| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor related receptor ( IRR ) ( 1271 amino acids ) is expected to have unique functions as a novel member of the insulin receptor family . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor related receptor ( IRR ) is a member of the insulin receptor family . ^^^ In contrast to the widespread expression of insulin receptor and insulin like growth factor 1 receptor mRNAs in the brain , the expression of IRR mRNA was highly restricted to the forebrain cholinergic neurons . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| A gene encoding a putative third member of the insulin receptor family ( called the insulin receptor related receptor or IRR ) was isolated in 1989 . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor related receptor ( IRR ) is a member of the insulin receptor family . ^^^ In contrast to the widespread expression of insulin receptor and insulin like growth factor 1 receptor messenger RNA ( mRNA ) , the expression of IRR mRNA is highly restricted to the kidney and stomach . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| In 1989 , Shier and Watt identified a gene which was predicted to encode a new member of the insulin receptor ( IR ) family , and they called it the insulin receptor related receptor ( IRR ) ( Shier , P . , and Watt , 5 . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| Shier and Watt isolated human and guinea pig genomic DNA encoding a putative protein , insulin receptor related receptor ( IRR ) , the primary structure of which is similar to that of other members of the insulin receptor family , the insulin receptor and type 1 IGF receptor ( J . ^^^ In contrast to the wide distribution of the insulin receptor and type 1 IGF receptor mRNAs , the IRR mRNA is expressed preferentially in the kidney , which indicates that IRR has unique functions as a member of the insulin receptor family . . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| We constructed and expressed chimeric receptor cDNAs with insulin receptor exon 3 ( residues 191 297 of the cysteine rich region ) replaced with either the comparable region of the insulin like growth factor 1 receptor ( IGF IR ) or the insulin receptor related receptor ( IRR ) . ^^^ These results indicate that ( 1 ) the high affinity of binding of insulin to its receptor can occur in the absence of insulin receptor specific residues encoded by exon 3 , the cysteine rich region ; ( 2 ) the cysteine rich region of the IGF 1 receptor can confer high affinity binding to both IGF 1 and IGF 2 ; and 3 ) the IRR is unlikely to be a receptor for either IGF 1 , IGF 2 , or relaxin . . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| A novel member of the insulin receptor family , the insulin receptor related receptor ( IRR ) , was initially identified by cloning genomic DNA homologous to the insulin receptor . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| Characterization of a hybrid receptor formed by dimerization of the insulin receptor related receptor ( IRR ) with the insulin receptor ( IR ) : coexpression of cDNAs encoding human IRR and human IR in NIH 3T3 cells . ^^^ In many tissues , the insulin receptor related receptor ( IRR ) is colocalized with the homologous receptors for insulin and insulin like growth factor 1 ( IGF 1 ) . ^^^ To test this hypothesis , we have coexpressed the human IRR and the human insulin receptor ( IR ) in NIH 3T3 cells . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor related receptor ( IRR ) is a novel receptor tyrosine kinase in the insulin receptor family . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor related receptor ( IRR ) , a member of the insulin receptor family , is most abundantly expressed in the kidney . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| Selective coexpression of insulin receptor related receptor ( IRR ) and TRK in NGF sensitive neurons . ^^^ The insulin receptor related receptor ( IRR ) has recently been identified as a member of the insulin receptor tyrosine kinase family ; however , its endogenous ligand and biological function are still unknown . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor related receptor ( IRR ) gene encodes a protein that is homologous to the receptors for insulin and insulin like growth factor 1 ( IGF 1 ) . ^^^ However , both subunits of the IRR had smaller apparent molecular mass than the homologous subunits of the insulin receptor ( 108 , 000 versus 135 , 000 for the alpha subunits and 66 , 000 versus 95 , 000 for the beta subunits ) . ^^^ IRR tyrosine phosphorylation could be stimulated by vanadate plus H2O2 , which have been demonstrated previously to increase the phosphotyrosine content of the insulin receptor tyrosine kinase . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor related receptor ( IRR ) demonstrates striking structural homology to the insulin receptor ( IR ) and insulin like growth factor 1 receptor ( IGFR ) , suggesting that IRR is a member of the IR family . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| IRR : a novel member of the insulin receptor family . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| Primary sequence comparisons show that the ILP receptor is a member of the insulin receptor family , which in mammals includes the insulin receptor ( IR ) , type 1 IGF receptor ( IGF IR ) , and IR related receptor ( IRR ) . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor related receptor ( IRR ) is a member of the insulin receptor family . ^^^ Its restricted pattern indicates that IRR plays unique roles in the brain , in contrast to insulin and insulin like growth factor 1 receptors , other members of the insulin receptor family , which are widely expressed in the brain . . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor related receptor ( IRR ) is an orphan receptor of the insulin receptor gene ( Ir ) subfamily . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| Here we show that the insulin receptor tyrosine kinase family , comprising Ir , Igf1r and Irr , is required for the appearance of male gonads and thus for male sexual differentiation . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| In the present work a chimeric receptor containing the intracellular domain of the insulin receptor related receptor ( IRR ) and the extracellular domain of the colony stimulating factor 1 ( CSF 1 ) receptor was expressed in 3T3 L 1 adipocytes and compared with the parallel chimeric receptor containing the cytoplasmic domain of the insulin receptor ( IR ) . ^^^ These results indicate that despite the extensive differences in sequence between the cytoplasmic domains of the IRR and IR , the elements required for insulin specific responses have been conserved in this distinct member of the insulin receptor family . . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| The physiological aspects and roles of the insulin receptor related receptor ( IRR ) , a novel member of the insulin receptor family , are unknown . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor related receptor ( IRR ) , a member of the insulin receptor tyrosine kinase family , has structural homology to the insulin receptor ( IR ) and the IGF 1 receptor ( IGF IR ) . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor related receptor ( IRR ) is a heterotetrameric transmembrane receptor with intrinsic tyrosine kinase activity . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| The analysis revealed that insulin receptor related receptor ( IRR ) is highly expressed in the islets as well as in several highly differentiated beta cell lines derived from transgenic mice . ^^^ To examine the IRR signaling pathway , a chimeric receptor consisting of the extracellular domain of insulin receptor and the intracellular domain of IRR was expressed in Chinese hamster ovary cells . ^^^ It also stimulates the tyrosine phosphorylation of insulin receptor substrate ( IRS ) 1 and IRS 2 , indicating that both proteins serve as substrates of IRR protein tyrosine kinase in intact cells . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| Correlation of type 1 insulin like growth factor receptor ( IGF 1 R ) and insulin receptor related receptor ( IRR ) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin . ^^^ The insulin receptor related receptor ( IRR ) is a member of the insulin receptor family . ^^^ IRR , insulin receptor ( IR ) , and insulin like growth factor 1 receptor ( IGF 1 R ) are all tyrosine kinases . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor related receptor ( IRR ) , an orphan receptor in the insulin receptor ( IR ) family of receptor tyrosine kinases , is primarily localized to neural crest derived sensory neurons during embryonic development . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| In the present work , we investigated the potential of the third member of the family , insulin receptor related receptor ( IRR ) , to associate with known interaction partners of the InsR and the IGF 1 receptor in a yeast two hybrid assay . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor related receptor ( IRR ) is a member of the insulin receptor family that , on its own , recognizes neither insulin nor any of the identified insulin related peptides . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : We hypothesised that glucose concentration might regulate expression of Igf1r , Insr and insulin receptor related receptor ( Insrr ) in islets and beta cells . ^^^ RESULTS : In rat islets , high glucose exposure ( 25 mmol / l ) increased gene expression of Igf1r , Insr and Insrr but also of the metabolic glycolysis gene liver type pyruvate kinase ( Pklr ) compared with intermediate ( 6 . 2 mmol / l ) or low glucose concentration ( 1 . 6 mmol / l ) after 24 h . ^^^ In rat INS 1E beta cells , only Pklr expression was suppressed by low glucose as in islets , while Insr and Insrr were suppressed by high and increased by low glucose levels . ^^^ Activation of AMPK by 5 amino imidazolecarboxamide riboside ( AICAR , 0 . 5 mmol / l ) suppressed Pklr expression , but strongly stimulated gene expression of Igf1r , Insr and Insrr . ^^^ Stimulation of Igf1r and Insr gene expression by the AMPK activator AICAR might indicate involvement of AMPK in the regulation of Igf1r , Insr and Insrr expression in beta cells . . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| We also report on the existence of likely dominant negative forms for many of the receptor kinases and phosphatases , including some 26 secreted decoys ( seven known and 19 novel : Alk , Csf1r , Egfr , Epha 1 , 3 , 5 , 7 and 10 , Ephb 1 , Flt 1 , Flt 3 , Insr , Insrr , Kdr , Met , Ptk 7 , Ptprc , Ptprd , Ptprg , Ptprl , Ptprn , Ptprn 2 , Ptpro , Ptprr , Ptprs , and Ptprz 1 ) and 13 transmembrane forms ( four known and nine novel : Axl , Bmpr1a , Csf1r , Epha 4 , 5 , 6 and 7 , Ntrk 2 , Ntrk 3 , Pdgfra , Ptprk , Ptprm , Ptpru ) . ^^^ |
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| Interacting proteins: P14616 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
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