| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Once induced , SOCS 3 interacts with the insulin receptor , JAK 2 , IRS 1 , and IRS 2 . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| The 145 kDa protein , which appears , from antiphosphotyrosine blots of two dimensional O ' Farrell gels , to exist in four different phosphorylation states following cytokine stimulation ( with isoelectric points ranging from 7 . 2 to 7 . 8 ) , does not appear to be immunologically related to the beta subunit of the interleukin 3 receptor , c Kit , BCR , ABL , JAK 1 , JAK 2 , Sos 1 , eps 15 , or insulin receptor substrate 1 protein . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| These data indicate that in colon carcinoma cells JAK 1 , JAK 2 , Tyk 2 , and insulin receptor substrate 1 are phosphorylated after IL 4 stimulation . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| GH also induced an increase in the PI 3 kinase activity associated with both JAK 2 and insulin receptor substrate 1 ( IRS 1 ) immunoprecipitates . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Co immunoprecipitation with anti insulin receptor antibody , anti JAK 2 antibody , and anti IRS 1 antibody showed that JAK 2 interacts with the insulin receptor and IRS 1 to form stable complexes following stimulation by insulin . ^^^ In two animal models of insulin resistance the regulation of JAK 2 tyrosine phosphorylation after insulin infusion paralleled the phosphorylation of the insulin receptor and of IRS 1 . ^^^ In conclusion , our data indicate that after physiological stimulation by insulin in the intact animal , JAK 2 associates with the insulin receptor and is tyrosine phosphorylated in insulin sensitive tissues in a time and dose dependent fashion . . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Growth hormone stimulates tyrosine phosphorylation of JAK 2 and STAT 5 , but not insulin receptor substrate 1 or SHC proteins in liver and skeletal muscle of normal rats in vivo . ^^^ GH has been shown to stimulate tyrosine phosphorylation of JAK 2 , several STAT proteins , insulin receptor substrate 1 ( IRS 1 ) , and SHC proteins in cultured cells . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Tyrosyl phosphorylation of GH receptor and JAK 2 recruits and activates signaling molecules such as Stat transcription factors , SHC , and insulin receptor substrates 1 and 2 that lead to the release of second messengers such as diacylglycerol , calcium , and nitric oxide and the activation of enzymes such as mitogen activated protein kinase , protein kinase C , phospholipase A 2 , and phosphatidylinositol 3 ' kinase . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Recent data suggest involvement of the Janus tyrosine kinase 2 ( JAK 2 ) in human GH induced tyrosine phosphorylation of the GH receptor and the insulin receptor substrates 1 and 2 ( IRS 1 and IRS 2 ) , leading to activation of the phosphatidylinositol 3 kinase and the acute insulin like effects in primary rat adipocytes . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| After insulin stimulation , pp 185 proteins ( insulin receptor substrate , IRS ) were co immunoprecipitated with both kinases by alpha JAK 1 and alpha JAK 2 antibodies . ^^^ SHPTP 2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Within the Jak 2 kinase domain , there is a region that has considerable sequence homology to the regulatory region of the insulin receptor and contains two tyrosines , Y 1007 and Y 1008 , that are potential regulatory sites . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| The signaling molecules that are recruited and activated by the GHR JAK 2 complex include signal transducers and activators of transcription ( Stat ) factors , the adapter protein Shc , and the insulin receptor substrates ( IRSs ) 1 and 2 . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Leptin activates PI 3 kinase in C2C12 myotubes via janus kinase 2 ( JAK 2 ) and insulin receptor substrate 2 ( IRS 2 ) dependent pathways . ^^^ We stimulated C2C12 myotubes with insulin ( 100 nmol / l , 5 min ) or leptin ( 0 . 62 nmol / l , 10 min ) and determined PI 3 kinase activity in immunoprecipitates with specific non crossreacting antibodies against insulin receptor substrate ( IRS 1 / IRS 2 ) and against janus kinase ( JAK 1 and JAK 2 ) . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| JAK 2 activation by GH is believed to facilitate initiation of various pathways including the Ras , mitogen activated protein kinase , STAT , insulin receptor substrate ( IRS ) , and phosphatidylinositol 3 kinase systems . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Interaction of Janus kinases JAK 1 and JAK 2 with the insulin receptor and the insulin like growth factor 1 receptor . ^^^ Insulin and insulin like growth factor 1 ( IGF 1 ) treatment of cells overexpressing the insulin receptor or the IGF 1 receptor promotes phosphorylation and activation of Janus kinases JAK 1 and JAK 2 but not of TYK 2 . ^^^ Taking our data together , we conclude that : 1 ) insulin and IGF 1 lead to phosphorylation and activation of JAK 1 and JAK 2 in intact cells ; 2 ) phosphorylation of IRS 1 by JAK 1 seems to occur on sites different from those phosphorylated by the insulin receptor ; 3 ) JAK 1 interacts directly with phosphorylated insulin and IGF 1 receptors ; and 4 ) the JH 7 JH6 and JH 1 domains of JAK 1 are responsible for the interaction with insulin and IGF 1 receptors . . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate 1 , 2 , and 3 , their association with p 85 phosphatidylinositol 3 kinase ( PI 3 kinase ) , and concomitantly PI 3 kinase activation via JAK 2 kinase . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| In a transient expression system in human kidney 293 cells , however , Grb10 / GrbIR becomes profoundly tyrosine phosphorylated by Tec , but not by Syk , Jak 2 or insulin receptor . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Insulin signalling in heart involves insulin receptor substrates 1 and 2 , activation of phosphatidylinositol 3 kinase and the JAK 2 growth related pathway . ^^^ Besides activation of the lipid metabolising enzyme phosphatidylinositol 3 kinase , the phosphorylation of insulin receptor substrates 1 and 2 engages the intracellular kinase JAK 2 and induces JAK 2 STAT 1 complex formation . ^^^ CONCLUSIONS : We demonstrate that the early steps of insulin signalling in heart include the phosphorylation activation of the insulin receptor , engagement of insulin receptor substrates 1 and 2 with the consequent activation of phosphatidylinositol 3 kinase and the involvement of the recently discovered growth related pathway JAK 2 STAT 1 . . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Growth hormone stimulates the tyrosine kinase activity of JAK 2 and induces tyrosine phosphorylation of insulin receptor substrates and Shc in rat tissues . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the lead dimethoxyquinazoline compound , WHI P 131 , which showed potent JAK 3 inhibitory activity ( IC 50 of 78 microM ) , did not inhibit JAK 1 and JAK 2 , the ZAP / SYK family tyrosine kinase SYK , the TEC family tyrosine kinase BTK , the SRC family tyrosine kinase LYN , or the receptor family tyrosine kinase insulin receptor kinase , even at concentrations as high as 350 microM . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| In vitro , Tub is phosphorylated by purified insulin receptor kinase as well as by Abl and JAK 2 but not by epidermal growth factor receptor and Src kinases . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Stimulation of pancreatic beta cell proliferation by growth hormone is glucose dependent : signal transduction via janus kinase 2 ( JAK 2 ) / signal transducer and activator of transcription 5 ( STAT 5 ) with no crosstalk to insulin receptor substrate mediated mitogenic signalling . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Activation of STAT 5 is typically mediated by JAK 2 , but more recent data indicate a direct activation by the insulin receptor kinase . ^^^ Blocking insulin signalling by HNMPA ( AM ) ( 3 ) , an insulin receptor kinase inhibitor , resulted in the loss of insulin induced STAT5b tyrosine phosphorylation , whereas the inhibition of JAK 2 by the JAK selective inhibitor tyrphostin AG 490 had no effect . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| In response to GH , JAK 2 is also known to phosphorylate the insulin receptor substrates , leading to activation of phosphatidyl inositol 3 ' kinase and most likely other molecules that have been implicated in the regulation of metabolism . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Interaction of GH with the cell surface GH receptor ( GHR ) causes activation of the GHR associated tyrosine kinase , JAK 2 , and consequent triggering of signaling cascades including the STAT , Ras / Raf / MEK1 / MAP kinase , and insulin receptor substrate 1 ( IRS 1 ) / PI3kinase pathways . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| The activation of insulin receptors following insulin treatment , and the involvement of insulin receptor substrates 1 and 2 , Shc , JAK 2 and STAT 1 , were analyzed by immunoprecipitation , followed by SDS PAGE and immunoblotting of rat lacrimal and salivary glands after exposure to insulin . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| We therefore tested the C2C12 myogenic cell line for its response to GH and demonstrate that C2C12 skeletal muscle cells rapidly respond to physiological levels of GH with increased tyrosine phosphorylation of the GH receptor , Janus kinase 2 , signal transducer and activator of transcription 5a and 5b , insulin receptor substrate 1 , and activation of MAPKs / ERKs and protein kinase B / Akt . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Furthermore , overexpression of the insulin receptor in HEK 293 cells clearly reduced JAK 2 phosphorylation and led further downstream to a diminished phosphatidylinositol 3 kinase activity . ^^^ CONCLUSION / INTERPRETATION : In summary , our data suggest that the insulin receptor signalling pathway interferes with leptin signalling at the level of JAK 2 . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| We have shown that JAK 2 and TYK 2 are substrates of PTP1B and that the substrate recognition site within theses kinases is similar to the site of dephosphorylation previously identified within the insulin receptor . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Our results demonstrate that JAK 2 , insulin receptor substrate ( IRS ) 1 , Shc , ERKs , and Akt are widely distributed in the kidney , and after GH treatment , there is a significant increase in phosphorylation of these proteins in STZ induced diabetic rats compared with controls . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| After receptor binding , growth hormone ( GH ) induces GH receptors ( GHR ) dimerization and JAK 2 is activated after its association with a dimerized GHR , stimulating the tyrosyl phosphorylation of insulin receptor substrate 1 ( IRS 1 ) , IRS 2 and Shc proteins . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| On the other hand , within the protein tyrosine kinases involved in the phosphorylation of CaM are receptors with tyrosine kinase activity , such as the insulin receptor and the epidermal growth factor receptor , and nonreceptor protein tyrosine kinases , such as several members of the Src family kinases , Janus kinase 2 , and p38Syk . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Upon JAK 2 activation , tyrosine phosphorylation of signal transducer and activator of transcription 1 ( STAT 1 ) , STAT 5b , insulin receptor substrate 1 ( IRS 1 ) , and Src homology and collagen homology ( Shc ) were detected . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| The ability of GH to stimulate lipogenesis and tyrosine phosphorylation of the GH receptor ( GHR ) , Janus kinase 2 ( Jak 2 ) , insulin receptor substrate 1 ( IRS 1 ) and 2 ( IRS 2 ) was greatly reduced in refractory as compared to responsive primary rat adipocytes . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| AngII induced Janus kinase 2 tyrosine phosphorylation and coimmunoprecipitation with insulin receptor substrate 1 ( IRS 1 ) and IRS 2 as well as an increase in tyrosine phosphorylation of IRS and its association with growth factor receptor binding protein 2 . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| The Jak 2 dependent activation of the insulin receptor substrate ( IRS ) protein > phosphatidylinositol 3 kinase ( PI3 ' K ) pathway appears to regulate membrane potential in LRb expressing neurons and contributes to the regulation of feeding . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| The tyrosine kinase JAK 2 is a key signaling protein for at least 20 receptors in the cytokine / hematopoietin receptor superfamily and is a component of signaling by insulin receptor and several G protein coupled receptors . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Here we report that SH 2 B , a JAK 2 interacting protein , promotes activation of the PI 3 kinase pathway by recruiting insulin receptor substrate 1 ( IRS 1 ) and IRS 2 in response to leptin . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| A newly developed bridging yeast tri hybrid assay showed that APS dimerizes JAK 2 , insulin receptor and IGF 1 receptor kinases using its SH 2 and dimerization domains . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| The insulin like effects are mediated by the cytosolic tyrosine kinase Janus kinase 2 ( JAK 2 ) upon GH GH receptor interaction , resulting in tyrosine phosphorylation of downstream targets including the GH receptor itself and insulin receptor substrate 1 ( IRS 1 ) and IRS 2 . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| Using pharmacological , biochemical , and cell biological approaches , we show that leptin induced platelet activation required activation of a signaling cascade that included the long form of the leptin receptor , three kinases [ Janus kinase 2 ( JAK 2 ) , phosphatidylinositol 3 kinase ( PI3K ) , and protein kinase B ( PKB / Akt ) ] , the insulin receptor substrate 1 ( IRS 1 ) , and the major human platelet cAMP phosphodiesterase phosphodiesterase 3A ( PDE3A ) . ^^^ |
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| Interacting proteins: P06213 and O60674 |
Pubmed |
SVM Score :0.0 |
| SH 2 B is recruited via its SH 2 domain to various protein tyrosine kinases , including Janus kinase 2 ( Jak 2 ) and the insulin receptor . ^^^ Biochemical studies of SH 2 B and APS demonstrate that , although the SH 2 domains of these two adapter proteins share 79 % sequence identity , the SH 2 B SH 2 domain binds preferentially to Jak 2 , whereas the APS SH 2 domain has higher affinity for the insulin receptor . ^^^ |
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