| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| The PTPN 1 gene codes for protein tyrosine phosphatase 1B ( PTP1B ) ( EC 3 . 1 . 3 . 48 ) , which negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment . ^^^ |
|
| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor apparent affinity was markedly decreased in fat cells treated with lectins specific either for D galactose ( Ricinus communis agglutinin 1 , RCAI ) , D mannose ( concanavalin A , Con A , Lens culinaris agglutinin , LCA ) or N acetyl D glucosamine ( wheat germ agglutinin , WGA ) , as indicated by a rightward shift of the binding competition curves and almost lineared Scatchard plots . ^^^ |
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| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| Autophosphorylated preparations of epidermal growth factor receptor , insulin receptor , and p56lck protein tyrosine kinases were also substrates for CD 45 in vitro . . ^^^ |
|
| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| The transmembrane protein tyrosine phosphatase CD 45 is associated with decreased insulin receptor signaling . ^^^ Consistent with these data , insulin receptor signaling is increased when the CD 45 related PTPase LAR is reduced by antisense suppression in a rat hepatoma cell line . ^^^ To test whether the hematopoietic cell specific PTPase CD 45 functions in a manner similar to LAR by negatively modulating insulin receptor signaling in hematopoietic cells , the insulin responsive human multiple myeloma cell line U 266 was isolated into two subpopulations that differed in CD 45 expression . ^^^ In CD 45 nonexpressing ( CD 45 ) cells , insulin receptor autophosphorylation was increased by 3 fold after insulin treatment when compared to CD 45 expressing ( CD45+ ) cells . ^^^ Insulin dependent tyrosine phosphorylation of insulin receptor substrate 1 ( IRS 1 ) and Shc was 3 fold greater in CD 45 cells . ^^^ |
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| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| Sulfotyrosyl peptides corresponding to the known high affinity substrate phosphotyrosyl peptide sequences in casein and the autophosphorylation sites of insulin receptor and EGF receptor were investigated as inhibitors of protein tyrosine phosphatases PTP1B and CD 45 . ^^^ |
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| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| PTP1B is a cytosolic protein tyrosine phosphatase that is a regulator of the kinase activity of the insulin receptor ; the two protein tyrosine phosphatases LAR and CD 45 are receptor type phosphatases crucially important to cell function . ^^^ LAR also is involved in regulation of the insulin receptor while CD 45 is critical for T cell activation . ^^^ |
|
| Interacting proteins: P08575 and P06213 |
Pubmed |
SVM Score :0.0 |
| We also report on the existence of likely dominant negative forms for many of the receptor kinases and phosphatases , including some 26 secreted decoys ( seven known and 19 novel : Alk , Csf1r , Egfr , Epha 1 , 3 , 5 , 7 and 10 , Ephb 1 , Flt 1 , Flt 3 , Insr , Insrr , Kdr , Met , Ptk 7 , Ptprc , Ptprd , Ptprg , Ptprl , Ptprn , Ptprn 2 , Ptpro , Ptprr , Ptprs , and Ptprz 1 ) and 13 transmembrane forms ( four known and nine novel : Axl , Bmpr1a , Csf1r , Epha 4 , 5 , 6 and 7 , Ntrk 2 , Ntrk 3 , Pdgfra , Ptprk , Ptprm , Ptpru ) . ^^^ |
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