| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| The blots were hybridized with radioactive probes prepared from the factor 8 , type 2 collagen , insulin receptor , beta 2 adrenergic receptor , and 21 hydroxylase genes ; in unrelated individuals , several RFMPs were found in fragments from every locus tested . ^^^ |
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| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| This hypothesis was evaluated directly using recombinant human insulin receptor , hamster beta 2 adrenergic receptor , and an vitro reconstitution and phosphorylation assay . ^^^ Insulin is shown to stimulate insulin receptor catalyzed phosphorylation of the beta 2 adrenergic receptor . ^^^ Phosphoamino acid analysis establishes that insulin receptor catalyzed phosphorylation of the beta 2 adrenergic receptor in vitro is confined to phosphotyrosine . ^^^ High pressure liquid chromatography and two dimensional mapping reveal insulin receptor catalyzed phosphorylation of the beta 2 adrenergic receptor at residues Tyr132 / Tyr141 , Tyr350 / Tyr354 , and Tyr 364 , known sites of phosphorylation in response to insulin in vivo . ^^^ Insulin like growth factor 1 receptor as well as the insulin receptor displays the capacity to phosphorylate the beta 2 adrenergic receptor in vitro , establishing a new paradigm , i . e . ^^^ |
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| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| The results of these separate analyses reveal that IGF 1 stimulates phosphorylation predominantly on tyrosyl residues Y132 / 141 of the second intracellular loop of the beta 2 adrenergic receptor rather than the C terminal region targeted by the activated insulin receptor ( Y350 / 354 , Y 364 ) , although both growth factors block beta adrenergic agonist action . ^^^ |
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| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| The full length , cytoplasmic C terminus of the beta 2 adrenergic receptor expressed in E . coli acts as a substrate for phosphorylation by protein kinase A , insulin receptor tyrosine kinase , GRK 2 , but not protein kinase C and suppresses desensitization when expressed in vivo . ^^^ |
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| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin stimulates phosphorylation of the beta 2 adrenergic receptor by the insulin receptor , creating a potent feedback inhibitor of its tyrosine kinase . ^^^ |
|
| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| Taken together , these findings represent a hitherto unknown mechanism ( degradation and phosphorylation of beta arrestin , whereby the activation of the insulin receptor , belonging to the family of receptor tyrosine kinases , causes supersensitization of Galpha ( s ) associated signaling and inhibition of Galpha ( 1 ) associated signaling by the beta2AR , a prototypical G protein coupled receptor . . ^^^ |
|
| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|