Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: Q07666 and P06213 Pubmed SVM Score :0.0
These data suggest that 1 ) GAP associated protein , but not Sam 68 , is a part of insulin signaling complexes ; and 2 ) p85alpha and p85beta form similar , but distinct , insulin receptor signaling complexes . . ^^^
Interacting proteins: Q07666 and P06213 Pubmed SVM Score :0.0
Sam 68 is a docking protein linking GAP and PI3K in insulin receptor signaling . ^^^ We have recently found that Sam 68 is a substrate of the insulin receptor ( IR ) and that Tyr phosphorylated Sam 68 associates with the SH 2 domains of p 85 PI3K . ^^^ In the present work , using HTC IR cells , we have found that insulin stimulation promotes the relocalization of Sam 68 from the nucleus to the cytoplasm , and we have further studied the role of Sam 68 in insulin receptor signaling complexes , by co precipitating experiments . ^^^
Interacting proteins: Q07666 and P06213 Pubmed SVM Score :0.0
Sam 68 associates with the SH 3 domains of Grb 2 recruiting GAP to the Grb 2 SOS complex in insulin receptor signaling . ^^^ We have recently found that Sam 68 is a substrate of the insulin receptor ( IR ) that translocates from the nucleus to the cytoplasm and that Tyr phosphorylated Sam 68 associates with the SH 2 domains of p 85 PI3K and GAP , in vivo and in vitro . ^^^
Interacting proteins: Q07666 and P06213 Pubmed SVM Score :0.0
The role of Sam 68 , an RNA binding protein and putative substrate of the insulin receptor ( IR ) in insulin signaling was studied using CHO wild type ( WT ) cells , CHO cells overexpressing IR , and rat white adipocytes as a physiological system . ^^^
Interacting proteins: Q07666 and P06213 Pubmed SVM Score :0.0
Besides , tyrosine phosphorylation of Sam 68 allows the formation of signalling complexes with other proteins containing SH 2 and SH 3 domains , suggesting a role in signal transduction of different systems in human lymphocytes , such as the T cell receptor , and leptin receptor , or the insulin receptor in other cell types . ^^^
Interacting proteins: Q07666 and P06213 Pubmed SVM Score :0.0
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