| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.87284251 |
| T APS cells overexpressing the insulin receptor and APS , APS co precipitated with c Cbl but not in CHO . 0.87284251^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.55751878 |
| Thiazolidinediones and insulin resistance : peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene . c Cbl associated protein ( CAP ) is a signaling protein that interacts with both c Cbl and the insulin receptor that may be involved in the specific insulin stimulated tyrosine phosphorylation of c Cbl . 0.55751878^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| A novel , multifuntional c Cbl binding protein in insulin receptor signaling in 3T3 L 1 adipocytes . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| APS couples c Cbl to the insulin receptor , resulting in ubiquitination of the insulin receptor . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| Moreover , c Cbl is not tyrosine phosphorylated in response to insulin in cells expressing high levels of the human insulin receptor , or in hepatocytes , despite comparable levels of c Cbl expression . ^^^ These results suggest that c Cbl might have a novel function in the regulation of insulin receptor intracellular signalling in 3T3 L 1 adipocytes . . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| IGF 1 induced PI 3 kinase activation is generally mediated via insulin receptor substrate ( IRS ) 1 , but EGF induced PI 3 kinase activation is mediated by various signalling molecules such as ErbB 3 and c Cbl in different cells . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| Cbl is recruited to the insulin receptor by interaction with the adapter protein CAP , through one of three adjacent SH 3 domains in the carboxy terminus of CAP . ^^^ Upon phosphorylation of Cbl , the CAP Cbl complex dissociates from the insulin receptor and moves to a caveolin enriched , triton insoluble membrane fraction . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| We previously described a pathway involving the insulin stimulated tyrosine phosphorylation of Cbl , which is recruited to the insulin receptor by the adapter protein CAP . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| The increase in c Cbl tyrosine phosphorylation caused by Et 3 , 4 dephostatin was stronger than that in insulin receptor phosphorylation . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| On phosphorylation of Cbl , the c Cbl associated protein ( CAP ) / Cbl complex dissociates from the insulin receptor and translocates to a lipid raft membrane fraction to form a ternary complex with flotillin . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| The dissolution of the cortical actin network had no significant effect on proximal insulin receptor signaling events including insulin receptor autophosphorylation , tyrosine phosphorylation of insulin receptor substrate and Cbl , or serine / threonine phosphorylation of Akt . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| This pathway begins with the phosphorylation of the adaptor protein Cbl by the insulin receptor , and results in the activation of a small GTP binding protein , TC 10 , a member of the Rho family . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| The adapter protein APS has previously been shown to be involved in recruiting the ubiquitin E 3 ligase c Cbl to the insulin receptor , the platelet derived growth factor beta receptor and the erythropoietin receptor , leading to increased degradation of the receptors and inhibition of mitogenesis . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| We also showed that SHIP 2 was able to coimmunoprecipitate with endogenous c Cbl protein in the absence of CAP and with the insulin receptor in CHO IR cell extracts . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| The adaptor protein APS is a substrate of the insulin receptor and couples receptor activation with phosphorylation of Cbl to facilitate glucose uptake . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| In cells co expressing insulin receptor and CAP , without APS , no association of the insulin receptor and CAP could be detected and no insulin stimulated phosphorylation of Cbl was observed . ^^^ Insulin stimulated Cbl phosphorylation was reconstituted when APS was co expressed with insulin receptor , with or without CAP . ^^^ Taken together , these results indicate that APS plays a central role in recruiting both CAP and c Cbl to the insulin receptor after insulin stimulation and is necessary and sufficient for the insulin stimulated phosphorylation of c Cbl , whereas SH 2 Balpha may provide an alternative pathway for the recruitment of CAP . . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| The APS adapter protein plays a pivotal role in coupling the insulin receptor to CAP and c Cbl in the phosphatidylinositol 3 kinase independent pathway of insulin stimulated glucose transport . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| Cbl is phosphorylated by the insulin receptor and reportedly functions within the flotillin / CAP / Cbl / Crk / C3G / TC10 complex during insulin stimulated glucose transport in 3T3 / L1 adipocytes . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| Cbl is recruited to and phosphorylated by the insulin receptor in adipose cells through the adapter protein APS . ^^^ APS is phosphorylated by the insulin receptor on a C terminal tyrosine residue , which then serves as a binding site for the Cbl TKB domain . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| The APS adapter protein is recruited to the autophosphorylated kinase domain of the insulin receptor and initiates the phosphatidylinositol 3 kinase ( PI3K ) independent pathway of insulin stimulated glucose transport by recruiting CAP and c Cbl . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| In plasma membrane fractions , neither the high fat diet nor insulin altered the insulin receptor beta subunit ( IR beta ) , APS ( adaptor protein containing PH and SH 2 domains ) , c Cbl , or TC 10 protein concentration , but high fat feeding did decrease CAP protein concentration . ^^^ |
|
| Interacting proteins: P06213 and P22681 |
Pubmed |
SVM Score :0.0 |
| TC 10 activation by insulin is catalyzed by the exchange factor C3G , which is translocated to lipid rafts along with its binding partner CrkII as a consequence of Cbl tyrosine phosphorylation by the insulin receptor . ^^^ |
|