| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| Previously , by a yeast 2 hybrid screen , we identified signal transducer and activator of transcription 5b ( Stat5b ) as a substrate of the insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| Growth hormone stimulates tyrosine phosphorylation of JAK 2 and STAT 5 , but not insulin receptor substrate 1 or SHC proteins in liver and skeletal muscle of normal rats in vivo . ^^^ |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| Although IL 2 induced phosphorylation of IL 2R beta , JAK 1 , and STAT 5 all required the presence of JAK 3 , IL 4 mediated phosphorylation of JAK 1 , STAT 6 , and insulin receptor substrates 1 and 2 did not . ^^^ |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| The injection of peroxovanadate also enhanced the tyrosine phosphorylation of many of the proteins known to function downstream of these receptors , including SHC , signal transducer and activator of transcription ( Stat ) 1alpha , beta , Stat 3 , Stat 5 , phospholipase C gamma , insulin receptor substrate 1 , GTPase activating protein , beta catenin , gamma catenin , p120cas , SHP 1 , and SHP 2 . ^^^ |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| Stat 5 is a physiological substrate of the insulin receptor . ^^^ |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| TNF downregulated insulin induced insulin receptor kinase activity and insulin induced activation of the transcription factor STAT 5 . ^^^ |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| A cellular reporter assay to monitor insulin receptor kinase activity based on STAT 5 dependent luciferase gene expression . ^^^ A highly sensitive method for determination of insulin receptor ( IR ) kinase activity in whole cells , which is based on a STAT 5 ( signal transducer and activator of transcription 5 ) dependent reporter gene assay , has been developed . ^^^ |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| Stimulation of pancreatic beta cell proliferation by growth hormone is glucose dependent : signal transduction via janus kinase 2 ( JAK 2 ) / signal transducer and activator of transcription 5 ( STAT 5 ) with no crosstalk to insulin receptor substrate mediated mitogenic signalling . ^^^ |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| Activation of STAT 5 is typically mediated by JAK 2 , but more recent data indicate a direct activation by the insulin receptor kinase . ^^^ |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| Signaling by OSMRbeta containing receptors was characterized by highest activation of STAT 5 and ERK , recruitment of the insulin receptor substrate and Jun N terminal kinase pathways , and induction of a characteristic pattern of acute phase proteins . ^^^ |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin stimulates signal transducer and activator of transcription 5 ( Stat 5 ) activation in insulin receptor ( IR ) overexpressing cell lines and in insulin target tissues of mice . ^^^ |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| Once induced , SOCS 3 inhibits insulin activation of Stat5B without modifying the insulin receptor tyrosine kinase activity . ^^^ Two pieces of evidence suggest that this negative regulation likely results from competition between SOCS 3 and Stat5B binding to the same insulin receptor motif . ^^^ First , using a yeast two hybrid system , we show that SOCS 3 binds to the insulin receptor at phosphotyrosine 960 , which is precisely where Stat5B binds . ^^^ |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51692 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|