| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.95096249 |
| In transfected baby hamster kidney cells , Rat 1 fibroblasts , and normal IM 9 lymphoblasts , PTP1D directly binds activated insulin receptor . 0.95096249^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.76398368 |
| A full length SH PTP 2 was phosphorylated by insulin receptor kinase and associated with the insulin receptor in vitro . 0.76398368^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :1.9070927 |
| SH PTP 2 was shown to associate with a 115 kDa tyrosine phosphorylated protein ( pp 115 ) , as well as with insulin receptor substrate 1 , in insulin stimulated Chinese hamster ovary cells that overexpress human insulin receptors ( CHO IR cells ) . 1.9070927^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.65293093 |
| These results indicate that the opposite regulation of Cas phosphorylation by insulin and IGF 1 may be mediated through different properties of their receptors , and that the interaction of the insulin receptor with SHP 2 may play an important role in determining the tyrosine phosphorylation state of Cas . . 0.65293093^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.53587222 |
| On examining two lines of Tg mice identified by Southern blot , the transgene product was expressed in skeletal muscle , liver , and adipose tissues , and insulin induced association of insulin receptor substrate 1 with endogenous SHP 2 was inhibited , confirming that DeltaPTP has a dominant negative property . 0.53587222^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Shp 2 is required for protein kinase C dependent phosphorylation of serine 307 in insulin receptor substrate 1 . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| To clarify the role of protein tyrosine phosphatase containing Src homology 2 ( SH 2 ) regions on insulin signaling , we investigated the interactions among the insulin receptor , a pair of SH 2 domains of SH PTP 2 coupled to glutathione S transferase ( GST ) and insulin receptor substrate 1 ( IRS 1 ) GST fusion protein ( amino portion , IRS IN ; carboxyl portion , IRS 1C ) . ^^^ GST SH 2 protein of SH PTP 2 bound to the wild type insulin receptor , but not to that with a carboxyl terminal mutation ( Y / F2 ) . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Activation of the SH 2 containing protein tyrosine phosphatase , SH PTP 2 , by phosphotyrosine containing peptides derived from insulin receptor substrate 1 . ^^^ The cytoplasmic insulin receptor substrate 1 ( IRS 1 ) , which is multiply phosphorylated in vivo on tyrosine residues , is a known binding protein for the tandem src homology 2 ( SH 2 ) domain containing protein tyrosine phosphatase , SH PTP 2 . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C . ^^^ In the present study , we examined the activity of this enzyme and of a truncated form lacking the SH 2 domains ( delta PTP2C ) toward IRS 1 and also toward the cytoplasmic domain of the insulin receptor . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| The association of the src homology 2 ( SH 2 ) domain containing tyrosine phosphatase ( SH PTP 2 ) with the activated epidermal growth factor ( EGF ) and platelet derived growth factor receptors , as well as the insulin receptor substrate 1 and growth factor receptor bound protein 2 and its intrinsic tyrosine phosphatase activity suggests an important role for this phosphatase in signal transduction . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| SH PTP 2 is a nontransmembrane human protein tyrosine phosphatase that contains two Src homology 2 ( SH 2 ) domains and binds to insulin receptor substrate 1 ( IRS 1 ) via these domains in response to insulin . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| We found that SH 2 domains of SH PTP 2 were phosphorylated , but not those of PTP1C by insulin receptor kinase and the SH 2 domains of SH PTP 2 , but not those of PTP1C , directly bound to the phosphorylated COOH terminus of insulin receptors in vitro . . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| This induces the tyrosine phosphorylation of insulin receptor substrates 1 ( IRS 1 ) and a complex formation between IRS 1 and other proteins including GRB 2 , SH PTP 2 , Nck , and phosphoinositide ( PI ) 3 kinase consisting of a regulatory 85 kDa subunit and a catalytic 110 kDa subunit . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Activated insulin and insulin like growth factor 1 receptors transmit downstream signals via the insulin receptor substrate ( IRS 1 and IRS 2 ) and a series of proteins containing Src homology 2 ( SH 2 ) domains , including SH 2 containing protein tyrosine phosphatase 2 ( SHP 2 ) . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| The injection of peroxovanadate also enhanced the tyrosine phosphorylation of many of the proteins known to function downstream of these receptors , including SHC , signal transducer and activator of transcription ( Stat ) 1alpha , beta , Stat 3 , Stat 5 , phospholipase C gamma , insulin receptor substrate 1 , GTPase activating protein , beta catenin , gamma catenin , p120cas , SHP 1 , and SHP 2 . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| In order to determine whether the effects of TNF alpha might involve alterations in the expression of specific protein tyrosine phosphatases ( PTPases ) that have been implicated in the regulation of growth factor receptor signalling , KRC 7 rat hepatoma cells were treated with TNF alpha , and changes in overall tissue PTPase activity and the abundance of three major hepatic PTPases ( LAR , PTP1B , and SH PTP 2 ) were measured in addition to effects of TNF alpha on ligand stimulated autophosphorylation of insulin and epidermal growth factor ( EGF ) receptors and insulin stimulated insulin receptor substrate 1 ( IRS 1 ) phosphorylation . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Predominant expression of the src homology 2 containing tyrosine phosphatase protein SHP 2 in vascular smooth muscle cells . src homology 2 ( SH 2 ) containing protein tyrosine phosphatase SHP 2 is known to transduce positive signals from activated receptor protein tyrosine kinases such as platelet derived growth factor receptor ( PDGFR ) beta and insulin receptor . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| In rat aortic vascular smooth muscle cells , IGF 1 ( 20 ng / ml ) induced a sustained ( > 30 min ) increase in the tyrosine phosphorylation of both Src homology 2 domain docking insulin receptor substrate 1 ( IRS 1 ) and Src homology 2 binding tyrosine phosphatase 1D ( PTP 1D ) . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| On the other hand , IGF 1 promotes the association of insulin receptor substrate 1 with the focal adhesion kinase ( FAK ) , paxillin , and the tyrosine phosphatase SHP 2 , resulting in FAK and paxillin dephosphorylation . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Shp 2 becomes activated upon binding through one or both SH 2 domains to tyrosine phosphorylated molecules such as Shc or insulin receptor substrates . ^^^ We were interested in finding a new molecule ( s ) , tyrosine phosphorylated by the insulin receptor ( IR ) , that could interact with Shp 2 . ^^^ Taken together these results suggest that FRS 2 could participate in insulin signaling by recruiting Shp 2 and , hence , could function as a docking molecule similar to insulin receptor substrate proteins . . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| In this study , we used immunoprecipitation and immunoblotting to examine the levels and phosphorylation status of the insulin receptor ( IR ) and insulin receptor substrate 1 ( IRS 1 ) , as well as the association of the IRS 1 with phosphatidylinositol 3 kinase ( PI 3 kinase ) , and phosphotyrosine phosphatase ( SHP 2 ) in the liver and muscle of rats fed a control or high fructose diet for 28 d . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| As a consequence of IR inactivation , AT 2 receptor inhibits tyrosine phosphorylation of insulin receptor substrate 1 ( IRS 1 ) and signal regulatory protein ( SIRPalpha 1 ) and prevents subsequent association of both IRS 1 and SIRPalpha 1 with Src homology 2 ( SH 2 ) containing tyrosine phosphatase SHP 2 . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Insulin binding and protein levels of insulin receptor substrate 1 ( IRS 1 ) , p 85 subunit of phosphatidylinositol 3 ' kinase ( p 85 ) and Src homology 2 domain containing phosphatase 2 ( SHP 2 ) were then determined in hindlimb muscle and liver . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Thrombopoietin induces phosphoinositol 3 kinase activation through SHP 2 , Gab , and insulin receptor substrate proteins in BAF 3 cells and primary murine megakaryocytes . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of SHP 2 by PKA resulted in a dramatic stimulation of phosphatase activity measured either with insulin receptor substrate 1 or with the synthetic peptide [ ( 32 ) P ] poly ( Glu / Tyr ) as substrate . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| To this end , 3T3L1 fibroblasts were stably transfected with either wild type or a catalytically inactive C463A mutant of SHP 2 , and analysed for insulin induced glycogen synthesis , tyrosine phosphorylation of the insulin receptor and IRS 1 , and activation of phosphatidylinositol 3 ' kinase ( PI 3 ' kinase ) . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| To study whether protein kinase C ( PKC ) isoforms can interact with protein tyrosine phosphatases ( PTPs ) which are connected to the insulin signaling pathway , we co overexpressed PKC isoforms together with insulin receptor , docking proteins , and the PTPs SHP 1 and SHP 2 in human embryonic kidney ( HEK ) 293 cells . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Antisense inhibition of SHP 2 reverted the effect of HG on basal and insulin stimulated insulin receptor and IRS 1 phosphorylation as well as that on thymidine incorporation . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Insulin stimulates tyrosine kinase activity of its receptor , resulting in phosphorylation of its cytosolic substrate , insulin receptor substrate 1 , which , in turn , associates with proteins containing SH 2 domains , including phosphatidylinositol 3 kinase ( PI 3 kinase ) and the phosphotyrosine phosphatase SHP 2 . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Signalling by the insulin receptor substrate ( IRS ) proteins is critically dependent on the tyrosine phosphorylation of specific binding sites that recruit Src homology 2 ( SH 2 ) domain containing proteins , such as the p 85 subunit of phosphoinositide 3 kinase ( PI 3 kinase ) , the tyrosine phosphatase SHP 2 and the adapter protein Grb 2 . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor phosphorylated IRS5 / DOK4 associates with RasGAP , Crk , Src , and Fyn , but not phosphatidylinositol 3 kinase p 85 , Grb 2 , SHP 2 , Nck , or phospholipase Cgamma Src homology 2 domains , and activates MAPK in cells . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Vanadate regulates the insulin mitogenic effect by modulating SHP 2 association with insulin receptor substrate 1 in JAr human choriocarcinoma cells . ^^^ This action is related to a modulation of the SHP 2 association with IRS 1 that in turn might regulate the phosphorylation state of the main substrates involved in mitogenesic signaling of the insulin receptor . . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Gab 2 ( Grb 2 associated binder 2 ) , a member of the IRS ( insulin receptor substrate ) / Gab family of adapter proteins , undergoes tyrosine phosphorylation in response to cytokine or growth factor stimulation and serves as a docking platform for many signal transduction effectors , including the tyrosine phosphatase SHP 2 [ SH 2 ( Src homology 2 ) domain containing tyrosine phosphatase ] . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor substrate 1 / SHP 2 interaction , a phenotype dependent switching machinery of insulin like growth factor 1 signaling in vascular smooth muscle cells . ^^^ In differentiated VSMCs , IGF 1 activated a protein tyrosine phosphatase , SHP 2 , recruited by insulin receptor substrate 1 ( IRS 1 ) . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| In the present study , we examined the protein levels and phosphorylation state of insulin receptor ( IR ) , IRS 1 and IRS 2 , the association between IRSs and PI3K and SHP 2 , the insulin induced IRSs associated PI 3 kinase activities , and the phosphorylation status of AKT and atypical PKCzeta / lambda in the liver and the muscle of 6 month old Wistar rats treated with DHEA . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| The PTPN 1 gene codes for protein tyrosine phosphatase 1B ( PTP1B ) ( EC 3 . 1 . 3 . 48 ) , which negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| DOK 1 is a member of insulin receptor substrate protein family that binds beta 3 and contains YXXL / I motifs that are potential binding sites for SHP 2 . ^^^ |
|
| Interacting proteins: P06213 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Substitution for these tyrosines in p 85 resulted in loss of SHP 2 recruitment and was associated with a reduction in association of the p85 / p110 complex with insulin receptor substrate 1 . ^^^ SHP 2 recruitment to p 85 is required for IGF 1 stimulated association of the p85 / p110 complex with insulin receptor substrate 1 and for the subsequent activation of the PI 3 kinase pathway leading to increased cell migration . . ^^^ |
|