| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| Here we show that the tyrosine phosphatase SHP 1 was associated with the insulin receptor ( IR ) at the basal level . ^^^ |
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| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor tyrosine kinase catalyzed the tyrosine phosphorylation of PTP1C in a cell free system . ^^^ The tyrosine phosphorylation of PTP1C by the insulin receptor kinase increased phosphatase activity . ^^^ These results suggest that PTP1C is a target protein for the insulin receptor tyrosine kinase and that the C terminal region of PTP1C may function both in the regulation of phosphatase activity and in the association of PTP1C with autophosphorylated insulin receptors . . ^^^ |
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| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| The sites of tyrosine phosphorylation were characterized from purified enzyme following treatment with insulin receptor kinase and from PTP1C expressed in 293 cells which had been stimulated with platelet derived growth factor . ^^^ |
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| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| We found that SH 2 domains of SH PTP 2 were phosphorylated , but not those of PTP1C by insulin receptor kinase and the SH 2 domains of SH PTP 2 , but not those of PTP1C , directly bound to the phosphorylated COOH terminus of insulin receptors in vitro . . ^^^ |
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| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| The injection of peroxovanadate also enhanced the tyrosine phosphorylation of many of the proteins known to function downstream of these receptors , including SHC , signal transducer and activator of transcription ( Stat ) 1alpha , beta , Stat 3 , Stat 5 , phospholipase C gamma , insulin receptor substrate 1 , GTPase activating protein , beta catenin , gamma catenin , p120cas , SHP 1 , and SHP 2 . ^^^ |
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| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| To study whether protein kinase C ( PKC ) isoforms can interact with protein tyrosine phosphatases ( PTPs ) which are connected to the insulin signaling pathway , we co overexpressed PKC isoforms together with insulin receptor , docking proteins , and the PTPs SHP 1 and SHP 2 in human embryonic kidney ( HEK ) 293 cells . ^^^ This phosphorylation was not dependent on insulin receptor or insulin receptor substrate 1 ( IRS 1 ) overexpression and did not occur for the closely related phosphatase SHP 1 . ^^^ |
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| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| The PTPN 1 gene codes for protein tyrosine phosphatase 1B ( PTP1B ) ( EC 3 . 1 . 3 . 48 ) , which negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment . ^^^ |
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| Interacting proteins: P06213 and P29350 |
Pubmed |
SVM Score :0.0 |
| Here we show that Ptpn 6 ( me v / me 5 ) ( also known as viable motheaten ) mice bearing a functionally deficient SHP 1 protein are markedly glucose tolerant and insulin sensitive as compared to wild type littermates , as a result of enhanced insulin receptor signaling to IRS PI3K Akt in liver and muscle . ^^^ |
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