Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
We previously identified SH 2 B as an insulin receptor binding protein and substrate [ Kotani , Wilden and Pillay ( 1998 ) Biochem J . 335 , 103 109 ] . ^^^
Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
Alternative splicing , gene localization , and binding of SH 2 B to the insulin receptor kinase domain . ^^^ The SH 2 B protein is an SH 2 domain containing molecule that interacts with a number of phosphorylated kinase and receptor molecules including the insulin receptor . ^^^ Here we have identified a third isoform of the SH 2 B protein , SH 2 Bgamma , that interacts specifically with the insulin receptor . ^^^
Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
Functional effects of APS and SH 2 B on insulin receptor signalling . ^^^ Both APS and SH 2 Balpha interact with the insulin receptor activation loop phosphorylation sites and undergo insulin stimulated tyrosine phosphorylation , although the phosphorylation of SH 2 B is considerably weaker . ^^^ T SH 2 B cells ] overexpressing APS and SH 2 Balpha to study their roles in insulin receptor signalling . ^^^ Thus APS and SH 2 B have similar effects on insulin receptor signalling , although the effects of SH 2 B are independent of its phosphorylation . . ^^^
Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
SH 2 B , an Src homology 2 ( SH 2 ) and pleckstrin homology domain containing adaptor protein , binds via its SH 2 domain to insulin receptor in response to insulin ; however , its physiological role remains unclear . ^^^ Systemic deletion of SH 2 B impaired insulin receptor activation and signaling in the liver , skeletal muscle , and fat , including tyrosine phosphorylation of insulin receptor substrate 1 ( IRS 1 ) and IRS 2 and activation of the phosphatidylinositol 3 kinase / Akt and the Erk1 / 2 pathways . ^^^ Moreover , SH 2 B directly enhanced autophosphorylation of insulin receptor and tyrosine phosphorylation of IRS 1 and IRS 2 in an SH 2 domain dependent manner in cultured cells . ^^^ Our data suggest that SH 2 B is a physiological enhancer of insulin receptor activation and is required for maintaining normal insulin sensitivity and glucose homeostasis during aging . . ^^^
Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
SH 2 B promotes insulin receptor substrate 1 ( IRS 1 ) and IRS 2 mediated activation of the phosphatidylinositol 3 kinase pathway in response to leptin . ^^^ Here we report that SH 2 B , a JAK 2 interacting protein , promotes activation of the PI 3 kinase pathway by recruiting insulin receptor substrate 1 ( IRS 1 ) and IRS 2 in response to leptin . ^^^
Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
SH 2 B is recruited via its SH 2 domain to various protein tyrosine kinases , including Janus kinase 2 ( Jak 2 ) and the insulin receptor . ^^^ Biochemical studies of SH 2 B and APS demonstrate that , although the SH 2 domains of these two adapter proteins share 79 % sequence identity , the SH 2 B SH 2 domain binds preferentially to Jak 2 , whereas the APS SH 2 domain has higher affinity for the insulin receptor . ^^^
Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
Adapter protein with a pleckstrin homology ( PH ) and an Src homology 2 ( SH 2 ) domain ( APS ) and SH 2 B enhance insulin receptor autophosphorylation , extracellular signal regulated kinase and phosphoinositide 3 kinase dependent signalling . ^^^ Adapter protein with a pleckstrin homology ( PH ) and an Src homology 2 ( SH 2 ) domain ( APS ) and SH 2 B are adapter proteins and substrates that interact with the activation loop of the insulin receptor ( IR ) kinase . ^^^
Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
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Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
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Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
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Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
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Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
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Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
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Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
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Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
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Interacting proteins: Q9NRF2 and P06213	Pubmed	SVM Score :0.0
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