| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| Yeast two hybrid screening of a bovine retinal cDNA library with the cytoplasmic domain of the retinal insulin receptor ( IRbeta ) identified a member of the Grb 7 ( growth factor receptor bound protein 7 ) gene family , Grb 14 . ^^^ |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| Evidence for an interaction between the insulin receptor and Grb 7 . ^^^ Interestingly , Grb 7 is not a substrate of the insulin receptor tyrosine kinase activity . ^^^ Two domains of Grb 7 are implicated in the insulin receptor binding : the SH 2 domain and the PIR ( phosphotyrosine interacting region ) . ^^^ The role of these two domains in the interaction with the insulin receptor was already reported for Grb 10 and Grb 14 , the other members of the Grb 7 family of proteins . ^^^ |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 14 belongs to the Grb 7 family of adapters and was recently identified as a partner of the insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the phosphorylated insulin receptor interacting region ( PIR ) and Src 2 homology domains ( SH 2 ) of Grb 7 and Grb 14 were differently implicated in the inhibition of FGFR signalling . ^^^ |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| Both PIR and SH 2 domains interact with the insulin receptor , but their relative role varies considering the member of the Grb 7 family and the tyrosine kinase receptor . ^^^ |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 and Grb 14 , in particular , have been implicated in the regulation of insulin receptor signalling , whereas Grb 7 appears predominantly to be involved in focal adhesion kinase mediated cell migration . ^^^ |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| Yeast two hybrid screening of a bovine retinal cDNA library with the cytoplasmic domain of retinal insulin receptor identified a novel member of the Grb 7 gene family , Grb 14 . ^^^ |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14451 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|