| Interacting proteins: P20151 and P05121 |
Pubmed |
SVM Score :0.69705387 |
| N Terminal sequencing shows that hK 2 forms a covalent complex with PAI 1 , PCI and ACT after cleavage at Arg 346 Met347 , Arg 354 Ser355 and Leu 358 Ser359 , respectively . 0.69705387^^^ We show here that hK 2 rapidly forms a complex with plasminogen activator inhibitor 1 ( PAI 1 ) , the primary inhibitor of uPA in tissues . 0.58004587^^^ |
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| Interacting proteins: P20151 and P05121 |
Pubmed |
SVM Score :0.0 |
| METHODS : In this study , we sought to evaluate the effects of Ang 4 on PAI 1 gene and protein expression in a well characterized and immortalized human proximal tubular cell line ( HK 2 ) by Northern blot and enzyme linked immunosorbent assay . ^^^ Finally , pretreatment of HK 2 cells with losartan and N Nicotinoyl Tyr N 3 ( Nalpha CBZ Arg ) Lys His Pro Ile , the specific antagonists of AT 1 and AT 2 receptors , failed to modify PAI 1 mRNA expression as induced by Ang 2 . ^^^ |
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| Interacting proteins: P20151 and P05121 |
Pubmed |
SVM Score :0.0 |
| The present study examined the signaling pathway that is activated by uremic toxins to induce PAI 1 and activate NF kappaB in human renal proximal tubular cells ( HK 2 ) . ^^^ METHODS : Uremic toxins in the form of organic anion were examined their ability to induce oxidative stress , PAI 1 gene expression , and NF kappaB activation in HK 2 . ^^^ |
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| Interacting proteins: P20151 and P05121 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P20151 and P05121 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20151 and P05121 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20151 and P05121 |
Pubmed |
SVM Score :0.0 |
| NA |
|