Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
This low molecular weight insulin like growth factor ( IGF ) binding protein 1 ( IBP 1 ) is one of two distinct classes of IGF binding proteins which bind IGF 1 and IGF 2 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Effect of recombinant IGF binding protein 1 on primary cultures of human keratinocytes and fibroblasts : selective enhancement of IGF 1 but not IGF 2 induced cell proliferation . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
B glucose , P insulin , serum IGF 2 , procollagen 3 peptide and phosphate increased and urea , creatinine and IGF binding protein 1 decreased during treatment . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGF 2 was measured after separation by gel chromatography at low pH and compared with IGF 1 levels in the same samples , whereas IGF binding protein 1 was measured in dialysed urine . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We have examined the developmental pattern of IGF binding protein 1 ( IGFBP 1 ) , 2 , and 3 in serum by Western ligand blotting , the levels of IGFBP 3 , IGF 1 , and IGF 2 in serum by RIA , and the IGFBP mRNA levels of IGFBP 1 , 2 , and 3 in the livers of rhesus monkeys from fetal life through adulthood by Northern analysis . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
To test the hypothesis that growth hormone ( GH ) insensitivity is responsible , amongst other mechanisms , for impaired growth in uraemic children , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 and IGFBP 3 were measured by radioimmunoassay in normal control children , in patients with end stage renal failure ( n = 51 ) and in patients with preterminal chronic renal failure ( n = 11 ) and the production rate of IGF was calculated . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Spontaneous overnight and arginine stimulated GH secretion , insulin , IGF 1 , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , and IGFBP 3 levels were measured before , during , and after daily 10 h sc infusions of saline or IGF 1 ( 20 micrograms / kg . h ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGF 1 , IGF 2 , and IGF binding protein 1 ( IGFBP 1 ) , 2 , 3 , and 4 were identified in PF by immunoassays . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Serum levels of insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 were measured in 94 children with chronic renal failure ( CRF ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Serum and follicular fluid levels of insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 and 3 during the normal menstrual cycle . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Serum levels of insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 were measured in 54 children with end stage renal disease ( ESRD ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We also measured ultrafiltrated serum free IGF 1 and IGF 2 , total IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 3 , and insulin in a subgroup of 18 placebo treated and 20 lanreotide treated patients . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The patterns of expression insulin like growth factor 2 ( IGF 2 ) and IGF binding protein 1 ( IGFBP 1 ) mRNAs were compared between term human and rhesus monkey placenta using in situ hybridization histochemistry . ^^^ Expression of insulin like growth factor 2 and IGF binding protein 1 mRNAs in term rhesus monkey placenta : comparison with human placenta . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Plasmon resonance spectroscopy experiments revealed that all the high Mr isoforms and mature 7 . 5 kDa IGF 2 bound to immobilized recombinant soluble human IGF 1 receptor , recombinant human IGF binding protein 1 , and sIGF II / MPR with similar kinetics . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We compared levels of GH , IGF 1 , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , insulin , and C peptide in nondepressed CFS patients and normal controls . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
RNA expression of insulin like growth factor 1 ( IGF 1 ) is suppressed and those of IGF 2 and IGF binding protein 1 are constantly expressed in the endometrium during use of an intrauterine levonorgestrel system . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We examined the ontogeny of mRNA levels of IGF 1 and 2 , IGF type 1 ( IGFI R ) and type 2 receptors ( IGFII R ) , IGF binding protein 1 and 3 ( IGFBP 1 and 3 ) , GH receptor ( GHR ) , and tissue concentrations of IGF and IGFBP in the pancreas of pigs . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We studied 11 elderly male ( 50 78 years ) marathon runners and 10 age matched male ( 52 73 years ) sedentary controls to evaluate plasma concentrations of GH , total and free IGF 1 and IGF 2 and of IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , IGFBP 3 and insulin . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We evaluated the GH bioactivity ( GH BIO ) , GH serum level by immunofluorimetric assay ( GH IFMA ) , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 in 21 prepubertal obese children ( 13 boys and eight girls ) aged 5 . 7 to 9 . 4 years affected by simple obesity and in 32 ( 22 boys and 10 girls ) age and sex matched normal weight controls . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Other results were : IGF 1 , 3 11 ng / mL ( normal , 114 492 ) ; IGF 2 , 185 299 ng / mL ( normal , 358 854 ) ; IGF binding protein 1 ( IGFBP 1 ) , 12 200 ng / mL ( normal , 13 73 ) ; IGFBP 2 , 60 384 ng / mL ( normal , 55 480 ) ; and IGFBP 3 , 400 600 ng / mL ( normal , 2000 4000 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Leptin , insulin , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 were measured by specific immunoassays . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGF 1 , IGF 2 , IGF binding protein 1 , and C peptide in second trimester amniotic fluid are dependent on gestational age but do not predict weight at birth . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We therefore measured IGF 1 , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , IGFBP 3 , and acid labile subunit ( ALS ) in 27 GHD subjects ( aged 5 82 yr ) from an extended kindred in Northeast Brazil with an identical GHRH receptor mutation and in 55 indigenous controls ( aged 5 80 yr ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Insulin like growth factor 2 ( IGF 2 ) and IGF binding protein 1 ( IGFBP 1 ) appear to play an important role in paracrine interactions at the maternal fetal interface in human pregnancy . ^^^ Insulin like growth factor 2 ( IGF 2 ) and IGF binding protein 1 ( IGFBP 1 ) appear to play an important role in paracrine interactions at the maternal fetal interface in human pregnancy . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We have extended the analysis of specimens to include measurements of GHBP , PGH , IGF 1 , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 and have related these to maternal characteristics , fetal growth , and glycemia . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We measured basal levels of serum insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 and IGFBP 3 together with 24 h urinary GH excretion . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Size at birth and cord blood levels of insulin , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 3 , and the soluble IGF II / mannose 6 phosphate receptor in term human infants . ^^^ We measured cord blood levels of IGF 2 , soluble IGF2R , insulin , IGF 1 , IGF binding protein 1 ( IGFBP 1 ) , and IGFBP 3 and examined their relationships to weight , length , head circumference , ponderal index , and placental weight at birth in 199 normal term singletons . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
To determine the role of IGF binding proteins in mediating the direct effects of recombinant human IGF 1 on insulin requirements in type 1 ( insulin dependent ) diabetes mellitus , overnight changes in IGF 1 , IGF 2 , and IGF binding protein 1 , 2 , and 3 , collected under euglycemic conditions , were compared in nine subjects after double blind , randomized , sc administration of recombinant human IGF 1 ( 40 microg / kg ) or placebo at 1800 h . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Insulin like growth factor 2 ( IGF 2 ) and IGF binding protein 1 ( IGFBP 1 ) gene variants are associated with overfeeding induced metabolic changes . ^^^ AIMS / HYPOTHESIS : The aim of this study was to investigate the role of insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) and IGFBP 3 gene variants on the metabolic changes observed in response to a 100 day overfeeding protocol conducted with 12 pairs of monozygotic twins . ^^^ Insulin like growth factor 2 ( IGF 2 ) and IGF binding protein 1 ( IGFBP 1 ) gene variants are associated with overfeeding induced metabolic changes . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We examined whether the concentrations of estrone , E 2 , IGF 1 , IGF 2 , and IGF binding protein 1 ( IGFBP 1 ) , 2 , and 3 in umbilical cord blood plasma differed in female neonates of three racial / ethnic groups with contrasting breast cancer risk . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Transforming growth factor beta ( TGF beta ) , decorin ( a proteoglycan in the ECM ) , and melanoma cell adhesion molecule ( Mel CAM ) inhibit , and insulin like growth factor 2 ( IGF 2 ) , IGF binding protein 1 ( IGFBP 1 ) , and endothelin 1 ( ET 1 ) stimulate EVT cell migration / invasion . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Fasting IGF 1 , IGF 2 and IGF binding protein 1 ( IGFBP 1 ) concentrations were determined and their relationship to specific dietary constituents was analysed . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Fasting glucose , insulin , IGF 1 , and glucagon were higher on Pred vs . placebo , whereas IGF 2 and IGF binding protein 1 and 2 were lower . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Early developmental changes in IGF 1 , IGF 2 , IGF binding protein 1 , and IGF binding protein 3 concentration in the cerebrospinal fluid of children . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The circulating levels of IGF 1 , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , and IGFBP 3 did not differ between patients and controls . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Measures at baseline , 6 and 12 months included body weight , height , body fat , lean mass , body fat % , and waist circumference , as well as fasting glucose , insulin , insulin resistance , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 , IGFBP 2 , and IGFBP 3 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Before and after intervention , levels of fasting insulin , GH , total IGF 1 , free IGF 1 , IGF binding protein 1 , IGF 2 , free fatty acids , testosterone , and SHBG were measured . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Serum levels of insulin like growth factors ( IGF 1 and IGF 2 ) , insulin , insulin like growth factor binding protein 1 ( IGFBP 1 ) , growth hormone ( GH ) and growth hormone binding protein ( GH BP ) activity were assessed in a group of healthy newborns and reevaluated at one and three months of life in six of them . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Serum IGF 1 , IGF 2 , IGF binding proteins ( IGFBP 1 , IGFBP 3 ) , GH and insulin were measured by radioimmunoassay . ^^^ Mean levels of IGFBP 1 and IGFBP 3 , IGF 2 and GH were unaffected by IGF 1 administration . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGFBP 2 has a higher affinity for IGF 2 than for IGF 1 and its affinity for both forms of IGF is greater than for human IGFBP 1 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We investigated the effect of insulin like growth factor 2 ( IGF 2 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) on 3 O methylglucose transport in incubated human skeletal muscle strips . ^^^ Exposure of muscle strips to IGFBP 1 ( 500 ng / ml ) inhibited the maximal effect of IGF 2 on glucose transport by 40 % . ^^^ Thus , it is conceivable that IGF 2 and IGFBP 1 are physiological regulators of the glucose transport process in human skeletal muscle . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The binding proteins IGFBP 1 and IGFBP 3 did not cross react , but both IGF 1 and IGF 2 markedly inhibited IGFBP 6 tracer binding to antiserum . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We studied the relationship of serum insulin like growth factor 1 ( IGF 1 ) , IGF 2 , the IGF binding proteins IGFBP 1 , IGFBP 2 , and IGFBP 3 , and GH binding protein ( GHBP ; which is postulated to be derived from the extracellular portion of the GH receptor ) in normal volunteers and patients with anorexia nervosa before and after a refeeding program . ^^^ Both serum IGF 1 and IGF 2 were positively correlated with serum IGFBP 3 and negatively correlated with serum IGFBP 1 and IGFBP 2 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The effect of endocrine therapy with medroxyprogesterone acetate , 4 hydroxyandrostenedione or tamoxifen on plasma concentrations of insulin like growth factor ( IGF ) 1 , IGF 2 and IGFBP 1 in women with advanced breast cancer . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
As assessed by solution hybridization , UA lig fetuses exhibited significantly higher hepatic IGFBP 1 , IGFBP 2 , and IGF 2 transcript abundance than UA nonlig controls ( increased 110 , 50 , and 31 % , respectively ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Serum concentrations of insulin like growth factors 1 and 2 ( IGF 1 and IGF 2 ) , the low molecular weight form of IGF binding protein ( IGFBP 1 ) , insulin , C peptide and GH were determined in six healthy subjects and four patients with GH deficiency during 30 min of moderate physical exercise on the cycle ergometer . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Addition of the IGF binding protein IGFBP 1 ( BP 28 , PP 12 ) caused dose dependent inhibition of IGF 2 tracer binding to antiserum , increasing to greater than 90 % inhibition at 400 ng / ml IGFBP 1 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
This study was undertaken to investigate the presence of IGF 1 and IGF 2 , as well as that of their binding proteins ( BP ) , IGFBP 1 and IGFBP 3 in human serum and follicular fluid ( FF ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We examined regulation of the genes for IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 2 in fetal rat liver in an experimental model for intrauterine growth retardation caused by maternal fasting on days 17 21 of gestation . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In contrast with binding proteins produced by normal human fibroblasts , TFBP does not cross react in radioimmunoassays for the plasma protein IGFBP 3 or the amniotic fluid protein IGFBP 1 ; however , after affinity labeling with IGF 2 , it is immunoprecipitable by an anti IGFBP 3 antiserum . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The effects of IGF 1 and IGF 2 on IGFBP 1 secretion were biphasic , with initial stimulation ( 200 250 % ) that peaked at 1 and 10 ng / ml , respectively , followed by inhibition at higher concentrations ( half maximal inhibition at 3 ng / ml and 30 ng / ml , respectively ) . ^^^ The decrease in IGFBP 1 levels in decidualized stromal cultures was associated with the induction of mitogenesis by IGF 1 and IGF 2 , while IGF effects on prolactin secretion paralleled those of IGFBP 1 secretion , with stimulation ( 243 324 % ) in the low concentration range followed by inhibition at higher concentrations . ^^^ These data indicate that endometrial stromal cell IGFBP 1 is regulated by insulin , at concentrations that are compatible with insulin acting via its own receptor , while the effects of IGF 1 and IGF 2 on IGFBP 1 secretion , are suggestive of their acting probably through the type 1 IGF receptor . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In serum and other biological fluids , IGF 1 and IGF 2 are reversibly bound to six molecular species of specific binding proteins ( IGFBP 1 to 6 ) which regulate their transport to target cells as well as their biological activities . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The regulation of insulin like growth factor binding protein 1 ( IGFBP 1 ) by its ligands , IGF 1 and IGF 2 , was studied in continuous cultures of HepG 2 human hepatoma cells . ^^^ Both IGF 1 and IGF 2 in concentrations as low as 1 10 nmol / l caused significant suppression of IGFBP 1 protein levels . ^^^ This suppression was accompanied by decreased IGFBP 1 mRNA levels occurring within 2 4 h of exposure to IGF 1 or IGF 2 , and by a significant decrease in IGFBP 1 promoter activity . ^^^ IGF 1 and IGF 2 were equipotent in suppressing basal levels of IGFBP 1 protein , mRNA and promoter activity . ^^^ IGF 1 , IGF 2 , and IGF analogs with low IGFBP 1 affinity , ( des 1 3 ) IGF 1 and long R3IGF 1 , all potently suppressed the previously characterized increase in IGFBP 1 protein levels and promoter activity induced by cAMP and theophylline . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Cord sera were obtained from 44 term , human infants exhibiting various patterns of intrauterine growth and were assayed for IGF 1 , IGF 2 , and IGFBP 1 , 2 , and 3 by specific RIAs . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We have examined the IGFBPs secreted by monolayer cultures of neonatal fibroblasts by ligand blotting with [ 125I ] IGF 2 and immunoblotting with antisera raised against three well characterized IGFBPs : IGFBP 1 , IGFBP 2 , and IGFBP 3 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We report the relationship between serum IGF 1 , IGF 2 , their binding proteins IGFBP 1 and IGFBP 3 , and GH binding protein in 600 normal Spanish children who were divided into 5 groups according to Tanner stage : 1 , 150 males and 102 females ; 2 , 40 males and 42 females ; 3 , 45 males and 45 females ; 4 , 42 males and 55 females ; and 5 , 23 males and 56 females . ^^^ IGFBP 1 ( r = 0 . 51 ; P < 0 . 0001 ) as well as between the sum of serum IGF 1 plus IGF 2 vs . ^^^ IGFBP 1 ( r = 0 . 47 ; P < 0 . 0001 ) , but not between serum IGF 2 and IGFBP 1 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Insulin like growth factors 1 ( IGF 1 ) and 2 ( IGF 2 ) and their binding proteins ( IGFBP 1 , IGFBP 2 and IGFBP 3 ) were measured by radioimmunoassay in plasma and milk samples collected throughout the study . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
More than 95 % of IGF 1 circulates bound to binding proteins ( IGFBPs ) ; of these IGFBP 1 is of particular interest as it is inversely regulated by insulin and is thought to inhibit the action of IGF 1 and IGF 2 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
There is a growing body of evidence that the insulin like growth factors ( IGF 1 and IGF 2 ) are dynamically involved in the regulation of glucose homeostasis , with one of their binding proteins , IGFBP 1 , playing a counterregulatory role . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Our results showed that IGF 1 , IGF 2 , IGFBP 2 and 3 mRNAs were expressed in uterine fibroids , and that IGFBP 1 mRNA or protein was not detected in fibroids . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In all subjects a single blood sample was drawn for IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 and GH measurements by specific RIAs . ^^^ Serum levels of IGF 2 were normal in all three groups ( 588 + / 240 micrograms / l ) whereas IGFBP 1 and IGFBP 2 levels were low and IGFBP 2 levels decreased significantly with increasing serum GH levels ( P < 0 . 0001 ) . ^^^ As IGF 2 is normal and IGFBP 1 and IGFBP 2 are inversely correlated to the serum GH levels in the acromegalic patients , we speculate that the molar ratio between IGF 1 and IGFBP 3 reflects free ( biologically active ) IGF 1 and is dependent on GH levels . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In contrast , IGF 2 stimulates healing only when used in combination with IGFBP 1 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We have therefore examined the effects of recombinant human IGF 1 ( rhIGF 1 ) administration on the levels of IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 and IGF bioactivity in a group of 9 late pubertal adolescents with IDDM . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The present study investigates the effects of the insulin like growth factors ( IGF 1 , IGF 2 ) on decidualization in vitro , as indicated by a P dependent growth response and by the secretion of PRL and IGFBP 1 . ^^^ Stimulation of IGFBP 1 ( 200 250 % ) and PRL ( 243 324 % ) peaked at 1 ng / ml for IGF 1 , and 10 ng / ml for IGF 2 , followed by inhibition at higher peptide concentrations ( ED50s 3 and 30 ng / ml , respectively ) . ^^^ Maximal physiological doses ( 100 ng / ml ) of IGF 1 and IGF 2 virtually abolished IGFBP 1 secretion ( 1 % and 2 % of basal levels , respectively ) , but did not cause total suppression of PRL secretion ( 8 % and 22 % of basal levels ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Functional role of cell surface integrins on human trophoblast cell migration : regulation by TGF beta , IGF 2 , and IGFBP 1 . ^^^ Since migration is a necessary step in the invasion cascade , we tested whether certain integrins or invasion regulating molecules , i . e . , TGF beta , IGF 2 , and IGFBP 1 produced at the fetomaternal interface had a functional role on trophoblast migration . ^^^ These studies demonstrate that the migration of first trimester invasive trophoblast in vitro ( 1 ) requires the expression of alpha 5 and beta 1 integrin subunits , ( 2 ) is inhibited by TGF beta , possibly due to increased cell adhesiveness to the extracellular matrix , ( 3 ) is stimulated by IGF 2 by an as yet undetermined mechanism , and ( 4 ) is stimulated by IGFBP 1 , likely by interaction with the RGD binding site of the alpha 5 beta 1 integrin . ^^^ The invasion regulating effects of TGF beta , IGF 2 , and IGFBP 1 may thus , at least in part , be due to their migration regulating effects on the invasive trophoblast . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In the present study , serum levels of IGF 1 and IGF 2 and IGFBP 1 , 2 , and 3 were measured in 58 patients ( age , 0 . 8 17 yr ) with treated ( 51 subjects ) or untreated ( 7 subjects ) insulin dependent diabetes mellitus ( IDDM ) and were compared with the levels in normal subjects . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Before insulin therapy , serum IGF 1 , IGF 2 , IGF binding protein 3 ( IGFBP 3 ) , and GH binding protein ( GHBP ) levels were significantly decreased , whereas IGFBP 1 and cortisol were significantly increased in diabetic children compared to those in an age , sex , and stage of puberty matched control group . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Blood , collected from a cohort ( n = 3 ) of these patients within 24 h of their discharge from the hospital , indicated that IGF 1 and IGF 2 were still reduced ( 30 % ) and that the decrease in IGFBP 3 and the elevation in IGFBP 1 were still evident at this time . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In normal term FCS , the following levels ( + / SE ) were present : IGF 1 , 76 + / 16 ; IGF 2 , 401 + / 38 ; IGFBP 3 , 700 + / 112 ; IGFBP 1 , 77 + / 10 ng / mL ; and insulin , 3 . 8 + / 1 . 6 microU / mL . ^^^ In IUGR FCS , IGF 1 , IGF 2 , and IGFBP 3 were significantly reduced , and IGFBP 1 was 7 fold higher than in FCS from normal weight fetuses . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In control cultures , MC3T3 E 1 cells expressed the mRNAs for IGF 1 , IGF 2 , and IGFBP 2 , 4 , 5 , and 6 but not IGFBP 1 or 3 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In a double blind , crossover design we studied the impact of 5 weeks of placebo or GH administration ( 0 . 03 mg . kg 1 body wt . day 1 ) in nine obese women ( mean + / SEM : age 30 . 4 + / 2 . 4 years ; body mass index 37 . 0 + / 2 . 8 kg / m2 ) on IGF 1 , IGF 2 , IGFBP 1 and 3 and GHBP . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Serum levels of insulin like growth factor ( IGF ) binding protein 3 ( IGFBP 3 ) in healthy infants , children , and adolescents : the relation to IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , age , sex , body mass index , and pubertal maturation . ^^^ Therefore , we measured IGFBP 3 , IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 2 levels by RIA in 907 healthy children to establish well characterized normative data on IGFBP 3 according to age , sex , and pubertal stage and to study the complex relationship between IGFs and their BPs in puberty . ^^^ Concomitantly , IGF 2 and IGFBP 2 levels were unchanged throughout puberty , whereas IGFBP 1 levels declined with age in prepubertal children , with lowest values in puberty . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The addition of IGFBP 1 caused a 19 21 % inhibition of IGF 1 or IGF 2 stimulated migration , whereas the addition of IGFBP 2 inhibited the effect of both by greater than 60 % . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The validity of the IGFBP 5 RIA was established from the following data : 1 ) recombinant human IGFBP 5 and purified human bone derived IGFBP 5 inhibited the binding of tracer to the antisera in an identical manner ; 2 ) the immunoreactive IGFBP 5 in serum co migrated with recombinant human IGFBP 5 in both sodium dodecyl sulfate polyacrylamide gel electrophoresis and high performance gel filtration chromatography ; 3 ) none of the other known IGFBPs ( IGFBP 1 , 2 , 3 , 4 , and 6 ) exhibited significant cross reactivity ; 4 ) the addition of IGF 1 or IGF 2 to the samples did not affect the recovery of IGFBP 5 ; and 5 ) the recovery of the exogenously added IGFBP 5 to serum was greater than 90 % . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Preincubation of fresh medium with recombinant IGFBP 1 or IGFBP 3 in the presence of IGF 2 suppressed IGF 2 stimulation of glycogen synthesis . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Serine phosphorylation of insulin like growth factor binding protein 1 ( IGFBP 1 ) has been shown to alter its affinity for the insulin like growth factors ( IGF 1 and IGF 2 ) and to modify its capacity to modulate cellular responses to the IGFs . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We have characterized the affinities of IGFBP 1 4 for IGF 1 and 2 by employing 1 ) purified IGFBP preparations , 2 ) both [ 125I ] IGF 1 and [ 125I ] IGF 2 as radioligands , and 3 ) multiple IGF analogs designed to have altered affinities for IGFBPs . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The median effective dose ( ED 50 ) of IGFBP 1 to cause inhibitory effects on IGF activated glucose consumption was 100 200 micrograms / l and was similar for both IGF 1 and IGF 2 at a concentration of 1 . 0 microgram IGF / l . ^^^ Therefore , at IGF concentrations of comparable activity , the inhibitory effects of IGFBP 1 were greater for IGF 1 than for IGF 2 , because of the higher activity of IGF 1 in this assay . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Substitution of Phe 26 with Ser or Leu , which decreased binding to the IGF 1 and insulin receptors , reduced binding to IGFBP 1 and 6 up to 80 fold , but had lesser effects on the other IGFBPs . [ Leu 27 ] IGF 2 and [ Leu 43 ] IGF 2 , which had a more markedly reduced affinity for the IGF 1 and insulin receptors than did [ Ser 26 ] IGF 2 , were bound by the IGFBPs with relatively unchanged affinity compared with IGF 2 . ^^^ IGFBP 1 and IGFBP 6 are most sensitive to changes in IGF 2 structure , although IGFBP 1 binds IGF 1 and IGF 2 with equal affinity , whereas IGFBP 6 has a marked preferential binding affinity for IGF 2 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We have examined the presence of mRNA encoding both IGF 1 and IGF 2 and IGFBP 1 , 2 , and 3 in fibroids and corresponding myometrium from 20 women undergoing hysterectomy for symptomatic uterine fibroids . ^^^ Northern blots of total cellular RNA were probed with oligonucleotides for IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 and a human IGFBP 1 cDNA . ^^^ The data showed that in fibroids compared to myometrium , 1 ) the relative abundance of IGF 1 mRNA was not different , but there was an increase in the relative abundance of IGF 2 mRNA ( P < 0 . 001 ) ; 2 ) IGFBP 1 mRNA was undetectable in fibroids and detectable in only 1 specimen of myometrium ; 3 ) there was no difference in the relative abundance of IGFBP 2 mRNA , but there was an increase in the relative abundance of IGFBP 3 mRNA in myometrium ( P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Plasma immunoreactive IGF 1 and IGF 2 , and serum IGFBP 1 levels were normal , but serum levels of IGFBP 3 were increased . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The quantitative capabilities of Western `` ligand ' ' blot analysis ( LBA ) of insulin like growth factor binding protein have been evaluated using iodine labeled insulin like growth factor 2 ( 125I IGF 2 ) , purified amniotic fluid insulin like growth factor binding protein 1 ( IGFBP 1 ) , and IGFBP 1 in conditioned medium ( CM ) from Hep G 2 cells . ^^^ Optimal conditions were evaluated for analysis of IGFBP 1 using IGF 2 2 as the ligand . ^^^ Displacement curves for IGF 2 against membrane bound IGFBP 1 measured by LBA were similar to those obtained with IGFBP 1 solutions using antibody precipitation of IGFBP 1 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In the patients with GHIS , chronic IGF 1 treatment , with twice daily injections for 6 months , caused a significant steady decline of IGF 2 and an increase in IGFBP 2 , but had no effect on IGFBP 1 and IGFBP 3 levels . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
DESIGN : In situ hybridization histochemistry was used to localize messenger ribonucleic acids ( mRNAs ) for IGF 1 and IGF 2 , the IGF 1 and IGF 2 receptors and IGFBP 1 to 6 in fresh frozen testis sections from healthy young men who died of trauma . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding proteins ( IGFBP 1 , 2 , and 3 ) , and IGF binding capacity ( IGF BC ) were evaluated in samples collected at 7 : 00 AM , 3 : 00 PM , and 11 : 00 PM . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Blood was sampled for measurement of serum estradiol , IGF 1 , IGF 2 , and IGFBP 1 , 2 and 3 at various times during estradiol treatment . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Recombinant human IGFBP 1 , which binds IGF 2 with high affinity , inhibited IGF 2 induced monolayer growth and both baseline and IGF 2 induced anchorage independent growth in this cell line . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
To gain insight into the role of the insulin like growth factors ( IGFs ) in regulating lung development , we have used in situ hybridization histochemistry ( ISHH ) to examine the ontogeny and sites of expression of IGF 1 and IGF 2 , IGF binding proteins ( IGFBP 1 to IGFBP 6 ) , and IGF cell surface receptors in fetal rat lung from 15 to 21 days of gestation . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In biological media , IGF 1 and IGF 2 are reversibly associated with specific high affinity ( 10 ( 9 ) 10 ( 11 ) M 1 ) binding proteins ( IGFBP 1 to 6 ) differing in expression according to tissue of origin and playing a variety of roles in IGF transport and half lives , delivery of IGFs to their target cells and modulation of IGF interactions with their receptors . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Levels of messenger RNA ( mRNA ) encoding insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF 1 receptor , and IGF binding proteins ( IGFBP 1 to 6 ) were determined after OP 1 treatment . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We examined cardiovascular risk factors , IGF 1 , IGF 2 and IGFBP 1 in 74 NIDDM patients analysed as a whole group and according to treatment type . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In this study , we examined the effect of fetal exposure to alcohol IGF 1 and on IGF 2 and IGFBP 1 and IGFBP 2 mRNA in placenta and fetal lung tissue . ^^^ At G 20 , dams were killed , and we examined placenta and fetal lung for the steady state levels of mRNA for IGF 1 and IGF 2 and for IGFBP 1 and IGFBP 2 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The spatial pattern and relative abundance of expression of IGFBP mRNAs suggest IGFBP 1 to be the predominant IGFBP synthesized by the maternal decidual cells , interacting with the IGF 2 that synthesizes fetal intermediate trophoblasts . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
MEASUREMENTS : Serum IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 , insulin and C peptide were measured by radioimmunoassay . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
MEASUREMENTS : Serum levels of GH and IGF 1 were measured by radioimmunoassay , IGF 2 was measured by radioreceptor assay , and IGFBP 1 was measured by an enzyme linked immunoassay . ^^^ CONCLUSIONS : AIDS wasting is associated with a GH resistant state that results in low levels of serum IGF 1 , IGF 2 and IGFBP 3 , elevated levels of phosphorylated IGFBP 1 , and a reduced ability to form the IGFBP 3 ternary complex . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We have determined the cellular distribution of IGF 2 and IGFBP 1 , 3 and 4 in 12 week gestation human fetal tissues using immunocytochemistry . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Insulin like growth factor 2 ( IGF 2 ) inhibits insulin like growth factor binding protein 1 ( IGFBP 1 ) production in luteinized human granulosa cells with a potency similar to insulin like growth factor 1 ( IGF 1 ) and higher than insulin . ^^^ It had not been known if IGF 2 affected IGFBP 1 production in these cells . ^^^ We examined the effect of IGF 2 on IGFBP 1 production in human granulosa cells and compared this effect of IGF 2 to similar effects of insulin and IGF 1 . ^^^ After 24 h of incubation with insulin , IGF 1 , or IGF 2 , the medium was removed and frozen at 20 C until assayed for IGFBP 1 . ^^^ Concentration of IGFBP 1 in the medium collected from cells incubated with hormones was statistically lower than that for control cells starting at 10 ( 3 ) ng / mL of insulin ( P < 0 . 05 ) , 0 . 5 ng / mL of IGF 1 ( P < 0 . 05 ) and 1 ng / mL of IGF 2 ( P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Recent studies demonstrate that IGF 2 in FFe is higher than in FFa ' whereas IGF 1 , IGFBP 3 and IGFBP 1 levels do not differ , underscoring the importance of local IGF 2 production by the granulosa and the importance of IGFBP 4 and IGFBP 2 in regulation of IGF 2 action within the follicle during its developmental pathway as an E 2 or A dominant follicle . ^^^ In the androgen treated female to male transsexual ( TSX ) model for PCOS , IGF 1 , IGF 2 , IGFBP 3 and IGFBP 1 levels do not differ . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The relative abundance of the mRNAs encoding IGF 2 and the IGF IR was increased after metyrapone treatment , whereas the localization and relative abundance of IGFBP 1 6 mRNAs were not altered by metyrapone treatment . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGFBP 1 significantly inhibited cell division stimulated by IGF 1 ( P < 0 . 001 ) and IGF 2 ( P < 0 . 001 ) , but not that stimulated by the analogue , LR3IGF 1 , which has low affinity for IGFBPs . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In this study , we have measured PSA , IGF 1 , IGF 2 , IGFBP 1 and IGFBP 3 in tumour tissue cytosols from 200 women with primary breast cancer , and have examined relationships between IGFs or IGFBPs and PSA along with other markers , including p 53 protein , steroid hormone receptors ( oestrogen and progesterone ) , cathepsin D , epidermal growth factor receptor , Her 2 / neu protein , S phase fraction and DNA ploidy . ^^^ Correlations or associations between PSA and IGF 1 , IGF 2 , IGFBP 1 or IGFBP 3 were not observed . ^^^ IGF 2 was positively correlated with both IGFBP 3 and IGFBP 1 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We measured levels of maternal and cord serum IGF 1 , IGF 2 , C peptide , IGFBP 1 , IGFBP 2 and IGFBP 3 in 8 White Class B insulin dependent DP and 8 non diabetic pregnancies ( NP ) . ^^^ No significant differences were found between DP and NP with respect to cord serum IGF 2 , maternal serum IGF 1 , IGF 2 , C peptide , IGFBP 1 , IGFBP 2 and IGFBP 3 , and the concentration and affinity of TR for IN , IGF 1 and IGF 2 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In biological media , IGF 1 and IGF 2 are reversibly associated with specific , high affinity binding proteins . ( IGFBP 1 to 6 ) whose expression varies with tissue of origin , stage of development , and hormonal and nutritional status . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGFBP 1 , 3 , 4 , or 5 did not have increased heparin binding in the presence of IGF 1 or IGF 2 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Cord sera were obtained from term , Chilean newborns exhibiting various patterns of intrauterine growth and assayed for IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , and IGFBP 3 by specific radioimmunoassays ( RIA ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
To determine the developmental pattern of expression of IGF 1 , IGF 2 , IGF 1 R and IGFBP 1 6 mRNAs in the rhesus monkey placenta , in situ hybridization histochemistry was performed in placentae and fetal membranes from 65 days until term ( 165 + / 5 days ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
MEASUREMENTS : Fasting measurements of glucose , insulin , IGF 1 , IGF 2 , IGFBP 1 and IGFBP 3 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Genetic and environmental components of interindividual variation in circulating levels of IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 3 . ^^^ We assessed the magnitude of the genetic component in the variation of circulating levels of insulin like growth factors 1 and 2 ( IGF 1 and IGF 2 ) , and their binding proteins IGFBP 1 and IGFBP 3 by measuring their serum concentrations in 32 monozygotic and 47 dizygotic adult twin pairs of the same sex . ^^^ Our results show that , in adults , there is a substantial genetic contribution responsible for interindividual variation of the circulating levels of IGF 1 , IGF 2 , and IGFBP 3 , but not for the IGFBP 1 levels . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
RESULTS : ( 1 ) Compared to 100 normal weight girls of same age the obese subjects had increased levels of IGF 1 , IGFBP 1 , IGFBP 2 , and IGFBP 3 and normal levels of IGF 2 . ( 2 ) After weight loss ( 8 . 1 + / 2 . 0 kg ) IGF 2 and IGFBP 2 increased and IGF 1 , IGFBP 1 , IGFBP 3 and the ratio IGF I / IGFBP 3 decreased significantly . ( 3 ) Correlation analysis revealed that fasting insulin levels of the patients were positively correlated with IGF 1 but inversely with IGFBP 1 and IGFBP 2 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We report maternal serum levels of IGF 1 , IGF 2 , and IGFBP 1 , 2 , and 3 ; IGFBP 1 phosphorylation ; and IGFBP 3 proteolysis in pregnancies ( n = 139 ) complicated by trisomy 18 or trisomy 21 compared with those in normal controls . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Ontogeny of mRNA levels of IGFs , IGF type 1 and type 2 receptors ( IGFI R and IGFII R ) , IGFBP 1 and 3 ( IGFBPs ) and growth hormone receptor ( GHR ) were also examined by Northern blot analysis in liver , kidney and skeletal muscle of pig . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
MEASUREMENTS : IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 , oestradiol and norethisterone were analysed by radioimmuno assays . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The affinity of this highly phosphorylated IGFBP 1 was compared with that of nonphosphorylated IGFBP 1 and recombinant human ( rh ) IGFBP 3 by equilibrium binding to IGF 2 and IGF 2 . ^^^ However , when binding to IGF 2 , phosphorylation had no affect on the affinity of IGFBP 1 ( 3 . 6 + / 2 10 10 ( 9 ) M 1 vs . 1 . 8 + / 3 10 10 ( 9 ) M 1 , P not significant ) . ^^^ Therefore , in the circulation , IGF 1 has a considerably higher affinity than IGF 2 for IGFBP 1 ( P < 0 . 02 ) . ^^^ These data suggest that the highly phosphorylated IGFBP 1 in the normal circulation will preferentially bind IGF 1 rather than IGF 2 , whereas in pregnancy , the affinity of IGFBP 1 for IGF 1 will be reduced because of the appearance of non and lesser phosphorylated forms . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Fetal hepatic IGFBP 1 mRNA levels increased in 4 of 6 nephrectomized fetuses , while those of IGF 1 , IGF 2 , IGFBP 2 were unchanged . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Forty three pediatric IDDM patients were randomly assigned to groups receiving daily , fasting subcutaneous injections of placebo or rhIGF 1 ( 80 micrograms . kg . day ) for 28 days , while continuing to receive splitmix insulin therapy and intensive outpatient management . rhIGF 1 therapy corrected IGF 1 deficiency , suppressed IGFBP 1 levels ( P < 0 . 01 ) , and induced a trend toward lower circulating GH levels throughout the study . rhIGF 1 therapy also induced an approximate 50 % decrease in IGF 2 levels ( P < 0 . 001 ) and an approximate 70 % increase in IGFBP 2 levels ( P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Insulin like growth factor binding protein 1 ( IGFBP 1 ) modulates the mitogenic actions of IGF 1 and IGF 2 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGFBP 1 and IGFBP 3 , but not an N terminal fragment of IGFBP 3 , could effectively block binding of both IGF 1 and IGF 2 to the solid phase IGFBP 3 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Following a five day maternal fast , both IGF 1 and IGF 2 levels were decreased in the maternal and fetal circulation ( P < 0 . 05 ) , accompanied by a decrease in fetal hepatic IGF 1 mRNA levels , but the IGFBP 2 level was increased and the IGFBP 3 level was decreased in maternal circulation , whereas the IGFBP 1 level was increased in fetal circulation . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In FGR cases , maternal IGF 1 was low ( P = 0 . 0001 ) and IGFBP 1 was high ( P = 0 . 03 ) and maternal IGF 2 was low in SGA ( P = 0 . 005 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
After 12 months of study , the 30 children receiving rhGH showed : ( 1 ) greater increase in height ( 9 . 1 + / 2 . 8 vs . 5 . 5 + / 1 . 9 cm , P < 0 . 0001 ) ; ( 2 ) increases in serum levels of IGF 1 , IGF 2 , free IGF 1 , IGFBP 3 and acid labile subunit ( ALS ) ; ( 3 ) a greater decrease in serum IGFBP 1 levels ; and ( 4 ) no significant difference in serum IGFBP 2 levels , when compared to the 14 control patients . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Fasting levels of IGF 1 , free IGF 1 , IGF 2 , IGFBP 3 , and insulin increased significantly within 3 months of GH treatment , whereas IGFBP 1 , IGFBP 2 , and IGFBP 6 showed no change . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
These findings suggest that the high IGF 2 concentrations and lack of inhibitory phosphoforms of IGFBP 1 in coelomic fluid could potentially enhance mitogenic activity in the early human gestational sac . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In contrast , free IGF 2 was not correlated to IGFBP 1 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGF 1 , IGF 2 , free IGF 1 and IGFBP 1 , 2 and 3 levels in venous cord blood : relationship to birthweight , length and gestational age in healthy newborns . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Insulin like growth factors ( IGF 1 and IGF 2 ) in biological fluids bind to high affinity binding proteins ( IGFBP 1 to 6 ) , which transport them and regulate their activities . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The temporal variations in endometrial expression of mRNA encoding insulin like growth factor 1 ( IGF 1 ) and IGF 2 , and insulin like growth factor binding protein 1 ( IGFBP 1 ) and IGFBP 2 were investigated between oestrus and day 20 of pregnancy in ewes . ^^^ Northern blot analysis of endometrial total RNA revealed major transcripts for IGF 1 ( 7 . 1 kb ) , IGF 2 ( 5 . 8 kb ) , IGFBP 1 ( 1 . 3 kb ) and IGFBP 2 ( 1 . 7 kb ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGF 1 and IGF 2 also have specific inhibitory effects on IGFBP 1 expression . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
A 520 bases human IGF 1 , a 556 bases human IGF 2 , a 480 bases human IGF 1 receptor and a 250 human IGF II / mannose 6 phosphate ( M6P ) receptor probe were radiolabelled as were human IGFBP 1 , 2 , 3 , 4 , 5 and 6 probes . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Ligand blot analysis revealed a significant increase in IGF 2 binding to a 29 31 kilodalton region where positive staining with specific antibodies to IGFBP 3 or IGFBP 1 was observed . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Serum IGF 1 and IGF 2 were quantified by radioimmunoassay ( RIA ) , IGFBP 3 by immunoradiometric assay ( IRMA ) , and changes in IGFBP 1 , 2 , 3 , and 4 were estimated by Western ligand blotting ( WLB ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Spontaneous GH secretion , IGF 1 , free IGF 1 ( fIGF 1 ) , IGF 2 , their binding proteins ( IGFBP 1 , IGFBP 2 , and IGFBP 3 ) , and GH binding protein ( GHBP ) values at the time of clinical diagnosis ( n = 65 ) , after a 25 % decrease in the body mass index ( BMI ) expressed as the SD score ( BMI SD score ; n = 29 ) , and after a diminution of at least 50 % of the initial BMI SD score ( n = 9 ) are reported . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We report their spontaneous GH secretion and IGF 1 , free IGF 1 ( fIGF 1 ) , IGF 2 , the IGF binding proteins ( IGFBP 1 , IGFBP 2 , and IGFBP 3 ) , and GH binding protein ( GHBP ) levels at the time of the clinical diagnosis ( n = 50 ) and after recuperation of between 6 8 % ( n = 42 ) and 10 % or less of the initial weight ( n = 20 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The aim of our study was to determine the serum levels of IGF 1 , IGF 2 , and their binding proteins IGFBP 1 and IGFBP 3 in young children 3 months to 2 years of age with nonorganic failure to thrive ( NOFTT ) . 29 children with NOFTT and 32 normal controls were recruited and studied for auxologic and hormonal parameters . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Fetal weight was positively associated with maternal circulating IGF 2 and negatively associated with maternal circulating IGFBP 1 and 2 . ^^^ Significant interactions indicate , however , that the role of IGF 2 and IGFBP 1 on fetal growth is dependent on the nutritional status of the mother . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
GH and IGF 1 basal concentrations were significantly higher in pre menopausal than in post menopausal women , while IGF 2 , IGFBP 1 and IGFBP 3 concentrations did not vary significantly . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Plasma levels of IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 , estradiol and progesterone were measured by radioimmunoassay ( RIA ) in each sample . ^^^ No change in plasma levels of IGFBP 1 and IGF 2 was found and immunoblots did not reveal any alteration in the ratio of fragmented to intact IGFBP 3 during the menstrual cycle . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We measured serum levels of free IGF 1 and free IGF 2 , total IGF 1 , total IGF 2 , big IGF 2 and IGFBP 1 , IGFBP 2 and IGFBP 3 in patients with NICTH before ( n=14 ) and after surgical removal of the tumour ( n=3 ) . ^^^ In accordance with earlier observations levels of total IGF 1 , total IGF 2 , and IGFBP 3 were decreased , whereas IGFBP 1 and IGFBP 2 were increased in NICTH ( all p values < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
OBJECTIVE : To determine the effects of hMG and highly purified FSH on follicular production of the ovarian growth factors transforming growth factor beta 1 ( TGF beta 1 ) , insulin like growth factors 1 and 2 ( IGF 1 and IGF 2 ) , and insulin like growth factor binding proteins 1 and 3 ( IGFBP 1 and IGFBP 3 ) . ^^^ IGF 2 , IGFBP 1 and IGFBP 3 in follicular fluid and levels of E 2 in serum were measured . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Plasma insulin like growth factor ( IGF ) 1 decreased by 49 53 % , IGF 2 by 27 37 % and total IGF binding protein ( IGFBP ) 3 by 16 19 % , whereas IGFBP 1 increased by 35 55 % . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
This is the first study to give a complete overview of the mRNA expression patterns of Igf 1 , Igf 2 , type 1 Igf receptor ( Igf1r ) and six Igf binding proteins ( IGFBP 1 6 ) in embryonic mouse limbs , at various stages of development , by whole mount in situ hybridization ( ISH ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Our data show that leucine limitation strongly induces IGFBP 1 without affecting IGF 1 and IGF 2 expression in human HepG 2 cells and in isolated rat hepatocytes . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Overexpression of IGF 2 or IGFBP 1 can result in nesidioblastosis . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Concomitant with IGFBP 2 expression in these tumours , were a decrease in IGFBP 1 expression and an increase in IGFBP 3 proteolysis , both of which increase the bioavailability of the IGF 2 produced by the cells . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Dialysate / serum ratios for IGF 1 , IGF 2 , and IGFBP 1 , 2 , and 3 were significantly increased at 2 h and increased further at 4 h , at which time values averaged 1 . 3+ / 0 . 2 % , 3 . 1+ / 0 . 5 % , 6 . 2+ / 1 . 0 % , 2 . 4+ / 0 . 2 % , and 1 . 3+ / 0 . 2 % of serum levels , respectively . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Analysis of the promoter region of IGFBP 1 and IGF 2 failed to find major alterations . ^^^ IGFBP 1 was reduced ( 216 ng / mL ) , although still in the high range , whereas IGF 1 ( 71 ng / mL ) , IGFBP 3 ( 0 . 62 microg / mL ) , and IGF 2 ( 111 ng / mL ) were only slightly increased . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Proliferation of serum starved EVT cells was stimulated by addition of serum but unaffected by a wide range of IGF 1 , IGF 2 , and IGFBP 1 concentrations . ^^^ IGF 2 and IGFBP 1 or their combination stimulated EVT cell invasiveness and migration , when assays were conducted in serum reduced media . ^^^ Secretion of gelatinases or plasminogen activators was unaltered by IGF 2 or IGFBP 1 . ^^^ We conclude that trophoblast derived IGF 2 and decidua derived IGFBP 1 provide autocrine / paracrine enhancement of trophoblast invasiveness largely by stimulating migration , an essential step in invasion . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Insulin like growth factors , IGF 1 , IGF 2 , and IGF binding protein ( IGFBP 1 ) appear to play major roles in endometrial development during the menstrual cycle and in the process of implantation . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
RESULTS : The mean follicular fluid concentrations of IGF 1 and IGFBP 1 were significantly lower in the `` decreased ' ' ovarian reserve group compared with the `` normal ' ' ovarian reserve group , with no change in estradiol or IGF 2 levels . ^^^ This resulted in a decreased molar IGF 1 : BP ratio and an increased molar IGF 2 : IGFBP 1 ratio . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Between 1 7 days post lesion ( dpl ) , in the acute phase following a penetrant wound to the CNS , IGF 2 and IGF IIR protein , but not messenger RNA , were colocalized , with IGF 1 , IGF IR , and IGFBP 1 , 2 , 3 , and 6 , to neurons , macrophages , astrocytes , and microglia within the damaged tissue . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
After implantation , decidual IGFBP 1 may regulate IGF actions at the embryo endometrial interface , since trophoblast cells contain IGF receptors and express IGF 2 , but do not express IGFBP 1 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Chronic liver disease was characterised by low serum IGF 1 , IGF 2 , IGFBP 3 and ALS levels with raised IGFBP 1 and 2 levels . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Since no single factor acts in isolation , this study was performed to assess the influence of oestradiol ( total and unbound ) , insulin , insulin like growth factor ( IGF ) 1 , IGF 2 and the binding proteins IGFBP 1 , and IGFBP 3 , on basal and adrenocorticotrophic hormone ( ACTH ) stimulated adrenal androgen secretion in 25 women with PCOS and 10 matched ovulatory controls . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In AN , the levels of GH binding protein , free and total IGF 1 , free IGF 2 , and IGFBP 3 were significantly reduced ; total IGF 2 , IGFBP 2 , and IGFBP 4 levels were unchanged ; and IGFBP 1 was increased . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Serum was collected at baseline and at intervals throughout the study for the measurement of total IGF 1 , IGF 2 , IGFBP 1 , 2 , 3 , free insulin and growth hormone ( GH ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
MEASUREMENTS : Serum IGF 1 and IGF 2 were measured by RIA while IGFBP 1 3 were measured by Western ligand blot ( WLB ) and compared with determinations by specific immunoassays . ^^^ Stepwise ( backwards ) multiple regression analyses showed that the changes in IGF 1 and IGF 2 , and age correlated with the change in serum IGFBP 1 . ^^^ CONCLUSION : GH significantly increased serum IGF 1 , IGF 2 , IGFBP 3 , and IGFBP 4 and decreased serum IGFBP 1 and IGFBP 2 in post menopausal women . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGF 2 action is negatively regulated by IGFBP 1 whose synthesis increases in the presence of glucocorticoids . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The autocrine release of IGF 1 , IGF 2 and IGFBP 1 through 3 was determined by specific RIAs and western ligand blotting . ^^^ At switch from CaCo 2 cell proliferation to differentiation a marked increase in the secretion of IGF 2 ( 10 fold ) , IGFBP 1 ( 2 . 5 fold ) , IGFBP 2 ( 3 fold ) , and IGFBP 3 ( 6 fold ) was measured . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In contrast , IGF 1 or IGF 2 ( 6 . 5 nM ) preferentially induced the accumulation of IGFBP 3 ( 1 . 9 fold ) and to a lesser extent of IGFBP 4 , but did not show any effect on IGFBP 1 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Fasting ALS , IGF 2 , IGFBP 3 , IGFBP 2 , IGFBP 1 , and insulin levels before rhIGF 1 treatment were 46 . 3 mg / L , 1044 microg / L , 5 . 8 mg / L , 73 ng / mL , 4 . 7 ng / mL , and 27 . 3 mU / L , respectively . ^^^ IGF 2 , ALS , and insulin levels were elevated , whereas IGFBP 1 and IGFBP 2 levels were decreased compared to reference values . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
DESIGN : Cross sectional analysis of the relationship between insulin resistance syndrome variables and concentrations of IGF 1 , IGF 2 , IGFBP 1 and IGFBP 3 in 80 subjects with NIDDM . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In active MS lesions , the expression of IGF 1 , insulin and IGFBP 1 was detected in hypertrophic astrocytes while that of IGF 2 and IGFBP 2 and 3 was confined to foamy macrophages within lesions and activated microglia in adjacent white matter . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
MEASUREMENTS : IGFBP 1 and insulin were measured in samples drawn every 4 h over the 24 h period while IGF 1 , IGF 2 , IGFBP 2 and IGFBP 3 were determined in samples collected at the end of the study . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Northern blot analysis of total mRNA isolated from the tumour demonstrated high expression of the IGF 2 gene and abundant 1 . 1 kb IGFBP 6 transcript , while the genes encoding IGFBP 3 , 4 and 5 were only weakly expressed and mRNA of IGFBP 1 , 2 and IGF 1 could not be detected . mRNAs for the IGF type 2 receptor could be easily demonstrated , whereas those for the insulin and IGF type 1 receptor were hardly detectable . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
DESIGN , PATIENTS AND MEASUREMENTS : Serum IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 , osteocalcin ( OST ) , bone specific alkaline phosphatase ( BAP ) , urinary deoxypyridinoline ( DPYD ) and N telopeptide of type 1 collagen ( NTX ) were measured in 31 premenopausal women aged 31 43 and 65 postmenopausal women aged 47 60 : this latter group comprised 30 normal healthy women and 35 osteoporotic women . ^^^ RESULTS : Compared with premenopausal women or normal postmenopausal women , serum IGF 1 and IGFBP 3 levels were significantly lower in osteoporotic postmenopausal women while no significant differences in serum levels of IGF 2 , IGFBP 1 and IGFBP 2 were observed . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In addition to measuring IGF 1 , IGF 2 and IGFBP 3 , serum IGFBP 1 , 2 , 4 and 5 were measured . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Insulin like growth factors , particularly IGF 2 , are produced in abundance by the trophoblast cells of the placenta , whereas one of the insulin like growth factor binding proteins , IGFBP 1 , is the major secretory product of the maternal decidualized endometrium . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
RESULTS : Compared with controls , estrogen treated monkeys had 2 fold higher SF levels of IGF 1 ( P < 0 . 001 ) , 1 . 7 fold higher IGF 2 ( P < 0 . 006 ) , 5 . 9 fold higher IGFBP 1 ( P < 0 . 02 ) , and 2 . 5 fold higher IGFBP 3 ( P < 0 . 001 ) . ^^^ Estrogen plus progesterone treated monkeys had SF levels of IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 3 that were intermediate between the levels in the control and estrogen groups , except that the level of IGFBP 3 was significantly greater than that in the control group ( P < 0 . 001 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Because the anatomical distribution of IGFBPs is likely to dictate IGF bioavailability , we determined the cellular distribution and expression of IGF 1 , IGF 2 , and IGFBP 1 to IGFBP 6 in epiphyseal growth plates of the fetal sheep , using immunocytochemistry and in situ hybridization . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
RESULTS : Non diabetic obese subjects had increased free IGF 1 and 2 , total IGF 2 , IGFBP 3 and GHBP , reduced IGFBP 1 and 2 ( p < 0 . 05 ) , but normal total IGF 1 , when compared to lean subjects . ^^^ Also IGFBP 1 and total IGF 1 were normal in obese Type 2 diabetics , whereas free and total IGF 2 and IGFBP 3 remained elevated to a similar extent as in simple obesity ( p < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
RESULTS : The patients had reduced serum free IGF 1 ( 53 % ) and increased levels of total IGF 2 ( 40 % ) , IGFBP 1 ( 546 % ) , and IGFBP 2 ( 270 % , P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Content of IGFII in tumor cells correlated with IGFBP 1 , IGFBP 2 , IGFBP 5 . ^^^ IGFBP 1 , 2 , and 5 , blocking IGFII , are detected in large amounts in areas of cell death inducing apoptosis while IGFII accumulates in dividing cells and foci of keratinization . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Expression of mRNA for IGF 1 , IGF 2 , type 1 IGF receptor , IGFBP 1 , oestrogen receptor ( ER ) and progesterone receptor ( PR ) in the endometrium was explored by a semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Levels of serum total IGF 1 , total IGF 2 , IGFBP 1 , IGFBP 2 and IGFBP 3 were determined experimentally , while those of IGFBP 4 , IGFBP 5 and IGFPB 6 , as well as the 12 affinity constants of association of the two IGFs with the six IGFBPs , were taken from published values . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In patients with renal osteodystrophy , an elevation of some IGF binding proteins ( IGFBPs ) has been described , but there is no study measuring serum levels of both IGF 1 and IGF 2 as well as IGFBP 1 to 6 in different forms of renal osteodystrophy and hyperparathyroidism . ^^^ Serum levels of total and free IGF 1 , IGF 2 , IGFBP 1 to 6 , and biochemical bone markers including intact parathyroid hormone ( PTH ) , bone alkaline phosphatase ( B ALP ) , and osteocalcin ( OSC ) were measured by specific immunometric assays . ^^^ CONCLUSION : Patients with primary and secondary hyperparathyroidism showed lower levels of the putative stimulatory IGFBP 5 but higher levels of IGFBP 1 , 2 , 3 , and 6 , whereas total IGF 1 and IGF 2 levels were not or only moderately increased . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In addition , transglutaminase inhibitors , antibodies to thrombospondin , insulin like growth factor 2 in the presence of its binding protein IGFBP 2 , but not IGFBP 1 , suppressed the activation of TGF beta . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Using RNAase protection analysis ( RPA ) , we examined the gene expression for IGF 1 , IGF 2 , IGF1R , M6P / IGF2R , IGFBP 1 and IGFBP 2 in a series of hepatoblastomas with corresponding normal liver from the same individuals . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In the basal plate of human , rhesus monkey and baboon placentae , extravillous trophoblasts express IGF 2 mRNA and uterine decidual cells IGFBP 1 6 mRNAs . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
There was a positive correlation between IGFBP 4 and IGFBP 2 ( r=0 . 46 , P < 0 . 001 ) ; IGFBP 5 was positively correlated with IGF 1 ( r=0 . 59 , P < 0 . 001 ) , IGF 2 ( r=0 . 42 , P < 0 . 001 ) and IGFBP 3 ( r=0 . 47 , P < 0 . 001 ) and inversely correlated with IGFBP 1 ( r= 0 . 41 , P < 0 . 001 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
MATERIALS AND METHODS : This study searched for the mRNA expression patterns of components of the IGF system : IGF 1 and IGF 2 , IGF receptors 1 and 2 ( IGF 1R , IGF 2R ) , IGF binding proteins 1 6 ( IGFBP 1 6 ) ) in the most frequent human gastroenteropancreatic neuroendocrine tumours ( gastrinomas , insulinomas , tumours associated with carcinoid syndrome and functionally inactive tumours ) employing reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Insulin like growth factor ( IGF ) binding protein 1 ( IGFBP 1 ) is a 28 kDa plasma protein that binds to IGF 1 and IGF 2 with high affinity . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The expression of IGF 2 and IGFBP 1 to IGFBP 6 mRNAs was determined by in situ hybridization in the Fallopian tubes of extrauterine pregnancies and concurrent decidua ( n = 6 ) , and in the placentae and Fallopian tubes of intrauterine pregnancies ( n = 6 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
BACKGROUND : The insulin like growth factor ( IGF ) system , which is composed of two ligands ( IGF 1 and IGF 2 ) , two receptors ( IGFR 1 and IGFR 2 ) and six binding proteins ( IGFBP 1 to 6 ) , plays an important role in cell biology . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGF 1 mRNA is suppressed and mRNA encoding IGF 2 and IGFBP 1 are consistently up regulated in decidualized endometrium in women treated with the intrauterine levonorgestrel system ( LNG IUS ) . ^^^ Consequently , examination of local IGF 1 , IGF 2 and IGFBP 1 expression might provide additional information when evaluating the effect of different progestins on the endometrium at the molecular level . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Significant correlations ( p < 0 . 001 ) were seen between total and free ALS concentrations and IGF 1 ( r = 0 . 50 and 0 . 60 , respectively ) , free IGF 1 ( r = 0 . 37 and 0 . 36 ) , IGF 2 ( r = 0 . 37 and 0 . 27 ) , IGFBP 1 ( r = 0 . 48 and 0 . 49 ) , IGFBP 2 ( r = 0 . 44 and 0 . 51 ) and IGFBP 3 ( r = 0 . 67 and 0 . 59 ) at all Tanner stages . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Furthermore , the presence of mRNAs of IGF 2 and of receptors for IGF 1 ( IGF IR ) , growth hormone ( GHR ) and insulin ( IR ) , as well as mRNAs of IGF binding proteins ( IGFBP 1 , 2 and 3 ) were assessed by RT PCR . ^^^ The presence of IGF 2 , IGF IR , GHR , IR and IGFBP 1 , 2 and 3 mRNA was confirmed in the liver of 8 d old calves and older cattle as well , and among newborn calves their presence was independent of differences in nutrition . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Because growth is regulated by the GH insulin like growth factor ( IGF ) system , which may be altered in catabolic states , we studied serum IGF 1 , free IGF 1 , IGF 2 , the IGF binding proteins ( IGFBP 1 to 3 ) , and total and free acid labile subunit ( ALS ) levels in 26 prepubertal children with ALL at diagnosis ( n = 26 ) and 6 ( n = 21 ) , 12 ( n = 21 ) , 18 ( n = 21 ) , 24 ( n = 20 ) , 30 ( n = 16 ) , and 36 months ( n = 16 ) after beginning treatment to investigate the effects of disease and therapy on this system and its relationship with growth in these patients . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Classical and atypical GHIS groups were compared in terms of ( 1 ) phenotypic features , including high pitched voice , sparse hair , blue sclera , hypoglycaemia , microphallus , ( 2 ) birth length , height SDS , and ( 3 ) basal IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 , GHBP and increase in IGF 1 on IGF 1 generation testing . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We measured the serum levels of IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 3 . ^^^ However , the serum levels of IGF 2 , IGFBP 1 , and IGFBP 3 in the hemodialysis patients were significantly higher than those in the control group . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In contrast , syncytiotrophoblast IGFBP 1 and 2 mRNA levels decreased , and IGF 2 receptor mRNA expression remained relatively constant , with advancing baboon pregnancy . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In women < or = 50 years of age , measurements of IGF 2 , IGFBP 1 , and IGFBP 2 were also performed . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Systemic IGFBP 1 , primarily of hepatic origin , is a functional antagonist of IGF 2 ; thus , boosting IGFBP 1 production might be expected to lessen risk for BPH . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Under basal conditions , human decidualized endometrium produces both non phosphorylated ( np ) and phosphorylated ( p ) isoforms of IGFBP 1 ; however , in the presence of IGF 2 , which is a trophoblast secretory product , npIGFBP 1 was preferentially produced . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Expression of both IGF 2 and IGFBP 1 mRNA was elevated ( by 23 % and 35 % , respectively ) in granulosa cells from low responders after GH treatment as compared to that in low responders before GH treatment . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Common property was accumulation in the cells of various members of IGF system : high accumulation of IGF 2 , IGFBP 1 , 2 , 3 , 4 in dysplasia ; the same plus IGFBP 11 , 2 , 3 , 4 , 5 in squamous metaplasia . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The insulin like growth factor ( IGF ) system includes IGF 1 and IGF 2 , the type 1 and type 2 IGF receptors , and specific IGF binding proteins ( IGFBP 1 to IGFBP 6 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We measured IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 by immunoassays , IGFBP 3 by Western ligand blotting ( WLB ) and finally in vitro IGFBP 3 proteolysis by a ( 125 ) 1 IGFBP 3 degradation assay . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
To provide further insight into the effect of tamoxifen at low doses on the IGF system , we have correlated the drug serum levels attained after 2 months of either placebo ( n = 32 ) , tamoxifen 20 mg / day ( n = 26 ) , 10 mg / day ( n = 23 ) or 10 mg / every other day ( n = 29 ) with the changes in IGF 1 , Insulin like Growth Factor 2 ( IGF 2 ) , Insulin like Growth Factor Binding Protein 1 ( IGFBP 1 ) , Insulin like Growth Factor Binding Protein 3 ( IGFBP 3 ) , and IGF I / IGFBP 3 ratio . ^^^ Compared with placebo , tamoxifen induced a mean + / standard error ( SE ) reduction of IGF 1 of 16 . 9 + / 7 . 8 % , p < 0 . 05 , a non significant increase of 22 . 9 + / 12 . 2 % in IGF 2 , an increase in IGFBP 1 of 49 . 3 + / 22 . 7 % , p < 0 . 05 , and a non significant change of IGFBP 3 ( 4 . 0 % + / 9 . 2 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Fifteen IUGR and 12 normal short prepubertal subjects had a 90 min frequently sampled 4 glucose tolerance test performed to measure plasma glucose , insulin , IGF 1 , IGF 2 , IGFBP 3 , and IGFBP 1 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The assay was highly specific : no signal was obtained unless both IGF 1 and IGFBP 1 were present and neither IGFBP 2 , 3 , 4 , nor IGF 2 caused any cross reaction . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGFBP 6 SDS was low at baseline ( 2 . 5 ) and rose to 1 . 9 and 1 . 7 IGF 2 and IGFBP 1 showed an irregular pattern . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
However , functional studies showed that nitric oxide donors elicited a stimulatory action on production of IGF 1 in corpora lutea from the early luteal phase ( 80 % ) and on production of IGFBP 1 in corpora lutea from the late luteal phase ( 50 % ) ( P < 0 . 05 ) , whereas production of IGF 2 and IGFBP 3 was not affected by nitric oxide . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
BMD in total body , distal and UD radius , and femoral neck was positively correlated with serum IGF 1 ( r = 0 . 31 to 0 . 49 ) , IGF 2 ( r = 0 . 32 to 0 . 48 ) , IGFBP 3 ( r = 0 . 37 to 0 . 53 ) , and free androgen index ( FAI ) ( r = 0 . 32 to 0 . 40 ) , and negatively with IGFBP 1 ( r = 0 . 37 to 0 . 41 ) and IGFBP 2 ( r = 0 . 29 to 0 . 41 ) levels . ^^^ Age correlated negatively with serum IGF 1 , IGF 2 , IGFBP 3 , FAI , estradiol / SHBG ratio , and BMD in total body , distal and UD radius , and femoral neck , and positively with IGFBP 1 , IGFBP 2 , and SHBG levels . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The regional expression of insulin like growth factor 2 ( IGF 2 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) in the placentae of women with pre eclampsia . ^^^ IGF 2 and IGFBP 1 are abundantly expressed by cells at the maternal fetal interface and mediate cell to cell communication between trophoblasts and decidua . ^^^ We hypothesized that the expression of IGF 2 and IGFBP 1 by cells at the maternal fetal interface is altered in pre eclampsia . ^^^ We determined the regional abundance and cellular localization of IGF 2 mRNA and IGFBP 1 mRNA and protein in placentae from normotensive control and pre eclamptic pregnancies . ^^^ The altered IGF 2 and IGFBP 1 expression at the fetomaternal interface may be important in the pathophysiology of pre eclampsia . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
RESULTS : Birth weight ( BW ) , birth length ( BL ) , ponderal index , head circumference ( HC ) , and cord serum levels of albumin , prealbumin , retinol binding protein ( RBP ) , total and free IGF 1 , IGF 2 , IGFBP 3 , acid labile subunit ( ALS ) , and leptin were significantly lower , whereas levels of IGFBP 1 , IGFBP 2 , and IL 6 were significantly higher in preterm than in term neonates ( P < 0 . 05 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
METHODS : Plasma levels of IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 3 were determined from the fasting bloods of 206 BPH cases admitted for treatment and 306 randomly selected population controls in Shanghai , China . ^^^ No associations of BPH with IGF 2 and IGFBP 1 were observed . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGFBP 2 to 6 were expressed in the chondrocytes , IGFBP 1 was absent and both IGF 1 and IGF 2 , and the type 1 and type 2 IGF receptors were expressed . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Endoglin , PlGF , TGFbeta 3 , IGF 2 , IGFBP 1 , and a placental IGFBP protease have found new roles in regulating cytotrophoblast proliferation and invasiveness . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The actions of GCs are thought to be mediated in part by impaired action of the insulin like growth factors ( IGF 1 and IGF 2 ) and their binding proteins ( IGFBP 1 to 6 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
METHODS : Cross sectional study : urinary leptin , measured in the first morning urine voided and expressed as ng excreted overnight , and serum concentrations of leptin , IGF 1 , IGF 2 , IGFBP 3 and IGFBP 1 were determined in a cohort of 188 healthy schoolchildren aged 5 19 years ( 88 males , 100 females ) . ^^^ In the cross sectional study urinary leptin correlated significantly with serum IGF 1 ( r = +0 . 41 , P = 0 . 001 ) , IGF 2 ( r = +0 . 19 , P = 0 . 05 ) , IGFBP 3 ( r = +0 . 29 , P = 0 . 001 ) and IGFBP 1 ( r = 0 . 25 , P = 0 . 001 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Serum T and F IGF 1 and IGF 2 were determined using noncompetitive time resolved monoclonal immunofluorometric assays , IGFBP 1 was determined by an in house RIA , IGFBP 2 by a novel in house time resolved immunofluorometric assay , whereas IGFBP 3 by an immunoradiometric assay . ^^^ Specifically , mean T IGF 1 for patients group was 131 ( 61 ) , F IGF 1 was 0 . 47 ( 0 . 16 ) , T IGF 2 was 1056 ( 300 ) , F IGF 2 was 1 . 45 ( 0 . 54 ) , IGFBP 1 was 33 ( 14 ) , IGFBP 2 was 848 ( 377 ) , and finally IGFBP 3 was 3953 ( 1422 ) . ^^^ For controls , mean T IGF 1 was 146 ( 51 ) , F IGF 1 was 0 . 85 ( 0 . 43 ) , T IGF 2 was 939 ( 197 ) , F IGF 2 was 1 . 53 ( 0 . 53 ) , IGFBP 1 was 44 ( 24 ) , IGFBP 2 was 764 ( 316 ) and finally IGFBP 3 was 3721 ( 1017 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The following features of LC were found in the groups in question : constant observation of dust particles and interstitial and focal fibrosis in tumours of various localization and histological type ; prevailing small cell carcinoma as compared to other histological types ; high frequency of nonsmall cell lung carcinoma ; higher expression of IGFII , IGFBP 1 , 2 and rare expression of IGFB 3 ; proliferative activity followed by an increased expression of c myc , bcl 2 . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
These results show that expression of the IGFBP 1 transgene leads to a marked inhibition of hepatic preneoplasia , possibly by decreasing the mitogenic activity of IGF 1 and / or IGF 2 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
A decrease in IGF 2 concentration and maximal intensity of the putative IGFBP 1 band occurred at parturition . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
To this end , we evaluated the behavior not only of IGF 1 but also of IGF 2 , IGF binding protein ( IGFBP ) 3 , and acid labile subunit , the subunits that constitute the main IGF complex in circulation ( 150 kDa complex ) , as well as of IGFBP 1 and IGFBP 2 , which are negatively regulated by GH and , like IGFBP 3 , able to influence the bioavailability of the IGFs . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Our earlier studies provided evidence for a positive regulation of migration / invasion of EVT by an autocrine factor IGFII and a paracrine , decidua derived factor IGFBP 1 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
High affinity interactions between insulin like growth factors ( IGF 1 and IGF 2 ) and insulin like growth factor binding proteins ( IGFBP 1 , 2 , 3 , 4 , 5 and 6 ) antagonize the binding of IGF to the type 1 IGF receptor . ^^^ Proteases found in a variety of biological fluids can degrade IGFBP 1 6 into fragments that have a greatly reduced affinity for IGF 1 and IGF 2 , increasing the concentration of free IGFs at the cell surface and allowing IGFs to bind to and activate the IGF receptor . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
OBJECTIVES : To determine whether expressions of insulin like growth factor 2 ( IGF 2 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) are altered in pre eclamptic placenta and to elucidate the possible relationship between their expressions and a mechanism for inadequate trophoblast invasion in pre eclampsia . ^^^ After total ribonucleic acid was extracted , reverse transcriptase polymerase chain reaction was performed to determine IGF 2 and IGFBP 1 mRNA expression . ^^^ Western blot analysis was also done to determine IGF 2 and IGFBP 1 protein expression . ^^^ CONCLUSIONS : This study suggests that IGF 2 and IGFBP 1 might be associated with the impaired trophoblastic invasion that may lead to pathogenesis of pre eclampsia . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
With respect to the gene expression of other IGF system components , VA deficiency caused a twofold induction of IGF 1 receptor ( IGF IR ) mRNA in the heart and a twofold reduction in IGFBP 6 mRNA in the lungs , but did not alter the expression of IGF 2 , IGFBP 1 , IGFBP 3 , IGFBP 4 or IGFBP 5 in all tissues examined . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
However , despite the reduction in IGFBP 1 , glucose infusion did not increase free IGF 1 over the control level , and free IGF 2 was slightly reduced ( P < 0 . 02 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
End points included changes in fasting insulin , glucose , insulin resistance , IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 , and IGF 1 : IGFBP 3 molar ratio between baseline and week 15 . ^^^ No significant differences between groups were observed for changes in fasting insulin ( +6 . 3 pmol / liter ; P = 0 . 941 ) , glucose ( +0 . 09 mmol / liter ; P = 0 . 824 ) , insulin resistance ( +0 . 4 ; P = 0 . 247 ) , IGF 2 ( 40 . 7 ng / ml ; P = 0 . 101 ) , or IGFBP 1 ( +1 . 4 ng / ml ; P = 0 . 774 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 and IGFBP 6 were examined by specific assays . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
CONCLUSION : Low total IGF 1 and , in relation to the obesity , low free IGF 1 , low total IGF 2 and non suppressed IGFBP 1 are consistent with the concept that PWS patients have a partial GH deficiency , which can be corrected by GH replacement . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We compared the regulation of IGFBP 1 and SHBG production by insulin and insulin like growth factors ( IGF 1 and IGF 2 ) in human hepatoma cell cultures . ^^^ IGF 1 and IGF 2 also inhibited the IGFBP 1 and SHBG levels . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Real time RT PCR using SYBR Green 1 detection was employed to determine mRNA expressions of the following factors : ubiquitin ( UBQ ) , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF receptor type 1 ( IGFR 1 ) , growth hormone receptor ( GH R ) and IGF binding proteins 1 6 ( IGFBP 1 6 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Co expression of messenger ribonucleic acids encoding IGF 1 , IGF 2 , type 1 and 2 IGF receptors and IGF binding proteins ( IGFBP 1 to 6 ) during follicular development in the ovary of seasonally anoestrous ewes . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
METHODS : For in vivo studies , implantation sites from day 22 of pregnancy in the baboon were analyzed for insulin like growth factor 2 ( IGF 2 ) and insulin like growth factor binding protein 1 ( IGFBP 1 ) mRNAs using in situ hybridization . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
All samples were analyzed for total and free IGF 1 and IGF 2 , IGFBP 3 and IGFBP 3 proteolysis , total and non phosphorylated ( np ) IGFBP 1 , and IGFBP 1 complexed IGF 1 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
MEASUREMENTS : We analysed the strength and independence of associations of angiographically assessed presence of CHD with BMI , systolic and diastolic blood pressure , total , high density lipoprotein ( HDL ) and LDL cholesterol , triglycerides , lipoprotein ( a ) , apolipoproteins A 1 and B , total and free IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 , IGFBP 5 , acid labile subunit ( ALS ) , insulin , C peptide , testosterone , DHEAS and sex hormone binding globulin . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Total and free IGF 1 , IGF 2 , IGFBP 3 , and IGFBP 3 protease were similar between groups ( all P > . 5 ) , whereas , in LIPO , IGFBP 1 and IGFBP 2 were reduced ( 36 % , P < . 05 and 50 % , P < . 01 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Free IGF 1 , total IGF 2 , IGFBP 3 , and GH binding protein were lower , whereas IGFBP 1 , IGFBP 1 bound IGF 1 , and IGFBP 2 were elevated compared with control values . ^^^ Patients with detectable C peptide ( > or =100 pmol / liter ) had higher levels of total IGF 1 , free IGF 1 , and total IGF 2 and lower levels of IGFBP 1 and IGFBP 2 than those with an undetectable C peptide level despite having identical average HbA1c . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
We have obtained highly enriched villous cytotrophoblast ( VCT ) from first trimester and term human placentae , and investigated the effects of IGF 1 , IGF 2 and phosphoisoforms of IGFBP 1 . ^^^ IGFBP 1 did not modify the effects of IGF 2 on cell numbers or on MMP production . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
When tested in vitro with cultured zebrafish embryonic cells , IGFBP 1 itself had no mitogenic activity , but it inhibited IGF 1 and IGF 2 stimulated cell proliferation . ^^^ This inhibitory effect was abolished when IGF 1 or IGF 2 was added in molar excess , suggesting that IGFBP 1 inhibits embryonic growth and development by binding to and inhibiting the activities of IGFs . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
At diagnosis we found elevated IGFBP 2 , low IGFBP 3 , low IGF 1 , and low normal IGF 2 , but normal IGFBP 1 levels . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
The mean serum concentrations of IGF 2 , IGFBP 1 , IGFBP 3 , SHBG , fasting insulin , blood glucose and HOMA IR did not differ between the SGA and the AGA group . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Combined treatment caused a higher increase in IGFBP 1 and larger suppression of total and free IGF 1 , IGF 2 , and IGFBP 3 ( P < 0 . 01 for all ) , but less suppression of IGFBP 2 ( P < 0 . 05 ) compared with tamoxifen monotherapy . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGF 2 , IR B , IGFBP 1 , IGFBP 4 , and IGFBP 6 mRNA were downregulated in seminoma . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Infection with the human immunodeficiency virus ( HIV ) is often associated with a decrease of the concentrations of IGF 1 , IGF 2 , IGF binding protein 3 ( IGFBP 3 ) and an increase of IGFBP 1 and 2 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Iron ( 2 ) decreases the binding of intact IGFBP 1 and the C terminal domain to IGF 2 , suggesting that the metal binding site is close to or part of the surface of interaction of the two molecules . . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
IGF 1 and IGF 2 ( IGFs ) form higher molecular weight complexes with specific binding proteins ( IGFBP 1 to 6 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
There was no correlation of plasma IGFBP 4 level with age , sex , immunophenotype , or ALL risk group , and there was no correlation of IGFBP 4 level with plasma IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , and IGFBP 3 levels . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Changes in total IGF 1 ( tIGF 1 ) and total IGF 2 ( tIGF 2 ) , free IGF 1 ( fIGF 1 ) , IGF binding proteins ( IGFBP 1 and IGFBP 3 ) , IGFBP 3 protease activity and insulin levels were examined in 31 patients with active CD ( CDAI : 186 603 ) during treatment with prednisolone ( 40 mg for 1 week ) and tapering the dose by 5 mg / week . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In contrast , during the study period total and free IGF 2 decreased ( P < 0 . 05 ) , whereas total IGF 1 , IGFBP 1 and IGFBP 2 increased ( P < 0 . 001 ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In the yolk sac , IGF 2 mRNA was expressed in endoderm and mesoderm , whereas IGFBP 1 , 2 and 4 mRNAs were expressed only in endoderm , and IGFBP 4 mRNA in mesoderm . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
In the present study , circulating IGF 1 , IGF 2 and their binding proteins ( IGFBP 3 , IGFBP 2 and IGFBP 1 ) were determined in 92 adult patients with gastrointestinal inflammation ( Crohn ' s disease , colitis ulcerosa , gastritis , duodenitis errosiva , gastrointestinal candidiasis , and rotaviral and adenoviral enteritis ) . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
A bound dipeptide yields information on the substrate specificity of ulilysin , which specifically hydrolyzes IGFBP 2 to 6 , insulin , and extracellular matrix proteins but not IGFBP 1 or IGF 2 . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
These results suggest that prolactin influences hepatocyte proliferation in vitro by inhibiting IGFBP 1 , IGFBP 2 , and IGF 2 levels , which may coincide with the decline of IGF 2 observed in rodents during late gestation in vivo . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
METHODS : Fasting IGFBP 2 , IGFBP 1 , IGFBP 3 , IGF 1 , IGF 2 , insulin , C peptide , glucose , lipids , NEFAs , and HbA1c were measured in a cohort of 163 patients with type 2 diabetes . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Maternal and mixed umbilical cord blood was collected at delivery and analyzed for insulin , glucose , IGF 1 , IGF 2 , IGFBP 1 , IGFBP 3 , GH , and GHBP . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Insulin like growth factor binding protein 1 ( IGEBP 1 ) is a member of the family of soluble proteins that bind insulin like growth factors ( IGF 1 and IGF 2 ) and modulate their biological actions at the cellular level . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
STUDY DESIGN : Five hundred thirty eight cord serum samples were analyzed for insulin like growth factor 1 , insulin like growth factor 2 , C peptide , and insulin like growth factor binding protein 1 by immunoassay . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
OBJECTIVE : Our purpose was to examine the regulation of fetal serum concentrations of insulin ( C peptide ) , insulin like growth factor 1 , insulin like growth factor 2 , and insulin like growth factor binding protein 1 , which are growth regulating factors in the fetus , in monozygotic and dizygotic twin pairs . ^^^ Insulin like growth factor 2 and insulin like growth factor binding protein 1 are regulated by both genetic and environmental factors . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
Insulin like growth factor binding protein 1 at the maternal fetal interface and insulin like growth factor 1 , insulin like growth factor 2 , and insulin like growth factor binding protein 1 in the circulation of women with severe preeclampsia . ^^^ Circulating levels of insulin like growth factor binding protein 1 , insulin like growth factor 1 , and insulin like growth factor 2 in 16 patients with severe preeclampsia and 29 controls at the same gestational age were determined by an immunoradiometric assay and correlated with clinical parameters . ^^^
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
NA
Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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Interacting proteins: P08833 and P01344 Pubmed SVM Score :0.0
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