| Interacting proteins: P05121 and P98164 |
Pubmed |
SVM Score :0.7161492 |
| In addition , gp 330 acts in concert with LRP in type 2 pneumocytes to mediate clearance of a variety of proteins involved in plasminogen activation , including uPA : PAI 1 complexes PAI 1 and pro uPA . ( ABSTRACT TRUNCATED AT 250 WORDS ) . 0.7161492^^^ |
|
| Interacting proteins: P05121 and P98164 |
Pubmed |
SVM Score :1.0854593 |
| In the present report , we describe that affinity purified gp 330 from rabbit renal cortex binds plasminogen activator inhibitor type 1 ( PAI 1 ) complexed with urokinase type plasminogen activator ( uPA ) . alpha 2M methylamine , which binds with high affinity to alpha 2MR / LRP , did not bind to gp 330 . 1.0854593^^^ |
|
| Interacting proteins: P05121 and P98164 |
Pubmed |
SVM Score :0.0 |
| The activation of pro uPA to the active two chain uPA is accelerated with uPAR bound pro uPA and is achieved by plasmin and proteases of other classes like cathepsins G and L . uPAR bound uPA is susceptible to inhibition by its specific inhibitors ( PAI 1 , PAI 2 , and PN 1 ) . uPA PAI 1 and uPA PN 1 complexes , but not free uPA , are readily internalized and degraded through a mechanism that involves the multiligand receptors alpha 2 macroglobulin receptor / low density lipoprotein receptor associated protein ( alpha 2 MR ) and epithelial glycoprotein 330 ( gp 330 ) . ^^^ |
|
| Interacting proteins: P05121 and P98164 |
Pubmed |
SVM Score :0.0 |
| Activator / PAI 1 complexes and uncomplexed t PA bind to the multi ligand receptors alpha 2 macroglobulin receptor / low density lipoprotein receptor related protein ( alpha 2MR ) and epithelial glycoprotein 330 ( gp 330 ) . ^^^ The alpha 2MR and gp 330 mediated endocytosis of a ligand ( u PA / PAI 1 complex ) initially bound to another receptor ( u PAR ) is a novel kind of interaction between membrane receptors . ^^^ |
|
| Interacting proteins: P05121 and P98164 |
Pubmed |
SVM Score :0.0 |
| Low density lipoprotein receptor related proteins 1 ( LRP ) and 2 ( gp330 / megalin ) mediate the endocytosis of thrombin PAI 1 , since antagonists of receptor function such as LRP 1 and LRP 2 antibodies and the 39 kDa receptor associated protein blocked 125I thrombin PAI 1 endocytosis and degradation . ^^^ The results highlight a novel mechanism for cellular clearance of thrombin involving native VN promoting the interaction of thrombin and PAI 1 and the subsequent endocytosis of the complex by LRP 1 or LRP 2 . ^^^ |
|
| Interacting proteins: P05121 and P98164 |
Pubmed |
SVM Score :0.0 |
| Gp 330 is expressed by a number of specialized epithelia , including renal proximal tubules , where it can mediate endocytosis of ligands such as complexes of urokinase and the serpin , plasminogen activator inhibitor 1 . ^^^ |
|
| Interacting proteins: P05121 and P98164 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P98164 |
Pubmed |
SVM Score :0.0 |
| NA |
|