Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.92186362
Protein tyrosine phosphatase 1B interacts with the activated insulin receptor . 0.92186362^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.57738021
More recently , we demonstrated that the BRET methodology could also be used to monitor the interaction of the insulin receptor with protein tyrosine phosphatase 1B , one of the main tyrosine phosphatase that controls its activity . 0.57738021^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.5291154
PTP1B inhibits insulin signaling and has previously been shown to bind to the activated insulin receptor ( IR ) , but neither the mechanism nor the physiological importance of such binding have been established . 0.5291154^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.73645414
Interestingly , the basal ( insulin independent ) interaction of the insulin receptor with PTP1B was much weaker with a soluble form of the tyrosine phosphatase than with the endoplasmic reticulum ( ER ) targeted form . 0.73645414^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
The PTPN 1 gene codes for protein tyrosine phosphatase 1B ( PTP1B ) ( EC 3 . 1 . 3 . 48 ) , which negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Previous studies suggested that protein tyrosine phosphatase 1B ( PTP1B ) antagonizes insulin action by catalyzing dephosphorylation of the insulin receptor ( IR ) and / or other key proteins in the insulin signaling pathway . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
We have previously reported a direct in vivo interaction between the activated insulin receptor and protein tyrosine phosphatase 1B ( PTP1B ) , which leads to an increase in PTP1B tyrosine phosphorylation . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Protein tyrosine phosphatase 1B ( PTP1B ) negatively regulates insulin signaling in part by dephosphorylating key tyrosine residues within the regulatory domain of the beta subunit of the insulin receptor ( IR ) , thereby attenuating receptor tyrosine kinase activity . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
There was molecular evidence of improved hepatic insulin sensitivity with atorvastatin treatment based on assessment of the phosphorylation status of the insulin receptor and the expression of protein tyrosine phosphatase 1B . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Protein tyrosine phosphatase 1B ( PTP1B ) is a negative regulator of the tyrosine phosphorylation of the insulin receptor ( IR ) and insulin receptor substrate 1 ( IRS 1 ) . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Protein tyrosine phosphatase 1B ( PTP1B ) is a negative regulator of the insulin signal transduction cascade , initiated when insulin binds to the insulin receptor . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Protein tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine phosphorylated in the presence of insulin . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Tyrosine dephosphorylation and deactivation of insulin receptor substrate 1 by protein tyrosine phosphatase 1B . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Protein tyrosine phosphatase 1B ( PTP1B ) is a negative regulator of insulin receptor ( IR ) signal transduction and a drug target for treatment of type 2 diabetes . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Protein tyrosine phosphatase 1B ( PTP1B ) is an enzyme that downregulates the insulin receptor . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Here we report the crystal structures of the regulatory sulphenic and irreversible sulphinic and sulphonic acids of protein tyrosine phosphatase 1B ( PTP1B ) , an important enzyme in the negative regulation of the insulin receptor and a therapeutic target in type 2 diabetes and obesity . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Alpha lipoic acid decreases thiol reactivity of the insulin receptor and protein tyrosine phosphatase 1B in 3T3 L 1 adipocytes . ^^^ Alpha lipoic acid or insulin stimulated glucose uptake was inhibited ( 1 ) by alkylation of intracellular , but not extracellular , thiol groups downstream of insulin receptor activation , and ( 2 ) by diphenylene iodonium at the level of the insulin receptor autophosphorylation . alpha Lipoic acid also inhibited protein tyrosine phosphatase activity and decreased thiol reactivity of protein tyrosine phosphatase 1B . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
It also potentiated insulin induced Tyr phosphorylation of insulin receptor beta chain and protein tyrosine phosphatase 1B in co immunoprecipitates and impaired insulin activation of protein tyrosine phosphatase 1B activity . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Protein tyrosine phosphatase 1B ( PTP1B ) is implicated as a negative regulator of insulin receptor ( IR ) signaling and a potential drug target for the treatment of type 2 diabetes and other associated metabolic syndromes . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
In an indirect stimulation of the insulin receptor , metformin inhibited endogenous tyrosine phosphatases and purified human protein tyrosine phosphatase 1B that dephosphorylate and inhibit the insulin receptor kinase . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Protein tyrosine phosphatase 1B ( PTP 1B ) dephosphorylates various receptor protein kinases in vitro , including the beta subunit of the insulin receptor , therefore representing a potential candidate to be involved in the polygenic pathogenesis of DM 2 . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
AIM : To examine the effects of Astragalus polysaccharide ( APS ) , a component of an aqueous extract of Astragalus membranaceus roots , on protein tyrosine phosphatase 1B ( PTP1B ) , a negative regulator of insulin receptor ( IR ) signal transduction , and its potential role in the amelioration of insulin resistance . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
The use of protein tyrosine phosphatase 1B and insulin receptor immunostains to differentiate nonalcoholic from alcoholic steatohepatitis in liver biopsy specimens . ^^^ Protein tyrosine phosphatase 1B ( PTP1B ) negatively regulates the insulin receptor ( IR ) . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Surprisingly , protein tyrosine phosphatase 1B association with insulin receptor was also increased by undernutrition . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Protein tyrosine phosphatase 1B ( PTP1B ) is an enzyme that plays a critical role in down regulating insulin signaling through dephosphorylation of the insulin receptor . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Protein tyrosine phosphatase 1B ( PTP1B ) acts as a physiological negative regulator of insulin signaling by dephosphorylating the activated insulin receptor ( IR ) . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
A particularly sensitive target of zinc ions is protein tyrosine phosphatase 1B ( PTP 1B ) , a key regulator of the phosphorylation state of the insulin receptor . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
It also showed elevated expression of insulin receptor beta , insulin receptor tyrosine phosphorylation , peroxisome proliferator activated receptor gamma , protein tyrosine phosphatase 1B and phosphorylation of the transcription factor c Jun , associated with a reduced fold increase of insulin stimulated insulin receptor tyrosine phosphorylation in sucrose fed mice . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Protein Tyrosine Phosphatase 1B ( PTP1B ) has been shown to be a negative regulator of insulin signaling by dephosphorylating key tyrosine residues within the regulatory domain of the beta subunit of the insulin receptor . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Remarkably , active signaling from the InsR , as assessed by phosphorylation of downstream targets such as protein tyrosine phosphatase 1B , glycogen synthase ( GS ) , and GS kinase , was nearly absent in nonwounded and acutely healing skin from ob / ob mice . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
We analyzed the expression pattern and relative intensity of insulin receptor ( IR ) , phosphatidylinositol 3 kinase ( PI 3 kinase ) , and protein tyrosine phosphatase 1B ( PTP1B ) mRNAs by in situ hybridization in the brains of juvenile female hamsters acclimated to either long ( LD ) or short day length ( SD ) for 8 wk , with or without superimposed food deprivation for 48 h . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Expression of insulin receptor , protein tyrosine phosphatase 1B ( PTP1B ) , phosphorylation of insulin receptor ( Tyr 1146 ) and Akt were evaluated by Western blot analysis . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
BACKGROUND : ISIS 113715 is a 20 mer phosphorothioate antisense oligonucleotide ( ASO ) that is complementary to the protein tyrosine phosphatase 1B ( PTP 1B ) messenger RNA and subsequently reduces translation of the PTP 1B protein , a negative regulator of insulin receptor . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Compound 12 competitively inhibited insulin receptor dephosphorylation by PTP 1B . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Herein we find using the hexameric peptide sequence Ac D A D E 10 L amide , where 10 = ( D / L ) Pmp or L F2Pmp , that the half maximal inhibition values of these two peptides against PTP 1B mediated dephosphorylation of autophosphorylated insulin receptor to be 200 microM and 100 nM , respectively . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
We have synthesized a tris sulfotyrosyl dodecapeptide ( 3S peptide 1 ) that corresponds to the major autophosphorylation domain within the insulin receptor beta subunit and showed that it potently inhibited insulin receptor dephosphorylation by protein tyrosine phosphatases ( PTPases ) in vitro . 3S peptide 1 also inhibited tyrosine dephosphorylation of a synthetic peptide by the recombinant PTPase PTP 1B , indicating that 3S peptide 1 interacts directly with PTPase , causing its inactivation . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Enzyme studies done in vitro show that the bioactive compound ( s ) can stimulate autophosphorylation of a truncated form of the insulin receptor and can inhibit PTP 1 , a rat homolog of a tyrosine phosphatase ( PTP 1B ) that inactivates the insulin receptor . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
The PTP 1B / mice showed increased phosphorylation of the insulin receptor in liver and muscle tissue after insulin injection in comparison to PTP 1B+ / + mice . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Protein tyrosine phosphatases ( PTPs ) are required for the dephosphorylation of the insulin receptor ( IR ) and its initial cellular substrates , and it has recently been reported that PTP 1B may play a role in the pathogenesis of insulin resistance in obesity and type 2 diabetes mellitus ( DM ) . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
These results , combined with secondary dephosphorylation tests , confirm and extend earlier findings that PTP 1b and T cell PTP are physiological enzymes for the insulin receptor kinase . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
To validate this approach , substrate trapping PTP 1B was tested on its cognate ligand , the autophosphorylated insulin receptor ( IR ) . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
In this review , we discuss the hypothesis that the protein tyrosine phosphatase ( PTPase ) , PTP 1B , plays a central role in Ang 2 induced insulin resistance by inhibiting activation of the insulin receptor . ^^^ We hypothesize that Ang 2 induced PTP 1B activation leads to dephosphorylation of the insulin receptor and that this signaling pathway underlies the maladaptive responses observed in diabetic vascular and renal tissue during type 2 diabetes . . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
PTP 1B has been implicated in negatively regulating insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Conversely , adenoviral mediated overexpression of PTP 1B in HepG 2 cells downregulated the phosphorylation of insulin receptor and insulin receptor substrate 1 and caused increases in cellular and secreted apoB 100 as a result of increased intracellular apoB 100 stability . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
PTP 1B is considered a negative regulator of insulin signaling , mainly through insulin receptor dephosphorylation . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Initial attempts based on fusion of the luciferase to IGFR , and EYFP to IGFR , or to downstream signaling molecules , insulin receptor substrate 1 ( IRS 1 ) or protein tyrosine phosphatases 1B ( PTP 1B ) , failed . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
In order to characterize the potential site ( s ) of action of PTP1B in insulin signaling , we also determined that insulin stimulated receptor autophosphorylation and insulin receptor substrate 1 tyrosine phosphorylation were increased 2 . 2 and 2 . 0 fold , respectively , and that insulin stimulated receptor kinase activity toward an exogenous peptide substrate was increased by 57 % in the PTP1B antibody loaded cells . ^^^ These studies demonstrate that PTP1B has a role in the negative regulation of insulin signaling and acts , at least in part , directly at the level of the insulin receptor . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
In order to determine whether the effects of TNF alpha might involve alterations in the expression of specific protein tyrosine phosphatases ( PTPases ) that have been implicated in the regulation of growth factor receptor signalling , KRC 7 rat hepatoma cells were treated with TNF alpha , and changes in overall tissue PTPase activity and the abundance of three major hepatic PTPases ( LAR , PTP1B , and SH PTP 2 ) were measured in addition to effects of TNF alpha on ligand stimulated autophosphorylation of insulin and epidermal growth factor ( EGF ) receptors and insulin stimulated insulin receptor substrate 1 ( IRS 1 ) phosphorylation . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Sulfotyrosyl peptides corresponding to the known high affinity substrate phosphotyrosyl peptide sequences in casein and the autophosphorylation sites of insulin receptor and EGF receptor were investigated as inhibitors of protein tyrosine phosphatases PTP1B and CD 45 . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Protein tyrosine phosphatases ( PTPases ) PTP1B and PTPalpha are known to dephosphorylate the insulin receptor and may contribute to insulin resistance in diseases such as diabetes . ^^^ Furthermore , the inhibitor blocked the insulin stimulated association of PTP1B with the insulin receptor . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
PTP1B mRNA , like many other signaling molecules , including the insulin receptor , is alternatively spliced . ^^^ Since we have shown that the ratio of the insulin receptor splice variants is modulated by insulin in vitro and is related to insulin levels in vivo , we hypothesized that the relative ratios of the alternatively spliced PTP1B mRNA might also vary in humans in proportion to the degree of hyperinsulinemia . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
PTP1B is a cytosolic protein tyrosine phosphatase that is a regulator of the kinase activity of the insulin receptor ; the two protein tyrosine phosphatases LAR and CD 45 are receptor type phosphatases crucially important to cell function . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
In both cells , PTP1B overexpression blocked insulin stimulated tyrosine phosphorylation of the insulin receptor and IRS 1 by more than 70 % and resulted in a significant inhibition of the association between IRS 1 and the p 85 subunit of phosphatidylinositol 3 kinase and Akt phosphorylation as well as mitogen activated protein kinase phosphorylation . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Catalase pretreatment abolished the insulin stimulated production of H ( 2 ) O ( 2 ) as well as the inhibition of cellular PTPases , including PTP1B , and was associated with reduced insulin stimulated tyrosine phosphorylation of its receptor and high M ( r ) insulin receptor substrate ( IRS ) proteins . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
In mouse adipocytes , the inhibition of PTP1B activity and increased tyrosine phosphorylation of the enzyme were blocked by the insulin receptor tyrosine kinase inhibitor AG 1024 . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
PTP1B has been implicated in the negative regulation of the insulin signaling pathway by dephosphorylating the activated insulin receptor . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
We have examined the mechanism of dephosphorylation of the activation segments of the insulin receptor kinase and cyclin dependent kinase 2 by their respective phosphatases , namely the tyrosine specific phosphatase PTP1B and the dual specificity phosphatase KAP . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
This strategy has now been firmly validated for the insulin receptor and PTP1B ; inhibiting PTP1B activity results in stimulation of the insulin receptor and signaling , even in the absence of insulin . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Phosphotyrosine phosphatase 1B ( PTP1B ) dephosphorylates phosphotyrosine ( pTyr ) residues present on the insulin receptor ( IR ) . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
PTP1B negatively regulates insulin signaling , in part , by dephosphorylating key tyrosine residues within the regulatory domain of the beta subunit of the insulin receptor , thereby attenuating receptor kinase activity . ^^^ Inhibitors of PTP1B would therefore have the potential of prolonging the phosphorylated ( activated ) state of the insulin receptor and are anticipated to be a novel treatment of the insulin resistance characteristic of type 2 diabetes . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Here we show that PTP1B mutants that are defective in Src homology 3 domain binding fully retain the ability to inhibit insulin signalling , whereas mutants defective in insulin receptor binding fully retain the ability to inhibit integrin signalling . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Overexpression of wild type PTP1B via an adenoviral vector blocked the capacity of insulin to stimulate cell motility and insulin receptor phosphorylation , whereas expression of a dominant negative mutant of PTP1B attenuated the capacity of NO to decrease cell motility . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Even though the decrease in insulin receptor substrate protein 1 ( IRS 1 ) phosphorylation was identical with that seen in L 6 myocytes , overexpression of wild type PTP1B in L 1 adipocytes was associated with modest impairment of insulin stimulated Akt phosphorylation in addition to a small , but significant , attenuation in insulin stimulated glucose uptake , when compared with a phosphatase negative mutant . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
PTP1B dephosphorylates the insulin receptor and insulin receptor substrates ( IRS 1 / 2 ) , inhibiting the insulin signaling pathway . ^^^ These results demonstrate that reduction of PTP1B can modulate key insulin signaling events downstream of the insulin receptor . . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Phosphorylation of PTP1B at Ser ( 50 ) by Akt impairs its ability to dephosphorylate the insulin receptor . ^^^ PTP1B is a protein tyrosine phosphatase that negatively regulates insulin sensitivity by dephosphorylating the insulin receptor . ^^^ However , under the same conditions , PTP1B S50D had an impaired ability to dephosphorylate the insulin receptor . ^^^ Moreover , cotransfection of constitutively active Akt significantly inhibited the ability of wild type PTP1B , but not PTP1B S50A , to dephosphorylate the insulin receptor . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
We have shown that JAK 2 and TYK 2 are substrates of PTP1B and that the substrate recognition site within theses kinases is similar to the site of dephosphorylation previously identified within the insulin receptor . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
The mass of the insulin receptor beta subunit and the PTPases PTP1B and leukocyte antigen related was not significantly different between the two adipose depots . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Interestingly , a positively charged pocket is located near the PTPL 1 catalytic site , reminiscent of the second phosphotyrosine binding site in PTP1B , which is required to dephosphorylate peptides containing two adjacent phosphotyrosine residues ( as occurs for example in the activated insulin receptor ) . ^^^ We demonstrate that PTPL 1 , like PTP1B , interacts with and dephosphorylates a bis phosphorylated insulin receptor peptide more efficiently than monophosphorylated peptides , indicating that PTPL 1 may down regulate the phosphatidylinositol 3 kinase pathway , by dephosphorylating insulin or growth factor receptors that contain tandem phosphotyrosines . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
These results strongly suggest that PTP1B not only dephosphorylates the insulin receptor that has been activated by insulin , but also regulates the insulin receptor precursor during its biosynthesis . ^^^ Localisation of PTP1B to the endoplasmic reticulum may be important to prevent insulin independent autonomous activity of the immature insulin receptor precursor . . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
The level of insulin receptor phosphorylation in cells can be increased by inhibition of the opposing protein tyrosine phosphatase ( PTP1B ) , a target for drug development . ^^^ However , chromium did not inhibit recombinant human PTP1B using either p nitrophenyl phosphate or the tyrosine phosphorylated insulin receptor as the substrate . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
By their increased insulin sensitivity and insulin receptor hyperphosphorylation , PTP1B null mice demonstrated a clear function for this enzyme as a negative regulator of insulin signaling . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
The ortho substitution to the ( S ) IZD on the aryl ring afforded low nanomolar enzyme inhibitors of PTP1B that also displayed low caco 2 permeability and cellular activity in an insulin receptor ( IR ) phosphorylation assay and an Akt phosphorylation assay . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Compelling evidence for the existence of an insulin receptor specific PTP has come from the remarkable phenotype of the PTP1B deficient mouse . ^^^ In response to insulin administration PTP1B deficient mice have a significant increase in insulin receptor phosphorylation in liver and muscle compared to wild type controls . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
Insulin stimulated insulin receptor ( IR ) tyrosyl phosphorylation and phosphatidylinositol 3 ' kinase activity were impaired by 35 % and 40 60 % in muscle of PTP1B overexpressing mice compared with controls . ^^^
Interacting proteins: P18031 and P06213 Pubmed SVM Score :0.0
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