Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P24666 and P06213 Pubmed SVM Score :0.0
The PTPN 1 gene codes for protein tyrosine phosphatase 1B ( PTP1B ) ( EC 3 . 1 . 3 . 48 ) , which negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment . ^^^
Interacting proteins: P24666 and P06213 Pubmed SVM Score :0.0
To understand the physiological role of low Mr weight phosphotyrosine protein phosphatase ( LMW PTP ) in insulin mediated signaling , we established clonal cell lines overexpressing the dominant negative ( C12S mutant ) LMW PTP ( dnLMW PTP ) from NIH3T3 murine fibroblasts expressing insulin receptor . ^^^ Furthermore , in vitro binding experiments between dnLMW PTP and the insulin receptor reveal that the interaction is mediated by the LMW PTP catalytic site , as indicated by competition with orthovanadate . ^^^
Interacting proteins: P24666 and P06213 Pubmed SVM Score :0.0
LMW PTP associates and dephosphorylate many growth factor receptors , such as platelet derived growth factor receptor ( PDGF r ) , insulin receptor and ephrin receptor , thus downregulating many of the tyrosine kinase receptor functions that lead to cell division . ^^^
Interacting proteins: P24666 and P06213 Pubmed SVM Score :0.0
Recent experiments have shown that purified rat liver ACP , corresponding to human ACP 1 , is able to hydrolyze a phosphotyrosine containing synthetic peptide corresponding to the 1146 1158 sequence of the human insulin receptor , and shows a high affinity for it . ^^^ The data suggest that quantitative variations of ACP 1 may influence the clinical manifestations of diabetic disorders , and call for further studies on the role of this enzyme in the modulation of insulin receptor phosphotyrosine pathways . . ^^^
Interacting proteins: P24666 and P06213 Pubmed SVM Score :0.0
ACP 1 is an enzyme , expressed as two distinct isoforms designated F and S , that down regulates insulin receptor signal transduction and which shows a genetic polymorphism with strong quantitative enzymatic differences among genotypes . ^^^
Interacting proteins: P24666 and P06213 Pubmed SVM Score :0.0
Acid phosphatase locus 1 ( ACP 1 ) is a highly polymorphic enzyme that has an important role in flavoenzyme activity and in the control of insulin receptor activity and band 3 protein phosphorylation status . ^^^ Based on the hypothesis that ACP 1 counteracts insulin signaling by dephosphorylating the insulin receptor and that adenosine has an anti insulin action , we reasoned that low ACP 1 activity ( low dephosphorylating action on insulin receptor ) when associated with high ADA activity ( low adenosine concentration ) would result in a cumulative effect towards an increased glucose tolerance . ^^^
Interacting proteins: P24666 and P06213 Pubmed SVM Score :0.0
BACKGROUND : We have investigated the possible role of ACP 1 ( also known as cLMWPTP : cytosolic low molecular weight phosphotyrosine phosphatase ) , a highly polymorphic enzyme involved in signal transduction of T cell receptor , insulin receptor and other growth factors in the relationship between maternal age at delivery and risk of type 1 diabetes in the offspring . ^^^
Interacting proteins: P24666 and P06213 Pubmed SVM Score :0.0
Acid phosphatase locus 1 ( ACP 1 ) or cytosolic low molecular weight protein tyrosine phosphatase is a polymorphic enzyme that can hydrolyze phosphotyrosine containing peptides of the human insulin receptor and of band 3 protein . ^^^
Interacting proteins: P24666 and P06213 Pubmed SVM Score :0.0
NA