| Interacting proteins: P05121 and P24593 |
Pubmed |
SVM Score :0.82534237 |
| This was surprising because IGFBP 5 reportedly interacts with PAI 1 via its heparin binding domain . 0.82534237^^^ Biosensor analysis confirmed that , although wild type IGFBP 5 and N term both bound to PAI 1 , the C term E had greatly decreased interaction with PAI 1 . 0.57344194^^^ |
|
| Interacting proteins: P05121 and P24593 |
Pubmed |
SVM Score :0.57216019 |
| In summary , IGFBP 5 binds specifically to plasminogen activator inhibitor 1 . 0.57216019^^^ |
|
| Interacting proteins: P05121 and P24593 |
Pubmed |
SVM Score :0.0 |
| A potential interaction between the cell death and extracellular matrix remodelling is evident from the observation that IGFBP 5 binds to plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ We thus hypothesized that IGFBP 5 could activate cell death by sequestration of IGF 1 and activate plasminogen cleavage by sequestering PAI 1 . ^^^ |
|
| Interacting proteins: P05121 and P24593 |
Pubmed |
SVM Score :0.0 |
| Since alpha ( s 2 ) casein also binds plasminogen and tissue type plasminogen activator ( t PA ) , resulting in the conversion of plasminogen to plasmin , and since IGFBP 5 binds to plasminogen activator inhibitor 1 ( PAI 1 ) , we investigated whether apoptosis and extracellular matrix ( ECM ) degradation might be coordinately controlled by GH and PRL possibly acting through IGFBP 5 . ^^^ We propose that GH and PRL inhibit apoptosis and ECM remodelling by a process that involves the control of IGF 1 and PAI 1 availability by IGFBP 5 , thus allowing these processes to be tightly coordinated . . ^^^ |
|
| Interacting proteins: P05121 and P24593 |
Pubmed |
SVM Score :0.0 |
| IGFBP 5 also binds to other proteins in ECM , including type 4 collagen and plasminogen activator inhibitor 1 . ^^^ Specific antisera for plasminogen activator inhibitor 1 can coprecipitate IGFBP 5 . ^^^ |
|
| Interacting proteins: P05121 and P24593 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P24593 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P24593 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P24593 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P24593 |
Pubmed |
SVM Score :0.0 |
| NA |
|