| Interacting proteins: Q92569 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92569 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92569 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92569 and P06213 |
Pubmed |
SVM Score :0.68261377 |
| Here , we describe p55PIK , a new regulatory subunit that was isolated by screening expression libraries with tyrosine phosphorylated insulin receptor substrate 1 ( IRS 1 ) . p55PIK is composed of a unique 30 residue NH 2 terminus followed by a proline rich motif and two Src homology 2 ( SH 2 ) domains with significant sequence identify to those in p 85 . p55PIK mRNA is expressed early during development , remains abundant in adult mouse brain and testis tissue , and is detectable in adult adipocytes and heart and kidney tissues . p55PIK forms a stable complex with p 110 , and it associates with IRS 1 during insulin stimulation . 0.68261377^^^ |
|
| Interacting proteins: Q92569 and P06213 |
Pubmed |
SVM Score :0.64690937 |
| In 293 cells association of p55PIK with insulin receptor substrate 1 and with IGF IR was dependent on PI 3 kinase , since it was increased by wortmannin , an inhibitor of PI 3 kinase . 0.64690937^^^ |
|
| Interacting proteins: Q92569 and P06213 |
Pubmed |
SVM Score :0.0 |
| Interestingly , when C57MG cells were treated with insulin , only p55PIK , but not p50PIK , bound to insulin receptor substrate 1 protein , providing evidence that different forms of p55PIKs may have specific distinct roles in signal transduction pathways . . ^^^ |
|