| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.67102405 |
| The adapter protein Grb 10 associates preferentially with the insulin receptor as compared with the IGF 1 receptor in mouse fibroblasts . 0.67102405^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.67810168 |
| Several isoforms of Grb 10 are known to interact with either the insulin receptor or the insulin like growth factor 1 ( IGF 1 ) receptor , or both . 0.67810168^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.59994066 |
| Grb 10 interacts differentially with the insulin receptor , insulin like growth factor 1 receptor , and epidermal growth factor receptor via the Grb 10 Src homology 2 ( SH 2 ) domain and a second novel domain located between the pleckstrin homology and SH 2 domains . 0.59994066^^^ |
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| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :1.0975795 |
| Cloning , chromosome localization , expression , and characterization of an Src homology 2 and pleckstrin homology domain containing insulin receptor binding protein hGrb10gamma . hGrb10alpha ( previously named Grb IR ) is a Src homology 2 domain containing protein that binds with high affinity to the tyrosine phosphorylated insulin receptor and insulin like growth factor 1 receptor . 1.0975795^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Growth factor receptor bound protein 10 ( Grb 10 ) is an adapter protein that interacts with a number of tyrosine phosphorylated growth factor receptors , including the insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Interaction between the Grb 10 SH2 domain and the insulin receptor carboxyl terminus . ^^^ We identified and isolated the Grb 10 SH2 domain based on its interaction with the intracellular domain of the insulin receptor beta subunit using the yeast two hybrid system . ^^^ The interaction was specific for the insulin receptor and the insulin like growth factor 1 receptor , and it required a catalytically active receptor kinase domain and an intact Grb 10 SH2 domain . ^^^ The Grb 10 SH2 domain did not bind to an insulin receptor lacking 43 amino acids at the carboxyl terminus , and it exhibited highest affinity for a phosphopeptide containing Tyr ( P ) 1322 . ^^^ Unlike p 85 and Syp , which also bind to Tyr ( P ) 1322 , Grb 10 was not found to associate with insulin receptor substrate 1 . ^^^ |
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| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 protein was reported to bind to the insulin receptor and / or the insulin like growth factor ( IGF ) 1 receptor via its src homology 2 domain and to inhibit the associated tyrosine kinase activity that is involved in the growth promoting activities of insulin and IGFs ( IGF 1 and 2 ) . ^^^ |
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| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 has been described as a cellular partner of several receptor tyrosine kinases , including the insulin receptor ( IR ) and the insulin like growth factor 1 ( IGF 1 ) receptor ( IGF IR ) . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 proteins in insulin like growth factor and insulin receptor signaling ( review ) . ^^^ In the present review the focus is on the interaction between Grb 10 proteins and the insulin like growth factor receptor / insulin receptor , and the role of Grb 10 in IGF I / insulin induced mitogenesis is discussed , considering that the data available are also partially discordant . . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| The role of these two domains in the interaction with the insulin receptor was already reported for Grb 10 and Grb 14 , the other members of the Grb 7 family of proteins . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Treatment of cells with insulin and protein tyrosine phosphatase inhibitors such as vanadate and pervanadate resulted in the tyrosine phosphorylation of Grb 10 , a Src homology 2 ( SH 2 ) and pleckstrin homology domain containing adaptor protein which binds to a number of receptor tyrosine kinases including the insulin receptor ( IR ) . ^^^ |
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| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 is a member of a family of adapter proteins that binds to tyrosine phosphorylated receptors including the insulin receptor kinase ( IRK ) . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Here we show , using purified recombinant proteins , that the BPS domain of Grb 10 directly inhibits substrate phosphorylation by the activated tyrosine kinase domains of the insulin receptor and the insulin like growth factor 1 ( IGF 1 ) receptor . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Moreover , these Grb 10 effects on KDR seem to be specific since Grb 10 has no effect on the insulin receptor , and Grb 2 , another adapter protein , does not mimic the effect of Grb 10 on KDR . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 inhibits insulin stimulated insulin receptor substrate ( IRS ) phosphatidylinositol 3 kinase / Akt signaling pathway by disrupting the association of IRS 1 / IRS 2 with the insulin receptor . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 is an interacting partner of the insulin like growth factor 1 receptor ( IGF IR ) and the insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| We find mouse Grb 10 to be a critical component of the insulin receptor ( IR ) signaling complex that provides a functional link between IR and p 85 phosphatidylinositol ( PI ) 3 kinase and regulates PI 3 kinase activity . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 proteins are binding partners for several trans membrane tyrosine kinase receptors , including the insulin like growth factor receptor ( IGF IR ) and the insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 is a Pleckstrin homology and Src homology 2 ( SH 2 ) domain containing protein that binds to the tyrosine phosphorylated insulin receptor in response to insulin stimulation . ^^^ In the present study , we show that overexpression of Grb 10 in Chinese hamster ovary cells expressing the insulin receptor or in 3T3 L 1 adipocytes reduced insulin stimulated phosphorylation of MAPK . ^^^ The negative role of Grb 10 in insulin signaling was established by suppression of endogenous Grb 10 by RNA interference in HeLa cells overexpressing the insulin receptor , which enhanced insulin stimulated phosphorylation of MAPK , Shc , and Akt . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 binds to the regulatory kinase loop of the insulin receptor ( IR ) via its SH 2 and BPS domains . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Various Grb 10 isoforms have been identified as cellular partners of the insulin receptor ( IR ) and insulin like growth factor 1 ( IGF 1 ) receptor that provide the best established regulators of Grb 10 signaling . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 and Grb 14 , in particular , have been implicated in the regulation of insulin receptor signalling , whereas Grb 7 appears predominantly to be involved in focal adhesion kinase mediated cell migration . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Grb 10 is a Src homology 2 ( SH 2 ) and Pleckstrin homology ( PH ) domain containing protein that binds to several autophosphorylated receptor tyrosine kinases including the insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| Using small interfering RNA , we demonstrate that knockdown of Grb 10 enhances IGF 1 mediated phosphorylation of insulin receptor substrate proteins , Akt / protein kinase B , and ERK1 / 2 and leads to a corresponding increase in DNA synthesis . ^^^ |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|