| Interacting proteins: Q8WU20 and P06213 |
Pubmed |
SVM Score :0.0 |
| To determine effector functions of SNT that promote neuronal differentiation of PC 12 pheochromocytoma cells , we engineered a chimeric protein , SNT 1 ( IRS ) CX , bearing the effector region of SNT 1 and the insulin receptor recognition domains of IRS 2 . ^^^ |
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| Interacting proteins: Q8WU20 and P06213 |
Pubmed |
SVM Score :0.0 |
| Taken together these results suggest that FRS 2 could participate in insulin signaling by recruiting Shp 2 and , hence , could function as a docking molecule similar to insulin receptor substrate proteins . . ^^^ |
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| Interacting proteins: Q8WU20 and P06213 |
Pubmed |
SVM Score :0.0 |
| While FRS 3 over expression in PC 12 cells neither increases NGF induced neuritogenesis nor activation of Map kinase / AKT , comparable to previous reports on FRS 2 , over expression of a chimeric adapter containing the PH / PTB domains of the insulin receptor substrate ( IRS ) 2 , in place of the PTB domain of FRS 3 ( IRS 2 FRS3 ) supports insulin dependent Map kinase activation and neurite outgrowth in PC 12 cells . ^^^ |
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