| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| Interaction between the p21ras GTPase activating protein and the insulin receptor . ^^^ |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin induces a rapid activation of p21ras in NIH 3T3 and Chinese hamster ovary cells that overexpress the insulin receptor . ^^^ |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| Sos is the predominant coupling pathway from the activated insulin receptor to p21ras . ^^^ |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| We showed previously that upon insulin stimulation of an insulin receptor overexpressing cell line , most of the p21ras was rapidly converted into the GTP bound state ( Burgering , B . ^^^ These values argue against signal amplifying processes between the insulin receptor and p21ras . ^^^ |
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| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin treatment of fibroblasts overexpressing the insulin receptor causes a rapid accumulation of the GTP bound form of p21ras . ^^^ Since PAO did not affect overall phosphorylation of the insulin receptor beta chain , we conclude that a PAO sensitive protein is involved in the induction of p21ras activation by insulin . . ^^^ |
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| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor phosphorylates insulin receptor substrate 1 ( IRS 1 ) and Shc on tyrosine residues , both of which associate with the protein abundant Src homology / growth factor receptor bound protein 2 ( ASH / GRB2 ) leading to p21ras activation . ^^^ |
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| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| In conclusion , oncogenic p21ras and PyMT / pp60c src abolished insulin mitogenic signaling in Caco 2 cells through mechanisms involving ( 1 ) constitutive activation of MAP kinase , and ( 2 ) marked decreases in both insulin receptor function and expression which were mediated by PKC dependent and PKC independent pathways respectively . ^^^ This is the first evidence that , when oncogenically activated , p21ras and pp60c src not only exert a negative control on insulin receptor function but also repress insulin receptor gene expression in human colonic cells . . ^^^ |
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| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| A mutant insulin receptor induces formation of a Shc growth factor receptor bound protein 2 ( Grb 2 ) complex and p21ras GTP without detectable interaction of insulin receptor substrate 1 ( IRS 1 ) with Grb 2 . ^^^ Insulin receptors induce p21ras GTP formation by two possible mechanisms : tyrosine phosphorylation of insulin receptor substrate 1 ( IRS 1 ) and its subsequent association with Grb 2 , or Shc phosphorylation and its subsequent association with Grb 2 . ^^^ We conclude that phosphorylation of Tyr 1158 and Tyr 1162 of the insulin receptor is linked to distinct post receptor processes and that YFF receptors generate p21ras GTP via the Shc . ^^^ |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor signaling acutely stimulates GTP loading of p21ras , apparently by mobilizing complexes of Grb 2 and the guanine nucleotide exchangers Son of sevenless ( Sos ) 1 and 2 to associate with tyrosine phosphorylated proteins in the plasma membrane . ^^^ |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| Coexpression of IRS 1 or IRS 1F 895 with the insulin receptor was required for insulin stimulated mitogenesis in 32 D cells , while expression of the insulin receptor alone was sufficient to mediate insulin stimulated tyrosine phosphorylation of Shc and activation of p21ras and mitogen activated protein ( MAP ) kinase . ^^^ |
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| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin stimulated Raf 1 binding to p21Ras in HIRc ( wild type ) , delta CT ( insulin receptor lacking a 43 amino acid C terminal domain ) , and Y / F2 ( tyrosine 1316 and 1322 replaced by phenylalanine ) cells . ^^^ As an association of Raf 1 with p21Ras does not activate Raf 1 kinase , but merely targets Raf 1 to the plasma membrane , we examined the binding of Raf 1 to 14 3 3 proteins and to the insulin receptor itself . ^^^ |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| In these cells , both Shc tyrosine phosphorylation and mitogen activated protein kinase ( MAP K ) activity were increased by the insulin receptor ( indicating that the p21ras pathway may account for insulin stimulated cell growth in ZR 75 1 cells ) . ^^^ |
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| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| Transgenic models of insulin resistance ( heterozygous insulin receptor substrate 1 knockout mice , A ZIP / F 1 fatless mice , and animals overexpressing glutamine : fructose 6 phosphate amidotransferase ) contained increased amounts of farnesylated p21Ras . ^^^ |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| Furthermore , oxLDL increased Erk dependent phosphorylation of insulin receptor substrate 1 serine 616 that was prevented by inhibiting oxidant generation , Erk activation , or by the p21ras C118S mutant . ^^^ |
|
| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| We have investigated the in vitro tyrosine phosphorylation of the HRAS and KRAS proteins by human placental insulin receptor kinase . ^^^ Purified HRAS proteins are not phosphorylated by purified insulin receptor kinase . ^^^ We found that purified HRAS proteins are indeed phosphorylated by purified insulin receptor kinase in the presence of poly ( L lysine ) . ^^^ Further examination of the role of poly ( L lysine ) in potentiating tyrosine phosphorylation of the HRAS protein and calmodulin by purified insulin receptor kinase indicates that poly ( L lysine ) affects the conformation of these protein substrates as well as that of the receptor kinase domain . ^^^ |
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| Interacting proteins: P01112 and P06213 |
Pubmed |
SVM Score :0.0 |
| Transformed brown adipocyte cell line ( by permanent simian virus 40 large T antigen and pMEXneo H ras ( lys 12 ) cotransfection ) developed insulin resistance upstream from Ras , showing an impairment in the insulin receptor autophosphorylation , and in insulin receptor substrate 1 tyrosine phosphorylation and its association with phosphatidylinositol 3 kinase upon treatment with 1 nM insulin , although insulin receptor number and affinity ( Kd ) remained unaltered . ^^^ We conclude that the decreased tyrosine autophosphorylation rate of the insulin receptor from H ras ( lys 12 ) transformed brown adipocytes is a consequence of its basal serine / threonine phosphorylation , resulting in severe insulin resistance . . ^^^ |
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