were strongly associated with increased levels of insulin and glucose in men and women . ^^^ Body mass index was also positively related to the IGF 1 : IGFBP 1 ratio in men ( P < 0 . 001 ) and women ( P < 0 . 001 ) , independent of metabolic correlates of IGFBP 1 and IGF 1 . ^^^ Similarly , waist : hip ratio and waist circumference were also associated with an increased IGF 1 : IGFBP 1 ratio and low circulating IGFBP 1 levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The decline of free IGF 1 correlated with decreasing levels of IGFBP 3 and increasing levels of IGFBP 1 / 4 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Co expression of messenger ribonucleic acids encoding IGF 1 , IGF 2 , type 1 and 2 IGF receptors and IGF binding proteins ( IGFBP 1 to 6 ) during follicular development in the ovary of seasonally anoestrous ewes . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Before and after training , we measured serum levels of both total and free IGF 1 , IGFBP 1 and IGFBP 3 as well as plasma levels of branched chain amino acids ( valine , leucine and isoleucine ) and glucose from 26 cadets ( 21 + / 2 yr ) . ^^^ Total and free IGF 1 levels were decreased after training from 228 + / 12 to 160 + / 7 ng / ml and from 0 . 80 + / 0 . 08 to 0 . 52 + / 0 . 06 ng / ml , p < 0 . 001 respectively ) as well as IGFBP 3 ( p < 0 . 001 ) , while IGFBP 1 levels were increased ( p < 0 . 001 ) . ^^^ There were correlations between changes in total IGF 1 and IGFBP 3 ( p < 0 . 05 ) and between free IGF 1 and IGFBP 1 ( p < 0 . 01 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : Serum IGF 1 and the IGF 1 binding protein 1 ( IGFBP 1 ) were measured by specific radioimmunoassay ( RIA ) technique . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum IGF 1 concentrations were measured by RIA ; IGFBP 1 and IGFBP 2 by IRMA and IL 6 concentrations using quantitative ELISA immunoassays . ^^^ RESULTS : IL 6 and IGF 1 , IGFBP 1 and IGFBP 2 levels did not differ statistically significant between diabetic patients and controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The roles of IGFBP 1 and 2 in relation to IGF 1 bioactivity and cancer deserve further investigation . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVES : We investigated the relationship between maternal plasma free insulinlike growth factor 1 ( IGF 1 ) and insulinlike growth factor binding protein 1 ( IGFBP 1 ) concentrations and risk of preeclampsia . ^^^ Free IGF 1 and IGFBP 1 concentrations were measured using immunoassays . ^^^ RESULTS : Women who developed preeclampsia had 18 % and 27 % lower concentrations of free IGF 1 and IGFBP 1 , respectively , than controls ( P < 0 . 05 ) . ^^^ There was a 57 % reduced risk of preeclampsia among women with free IGF 1 concentrations of > or= 0 . 81 ng / mL ( OR = 0 . 43 , 95 % CI 0 . 23 0 . 83 ) and a 43 % reduced risk among women with IGFBP 1 concentrations of > or= 72 . 36 ng / mL ( OR = 0 . 53 , 95 % CI 0 . 23 1 . 21 ) . ^^^ CONCLUSIONS : Alterations of free IGF 1 and IGFBP 1 concentrations in maternal plasma during early pregnancy are associated with risk of preeclampsia . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Logistic regression , adjusted for age , sex , fasting insulin , and IGF 1 , demonstrated a striking 14 fold increased risk for the metabolic syndrome ( odds ratio 14 . 1 [ 4 . 1 48 . 4 ] , P < 0 . 001 ) in individuals with a CRP value in the highest tertile and IGFBP 1 levels below the median . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum was assayed for GH every 3 h ; total , free , and bioactive IGF 1 , IGF binding protein ( IGFBP ) 1 , 2 , and 3 as well as IGFBP 1 bound IGF 1 were assayed every morning . ^^^ IGFBP 1 increased from 38 + / 2 to 137 + / 24 , 212 + / 32 , and 214 + / 22 microg / liter ( d 1 vs . d 2 , d 3 , and end of d 3 ; P < 0 . 0001 ) , and these changes closely paralleled those of IGFBP 1 bound IGF 1 ( P < 0 . 0001 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
MEASUREMENTS : We analysed the strength and independence of associations of angiographically assessed presence of CHD with BMI , systolic and diastolic blood pressure , total , high density lipoprotein ( HDL ) and LDL cholesterol , triglycerides , lipoprotein ( a ) , apolipoproteins A 1 and B , total and free IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 , IGFBP 5 , acid labile subunit ( ALS ) , insulin , C peptide , testosterone , DHEAS and sex hormone binding globulin . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Total and free IGF 1 , IGF 2 , IGFBP 3 , and IGFBP 3 protease were similar between groups ( all P > . 5 ) , whereas , in LIPO , IGFBP 1 and IGFBP 2 were reduced ( 36 % , P < . 05 and 50 % , P < . 01 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin regulates energy metabolism and increases the bio activity of IGF 1 by enhancing its synthesis and by decreasing several of its binding proteins ( IGFBP 1 and 2 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Free IGF 1 , total IGF 2 , IGFBP 3 , and GH binding protein were lower , whereas IGFBP 1 , IGFBP 1 bound IGF 1 , and IGFBP 2 were elevated compared with control values . ^^^ Patients with detectable C peptide ( > or =100 pmol / liter ) had higher levels of total IGF 1 , free IGF 1 , and total IGF 2 and lower levels of IGFBP 1 and IGFBP 2 than those with an undetectable C peptide level despite having identical average HbA1c . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We analyzed plasma ghrelin levels and their correlation with plasma levels of leptin , insulin , insulin like growth factor 1 ( IGF 1 ) , insulin like growth factor binding protein 1 ( IGFBP 1 ) , insulin like growth factor binding protein 2 ( IGFBP 2 ) , insulin like growth factor binding protein 3 ( IGFBP 3 ) , and integrated concentration of growth hormone ( ICGH ) before and after dietary intervention . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In all subjects we assessed plasma levels of ghrelin , leptin , soluble leptin receptor , insulin , IGF 1 , IGFBP 1 , IGFBP 3 and IGFBP 6 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We have obtained highly enriched villous cytotrophoblast ( VCT ) from first trimester and term human placentae , and investigated the effects of IGF 1 , IGF 2 and phosphoisoforms of IGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
When tested in vitro with cultured zebrafish embryonic cells , IGFBP 1 itself had no mitogenic activity , but it inhibited IGF 1 and IGF 2 stimulated cell proliferation . ^^^ This inhibitory effect was abolished when IGF 1 or IGF 2 was added in molar excess , suggesting that IGFBP 1 inhibits embryonic growth and development by binding to and inhibiting the activities of IGFs . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Physical examinations ; serum leptin , IGF 1 , IGFBP 3 and IGFBP 1 levels ; and bone age 10 rays were performed annually for up to 48 months . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The reduction in serum IGF 1 and increase in IGFBP 1 with diet and exercise appear to be the most significant , as these changes lead to an increase in tumor cell p 53 protein and its down stream effector p 21 , which are responsible for the reduction in cell growth and induced apoptosis . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
At diagnosis we found elevated IGFBP 2 , low IGFBP 3 , low IGF 1 , and low normal IGF 2 , but normal IGFBP 1 levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum concentrations of luteinizing hormone , follicle stimulating hormone , estradiol , free testosterone , total testosterone , 17 hydroxyprogesterone , dehydroepiandrosterone sulfate , fasting insulin , IGF 1 , sex hormone binding globulin and insulin like growth factor binding protein 1 ( IGFBP 1 ) were evaluated before and after metformin treatment . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum IGF 1 and 2 , free IGF 1 , and insulin like growth factor binding protein 1 3 ( IGFBP 1 3 ) were measured by radioimmmunoassay ( RIA ) / immunoradiometric assay ( IRMA ) and IGFBPs by Western ligand blots ( WLB ) before and during treatment . ^^^ Combined treatment caused a higher increase in IGFBP 1 and larger suppression of total and free IGF 1 , IGF 2 , and IGFBP 3 ( P < 0 . 01 for all ) , but less suppression of IGFBP 2 ( P < 0 . 05 ) compared with tamoxifen monotherapy . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma concentrations of IGF 1 , free IGF , IGFBP 3 , and IGFBP 1 were measured in blood samples collected in 1989 to 1990 . ^^^ Findings : Among postmenopausal women , neither IGF 1 , IGFBP 3 , IGFBP 1 , nor free IGF was associated with breast cancer risk [ RRs , top versus bottom quintile : IGF 1 , 1 . 0 ; 95 % confidence interval ( 95 % CI ) , 0 . 7 1 . 4 ; IGFBP 3 , 0 . 8 ; 95 % CI , 0 . 6 1 . 1 ; IGFBP 1 , 0 . 9 ; 95 % CI , 0 . 6 1 . 5 ; and free IGF , 1 . 0 ; 95 % CI , 0 . 6 1 . 4 ] . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In fetal blood , IGFBP 1 is the primary IGF binding protein whose phosphorylation generates proteins with different affinities for IGF 1 . ^^^ Because hpIGFBP 1 has a higher affinity for IGF 1 than does lpIGFBP 1 , diabetes related changes in fetal IGFBP 1 phosphorylation may increase IGF 1 bioavailability and , consequently , stimulate fetal growth . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We conducted a randomized trial to determine the effects of 2 dietary patterns on serum IGF 1 , IGFBP 1 and IGFBP 3 in free living premenopausal women : phase 1 , an isocaloric low fat , high fiber ( LFHF ) vs . usual diet , and phase 2 , a soy supplement either with or without isoflavones ( soy+IF vs . soy IF ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The IGF 1 to IGFBP 3 molar ratio was associated with colon cancer risk ( MVRR , 2 . 82 ; 95 % CI , 1 . 35 5 . 88 ) , and women with low levels of both IGF I / IGFBP 3 and C peptide ( or high IGFBP 1 ) were at low risk , and elevation of either was sufficient to increase risk . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
METHODS : Preoperative sera from 141 patients undergoing RRP were analyzed for IGF 1 , IGFBP 1 , IGFBP 2 and IGFBP 3 . ^^^ Average levels of IGF 1 , IGFBP 1 , IGFBP 2 and IGFBP 3 were 156 . 5 ng / ml , 48 . 1 ng / ml , 396 . 8 ng / ml and 3303 . 7 ng / ml , respectively . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum IGF 1 and 2 , IGFBP 1 and 3 , and GH levels were measured on days 1 , 3 and 7 after admission . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Blood was drawn 0 , 10 , 20 , and 40 days postburn and serum insulin like growth factor 1 ( IGF 1 ) , insulin like growth factor binding protein 1 and 3 ( IGFBP 1 , and 3 ) , growth hormone , insulin , and cytokines were measured . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : To determine the relation between weight deficit at birth and IGF 1 , IGFBP 1 , Leptin , and AFP levels in amniotic fluid after 14 18 weeks ; to assess the diagnostic usefulness of these biochemical markers . ^^^ RESULTS : No significant correlation was found between severity of IUGR and IGF 1 , IGFBP 1 , or Leptin . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Circulating levels of insulin like growth factor 1 ( IGF 1 ) and its principal binding protein IGFBP 3 are reduced , whereas those of the inhibitory binding protein , IGFBP 1 , tend to be high in children and adolescents with type 1 diabetes mellitus ( T1DM ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We demonstrated that the level of IGF 1 and ALS mRNAs is dramatically decreased in both young and aged dwarf livers , transcripts encoding IGF IR and IGFBP 1 are elevated in young dwarfs , but normalize to control levels in aged dwarf livers while transcripts encoding IGFBP 3 are elevated only in aged controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum GH , IGF 1 , IGFBP 1 and IGFBP 3 were measured by ELISA . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In all subjects , we further assessed the concentrations of leptin , soluble leptin receptor , insulin , IGF 1 , free IGF 1 and IGFBP 1 , 2 , 3 and 6 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aim of the study was to test the hypothesis that in adolescents with type 1 diabetes mellitus and microalbuminuria ( MA ) there are specific disorders of serum insulin like growth factor 1 ( IGF 1 ) and concentrations of its binding proteins , IGFBP 1 and IGFBP 3 , that could be of importance in the pathogenesis of microvascular diabetic complications . ^^^ Serum fasting concentrations of IGF 1 and overnight urine albumin concentrations were measured by radioimmunoassay , IGFBP 1 and IGFBP 3 concentrations by immunoradiometric assay and HbA1c by high performance liquid chromatography methods . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
OBJECTIVE : A possible involvement of insulin like growth factor 1 ( IGF 1 ) and its binding protein IGFBP 1 in the pathogenesis of cardiovascular disorder has been suggested . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Infection with the human immunodeficiency virus ( HIV ) is often associated with a decrease of the concentrations of IGF 1 , IGF 2 , IGF binding protein 3 ( IGFBP 3 ) and an increase of IGFBP 1 and 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 mRNA expression in all classes of follicle was generally low throughout the oestrous cycle , while IGFBP 1 mRNA expression could not be demonstrated at all . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
CONCLUSION : Submaximal exercise induced minor changes in IGFBP 1 , 2 and 3 , without affecting IGFBP 3 proteolysis and IGF 1 bioavailability . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
These differences were still apparent when adjustment was made for BMI by location for IGF 1 ( F=57 . 4 , p < 0 . 001 ) and IGFBP 3 ( F=5 . 7 , p=0 . 02 ) , but were no longer apparent for IGFBP 1 and insulin . ^^^ CONCLUSIONS / INTERPRETATION : Environmental factors have profound effects on circulating IGF system components and on the relationship between IGFBP 1 , IGF 1 and related metabolic variables . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
RESULTS : In nondiabetic rats , mRNA for IGFBP 1 , 5 , and 6 ; IGF 1 ; and IGFIR were detected in the retina . ^^^ In addition , IGF 1 mRNA was present in the cornea , IGFBP 1 mRNA was observed in the cornea and iris , and IGFBP 5 and 6 mRNAs were identified in the ciliary body , iris , and cornea . mRNAs for IGFBP 2 , 3 , and 4 were not found in the eyes . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
PURPOSE : In the present article we propose to evaluate IGF 1 , IGFBP 1 and 3 in the follicular fluid of infertile patients submitted to in vitro fertilization . ^^^ We compared their follicular fluid concentration of IGF 1 , IGFBP 1 and IGFBP 3 between the patients who became pregnant ( n = 11 ) versus those nonpregnant ( n = 42 ) . ^^^ IGF 1 and IGFBP 1 were not significantly different between the groups ( p > 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Circulating levels of total and free IGF 1 and 2 , IGFBP 1 , 2 and 3 and GH binding protein ( GHBP ) as well as ghrelin were measured with validated in house immunoassays . ^^^ Fasting levels of total IGF 1 were 121+ / 33 microg / L after LNP and 117+ / 28 microg / L after HNP diet ( ns ) and the corresponding concentrations of IGFBP 1 were 142 ( 141 ) and 132 ( 157 ) mug / L [ median ( IQR ) ] ( ns ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Since SRIF analogues are also known to interact with other metabolic pathways , IGF 1 , IGFBP 1 , glucose and insulin concentrations on the control day ( CD ) and on treatment days following a single s . c . injection SOM 230 100 and 250 microg , were compared to those following OCT 100 microg . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Blood samples for determination of plasma glucose and serum concentrations of free T 3 and T 4 , TSH , albumin , cortisol , insulin , GH , IGF 1 , IGFBP 1 , leptin , and ghrelin were drawn in the morning from an antecubital vein . ^^^ This brought about increased IGF 1 bioavailability as reflected by a rising IGF 1 / IGFBP 1 ratio from 5 . 1 + / 1 . 1 to 13 . 8 + / 2 . 9 ( p < 0 . 01 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 , IGF 1 binding protein 1 ( IGFBP 1 ) , IGFBP 3 , and myoglobin were measured by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor binding protein 1 ( IGFBP 1 ) , a potent modulator of IGF 1 , is expressed in normal osteoblasts and inhibits collagen gene expression in bone , but little is known about the relationship between IGFBP 1 and bone mineral density ( BMD ) . ^^^ IGF 1 and IGFBP 1 were weakly and inversely associated with each other . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In liver cirrhosis the IGF axis is severely disturbed , and these alterations are associated with reduced IGF 1 , IGFBP 3 but elevated IGFBP 1 serum levels . ^^^ RESULTS : ISH revealed a homogeneous distribution of IGFBP 1 , IGFBP 4 and IGF 1 mRNA over hepatic parenchyma in normal and cirrhotic liver . ^^^ Fibrous septa of cirrhotic liver were IGFBP 1 mRNA negative , whereas IGFBP 4 and IGF 1 transcripts were detected in single cells . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
IGF 1 and IGF 2 ( IGFs ) form higher molecular weight complexes with specific binding proteins ( IGFBP 1 to 6 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
There was no correlation of plasma IGFBP 4 level with age , sex , immunophenotype , or ALL risk group , and there was no correlation of IGFBP 4 level with plasma IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , and IGFBP 3 levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We measured glucose , insulin , IGF 1 , IGFBP 1 , IGFBP 3 , glucagon , growth hormone ( GH ) , prolactin , adrenocorticotropin ( ACTH ) , cortisol and IL 6 in umbilical cord blood of infants born at term gestation after : A ) elective Cesarean section ( n = 37 ) , B ) normal delivery ( n = 87 ) or C ) complicated delivery ( n = 25 ) . ^^^ IGFBP 1 showed a significant positive correlation to IL 6 and lactate and a significant negative correlation to both IGF 1 and arterial pH . ^^^ Furthermore , IGFBP 1 and IL 6 increase steeply , presumably aimed at diminishing insulin like activity of IGF 1 , thereby reducing peripheral glucose utilization . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In this study , IGF 1 , IGFBP 3 , IGFBP 1 and leptin levels were investigated in 27 children with PA aged 5 . 4 8 . 6 years and 13 healthy children aged 5 . 7 8 . 58 years . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Changes in total IGF 1 ( tIGF 1 ) and total IGF 2 ( tIGF 2 ) , free IGF 1 ( fIGF 1 ) , IGF binding proteins ( IGFBP 1 and IGFBP 3 ) , IGFBP 3 protease activity and insulin levels were examined in 31 patients with active CD ( CDAI : 186 603 ) during treatment with prednisolone ( 40 mg for 1 week ) and tapering the dose by 5 mg / week . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The IGF system is a complex network comprised of two growth factors ( IGF 1 and 2 ) , cell surface receptors ( IGF IR and IIR ) , six specific high affinity binding proteins ( IGFBP 1 to IGFBP 6 ) , IGFBP proteases as well as several other IGFBP interacting molecules , which regulate and propagate IGF actions in several tissues . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In contrast , during the study period total and free IGF 2 decreased ( P < 0 . 05 ) , whereas total IGF 1 , IGFBP 1 and IGFBP 2 increased ( P < 0 . 001 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Before treatment , in women and men , IGF 1 was directly related to IGFBP 3 ( P < 0 . 001 and P < 0 . 0001 ) and IGFBP 1 to IGFBP 2 ( P = 0 . 0001 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Biochemical analyses of insulin , IGF 1 , IGFBP 1 , IGFBP 3 , IL 6 , high sensitivity ( hs ) CRP and other routine markers . ^^^ RESULTS : Both IGF 1 and IGFBP 1 showed significant and opposite correlations with most markers of nutritional status , including SGA ( rho= 0 . 29 and 0 . 27 ; P < 0 . 001 ) , nPNA ( rho=0 . 18 and 0 . 22 ; P < 0 . 05 ) , S creatinine ( rho=0 . 19 and 0 . 19 ; P < 0 . 01 ) and HGS ( rho=0 . 21 and 0 . 25 ; P < 0 . 01 ) . ^^^ Both IGF 1 and IGFBP 3 , but not IGFBP 1 , were significantly correlated with age ( rho= 0 . 25 for IGF 1 and 0 . 35 for IGFBP 3 ; P < 0 . 001 ) and hsCRP ( rho= 0 . 21 and 0 . 32 ; P < 0 . 01 ) . ^^^ In multivariate analysis , SGA and s albumin were independent predictors of both IGF 1 and IGFBP 1 . ^^^ CONCLUSION : Both IGF 1 and IGFBP 1 appear to correlate well with markers of protein energy malnutrition and sarcopenia . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Cross linking ( 125 ) 1 labelled IGFBP 1 with salmon IGF 1 eliminated interference by IGFs . ^^^ There was a clear trend that circulating IGFBP 1 levels were negatively correlated with body weight , condition factor ( body weight / body length ( 3 ) 10 100 ) , growth rates and circulating 41 kDa IGFBP levels but not IGF 1 levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Most of circulating IGF 1 is bound to an acid labile subunit and to one of six insulin like growth factor binding proteins ( IGFBPs ) , among which the most important are IGFBP 3 and IGFBP 1 . ^^^ We genotyped 23 common single nucleotide polymorphisms in IGF 1 , IGFBP 1 , IGFBP 3 and IGFALS , and measured serum levels of IGF 1 and IGFBP 3 in samples of cases and controls . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Fasting blood samples were obtained for measurement of glucose , insulin , IGF 1 , IGFBP 1 , IGFBP 3 and lipid levels . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Serum levels of CRP , serum amyloid A ( SAA ) , interleukin 6 ( IL 6 ) , tumor necrosis factor alpha ( TNFalpha ) , antibodies against oxidized LDL , insulin and insulin like growth factor 1 ( IGF 1 ) along with insulin like growth factor binding protein 1 ( IGFBP 1 ) and IGFBP 3 were analyzed before and during the two treatments . ^^^ Both preparations lowered IGF 1 and raised IGFBP 1 and IGFBP 3 concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The serum levels of PI , immunoreactive insulin ( IRI ) , IGFBP 1 and free insulin like growth factor 1 ( IGF 1 ) were measured in the fasting state . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In the present study , circulating IGF 1 , IGF 2 and their binding proteins ( IGFBP 3 , IGFBP 2 and IGFBP 1 ) were determined in 92 adult patients with gastrointestinal inflammation ( Crohn ' s disease , colitis ulcerosa , gastritis , duodenitis errosiva , gastrointestinal candidiasis , and rotaviral and adenoviral enteritis ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The aim of the present study was to investigate whether moderately elevated IL 6 levels have short term effects on circulating IGF 1 , IGFBP 1 and IGFBP 3 proteolysis in vivo . ^^^ Free IGF 1 , total IGF 1 , IGFBP 1 , insulin and cortisol were measured using immunoassays . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In experiments with saline infusion , levels of ghrelin ( P < 0 . 001 ) , C peptide ( P < 0 . 001 ) , glucagon ( P < 0 . 001 ) , adiponectin ( P = 0 . 005 ) , cortisol ( P = 0 . 012 ) , IGF 1 ( P < 0 . 001 ) , IGFBP 3 ( P = 0 . 038 ) , and IGFBP 1 ( P = 0 . 001 ) fell in response to euglycemic hyperinsulinemia . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
It shows that only in a few instances , such as for example , between IGF 1 and IGFBP 3 , and IGFBP 1 and leptin , significant and substantial genetic ( and environmental ) correlations were found . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
The high affinity IGF binding proteins ( IGFBP 1 to 6 ) have also been involved in IGF 1 regulation , and it is important to include the IGF independent properties , particularly those of IGFBP 3 that may be involved in the osteoblastic differentiation observed in human bone marrow stromal cell cultures . ^^^ Thus , maternal and umbilical cord serum IGF 1 and 1 , 25 ( OH ) D ( 3 ) concentrations are lower in preeclampsia and umbilical cord serum IGF 1 , IGFBP 1 and IGFBP 3 concentrations are associated with low newborn birth weights . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Plasma concentrations of IGF 1 , IGF binding protein ( IGFBP ) 3 , IGFBP 1 , and GH were measured in blood samples collected between 1996 and 1999 . ^^^ Overall , plasma IGF 1 , IGFBP 1 , IGFBP 3 , and GH levels were not associated with breast cancer risk ( relative risks , top vs bottom quartile ; IGF 1 , 0 . 98 , 95 % confidence interval ( CI ) , 0 . 69 1 . 39 ; IGFBP 1 , 0 . 95 , 95 % CI , 0 . 63 1 . 41 ; IGFBP 3 , 1 . 10 , 95 % CI , 0 . 78 1 . 54 ; GH , 1 . 09 , 95 % CI , 0 . 82 1 . 46 ) . ^^^ In conclusion , circulating IGF 1 , IGFBP 1 , IGFBP 3 , and GH levels appear to have no important association with breast cancer risk in a large cohort of premenopausal women . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Sixteen women patients with anorexia nervosa and thirteen healthy women of comparable age were examined clinically and blood samples were taken for estimation of serum levels of ghrelin , leptin , soluble leptin receptor , IGF 1 , IGFBP 1 and IGFBP 3 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Effects of betaine on ethanol stimulated secretion of IGF 1 and IGFBP 1 in rat primary hepatocytes : involvement of p42 / 44 MAPK activation . ^^^ AIM : To evaluate the effects of betaine on the ethanol induced secretion of IGF 1 and IGFBP 1 using radioimmunoassay and Western blotting , respectively , in primary cultured rat hepatocytes . ^^^ We measured IGF 1 and IGFBP 1 using radioimmunoassay and Western blotting , respectively . ^^^ At 10 ( 3 ) mol / L , betaine significantly increased IGF 1 secretion but decreased IGFBP 1 secretion . ^^^ Furthermore , the changes in IGF 1 and IGFBP 1 secretion resulting from the increased betaine induced p42 / 44 MAPK activity in primary cultured rat hepatocytes was blocked by treatment with the MAPK inhibitor PD 98059 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
However , in both groups , fasting serum insulin , total T , free T , LH , DHEA S , delta4A , and IGF 1 levels decreased significantly , and SHBG and IGFBP 1 exhibited significant increases . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
CONCLUSIONS : The interplay between GH secretion , NO production , IGF 1 , IGFBP 1 , and IGFBP 3 levels , lipid profile , insulin sensitivity and the degree of visceral obesity necessitates further study . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In addition , insulin like growth factors ( IGFs ) and their binding proteins are regulated in and act on endometrial cellular constituents , and hyperinsulinemia down regulates hepatic IGFBP 1 , resulting in elevated free IGF 1 in the circulation . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Compared with Pl , E ( 2 ) did not alter ghrelin concentrations but reduced IGF 1 and IGFBP 3 and elevated IGFBP 1 concentrations . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
PATIENTS AND METHODS : IGF 1 and binding proteins ( IGFBP 1 and 3 ) serum levels were measured at baseline and after 3 and 6 months of treatment in a selected group of patients with prostate cancer who were randomly assigned to treatment with bicalutamide , bicalutamide plus anastrozole or bicalutamide plus tamoxifen in a comparative study investigating the role of pharmacological medication in the development of bicalutamide induced gynecomastia . ^^^ No major changes from baseline up to month 6 either in IGF 1 or in IGFBP 1 and 3 were observed in the bicalutamide plus anastrozole arm . ^^^ The addition of tamoxifen to bicalutamide produced a sharp decrease in IGF 1 levels ( p < 0 . 001 ) coupled with an increase in both IGFBP 1 ( p=0 . 001 ) and , to a lesser extent , IGFBP 3 ( p=0 . 5 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin sensitivity ( insulin sensitivity index [ S ( 1 ) ] from intravenous glucose tolerance tests in nondiabetic subjects , or the rate constant for disappearance of glucose [ K ( ITT ) ] from insulin tolerance tests in type 2 diabetic subjects ) , circulating IGFBP rP 1 ( from enzyme linked immunosorbent assay ) , adiponectin ( from radioimmunoassay ) , C reactive protein ( CRP ; from immunoturbidimetry ) , soluble tumor necrosis factor receptor 2 ( sTNFR 2 ; from enzyme amplified sensitivity immunoassay ) , and IGF system parameters ( IGF 1 , free IGF 1 , and IGFBP 1 from immunoradiometric assay ) were assessed in all subjects . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
No significant differences between arterial and venous concentrations of total IGF 1 or IGFBP 1 were detected over the leg at any time . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To investigate their roles in tooth movement , root resorption , and repair , the occurrence of components of the IGF system , including the ligands IGF 1 and 2 , the IGF receptor 1 ( IGF1R ) and six IGF binding proteins ( IGFBP 1 to 6 ) , was investigated by immunohistochemistry on sections from rat maxillae where the first molar had been moved mesially by means of an orthodontic appliance for 9 d to induce root resorption . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Low IGFBP 1 , particularly coupled with low IGF 1 , is associated with increased cardiovascular risk . ^^^ METHODS : Fasting IGFBP 2 , IGFBP 1 , IGFBP 3 , IGF 1 , IGF 2 , insulin , C peptide , glucose , lipids , NEFAs , and HbA1c were measured in a cohort of 163 patients with type 2 diabetes . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Maternal and mixed umbilical cord blood was collected at delivery and analyzed for insulin , glucose , IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 , GH , and GHBP . ^^^ In Group 4 , birth weight correlated positively with cord IGF 1 levels ( r2=0 . 41 , p=0 . 0098 ) and negatively with cord IGFBP 1 levels ( r2=0 . 51 , p=0 . 0039 ) , and ponderal index correlated negatively with cord IGFBP 1 levels ( r2=0 . 27 , p < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
To analyze the effects of N and C terminal domain interactions , we determined several 10 ray structures : first , of a ternary complex of N and C terminal domain fragments of IGFBP 4 and IGF 1 and second , of a `` hybrid ' ' ternary complex using the C terminal domain fragment of IGFBP 1 instead of IGFBP 4 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Rat insulin like growth factor binding protein 1 ( rIGFBP 1 ) was purified from H4IIE rat hepatoma cells by IGF 1 affinity chromatography and reverse phase HPLC . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Insulin like growth factor binding protein 1 ( IGEBP 1 ) is a member of the family of soluble proteins that bind insulin like growth factors ( IGF 1 and IGF 2 ) and modulate their biological actions at the cellular level . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
However , correct disulfide bonds are formed very efficiently when insulin like growth factor binding protein 1 is added in equimolar amounts to IGF 1 to the refolding mixture . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
We used transgenic mice that overexpress insulin like growth factor binding protein 1 to investigate the role of IGF 1 in the accumulation of fat tissue . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Fasting blood samples for glucose and insulin , as well as for 2 markers of the glucose insulin homeostasis , i . e . , the growth hormone ( GH ) dependent insulin like growth factor 1 ( IGF 1 ) and the insulin dependent insulin like growth factor binding protein 1 , were analyzed . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Cloning of cDNA encoding human placental protein 12 ( PP 12 ) : binding protein for IGF 1 and somatomedin . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
It is discussed the possible importance of PP 12 , IGF BP 25 as a binding protein of growth factor s IGF 1 and 2 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In liquid phase RIA , IGF 1 did not affect the binding of [ 125I ] PP 12 to one antibody ( Mab 6303 ) , it slightly increased the binding to two antibodies ( Mab 6301 and 6304 ) , and it slightly decreased the binding to one antibody ( Mab 6302 ) . ^^^ All antibodies immunoprecipitated the cross linked PP 12 [ 125I ] IGF 1 complex , but Mab 6302 considerably less effectively than the others . ^^^ Preincubation of PP 12 with Mab 6302 completely inhibited the binding of [ 125I ] IGF 1 to PP 12 , whereas preincubation with Mab 6303 had no effect , and Mab 6301 as well as Mab 6304 increased it . ^^^ Conformational changes in PP 12 probably account for the IGF 1 induced increase in the binding of Mabs 6301 and 6304 to [ 125I ] PP 12 , and vice versa , for Mabs 6301 and 6304 induced increase in the binding of [ 125I ] IGF 1 to PP12 . . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Both placental PP 12 and amniotic fluid PP 12 were found to bind somatomedin C ( IGF 1 ) with high affinity , Ka = 1 10 10 ( 9 ) l / mol ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
PP 12 too binds somatomedin C , or IGF 1 ( insulin like growth factor 1 ) . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
In chromatographic experiments , plasmin completely dissociated complexes of [ 125I ] IGF 1 BP and [ 125I ] IGF 2 BP formed with purified decidual IGFBP ( hIGFBP 1 ) or IGFBPs present in medium conditioned by human osteosarcoma MG 63 cells . ^^^ In vitro experiments confirmed plasmin dissociation of bioactive IGF 1 from hIGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
Concurrent incubation of hIGFBP 1 with either 125I IGF 1 or 125I IGF 2 prevented the binding of both 125I IGFs to cells in a dose dependent manner . hIGFBP 1 inhibition of IGF binding occurred similarly under both 4 degrees and 37 degrees C conditions . ^^^ The inhibitory effect of hIGFBP 1 on IGF 1 mediated 3H thymidine incorporation into DNA was dose dependent . hIGFBP 1 did not inhibit binding to or stimulation of growth in MG 63 cells by des 3 IGF 1 , an IGF 1 analog with a 100 fold less affinity for hIGFBP 1 . ^^^
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P05019 Pubmed SVM Score :0.0
NA