| Interacting proteins: P06213 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and P19174 |
Pubmed |
SVM Score :0.52701688 |
| Role of the pleckstrin homology domain of PLCgamma 1 in its interaction with the insulin receptor . 0.52701688^^^ |
|
| Interacting proteins: P06213 and P19174 |
Pubmed |
SVM Score :0.71351079 |
| Second , disruption of the interaction of the insulin receptor with PLC gamma 1 by microinjection of SH 2 domains derived from PLC gamma 1 or Grb 2 but not Shc similarly blocks insulin induced DNA synthesis . 0.71351079^^^ |
|
| Interacting proteins: P06213 and P19174 |
Pubmed |
SVM Score :0.0 |
| Thrombin stimulates phosphorylation of insulin like growth factor 1 receptor , insulin receptor substrate 1 , and phospholipase C gamma 1 in rat aortic smooth muscle cells . ^^^ These proteins are insulin like growth factor 1 receptor beta subunit ( IGF IR beta ) , insulin receptor substrate 1 ( IRS 1 ) , and phospholipase C gamma 1 ( PLC gamma 1 ) . ^^^ |
|
| Interacting proteins: P06213 and P19174 |
Pubmed |
SVM Score :0.0 |
| Other tyrosine kinases such as the platelet derived growth factor receptor and erbB 2 , but not the insulin receptor , also stimulated PLC gamma 1 activity . ^^^ |
|
| Interacting proteins: P06213 and P19174 |
Pubmed |
SVM Score :0.0 |
| Further investigation as to how the signals of IGF 1 were transmitted for the biological activities demonstrated that the expression of insulin receptor substrate 1 ( IRS 1 ) is up regulated by IGF 1 treatment , while PLC gamma 1 expression is not altered by this growth factor . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
|
| Interacting proteins: P06213 and P19174 |
Pubmed |
SVM Score :0.0 |
| Two different beta subunits of IGF 1 receptor were detected , and their autophosphorylation was followed by increases in the phosphotyrosine content of extracellular signal regulated kinases ( ERKs ) , insulin receptor substrate 1 , phospholipase C gamma 1 , and phosphatidylinositol 3 kinase . ^^^ |
|
| Interacting proteins: P06213 and P19174 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor tyrosine kinase domain in a chimaeric epidermal growth factor insulin receptor generates Ca2+ signals through the PLC gamma 1 pathway . ^^^ |
|
| Interacting proteins: P06213 and P19174 |
Pubmed |
SVM Score :0.0 |
| In contrast to PLCgamma 1 , insulin receptor substrate ( IRS ) 2 , a protein involved in phosphatidylinositol 3 kinase signaling , and another putative IRS like protein were significantly down regulated within the VTA by 49 and 45 % , respectively . ^^^ |
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