| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| JAK 1 dependent phosphorylation of insulin receptor substrate 1 ( IRS 1 ) is inhibited by IRS 1 serine phosphorylation . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| The 145 kDa protein , which appears , from antiphosphotyrosine blots of two dimensional O ' Farrell gels , to exist in four different phosphorylation states following cytokine stimulation ( with isoelectric points ranging from 7 . 2 to 7 . 8 ) , does not appear to be immunologically related to the beta subunit of the interleukin 3 receptor , c Kit , BCR , ABL , JAK 1 , JAK 2 , Sos 1 , eps 15 , or insulin receptor substrate 1 protein . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| In addition to the activation of JAK 1 and JAK 3 tyrosine kinases , IL 9 , unlike most hematopoietic cytokines but similar to IL 4 , induces the tyrosine phosphorylation of a 170 kDa protein that is related to the insulin receptor substrate 1 ( IRS 1 ) . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| These data indicate that in colon carcinoma cells JAK 1 , JAK 2 , Tyk 2 , and insulin receptor substrate 1 are phosphorylated after IL 4 stimulation . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| After insulin stimulation , pp 185 proteins ( insulin receptor substrate , IRS ) were co immunoprecipitated with both kinases by alpha JAK 1 and alpha JAK 2 antibodies . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| Although IL 2 induced phosphorylation of IL 2R beta , JAK 1 , and STAT 5 all required the presence of JAK 3 , IL 4 mediated phosphorylation of JAK 1 , STAT 6 , and insulin receptor substrates 1 and 2 did not . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| The IL 4 induced tyrosine phosphorylation of the insulin receptor substrate is dependent on JAK 1 expression in human fibrosarcoma cells . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| Jak 1 expression is required for mediating interleukin 4 induced tyrosine phosphorylation of insulin receptor substrate and Stat 6 signaling molecules . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that , in addition to activation of the Jak 1 and Jak 3 kinases , IL 7 stimulation of human thymocytes results in the rapid tyrosine phosphorylation of insulin receptor substrate 1 ( IRS 1 ) and IRS 2 proteins . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| We stimulated C2C12 myotubes with insulin ( 100 nmol / l , 5 min ) or leptin ( 0 . 62 nmol / l , 10 min ) and determined PI 3 kinase activity in immunoprecipitates with specific non crossreacting antibodies against insulin receptor substrate ( IRS 1 / IRS 2 ) and against janus kinase ( JAK 1 and JAK 2 ) . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| Interaction of Janus kinases JAK 1 and JAK 2 with the insulin receptor and the insulin like growth factor 1 receptor . ^^^ Insulin and insulin like growth factor 1 ( IGF 1 ) treatment of cells overexpressing the insulin receptor or the IGF 1 receptor promotes phosphorylation and activation of Janus kinases JAK 1 and JAK 2 but not of TYK 2 . ^^^ Taking our data together , we conclude that : 1 ) insulin and IGF 1 lead to phosphorylation and activation of JAK 1 and JAK 2 in intact cells ; 2 ) phosphorylation of IRS 1 by JAK 1 seems to occur on sites different from those phosphorylated by the insulin receptor ; 3 ) JAK 1 interacts directly with phosphorylated insulin and IGF 1 receptors ; and 4 ) the JH 7 JH6 and JH 1 domains of JAK 1 are responsible for the interaction with insulin and IGF 1 receptors . . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| Even at concentrations as high as 100 micrograms / ml ( approximately 278 microM ) , this novel inhibitor did not affect the enzymatic activity of other protein tyrosine kinases , including JAK 1 , JAK 3 , HCK , epidermal growth factor receptor kinase , and insulin receptor kinase . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the lead dimethoxyquinazoline compound , WHI P 131 , which showed potent JAK 3 inhibitory activity ( IC 50 of 78 microM ) , did not inhibit JAK 1 and JAK 2 , the ZAP / SYK family tyrosine kinase SYK , the TEC family tyrosine kinase BTK , the SRC family tyrosine kinase LYN , or the receptor family tyrosine kinase insulin receptor kinase , even at concentrations as high as 350 microM . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that erythroid progenitor cells express several receptor and non receptor tyrosine kinases , like c kit , Jak 1 , Ryk , FAK , Syk , Arg , Csk and members of the insulin receptor family . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| Treatment with H 7 did not affect IL 4R mediated immediate signaling events such as tyrosine phosphorylation of Jak 1 , Jak 3 , insulin receptor substrate ( IRS ) 1 and IRS 2 , or tyrosine phosphorylation and DNA binding of Stat 6 . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| Even at very high concentrations ranging from 175 350 microM , this inhibitor did not affect the enzymatic activity of other PTKs , including the Janus kinases JAK 1 and JAK 3 , the Src family kinase HCK , the Tec family member Bruton ' s tyrosine kinase , SYK kinase , and the receptor family PTK insulin receptor kinase . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we found that the Box 1 region and the C terminal tail of IL 13R alpha 1 were critical for binding to Tyk 2 , and activation of Jak 1 , Tyk 2 , the insulin receptor substrate 1 and STAT 6 respectively . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that interferon alpha ( IFN alpha ) dependent tyrosine phosphorylation of insulin receptor substrate 1 ( IRS 1 ) is impaired by serine phosphorylation of IRS 1 due to the reduced ability of serine phosphorylated IRS 1 to serve as a substrate for Janus kinase 1 ( JAK 1 ) . ^^^ |
|
| Interacting proteins: P23458 and P06213 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation Western blotting experiments showed that phosphorylation levels of IL 4Ralpha , Janus kinase 1 , insulin receptor substrate 1 , and insulin receptor substrate 2 , factors with molecular mass close to the observed 130 kDa major phosphorylation band , increased in response to the combined CD 40 ligation and IL 4 action . ^^^ |
|