| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.59577983 |
| Preliminary data suggests a direct interaction between PC 1 and the insulin receptor . 0.59577983^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| The genetic investigation of early onset form of familial obesity linkage to chromosome 6q led to the identification of ENPP 1 , an inhibitor of the insulin receptor , as a possible molecular mechanism behind both obesity and type 2 diabetes . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| The ectonucleotide pyrophosphatase / phosphodiesterase 1 ( ENPP 1 ) is an inhibitor of the insulin receptor . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| The K173Q polymorphism of NPP 1 , which maps to the second somatomedin B like domain and has been associated with the aetiology of insulin resistance , did not affect the dimerization or catalytic activity of NPP 1 , and did not endow NPP 1 with an affinity for the insulin receptor . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Inhibition of insulin receptor phosphorylation by PC 1 is not mediated by the hydrolysis of adenosine triphosphate or the generation of adenosine . ^^^ Individuals with insulin resistance show increased levels of PC 1 expression in skeletal muscle and fibroblasts , and in transfected cell lines that overexpress PC 1 there is a reduction in the insulin stimulated insulin receptor tyrosine phosphorylation . ^^^ We have tested this hypothesis and find that the PC 1 mediated inhibition of insulin stimulated insulin receptor autophosphorylation is not altered by agents that alter the level or action of adenosine . ^^^ Further , a mutated PC 1 with a single amino acid change that abolishes the phosphodiesterase and pyrophosphatase activities is still able to inhibit insulin stimulated insulin receptor phosphorylation . ^^^ The results of these experiments indicate that the phosphodiesterase activity of PC 1 is not involved in the inhibition of insulin receptor autophosphorylation . . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| The inhibition of the insulin receptor by the receptor protein PC 1 is not specific and results from the hydrolysis of ATP . ^^^ The membrane protein plasma cell differentiation antigen 1 ( PC 1 ) has been purified as an inhibitor of insulin receptor tyrosine kinase activity and has been implicated in the pathogenesis of NIDDM . ^^^ When care was taken to avoid ATP depletion , PC 1 did not affect the insulin sensitivity of insulin receptor autophosphorylation . ^^^ We conclude that the reported inhibition of insulin signaling by PC 1 does not result from a direct inhibition of the insulin receptor kinase activity . . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Some evidence of involvement has been produced for insulin receptor substrate 1 , glycogen synthase , the glucagon receptor , a ras related protein ( Rad ) , histocompatibility antigens , PC 1 , and fatty acid binding protein , but the contributions of these genes to NIDDM is probably small . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin stimulated glucose transport was measured in incubated muscle strips , and PC 1 content , enzymatic activity , and insulin receptor content were measured in solubilized muscle extracts . ^^^ Insulin stimulation of muscle glucose transport was negatively related to muscle PC 1 content ( r = 0 . 68 , P = 0 . 001 ) and positively related to insulin receptor content ( r = 0 . 60 , P = 0 . 005 ) . ^^^ Multivariate analysis indicated that both skeletal muscle PC 1 content and insulin receptor content , but not BMI , were independent predictors of insulin stimulated glucose transport . ^^^ Muscle PC 1 content accounted for 42 % and insulin receptor content for 17 % of the variance in glucose transport values . ^^^ These studies raise the possibility that increased expression of PC 1 and a decreased insulin receptor content in skeletal muscle may be involved in the insulin resistance of obesity . . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| PC 1 content in skeletal muscle of non obese , non diabetic subjects : relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity . ^^^ Plasma membrane glyco protein PC 1 content is elevated in fibroblasts of insulin resistant subjects , and expression of PC 1 cDNA in cultured cells reduces both insulin receptor tyrosine kinase activity and the biological actions of insulin . ^^^ In the present study we investigated non obese , non diabetic subjects and found a significant negative correlation between muscle PC 1 content and both in vivo insulin action as measured by the intravenous insulin tolerance test ( r = 0 . 51 , p = 0 . 035 ) and the sensitivity ( ED 50 ) of in vitro insulin stimulation of insulin receptor tyrosine kinase activity ( r = 0 . 66 , p = 0 . 027 ) . ^^^ Moreover , they suggest a possible role for PC 1 in regulating insulin receptor function in human skeletal muscle . . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Overexpression of membrane glycoprotein PC 1 in MDA MB 231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| The development of insulin resistance with high fat feeding in rats does not involve either decreased insulin receptor tyrosine kinase activity or membrane glycoprotein PC 1 . ^^^ Recent studies have suggested that the insulin receptor tyrosine kinase inhibitor , membrane glycoprotein PC 1 , may play a role in certain insulin resistant states . ^^^ In the present study , we examined whether either insulin receptor function or PC 1 activity was altered during the development of insulin resistance that occurs with high fat feeding in normal rats . ^^^ Together , these data indicate that neither defects in insulin receptor function nor elevated PC 1 activities are involved in the development of insulin resistance in rats with high fat feeding , and the insulin resistance induced with high fat feeding is likely due to postreceptor defects in skeletal muscle . . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Increased adipose tissue PC 1 protein content , but not tumour necrosis factor alpha gene expression , is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine kinase activity . ^^^ In the present study we measured PC 1 content , tumour necrosis factor ( TNF ) alpha gene expression , and insulin stimulation of insulin receptor tyrosine kinase activity in adipose tissue from non obese , non diabetic subjects . ^^^ These studies in adipose tissue , together with our previous studies in skeletal muscle raise the possibility that PC 1 , by regulating insulin receptor function , may play a role in the degree of insulin sensitivity in non obese , non diabetic subjects . . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Expression of the putative inhibitor of the insulin receptor tyrosine kinase PC 1 in dermal fibroblasts from patients with syndromes of severe insulin resistance . ^^^ This protein appears to act as an endogenous inhibitor of the insulin receptor tyrosine kinase which suggests that primary over expression of PC 1 may play an aetiological role in some forms of insulin resistance . ^^^ Surprisingly , subjects with insulin receptor or IRS 1 mutations had a profound reduction in PC 1 activity ( p < or = 0 . 005 ) , protein ( p < or = 0 . 05 ) and mRNA levels ( P < or = 0 . 005 ) . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| In addition , in vitro overexpression of PC 1 in cultured cells induces insulin resistance associated with diminished insulin receptor tyrosine kinase activity . ^^^ We now find that PC 1 overexpression also influences insulin receptor signaling at a step downstream of insulin receptor tyrosine kinase , independent of insulin receptor tyrosine kinase . ^^^ In the present studies , we employed Chinese hamster ovary cells that overexpress the human insulin receptor ( CHO IR cells ; approximately 10 ( 6 ) receptors per cell ) , and transfected them with human PC 1 c DNA ( CHO IR PC 1 ) . ^^^ In CHO IR PC 1 cells , insulin receptor tyrosine kinase activity was unchanged , following insulin treatment of cells . ^^^ In CHO IR PC 1 cells , insulin stimulation of mitogen activated protein ( MAP ) kinase activity was normal , suggesting that PC 1 overexpression did not affect insulin receptor activation of Ras , which is upstream of MAP kinase . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Elevated PC 1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects : evidence that PC 1 may be an intrinsic factor in impaired insulin receptor signaling . ^^^ Membrane glycoprotein PC 1 inhibits insulin receptor ( IR ) tyrosine kinase activity and subsequent cellular signaling . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Membrane glycoprotein plasma cell 1 ( PC 1 ) has been shown to be increased in type 2 diabetes and involved in insulin resistance through inhibiting the insulin receptor tyrosine kinase , which was demonstrated using cultured breast cancer cells . ^^^ However , insulin induced tyrosine phosphorylation of the insulin receptor and insulin receptor substrate 1 , activation of phosphatidylinositol 3 kinase , and glucose uptake were not affected by PC 1 overexpression . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Plasma cell differentiation antigen ( PC 1 ) glycoprotein inhibits insulin receptor signaling and is associated with insulin resistance . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Membrane glycoprotein PC 1 ( plasma cell antigen 1 ) , which inhibits insulin receptor tyrosine kinase activity , was isolated from fibroblasts of NIDDM patients . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| An increased tissue content of PC 1 , an inhibitor of insulin receptor signaling , may play a role in insulin resistance . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Membrane glycoprotein PC 1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha subunit . ^^^ Plasma cell membrane glycoprotein 1 ( PC 1 ) inhibits insulin receptor ( IR ) tyrosine kinase activity and subsequent cellular signaling . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The plasma cell differentiation antigen ( PC 1 ) is an inhibitor of insulin receptor tyrosine kinase activity , and has been implicated in the pathogenesis of insulin resistance in Type 2 diabetes . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Results also suggest that increased insulin receptor serine / threonine phosphorylation and PC 1 could underlie the insulin resistance of pregnancy and pathogenesis of GDM . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| METHODS : The following measurements were performed : insulin sensitivity by euglycemic clamp ; PC 1 protein content and insulin receptor autophosphorylation by specific ELISAs ; PC 1 gene expression by competitive polymerase chain reaction ( PCR ) ; phosphatidyl inositol 3 kinase by immunoprecipitation and thin layer chromatography ; glycogen synthesis by ( 14 ) C glucose incorporation . ^^^ Exposure to high insulin ( 100 nmol / l for 16 h ) caused a significant ( p < 0 . 05 0 . 01 ) impairment of insulin receptor autophosphorylation , phosphatidyl inositol 3 kinase activity and glycogen synthesis , but not of PC 1 protein content ( 114+ / 3 vs 102+ / 14 ng / mg protein ) in HepG 2 cells . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| In cultured fibroblasts from an insulin resistant patient with Type 2 diabetes , we first identified membrane glycoprotein PC 1 as an inhibitor of the insulin receptor tyrosine kinase activity . ^^^ Transfection and expression of PC 1 in cultured cells demonstrate that overexpression of PC 1 produces impairments in insulin receptor tyrosine kinase activity , and the subsequent cellular responses to insulin . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| The membrane protein plasma cell membrane glycoprotein 1 ( PC 1 ) has been identified as an inhibitor of insulin receptor tyrosine kinase ( IRTK ) activity . ^^^ We investigated insulin receptor function and PC 1 levels in muscle from three groups of obese subjects : women with GDM , pregnant women with normal glucose tolerance , and nonpregnant control subjects . ^^^ IRTK activity , insulin receptor tyrosine phosphorylation , and protein levels of membrane glycoprotein PC 1 were determined in rectus abdominus muscle biopsies obtained at the time of either elective cesarean section or gynecological surgery . ^^^ PC 1 content was negatively correlated with insulin receptor phosphorylation ( r = 0 . 55 , P < 0 . 05 ) and IRTK activity ( r = 0 . 66 , P < 0 . 05 ) . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| The human plasma cell membrane differentiation antigen 1 ( PC 1 ) has been shown to inhibit insulin receptor tyrosine kinase activity . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| At the molecular level , a number of negative modulator and feedback systems somehow interacting with the beta subunit ( catecholamine , phorbolester , or tumor necrosis factor alpha induced serine / threonine phosphorylation , carboxy terminal trimming by a thiol dependent protease , association of inhibitory / regulatory proteins such as RAD , PC 1 , PED , alpha 2 HS glycoprotein ) have been identified as candidate mechanisms for the impairment of insulin receptor function by elevations in the activity and / or amount of the corresponding modification enzymes / inhibitors . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| In addition , an amino acid variant ( K121Q ) in the gene encoding the glycoprotein plasma cell differentiating antigen ( PC 1 ) , a specific inhibitor of insulin receptor signalling , has been reported to predict a faster progression of nephropathy in Italian and British type 1 diabetic patients . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| PC 1 is a membrane glycoprotein that impairs insulin receptor function . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| In obese humans , insulin resistance is accompanied by elevated levels of plasma cell membrane glycoprotein ( PC 1 ) and decreased insulin receptor ( IR ) tyrosine kinase activity in skeletal muscle . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Our data indicate that insulin stimulates PC 1 posttranslational processing and translocation to the plasma membrane , which in turn impairs insulin receptor signaling . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| The membrane protein plasma cell glycoprotein PC 1 has been identified as an inhibitor of insulin receptor tyrosine kinase activity and could have a role in insulin resistance . ^^^ This study aimed to examine the effects of insulin on glucose transport and changes in insulin receptor tyrosine phosphorylation , IRS 1 and PC 1 . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Plasma cell differentiation antigen ( PC 1 ) is an inhibitor of insulin receptor tyrosine kinase , and has been implicated in the pathogenesis of insulin resistance . ^^^ |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Increased hepatic levels of the insulin receptor inhibitor , PC 1 / NPP1 , induce insulin resistance and glucose intolerance . ^^^ The ectoenzyme , plasma cell membrane glycoprotein 1 ( PC 1 ) , is an insulin receptor ( IR ) inhibitor that is elevated in cells and tissues of insulin resistant humans . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| Overexpression of the insulin receptor inhibitor PC 1 / ENPP1 induces insulin resistance and hyperglycemia . ^^^ The ectoenzyme PC 1 is an insulin receptor inhibitor that is elevated in cells and tissues of humans with type 2 diabetes ( T2D ) . ^^^ |
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| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22413 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|