| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :1.0193517 |
| Grb 14 has been shown to bind to these activated RTKs through its Src homology 2 ( SH 2 ) domain , with the exception of the insulin receptor , where the primary binding interaction is via a small domain adjacent to the SH 2 domain ( the BPS or PIR domain ) . 1.0193517^^^ |
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| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.58541641 |
| Together with the crystal structure of the SH 2 domain , we present a model for the interaction of Grb 14 with the insulin receptor , which indicates how Grb 14 functions as a selective protein inhibitor of insulin signaling . . 0.58541641^^^ |
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| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| Lipid protein interactions of growth factor receptor bound protein 14 in insulin receptor signaling . ^^^ |
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| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| We cloned by interaction with the beta subunit of the insulin receptor the rat variant of the human adapter Grb 14 ( rGrb 14 ) . rGrb 14 is specifically expressed in rat insulin sensitive tissues and in the brain . ^^^ |
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| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| The role of these two domains in the interaction with the insulin receptor was already reported for Grb 10 and Grb 14 , the other members of the Grb 7 family of proteins . ^^^ |
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| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| Inhibition of insulin receptor catalytic activity by the molecular adapter Grb 14 . ^^^ Grb 14 belongs to the Grb 7 family of adapters and was recently identified as a partner of the insulin receptor ( IR ) . ^^^ |
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| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| Mapping studies indicated that ZIP interacted through its ZZ zinc finger domain with the phosphorylated insulin receptor interacting region ( PIR ) of Grb 14 . ^^^ The PIR of Grb 14 , which also interacts with the catalytic domain of the insulin receptor ( IR ) and inhibits its activity , was preferentially phosphorylated by PKCzeta . ^^^ |
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| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the phosphorylated insulin receptor interacting region ( PIR ) and Src 2 homology domains ( SH 2 ) of Grb 7 and Grb 14 were differently implicated in the inhibition of FGFR signalling . ^^^ |
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| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 14 is an effector of insulin signaling , which directly inhibits insulin receptor catalytic activity in vitro . ^^^ |
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| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| We used a directed proteomics based approach to identify the adaptor protein Grb 14 , which binds the insulin receptor through an SH 2 domain , as a novel PDK 1 binding partner . ^^^ Thus , Grb 14 serves as an adaptor protein to recruit PDK 1 to activated insulin receptor , thus promoting Akt phosphorylation and transduction of the insulin signal . . ^^^ |
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| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| In the case of Grb 14 , PIR is the main binding domain and is sufficient to inhibit the insulin receptor kinase activity . ^^^ |
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| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 and Grb 14 , in particular , have been implicated in the regulation of insulin receptor signalling , whereas Grb 7 appears predominantly to be involved in focal adhesion kinase mediated cell migration . ^^^ |
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| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| Yeast two hybrid screening of a bovine retinal cDNA library with the cytoplasmic domain of retinal insulin receptor identified a novel member of the Grb 7 gene family , Grb 14 . ^^^ |
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| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14449 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
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